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A randomized, double-blind, dose-ranging, pilot trial of piperine with resveratrol on the effects on serum levels of resveratrol.

Howard H Bailey, Jeremy J Johnson, Taja Lozar, Cameron O Scarlett, Barbara W Wollmer, KyungMann Kim, Thomas Havinghurst, Nihal Ahmad,

Resveratrol (3,4,5-trihydroxystilbene) is a naturally occurring phytoalexin with purported health-promoting effects, but with limited oral bioavailability. Our prior murine modeling research observed enhanced resveratrol bioavailability with piperine co-administration. In this study, single-dose pharmacokinetics of resveratrol with or without piperine and the associated toxicities were studied on a cohort of healthy ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, 30(3):285-290]

Cited: 0 times

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A phase II randomized placebo-controlled trial of pomegranate fruit extract in men with localized prostate cancer undergoing active surveillance.

David Jarrard, Mikolaj Filon, Wei Huang, Tom Havighurst, Katina DeShong, KyungMann Kim, Badrinath R Konety, Daniel Saltzstein, Hasan Mukhtar, Barbara Wollmer, Chen Suen, Margaret G House, Howard L Parnes, Howard H Bailey,

<h4>Introduction or objective</h4>Men with favorable-risk prostate cancer (PCa) on active surveillance may benefit from intervention strategies to slow or prevent disease progression and the need for definitive treatment. Pomegranate and its extracts have shown antiproliferative and proapoptotic effects in cell lines and animal models, but its effect on human prostate ... Read more >>

Prostate (The Prostate)
[2021, 81(1):41-49]

Cited: 1 time

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Early patient satisfaction following orthopaedic surgery.

Bailey Howard, Ali Aneizi, Vidushan Nadarajah, Patrick M J Sajak, Dominic J Ventimiglia, Cameran I Burt, Min Zhan, Ngozi M Akabudike, R Frank Henn,

<h4>Background</h4>The healthcare industry is shifting its focus from traditional clinical outcome measures to patient satisfaction metrics. This change has caused orthopaedic surgeons to become increasingly interested in factors influencing patient satisfaction, which would allow them to potentially modify these factors in an effort to increase postoperative satisfaction. The objective of ... Read more >>

J Clin Orthop Trauma (Journal of clinical orthopaedics and trauma)
[2020, 11(Suppl 5):S823-S828]

Cited: 0 times

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Effect of forced-air warming blanket position in elective lumbar spine surgery: Intraoperative body temperature and postoperative complications.

Morenikeji Ayodele Buraimoh, Alysa Nash, Bailey Howard, Imran Yousaf, Eugene Koh, Kelley Banagan, Daniel Gelb, David Schreibman, Steven C Ludwig,

Background:Perioperative hypothermia is linked to multiple postoperative complications including increased surgical bleeding, surgical site infection, myocardial events, and increased length of hospital stay. The purpose of this study is to determine the effects of forced-air warming blanket position, above the shoulders versus under the trunk/legs, on intraoperative core body temperature ... Read more >>

Surg Neurol Int (Surgical neurology international)
[2019, 10:229]

Cited: 0 times

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Oncologic Implications of Chronic Hepatitis C Virus Infection.

Jessica P Hwang, Noelle K LoConte, John P Rice, Lewis E Foxhall, Erich M Sturgis, Janette K Merrill, Harrys A Torres, Howard H Bailey,

Chronic hepatitis C virus (HCV) infection increases the risk for several types of cancer, including hepatocellular carcinoma (HCC) and B-cell non-Hodgkin lymphoma, as primary and second primary malignancies. HCV-infected patients with cancer, particularly those undergoing anticancer therapy, are at risk for development of enhanced HCV replication, which can lead to ... Read more >>

J Oncol Pract (Journal of oncology practice)
[2019, 15(12):629-637]

Cited: 1 time

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A Randomized, Placebo-Controlled, Double-Blind, Dose Escalation, Single Dose, and Steady-State Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers.

Jill M Kolesar, Shannon Andrews, Heather Green, Tom C Havighurst, Barbara W Wollmer, Katina DeShong, Douglas E Laux, Helen Krontiras, Donald D Muccio, KyungMann Kim, Clinton J Grubbs, Margaret G House, Howard L Parnes, Brandy M Heckman-Stoddard, Howard H Bailey,

9cUAB30 is a synthetic analogue of 9-cis retinoic acid with chemoprevention activity in cell lines and animal models. The purpose of this phase I placebo-controlled, double-blinded, dose escalation study of 9cUAB30 was to evaluate its safety, pharmacokinetics, and determine a dose for future phase II studies. Participants received a single ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2019, 12(12):903-912]

Cited: 0 times

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A Festschrift in Honor of Edward M. Messing, MD, FACS.

Jean V Joseph, Ralph Brasacchio, Chunkit Fung, Jay Reeder, Kevin Bylund, Deepak Sahasrabudhe, Shu Yuan Yeh, Ahmed Ghazi, Patrick Fultz, Deborah Rubens, Guan Wu, Eric Singer, Edward Schwarz, Supriya Mohile, James Mohler, Dan Theodorescu, Yi Fen Lee, Paul Okunieff, David McConkey, Hani Rashid, Chawnshang Chang, Yves Fradet, Khurshid Guru, Janet Kukreja, Gerald Sufrin, Yair Lotan, Howard Bailey, Katia Noyes, Seymour Schwartz, Kathy Rideout, Gennady Bratslavsky, Steven C Campbell, Ithaar Derweesh, Per-Anders Abrahamsson, Mark Soloway, Leonard Gomella, Dragan Golijanin, Robert Svatek, Thomas Frye, Seth Lerner, Ganesh Palapattu, George Wilding, Michael Droller, Donald Trump,

Bladder Cancer (Bladder cancer (Amsterdam, Netherlands))
[2018, 4(Suppl 1):S1-S43]

Cited: 0 times

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Using ultrahigh-resolution mass spectrometry and toxicity identification techniques to characterize the toxicity of oil sands process-affected water: The case for classical naphthenic acids.

Sarah A Hughes, Ashley Mahaffey, Bryon Shore, Josh Baker, Bruce Kilgour, Christine Brown, Kerry M Peru, John V Headley, Howard C Bailey,

Previous assessments of oil sands process-affected water (OSPW) toxicity were hampered by lack of high-resolution analytical analysis, use of nonstandard toxicity methods, and variability between OSPW samples. We integrated ultrahigh-resolution mass spectrometry with a toxicity identification evaluation (TIE) approach to quantitatively identify the primary cause of acute toxicity of OSPW ... Read more >>

Environ Toxicol Chem (Environmental toxicology and chemistry)
[2017, 36(11):3148-3157]

Cited: 2 times

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A phase I study of tivantinib in combination with temsirolimus in patients with advanced solid tumors.

Christos E Kyriakopoulos, Amy M Braden, Jill M Kolesar, Jens C Eickhoff, Howard H Bailey, Jennifer Heideman, Glenn Liu, Kari B Wisinski,

Background A wide variety of human cancers exhibit dysregulated c-Met activity that has implications in oncogenesis. Phosphorylation of c-Met results in activation of the PI3K/AKT/mTOR pathway. Combined blockade of c-Met and mTOR pathways has shown efficacy in preclinical studies. Tivantinib is a c-Met inhibitor and temsirolimus is a selective mTOR ... Read more >>

Invest New Drugs (Investigational new drugs)
[2017, 35(3):290-297]

Cited: 10 times

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Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy.

David Jarrard, Badrinath Konety, Wei Huang, Tracy Downs, Jill Kolesar, Kyung Mann Kim, Tom Havighurst, Joel Slaton, Margaret G House, Howard L Parnes, Howard H Bailey,

<h4>Introduction and objectives</h4>Prostate cancer (PCa) represents an important target for chemoprevention given its prolonged natural history and high prevalence. Epidemiologic and laboratory data suggest that vitamin D and genistein (soy isoflavone) may decrease PCa progression. The effect of vitamin D on prostate epithelial cell proliferation and differentiation is well documented ... Read more >>

Am J Clin Exp Urol (American journal of clinical and experimental urology)
[2016, 4(2):17-27]

Cited: 6 times

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Phase Ib placebo-controlled, tissue biomarker trial of diindolylmethane (BR-DIMNG) in patients with prostate cancer who are undergoing prostatectomy.

Jason R Gee, Daniel R Saltzstein, Edward Messing, KyungMann Kim, Jill Kolesar, Wei Huang, Thomas C Havighurst, Linda Harris, Barbara W Wollmer, David Jarrard, Margaret House, Howard Parnes, Howard H Bailey,

Epidemiologic, preclinical, and early phase I studies of the cruciferous vegetable bioactive metabolite, 3,3'-diindolylmethane (DIM), support its potential prostate cancer chemopreventive ability. We performed a multicenter, double-blind, placebo-controlled trial of DIM in patients diagnosed with prostate cancer and scheduled for radical prostatectomy. A total of 45 patients with organ-confined prostate ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2016, 25(4):312-320]

Cited: 3 times

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Application of sediment toxicity identification evaluation techniques to a site with multiple contaminants.

Howard C Bailey, Catherine A Curran, Peter Arth, Bonnie P Lo, Rich Gossett,

Sediment toxicity identification evaluations (TIEs) are conducted to determine causes of adverse effects observed in whole-sediment toxicity tests. However, in multiple contaminant scenarios, it is problematic to partition contributions of individual contaminants to overall toxicity. Using data from a site with multiple inputs and contaminants of concern, the authors describe ... Read more >>

Environ Toxicol Chem (Environmental toxicology and chemistry)
[2016, 35(10):2456-2465]

Cited: 1 time

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A Survey of Baseline Tobacco Cessation Clinical Practices and Receptivity to Academic Detailing.

Robert Adsit, Kari Wisinski, Ryan Mattison, Howard Bailey, Michael Fiore,

<h4>Background</h4>Thirty percent of all cancers are directly attributable to smoking, yet tobacco cessation treatment is not commonly provided at cancer clinics.<h4>Objectives</h4>To assess current tobacco cessation practices among Wisconsin cancer clinics and to measure their receptivity to onsite training and technical assistance to increase their delivery of evidence-based tobacco cessation treatment.<h4>Process</h4>An ... Read more >>

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2016, 115(3):143-146]

Cited: 2 times

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American Society of Clinical Oncology Statement: Human Papillomavirus Vaccination for Cancer Prevention.

Howard H Bailey, Linus T Chuang, Nefertiti C duPont, Cathy Eng, Lewis E Foxhall, Janette K Merrill, Dana S Wollins, Charles D Blanke,

American Society of Clinical Oncology (ASCO), the leading medical professional oncology society, is committed to lessening the burden of cancer and as such will promote underused interventions that have the potential to save millions of lives through cancer prevention. As the main providers of cancer care worldwide, our patients, their ... Read more >>

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2016, 34(15):1803-1812]

Cited: 29 times

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Serving the State Through Medical Research.

Howard H Bailey, Robert N Golden,

WMJ (WMJ : official publication of the State Medical Society of Wisconsin)
[2015, 114(6):274-275]

Cited: 0 times

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The effect of sulfate on selenate bioaccumulation in two freshwater primary producers: A duckweed (Lemna minor) and a green alga (Pseudokirchneriella subcapitata).

Bonnie P Lo, James R Elphick, Howard C Bailey, Josh A Baker, Christopher J Kennedy,

Predicting selenium bioaccumulation is complicated because site-specific conditions, including the ionic composition of water, affect the bioconcentration of inorganic selenium into the food web. Selenium tissue concentrations were measured in Lemna minor and Pseudokirchneriella subcapitata following exposure to selenate and sulfate. Selenium accumulation differed between species, and sulfate reduced selenium ... Read more >>

Environ Toxicol Chem (Environmental toxicology and chemistry)
[2015, 34(12):2841-2845]

Cited: 5 times

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A New Toxicity Test Using the Freshwater Copepod Cyclops vernalis.

Emma M Marus, James R Elphick, Howard C Bailey,

The cladocerans Ceriodaphnia dubia and Daphnia magna are widely used in environmental toxicity testing and the test methodologies for these species are well developed. However, copepods are a much more abundant contributor to zooplankton in many lakes, but they are not routinely used in toxicity tests. Therefore, we propose toxicity ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2015, 95(3):357-362]

Cited: 3 times

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Clinical Trial of Acolbifene in Premenopausal Women at High Risk for Breast Cancer.

Carol J Fabian, Bruce F Kimler, Carola M Zalles, Teresa A Phillips, Trina Metheny, Brian K Petroff, Thomas C Havighurst, KyungMann Kim, Howard H Bailey, Brandy M Heckman-Stoddard,

The purpose of this study was to assess the feasibility of using the selective estrogen receptor modulator (SERM) acolbifene as a breast cancer prevention agent in premenopausal women. To do so, we assessed change in proliferation in benign breast tissue sampled by random periareolar fine-needle aspiration (RPFNA) as a primary ... Read more >>

Cancer Prev Res (Phila) (Cancer prevention research (Philadelphia, Pa.))
[2015, 8(12):1146-1155]

Cited: 5 times

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Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma.

Clarke P Anderson, Katherine K Matthay, John P Perentesis, Joseph P Neglia, Howard H Bailey, Judith G Villablanca, Susan Groshen, Beth Hasenauer, John M Maris, Robert C Seeger, C Patrick Reynolds,

<h4>Purpose</h4>To evaluate BSO-mediated glutathione (GSH) depletion in combination with L-PAM for children with recurrent or refractory high-risk neuroblastoma (NB) as a means to enhance alkylator sensitivity.<h4>Procedure</h4>This pilot study (NCI #T95-0092) administered L-S,R-buthionine sulfoximine (BSO) as a bolus followed by 72 hr continuous infusion of either 0.75 g/m(2)/hr (level 1) or ... Read more >>

Pediatr Blood Cancer (Pediatric blood & cancer)
[2015, 62(10):1739-1746]

Cited: 15 times

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Clinical cancer advances 2015: Annual report on progress against cancer from the American Society of Clinical Oncology.

Gregory A Masters, Lada Krilov, Howard H Bailey, Marcia S Brose, Harold Burstein, Lisa R Diller, Don S Dizon, Howard A Fine, Gregory P Kalemkerian, Mark Moasser, Michael N Neuss, Steven J O'Day, Olatoyosi Odenike, Charles J Ryan, Richard L Schilsky, Gary K Schwartz, Alan P Venook, Sandra L Wong, Jyoti D Patel,

J Clin Oncol (Journal of clinical oncology : official journal of the American Society of Clinical Oncology)
[2015, 33(7):786-809]

Cited: 51 times

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Maintenance rituximab following induction chemo-immunotherapy for mantle cell lymphoma: long-term follow-up of a pilot study from the Wisconsin Oncology Network.

Vaishalee P Kenkre, Walter L Long, Jens C Eickhoff, Jules H Blank, Thomas A McFarland, Wayne Bottner, Hamied Rezazedeh, Jae E Werndli, Howard H Bailey, Brad S Kahl,

Mantle cell lymphoma (MCL) is challenging to manage, with a median survival of 3-5 years. While intensive strategies are often appropriate for younger patients, these approaches are often not appropriate for older patients. In 2006, we reported our initial results using modified R-hyperCVAD (rituximab with hyperfractionated cyclophosphamide, vincristine, doxorubicin, and ... Read more >>

Leuk Lymphoma (Leukemia & lymphoma)
[2011, 52(9):1675-1680]

Cited: 26 times

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Epidemiologic factors and urogenital infections associated with preterm birth in a midwestern U.S. population.

William A Agger, Danish Siddiqui, Steven D Lovrich, Steven M Callister, Andrew J Borgert, Kenneth W Merkitch, Tina C Mason, Dennis J Baumgardner, James K Burmester, Sanjay K Shukla, Joseph D Welter, Katharina S Stewart, M J Washburn, Howard H Bailey,

<h4>Objective</h4>To correlate epidemiologic factors with urogenital infections associated with preterm birth.<h4>Methods</h4>Pregnant women were sequentially included from four Wisconsin cohorts: large urban, midsize urban, small city, and rural city. Demographic, clinical, and current pregnancy data were collected. Cervical and urine specimens were analyzed by microscopy, culture, and polymerase chain reaction for ... Read more >>

Obstet Gynecol (Obstetrics and gynecology)
[2014, 124(5):969-977]

Cited: 15 times

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Cancer chemoprevention is not a failure.

Vaqar Mustafa Adhami, Howard H Bailey, Hasan Mukhtar,

Carcinogenesis (Carcinogenesis)
[2014, 35(9):2154-2155]

Cited: 11 times

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A phase I study to determine the maximum tolerated dose and safety of oral LR-103 (1α,24(S)Dihydroxyvitamin D2) in patients with advanced cancer.

Kari B Wisinski, Wendy M Ledesma, Jill Kolesar, George Wilding, Glenn Liu, Jeffrey Douglas, Anne M Traynor, Mark Albertini, Daniel Mulkerin, Howard H Bailey,

<h4>Background</h4>The objective of this study was to determine the maximum tolerated dose and safety of LR-103, a Vitamin D analogue, in patients with advanced cancer.<h4>Methods</h4>In Step A, patients received oral LR-103 once daily in 14-day cycles with intra-patient dose escalation per accelerated dose escalation design. Dose limiting toxicity for Step ... Read more >>

J Oncol Pharm Pract (Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners)
[2015, 21(6):416-424]

Cited: 0 times

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Molecular responses to 17β-estradiol in early life stage salmonids.

Vicki L Marlatt, Jinying Sun, Cat A Curran, Howard C Bailey, Chris K Kennedy, James R Elphick, Christopher J Martyniuk,

Environmental estrogens (EE) are ubiquitous in many aquatic environments and biological responses to EEs in early developmental stages of salmonids are poorly understood compared to juvenile and adult stages. Using 17β-estradiol (E2) as a model estrogen, waterborne exposures were conducted on early life stage rainbow trout (Oncorhynchus mykiss; egg, alevin, ... Read more >>

Gen Comp Endocrinol (General and comparative endocrinology)
[2014, 203:203-214]

Cited: 6 times

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