Full Text Journal Articles by
Author Hosny Fouad

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Impaired Endothelium-Dependent Hyperpolarization Underlies Endothelial Dysfunction during Early Metabolic Challenge: Increased ROS Generation and Possible Interference with NO Function.

Rana Alaaeddine, Mohammed A W Elkhatib, Ali Mroueh, Hosny Fouad, Evan I Saad, Marwan E El-Sabban, Frances Plane, Ahmed F El-Yazbi,

Endothelial dysfunction is a hallmark of diabetic vasculopathies. Although hyperglycemia is believed to be the culprit causing endothelial damage, the mechanism underlying early endothelial insult in prediabetes remains obscure. We used a nonobese high-calorie (HC)-fed rat model with hyperinsulinemia, hypercholesterolemia, and delayed development of hyperglycemia to unravel this mechanism. Compared ... Read more >>

J Pharmacol Exp Ther (The Journal of pharmacology and experimental therapeutics)
[2019, 371(3):567-582]

Cited: 4 times

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Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs.

Mohammed A W Elkhatib, Ali Mroueh, Rim W Rafeh, Fatima Sleiman, Hosny Fouad, Evan I Saad, Mohamed A Fouda, Ola Elgaddar, Khodr Issa, Ali H Eid, Assaad A Eid, Khaled S Abd-Elrahman, Ahmed F El-Yazbi,

The onset of vascular impairment precedes that of diagnostic hyperglycemia in diabetic patients suggesting a vascular insult early in the course of metabolic dysfunction without a well-defined mechanism. Mounting evidence implicates adipose inflammation in the pathogenesis of insulin resistance and diabetes. It is not certain whether amelioration of adipose inflammation ... Read more >>

Transl Res (Translational research : the journal of laboratory and clinical medicine)
[2019, 214:121-143]

Cited: 4 times

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