Full Text Journal Articles by
Author Hossam Shaltout

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Blood pressure and the kidney cortex transcriptome response to high sodium diet challenge in female nonhuman primates

Angelica Riojas, Kimberly Spradling-Reeves, Robert Shade, Sobha Puppala, Clinton Christensen, Shifra Birnbaum, Jeremy Glenn, Cun Li, Hossam Shaltout, Shannan Hall-Ursone, Laura Cox,

Blood pressure (BP) is influenced by genetic variation and sodium intake. Ninety percent of Americans consume more than the AHA recommended amount of sodium. Studies on the impact of genetic variation and sodium intake on BP in nonhuman primates (NHP) to date have focused on males. We hypothesized that variation ... Read more >>

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Children with chronic nausea and orthostatic intolerance have unique brain network organization: A case-control trial.

John E Fortunato, Paul J Laurienti, Ashley L Wagoner, Hossam A Shaltout, Debra I Diz, Jessy L Silfer, Jonathan H Burdette,

<h4>Background</h4>Determine whether subjects with chronic nausea and orthostatic intolerance share common alterations in key brain networks associated with central autonomic control: default mode, salience, and central executive networks, and the insula, a key component of the salience network.<h4>Methods</h4>Ten subjects (ages 12-18 years; 8 females, 2 males) with nausea predominant dyspepsia, orthostatic ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2021, :e14271]

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Sex Differences in MicroRNA Expression and Cardiometabolic Risk Factors in Hispanic Adolescents with Obesity.

Genesio M Karere, Laura A Cox, Andrew C Bishop, Andrew M South, Hossam A Shaltout, Maria-Gisela Mercado-Deane, Suzanne Cuda,

<h4>Objective</h4>To evaluate sex differences in microRNA (miRNA) expression, anthropometric measures, and cardiometabolic risk factors in Hispanic adolescents with obesity.<h4>Study design</h4>Cross-sectional study of 68 (60% male) Hispanic adolescents with obesity, aged 13-17 years, recruited from a pediatric weight management clinic. We used small RNA sequencing to identify differentially expressed circulating miRNAs. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2021, 235:138-143.e5]

Cited: 1 time

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Renin-angiotensin system blockade in the COVID-19 pandemic.

Jordana B Cohen, Andrew M South, Hossam A Shaltout, Matthew R Sinclair, Matthew A Sparks,

In the early months of the coronavirus disease 2019 (COVID-19) pandemic, a hypothesis emerged suggesting that pharmacologic inhibitors of the renin-angiotensin system (RAS) may increase COVID-19 severity. This hypothesis was based on the role of angiotensin-converting enzyme 2 (ACE2), a counterregulatory component of the RAS, as the binding site for ... Read more >>

Clin Kidney J (Clinical kidney journal)
[2021, 14(Suppl 1):i48-i59]

Cited: 5 times

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Mediterranean diet, stress resilience, and aging in nonhuman primates.

Carol A Shively, Susan E Appt, Haiying Chen, Stephen M Day, Brett M Frye, Hossam A Shaltout, Marnie G Silverstein-Metzler, Noah Snyder-Mackler, Beth Uberseder, Mara Z Vitolins, Thomas C Register,

Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the ... Read more >>

Neurobiol Stress (Neurobiology of stress)
[2020, 13:100254]

Cited: 6 times

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High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM) improves symptoms and autonomic function for insomnia: A randomized, placebo-controlled clinical trial.

Catherine L Tegeler, Hossam A Shaltout, Sung W Lee, Sean L Simpson, Lee Gerdes, Charles H Tegeler,

<h4>Introduction</h4>Effective insomnia interventions that also address autonomic dysregulation are lacking. We evaluate high-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM<sup>®</sup> ), in a randomized, controlled clinical trial. HIRREM is a noninvasive, closed-loop, allostatic, acoustic stimulation neurotechnology, to support self-optimization of brain rhythms.<h4>Methods</h4>One hundred and seven adults (mean age 45.7, SD ± 5.6, 73 women), ... Read more >>

Brain Behav (Brain and behavior)
[2020, 10(11):e01826]

Cited: 1 time

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Mediterranean Diet, Stress Resilience, and Aging in Nonhuman Primates

Carol Shively, Susan Appt, Haiying Chen, Stephen Day, Brett Frye, Hossam Shaltout, Marnie Silverstein-Metzler, Noah Snyder-Mackler, Beth Uberseder, Mara Vitolins, Thomas Register,

Persistent psychological stress increases the risk of many chronic diseases of aging. Little progress has been made to effectively reduce stress responses or mitigate stress effects suggesting a need for better understanding of factors that influence stress responses. Limited evidence suggests that diet may be a factor in modifying the ... Read more >>

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Lower urinary α-Klotho is associated with lower angiotensin-(1-7) and higher blood pressure in young adults born preterm with very low birthweight.

Andrew M South, Hossam A Shaltout, TanYa M Gwathmey, Elizabeth T Jensen, Patricia A Nixon, Debra I Diz, Mark C Chappell, Lisa K Washburn,

Early-life factors including preterm birth and VLBW increase the risk of hypertension, but the mechanisms remain poorly understood. Reductions in the anti-aging protein α-klotho are associated with hypertension, possibly due to angiotensin (Ang) II activation, but the mechanisms are incompletely understood and clinical evidence is lacking. The association of α-klotho ... Read more >>

J Clin Hypertens (Greenwich) (Journal of clinical hypertension (Greenwich, Conn.))
[2020, 22(6):1033-1040]

Cited: 1 time

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Association of Heart Rate Variability With Cognitive Performance: The Multi-Ethnic Study of Atherosclerosis.

Christopher L Schaich, Diego Malaver, Haiying Chen, Hossam A Shaltout, Adina Zeki Al Hazzouri, David M Herrington, Timothy M Hughes,

Background Heart rate variability (HRV) is associated with vascular risk factors for dementia, but whether HRV is associated with specific domains of cognitive performance is unclear. Methods and Results In the Multi-Ethnic Study of Atherosclerosis (N=3018; mean age 59.3±9.2 years), we assessed the relationship of 10-second HRV to scores on tests ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2020, 9(7):e013827]

Cited: 6 times

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Pilot Trial of a Noninvasive Closed-Loop Neurotechnology for Stress-Related Symptoms in Law Enforcement: Improvements in Self-Reported Symptoms and Autonomic Function.

Catherine L Tegeler, Hossam A Shaltout, Sung W Lee, Sean L Simpson, Lee Gerdes, Charles H Tegeler,

<h4>Background</h4>Law enforcement officers have decreased life expectancy, attributed to work-related exposure to traumatic stress and circadian disruption. Autonomic dysregulation is reported with traumatic stress and chronic insomnia.<h4>Objective</h4>We explore potential benefits for reduced symptoms related to stress and insomnia and improved autonomic function associated with open label use of high-resolution, relational, ... Read more >>

Glob Adv Health Med (Global advances in health and medicine)
[2020, 9:2164956120923288]

Cited: 1 time

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Association of circulating uric acid and angiotensin-(1-7) in relation to higher blood pressure in adolescents and the influence of preterm birth.

Andrew M South, Hossam A Shaltout, Patricia A Nixon, Debra I Diz, Elizabeth T Jensen, T Michael O'Shea, Mark C Chappell, Lisa K Washburn,

Elevated serum uric acid increases the risk of hypertension, and individuals born preterm have higher blood pressure (BP) and uric acid, but the mechanisms remain unclear. Preclinical studies demonstrate uric acid increases BP via increased renin-angiotensin system (RAS) expression, especially angiotensin (Ang) II, but the association of uric acid with ... Read more >>

J Hum Hypertens (Journal of human hypertension)
[2020, 34(12):818-825]

Cited: 2 times

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Influence of race on the effect of premature birth on salivary cortisol response to stress in adolescents.

Callie L Brown, Katherine Myers, Andrew M South, Hossam A Shaltout, Elizabeth T Jensen, Patricia A Nixon, Lisa K Washburn,

<h4>Background</h4>Adolescents born preterm have altered hypothalamic-pituitary-adrenal axis function with a blunted cortisol stress response, however, the influences of intrauterine growth restriction and race are unclear.<h4>Methods</h4>We measured salivary cortisol before and 20 min after a maximal-exercise stress test and calculated the cortisol stress response. We used linear regression to compare cortisol stress ... Read more >>

Pediatr Res (Pediatric research)
[2020, 87(6):1100-1105]

Cited: 0 times

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Antenatal Steroid Exposure, Aerobic Fitness, and Physical Activity in Adolescents Born Preterm with Very Low Birth Weight.

Patricia A Nixon, Hossam A Shaltout, Andrew M South, Elizabeth T Jensen, T Michael O'Shea, Callie L Brown, Lisa K Washburn,

<h4>Objective</h4>To determine whether antenatal corticosteroid exposure is associated with aerobic fitness or physical activity participation in adolescents born preterm with very low birth weight (VLBW).<h4>Study design</h4>Observational cohort study of 14-year-old adolescents (n = 173) born with VLBW between 1992 and 1996 at a regional perinatal center with 91 exposed to antenatal corticosteroids. ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 215:98-106.e2]

Cited: 0 times

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The Role of Heart Rate Variability in Mindfulness-Based Pain Relief.

Adrienne L Adler-Neal, Christian E Waugh, Eric L Garland, Hossam A Shaltout, Debra I Diz, Fadel Zeidan,

Mindfulness meditation is a self-regulatory practice premised on sustaining nonreactive awareness of arising sensory events that reliably reduces pain. Yet, the specific analgesic mechanisms supporting mindfulness have not been comprehensively disentangled from the potential nonspecific factors supporting this technique. Increased parasympathetic nervous system (PNS) activity is associated with pain relief ... Read more >>

J Pain (The journal of pain)
[2020, 21(3-4):306-323]

Cited: 9 times

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Children with orthostatic intolerance exhibit elevated markers of inflammation in the dorsal medulla.

Ashley L Wagoner, John D Olson, Brian M Westwood, John E Fortunato, Debra I Diz, Hossam A Shaltout,

Children with orthostatic intolerance (OI) have exaggerated decreases in heart rate variability (HRV) and suppression of baroreflex sensitivity (BRS) with standing. Accompanying brain transmitter and metabolite profiles are unknown. In this study, we used proton (<sup>1</sup>H) magnetic resonance spectroscopy (<sup>1</sup>H-MRS) to quantify markers of neuronal and glial integrity in a ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2019, 317(2):H323-H329]

Cited: 3 times

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Systemic Outcomes of (Pyr1)-Apelin-13 Infusion at Mid-Late Pregnancy in a Rat Model with Preeclamptic Features.

Liliya M Yamaleyeva, K Bridget Brosnihan, Ebrahim Elsangeedy, Carolynne McGee, Sara Shi, David Caudell, Cynthia Miller, Jasmina Varagic, Michael Bader, Ralf Dechend, Hossam A Shaltout,

Preeclampsia is a syndrome with diverse clinical presentation that currently has no cure. The apelin receptor system is a pleiotropic pathway with a potential for therapeutic targeting in preeclampsia. We established the systemic outcomes of (Pyr<sup>1</sup>)-apelin-13 administration in rats with preeclamptic features (TGA-PE, female transgenic for human angiotensinogen mated to ... Read more >>

Sci Rep (Scientific reports)
[2019, 9(1):8579]

Cited: 3 times

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Comparison of Candesartan and Angiotensin-(1-7) Combination to Mito-TEMPO Treatment for Normalizing Blood Pressure and Sympathovagal Balance in (mREN2)27 Rats.

Manisha Nautiyal, Hossam A Shaltout, Mark C Chappell, Debra I Diz,

Hypertensive transgenic (mRen2)27 rats exhibit impaired baroreflex sensitivity (BRS) for control of heart rate (HR). Intracerebroventricular infusion of Ang-(1-7) improves indices of vagal BRS independent of lowering mean arterial pressure (MAP), whereas AT1 receptor blockade normalizes MAP and indices of sympathetic tone without correcting the vagal BRS. Scavenging cellular reactive ... Read more >>

J Cardiovasc Pharmacol (Journal of cardiovascular pharmacology)
[2019, 73(3):143-148]

Cited: 2 times

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Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.

Ehab D AlFadly, Perihan A Elzahhar, Anna Tramarin, Salwa Elkazaz, Hossam Shaltout, Marwa M Abu-Serie, Jana Janockova, Ondrej Soukup, Doaa A Ghareeb, Ahmed F El-Yazbi, Rim W Rafeh, Nour-Mounira Z Bakkar, Firas Kobeissy, Isabel Iriepa, Ignacio Moraleda, Manal N S Saudi, Manuela Bartolini, Ahmed S F Belal,

Neuroinflammation and cholinergic deficit are key detrimental processes involved in Alzheimer's disease. Hence, in the search for novel and effective treatment strategies, the multi-target-directed ligand paradigm was applied to the rational design of two series of new hybrids endowed with anti-inflammatory and anticholinesterase activity via triple targeting properties, namely able ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2019, 167:161-186]

Cited: 7 times

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Central ANG-(1-7) infusion improves blood pressure regulation in antenatal betamethasone-exposed sheep and reveals sex-dependent effects on oxidative stress.

Alexa S Hendricks, Matthew J Lawson, Jorge P Figueroa, Mark C Chappell, Debra I Diz, Hossam A Shaltout,

Fetal exposure to betamethasone (BMX) as a consequence of glucocorticoid administration to women threatening premature delivery may lead to long-term deleterious effects on the cardiovascular system and dysregulation of blood pressure in exposed adults. Indeed, adult offspring of BMX sheep exhibit increased mean arterial pressure (MAP) and attenuated baroreflex sensitivity ... Read more >>

Am J Physiol Heart Circ Physiol (American journal of physiology. Heart and circulatory physiology)
[2019, 316(6):H1458-H1467]

Cited: 5 times

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Fetal programming and the angiotensin-(1-7) axis: a review of the experimental and clinical data.

Andrew M South, Hossam A Shaltout, Lisa K Washburn, Alexa S Hendricks, Debra I Diz, Mark C Chappell,

Hypertension is the primary risk factor for cardiovascular disease that constitutes a serious worldwide health concern and a significant healthcare burden. As the majority of hypertension has an unknown etiology, considerable research efforts in both experimental models and human cohorts has focused on the premise that alterations in the fetal ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2019, 133(1):55-74]

Cited: 32 times

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Obesity is Associated with Higher Blood Pressure and Higher Levels of Angiotensin II but Lower Angiotensin-(1-7) in Adolescents Born Preterm.

Andrew M South, Patricia A Nixon, Mark C Chappell, Debra I Diz, Gregory B Russell, Hossam A Shaltout, T Michael O'Shea, Lisa K Washburn,

<h4>Objectives</h4>To evaluate if obesity is associated with increased angiotensin II (Ang II) and decreased angiotensin-(1-7) or Ang-(1-7) in the circulation and urine among adolescents born prematurely.<h4>Study design</h4>In a cross-sectional analysis of 175 14-year-olds born preterm with very low birth weight, we quantified plasma and urinary Ang II and Ang-(1-7) and ... Read more >>

J Pediatr (The Journal of pediatrics)
[2019, 205:55-60.e1]

Cited: 11 times

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Association between preterm birth and the renin-angiotensin system in adolescence: influence of sex and obesity.

Andrew M South, Patricia A Nixon, Mark C Chappell, Debra I Diz, Gregory B Russell, Elizabeth T Jensen, Hossam A Shaltout, T Michael OʼShea, Lisa K Washburn,

OBJECTIVES:Preterm birth appears to contribute to early development of cardiovascular disease, but the mechanisms are unknown. Prematurity may result in programming events that alter the renin-angiotensin system. We hypothesized that prematurity is associated with lower angiotensin-(1-7) in adolescence and that sex and obesity modify this relationship. METHODS:We quantified angiotensin II ... Read more >>

J Hypertens (Journal of hypertension)
[2018, 36(10):2092-2101]

Cited: 20 times

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Chronic nausea and orthostatic intolerance: Diagnostic utility of orthostatic challenge duration, Nausea Profile Questionnaire, and neurohumoral measures.

Ashley L Wagoner, Sally E Tarbell, Hossam A Shaltout, Debra I Diz, Debra E Weese-Mayer, John E Fortunato,

<h4>Background</h4>Chronic nausea in pediatrics is a debilitating condition with unclear etiology. We aimed to define hemodynamic and neurohumoral characteristics of chronic nausea associated with orthostatic intolerance in order to improve identification and elucidate mechanism.<h4>Methods</h4>Children (10-18 years) meeting Rome III criteria for functional dyspepsia with nausea and symptoms of orthostatic intolerance (OI) ... Read more >>

Neurogastroenterol Motil (Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society)
[2018, 30(11):e13433]

Cited: 0 times

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Renal function and blood pressure are altered in adolescents born preterm.

Andrew M South, Patricia A Nixon, Mark C Chappell, Debra I Diz, Gregory B Russell, Elizabeth T Jensen, Hossam A Shaltout, T Michael O'Shea, Lisa K Washburn,

BACKGROUND:Preterm birth increases the risk of hypertension and kidney disease. However, it is unclear when changes in blood pressure (BP) and renal function become apparent and what role obesity and sex play. We hypothesized adolescents born preterm have higher BP and worse kidney function compared to term in an obesity- ... Read more >>

Pediatr Nephrol (Pediatric nephrology (Berlin, Germany))
[2019, 34(1):137-144]

Cited: 20 times

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Sex-dependent expression of brain medullary MAP and PI3 kinases in adult sheep with antenatal betamethasone exposure.

Alexa S Hendricks, Hossam A Shaltout, Brain M Westwood, Mark C Chappell, Debra I Diz,

Antenatal betamethasone (BM) therapy for women in jeopardy of premature delivery accelerates the lung development in preterm infants and reduces infant mortality rates, but may induce early programming events with chronic cardiovascular consequences. In a sheep model of fetal programming, <i>in utero</i> BM-exposed (BMX) offspring as adults exhibit elevated mean ... Read more >>

Clin Sci (Lond) (Clinical science (London, England : 1979))
[2018, 132(17):1953-1962]

Cited: 2 times

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