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Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy.

Zai-Lin Sheu, Chi-Ping Huang, Chao-Hsiang Chang, Chung-Hsin Chen, Jian-Hua Hong, Han-Yu Weng, Ta-Yao Tai, Shiu-Dong Chung, Chi-Wen Lo, Thomas Y Hsueh, Yao-Chou Tsai, Yuan-Hong Jiang, Bing-Juin Chiang, Yung-Tai Chen, Jen-Tai Lin, Wei-Yu Lin, Yeong-Chin Jou, Jen-Shu Tseng, Chia-Chang Wu, Wen-Jeng Wu, Hsin-Chih Yeh,

Tumor multifocality and location are prognostic factors for upper tract urothelial carcinoma (UTUC). However, confounding effects can appear when these two factors are analyzed together. Therefore, we aimed to investigate the impact of tumor distribution on the outcomes of multifocal UTUC after radical nephroureterectomy. From the 2780 UTUC patients in ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):19059]

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Mycotoxin Zearalenone Attenuates Innate Immune Responses and Suppresses NLRP3 Inflammasome Activation in LPS-Activated Macrophages.

Po-Yen Lee, Ching-Chih Liu, Shu-Chi Wang, Kai-Yin Chen, Tzu-Chieh Lin, Po-Len Liu, Chien-Chih Chiu, I-Chen Chen, Yu-Hung Lai, Wei-Chung Cheng, Wei-Ju Chung, Hsin-Chih Yeh, Chi-Han Huang, Chia-Cheng Su, Shu-Pin Huang, Chia-Yang Li,

Zearalenone (ZEA) is a mycotoxin that has several adverse effects on most mammalian species. However, the effects of ZEA on macrophage-mediated innate immunity during infection have not been examined. In the present study, bacterial lipopolysaccharides (LPS) were used to induce the activation of macrophages and evaluate the effects of ZEA ... Read more >>

Toxins (Basel) (Toxins)
[2021, 13(9):]

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Deep Learning-Based classification of Breast Cancer Cells Using Transmembrane Receptor Dynamics.

Mirae Kim, Soonwoo Hong, Thomas E Yankeelov, Hsin-Chih Yeh, Yen-Liang Liu,

<h4>Motivation</h4>Motions of transmembrane receptors on cancer cell surfaces can reveal biophysical features of the cancer cells, thus providing a method for characterizing cancer cell phenotypes. While conventional analysis of receptor motions in the cell membrane mostly relies on the mean-squared displacement plots, much information is lost when producing these plots ... Read more >>

Bioinformatics (Bioinformatics (Oxford, England))
[2021, :]

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Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.

Chi-Han Huang, Shu-Chi Wang, I-Chen Chen, Yi-Ting Chen, Po-Len Liu, Shih-Hua Fang, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Tzu-Chieh Lin, Wei-Chung Cheng, Chia-Cheng Su, Hsin-En Wu, Yuan-Ru Chen, Chia-Yang Li,

Piplartine (or Piperlongumine) is a natural alkaloid isolated from <i>Piper longum</i> L., which has been proposed to exhibit various biological properties such as anti-inflammatory effects; however, the effect of piplartine on sepsis has not been examined. This study was performed to examine the anti-inflammatory activities of piplartine in vitro, ex ... Read more >>

Pharmaceuticals (Basel) (Pharmaceuticals (Basel, Switzerland))
[2021, 14(6):]

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How to manage patients with suspected upper tract urothelial carcinoma in the pandemic of COVID-19?

Hsiang-Ying Lee, Erica On-Ting Chan, Ching-Chia Li, David Leung, Wei-Ming Li, Hsin-Chih Yeh, Peter Ka-Fung Chiu, Hung-Lung Ke, Chi-Hang Yee, Joseph Hon-Ming Wong, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Wen-Jeng Wu,

<h4>Background</h4>The pandemic of COVID-19 has disrupted the clinical pathway for patients with suspected upper tract urothelial carcinoma (UTUC). This aims to investigate the optimal management of UTUC during the pandemic by determining 1) Whether a three-month delay of RNU leads to worsened overall survival, 2) Whether radical nephroureterectomy (RNU) can ... Read more >>

Urol Oncol (Urologic oncology)
[2021, 39(10):733.e11-733.e16]

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Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma.

Yung-Chun Su, Sheng-Chen Wen, Ching-Chia Li, Hsiao-Chun Su, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Chia-Yang Li, Sheau-Fang Yang, Hung-Pin Tu, Wen-Jeng Wu, Hsin-Chih Yeh,

The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial ... Read more >>

Biomedicines (Biomedicines)
[2021, 9(6):]

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Recent developments in the characterization of nucleic acid hybridization kinetics.

Yuan-I Chen, Manasa P Sripati, Trung Duc Nguyen, Yin-Jui Chang, Yu-An Kuo, Soonwoo Hong, Hsin-Chih Yeh,

Hybridization of nucleic acids (NAs) is a fundamental molecular mechanism that drives many cellular processes and enables new biotechnologies as well as therapeutics. However, existing methods that measure hybridization kinetics of nucleic acids are either performed at the ensemble level or constrained to non-native physiological conditions. Recent advances in 3D ... Read more >>

Curr Opin Biomed Eng (Current opinion in biomedical engineering)
[2021, 19:]

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Zerumbone Suppresses the LPS-Induced Inflammatory Response and Represses Activation of the NLRP3 Inflammasome in Macrophages.

Chia-Cheng Su, Shu-Chi Wang, I-Chen Chen, Fang-Yen Chiu, Po-Len Liu, Chi-Han Huang, Kuan-Hua Huang, Shih-Hua Fang, Wei-Chung Cheng, Shu-Pin Huang, Hsin-Chih Yeh, Ching-Chih Liu, Po-Yen Lee, Ming-Yii Huang, Chia-Yang Li,

Zerumbone is a natural product isolated from the pinecone or shampoo ginger, <i>Zingiber zerumbet</i> (L.) Smith, which has a wide range of pharmacological activities, including anti-inflammatory effects. However, the effects of zerumbone on activation of the NLRP3 inflammasome in macrophages have not been examined. This study aimed to examine the ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2021, 12:652860]

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Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses.

Hsiang-Ying Lee, Ching-Chia Li, Wei-Ming Li, Ya-Ling Hsu, Hsin-Chih Yeh, Hung-Lung Ke, Bi Wen Yeh, Chun-Nung Huang, Chien-Feng Li, Po-Lin Kuo, Wen-Jeng Wu,

<h4>Background</h4>We aimed to identify prognostic biomarkers of upper tract urothelial carcinomas (UTUCs), including microRNAs (miRNAs) and genes which account for only 5% to 10% of all urothelial carcinomas (UCs). In Taiwan, this figure is markedly higher, where it can reach up to 30% of UC cases.<h4>Materials and methods</h4>Using next-generation sequencing ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11343]

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The impact of urine microbiota in patients with lower urinary tract symptoms.

Hsiang-Ying Lee, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Sung Yong Cho, Hsin-Chih Yeh, Kuang-Shun Chueh, Wen-Jeng Wu, Deng-Chyang Wu,

<h4>Introduction</h4>Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of BPH and can influence the severity of lower urinary tract symptoms (LUTS).<h4>Materials and methods</h4>We collected mid-stream voided urine samples ... Read more >>

Ann Clin Microbiol Antimicrob (Annals of clinical microbiology and antimicrobials)
[2021, 20(1):23]

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High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma.

Yi-Ru Wu, Yi-Chen Lee, Wei-Ming Li, Wei-Chi Hsu, Hui-Hui Lin, Lin-Li Chang, A-Mei Huang, Jhen-Hao Jhan, Wen-Jeng Wu, Ching-Chia Li, Hsiang-Ying Lee, Hsin-Chih Yeh, Hung-Lung Ke,

Upper tract urothelial carcinoma (UTUC) is a rare tumor with an incidence that varies greatly between Eastern and Western countries. Transaldolase 1 (TALDO1) is a rate-limiting enzyme of the pentose phosphate pathway. In humans, aberrant TALDO1 activity has been implicated in various autoimmune diseases and malignancies; however, the function of ... Read more >>

Pathol Int (Pathology international)
[2021, 71(7):463-470]

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Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region.

Yung-Tai Chen, Chih-Chin Yu, Hsin-Chih Yeh, Hsiang-Ying Lee, Yuan-Hong Jiang, Yu-Khun Lee, Chia-Hao Kuei, Chia-Chang Wu, Chao-Yuan Huang, Wei-Yu Lin, Cheng Kuang Yang, Yao Chou Tsai,

Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):4040]

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Bi-directional Modeling Between Cross-Scale Neural Activity

Yin-Jui Chang, Yuan-I Chen, Hsin-Chih Yeh, Jose Carmena, Samantha Santacruz,

Fundamental principles underlying computation in multi-scale brain networks illustrate how multiple brain areas and their coordinated activity give rise to complex cognitive functions. Whereas the population brain activity has been studied in the micro-to meso-scale in building the connections between the dynamical patterns and the behaviors, such studies were often ... Read more >>

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Deep learning enables rapid and robust analysis of fluorescence lifetime imaging in photon-starved conditions

Yuan-I Chen, Yin-Jui Chang, Shih-Chu Liao, Trung Duc Nguyen, Jianchen Yang, Yu-An Kuo, Soonwoo Hong, Yen-Liang Liu, Grady Rylander, Samantha Santacruz, Thomas Yankeelov, Hsin-Chih Yeh,

Fluorescence lifetime imaging microscopy (FLIM) is a powerful tool to quantify molecular compositions and study the molecular states in the complex cellular environment as the lifetime readings are not biased by the fluorophore concentration or the excitation power. However, the current methods to generate FLIM images are either computationally intensive ... Read more >>

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Prognostic Significance of Primary Tumor Location in Upper Tract Urothelial Carcinoma Treated with Nephroureterectomy: A Retrospective, Multi-Center Cohort Study in Taiwan.

Lian-Ching Yu, Chao-Hsiang Chang, Chi-Ping Huang, Chao-Yuan Huang, Jian-Hua Hong, Ta-Yao Tai, Han-Yu Weng, Chi-Wen Lo, Chung-You Tsai, Yu-Khun Lee, Yao-Chou Tsai, Thomas Y Hsueh, Yung-Tai Chen, I-Hsuan Chen, Bing-Juin Chiang, Jen-Shu Tseng, Chia-Chang Wu, Wei-Yu Lin, Tsu-Ming Chien, Zai-Lin Sheu, Ching-Chia Li, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Wen-Jeng Wu, Hsin-Chih Yeh,

We sought to examine the effect of tumor location on the prognosis of patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). This retrospective study came from the Taiwan UTUC Collaboration Group, which consisted of 2658 patients at 15 institutions in Taiwan from 1988 to 2019. Patients ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(12):]

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Single-Site Sutureless Partial Nephrectomy for Small Exophytic Renal Tumors.

Ching-Chia Li, Tsu-Ming Chien, Shu-Pin Huang, Hsin-Chih Yeh, Hsiang-Ying Lee, Hung-Lung Ke, Sheng-Chen Wen, Wei-Che Chang, Yung-Shun Juan, Yii-Her Chou, Wen-Jeng Wu,

Partial nephrectomy (PN) is the standard procedure for most patients with localized renal cancer. Laparoscopy has become the preferred surgical approach to target this cancer, but the steep learning curve with laparoscopic PN (LPN) remains a concern. In LPN intracorporeal suturing, the operation time is further extended even under robot ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(11):]

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The Impact of Urine Microbiota in Patients With Lower Urinary Tract Symptoms

Hsiang ying Lee, Jiunn‐Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Sung Yong Cho, Hsin-Chih Yeh, Kuang-Shun Chueh, Wen-Jeng Wu, Deng‐Chyang Wu,

<h4>Introduction: </h4> Inflammation and infection are causative factors of benign prostatic hyperplasia (BPH). Urine is not sterile, and urine microbiota identified by DNA sequencing can play an important role in the development of BPH and can influence the severity of lower urinary tract symptoms (LUTS).Materials and methodsWe collected mid-stream voided ... Read more >>

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Improving NanoCluster Beacon performance by blocking the unlabeled NC probes.

Yu-An Chen, Huong T Vu, Yen-Liang Liu, Yuan-I Chen, Trung Duc Nguyen, Yu-An Kuo, Soonwoo Hong, Yin-An Chen, Savannah Carnahan, Jeffrey T Petty, Hsin-Chih Yeh,

While NanoCluster Beacon (NCB) is a versatile molecular probe, it suffers from a low target-specific signal issue due to impurities. Here we show that adding a "blocker" strand to the reaction can effectively block the nonfunctional probes and enhance the target-specific signal by 14 fold at a 0.1 target/probe ratio. ... Read more >>

Chem Commun (Camb) (Chemical communications (Cambridge, England))
[2019, 55(4):462-465]

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Risk of developing hypertension after hormone therapy for prostate cancer: a nationwide propensity score-matched longitudinal cohort study.

Yi-Hsuan Wu, Jhen-Hao Jhan, Hung-Lung Ke, Shih-I Tseng, Yu-Han Chang, Hsin-Chih Yeh, Ching-Chia Li, Yung-Chin Lee,

BackgroundAndrogen deprivation therapy (ADT) is essential in the treatment of advanced and metastatic prostate cancer. As the correlation between hormone therapy and hypertension remains unclear and prostate cancer is less prevalent in the Asian population, the clinician should focus on not only anticancer therapy but also the side effects of ... Read more >>

Int J Clin Pharm (International journal of clinical pharmacy)
[2020, 42(6):1433-1439]

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Pathologic stage as a surrogate for oncologic outcomes after receipt of neoadjuvant chemotherapy for high-grade upper tract urothelial carcinoma.

Nirmish Singla, Alana Christie, Yuval Freifeld, Rashed A Ghandour, Solomon L Woldu, Timothy N Clinton, Firas G Petros, Haley Robyak, Hsin-Chih Yeh, Dong Fang, Dmitry Enikeev, Aditya Bagrodia, Arthur I Sagalowsky, Yair Lotan, Jay D Raman, Surena F Matin, Vitaly Margulis,

<h4>Objective</h4>Whether pathologic stage at radical nephroureterectomy (RNU) can serve as an appropriate surrogate for oncologic outcomes in patients with high-grade (HG) upper tract urothelial carcinoma (UTUC) treated with neoadjuvant chemotherapy (NAC) is not defined. We sought to determine whether patients who achieve pathologically non-muscle-invasive (ypT0, ypTa, ypT1, ypTis) HG UTUC ... Read more >>

Urol Oncol (Urologic oncology)
[2020, 38(12):933.e7-933.e12]

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Validation of Hyponatremia as a Prognostic Predictor in Multiregional Upper Tract Urothelial Carcinoma.

Hsin-Chih Yeh, Ching-Chia Li, Sheng-Chen Wen, Nirmish Singla, Solomon L Woldu, Haley Robyak, Chun-Nung Huang, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Chia-Yang Li, Bi-Wen Yeh, Sheau-Fang Yang, Hung-Pin Tu, Shahrokh F Shariat, Arthur I Sagalowsky, Jay D Raman, Yair Lotan, Jer-Tsong Hsieh, Vitaly Margulis, Wen-Jeng Wu,

Hyponatremia has been shown to be associated with prognosis in various cancers, but its role in upper tract urothelial carcinoma (UTUC) is largely unidentified. We created an international multiregional cohort of UTUC, consisting of 524 and 213 patients from Taiwan and the U.S., to validate the significance of hyponatremia. Clinicopathologic ... Read more >>

J Clin Med (Journal of clinical medicine)
[2020, 9(4):]

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Interethnic differences in the impact of body mass index on upper tract urothelial carcinoma following radical nephroureterectomy.

Hsin-Chih Yeh, Ching-Chia Li, Tsu-Ming Chien, Chia-Yang Li, Yen-Chen Cheng, Solomon L Woldu, Haley Robyak, Chun-Nung Huang, Hung-Lung Ke, Wei-Ming Li, Hsiang-Ying Lee, Bi-Wen Yeh, Sheau-Fang Yang, Hung-Pin Tu, Arthur I Sagalowsky, Jay D Raman, Nirmish Singla, Vitaly Margulis, Yair Lotan, Jer-Tsong Hsieh, Wen-Jeng Wu,

<h4>Purpose</h4>Inconsistent prognostic implications of body mass index (BMI) in upper tract urothelial carcinoma (UTUC) have been reported across different ethnicities. In this study, we aimed to analyze the oncologic role of BMI in Asian and Caucasian patients with UTUC.<h4>Methods</h4>We retrospectively collected data from 648 Asian Taiwanese and 213 Caucasian American ... Read more >>

World J Urol (World journal of urology)
[2021, 39(2):491-500]

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Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies.

Chao-Kai Chou, Yen-Liang Liu, Yuan-I Chen, Po-Jung Huang, Pei-Hsiang Tsou, Chun-Te Chen, Heng-Huan Lee, Ying-Nai Wang, Jennifer L Hsu, Jin-Fong Lee, Thomas E Yankeelov, Jun Kameoka, Hsin-Chih Yeh, Mien-Chie Hung,

While monoclonal antibodies are the fastest-growing class of therapeutic agents, we lack a method that can directly quantify the on- and off-target binding affinities of newly developed therapeutic antibodies in crude cell lysates. As a result, some therapeutic antibody candidates could have a moderate on-target binding affinity but a high ... Read more >>

ACS Sens (ACS sensors)
[2020, 5(2):296-302]

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Single-Port Sutureless Partial Nephrectomy for Small Renal Cancer

Ching-Chia Li, Tsu-Ming Chien, Hsin-Chih Yeh, Hsiang-Ying Lee, Hung-Lung Ke, Sheng-Chen Wen, Wei-Che Chang, Yung-Shun Juan, Yii-Her Chou, Wen-Jeng Wu,

<h4>Background: </h4> : Laparoscopic single-port (LESS) sutureless partial nephrectomy (PN) is a technically demanding procedure. Here we shared our experience to reduce the warm ischemia time and shorten the learning curve in performing LESS sutureless PN. <h4>Materials: </h4> and methods : Between 2015 and 2018, custom made LESS sutureless PN ... Read more >>

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Role of the NLRP3 Inflammasome: Insights Into Cancer Hallmarks.

Ting-Yi Lin, Meng-Chun Tsai, Wei Tu, Hsin-Chih Yeh, Shu-Chi Wang, Shu-Pin Huang, Chia-Yang Li,

In response to a variety of stresses, mammalian cells activate the inflammasome for targeted caspase-dependent pyroptosis. The research community has recently begun to deduce that the activation of inflammasome is instigated by several known oncogenic stresses and metabolic perturbations; nevertheless, the role of inflammasomes in the context of cancer biology ... Read more >>

Front Immunol (Frontiers in immunology)
[2020, 11:610492]

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