Full Text Journal Articles by
Author Hongyu Liu

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Current status and future perspectives on immunotherapy in neoadjuvant therapy of resectable non-small cell lung cancer.

Xingyu Liu, Huifang Xing, Hongyu Liu, Jun Chen,

Resectable non-small cell lung cancer (NSCLC) is defined as stage I-II, and some locally advanced (stage III) tumor. Despite the associated relatively high recurrence rates after surgery, surgical treatment remains the standard treatment for patients with early-stage NSCLC. At present, neoadjuvant therapy is becoming an increasingly popular therapeutic strategy for ... Read more >>

Asia Pac J Clin Oncol (Asia-Pacific journal of clinical oncology)
[2021, :]

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YKL-40 promotes invasion and metastasis of bladder cancer by regulating epithelial mesenchymal transition.

Hailong Hao, Huiqing Chen, Liwu Xie, Hongyu Liu,

<h4>Objective</h4>This study aims to explore the relevance between YKL-40 and recurrence and progression of bladder cancer, and determine whether YKL-40 can be used as a potential target in patients with bladder cancer.<h4>Methods</h4>We analyzed the invasion and metastasis ability of BIU-87, UMUC3, J82, T24, 5637 and immortalized human bladder epithelial cells ... Read more >>

Ann Med (Annals of medicine)
[2021, 53(1):1170-1178]

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Construction of a circular RNA-microRNA-messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis.

Yongwen Li, Ruifeng Shi, Guangsheng Zhu, Chen Chen, Hua Huang, Min Gao, Songlin Xu, Peijun Cao, Zihe Zhang, Di Wu, Xuanguang Li, Hongyu Liu, Jun Chen,

<h4>Background</h4>Patients with non-small cell lung cancer (NSCLC) are diagnosed in advanced stages and with a poor 5-year survival rate. There is a critical need to identify novel biomarkers to improve the therapy and overall prognosis of this disease.<h4>Methods</h4>Differentially expressed genes (DEGs) were identified from three profiles of GSE101586, GSE101684 and ... Read more >>

Thorac Cancer (Thoracic cancer)
[2021, :]

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Recent advances in the exonuclease III-assisted target signal amplification strategy for nucleic acid detection.

Hongyu Liu, Yuhao You, Youzhuo Zhu, Heng Zheng,

The detection of nucleic acids has become significantly important in molecular diagnostics, gene therapy, mutation analysis, forensic investigations and biomedical development, and so on. In recent years, exonuclease III (Exo III) as an enzyme in the 3'-5' exonuclease family has evolved as a frequently used technique for signal amplification of ... Read more >>

Anal Methods (Analytical methods : advancing methods and applications)
[2021, 13(43):5103-5119]

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A dendritic polyamidoamine supramolecular system composed of pillar[5]arene and azobenzene for targeting drug-resistant colon cancer.

Hongyu Liu, Jie Yang, Xiangjie Yan, Chaoqi Li, Mahmoud Elsabahy, Li Chen, Ying-Wei Yang, Hui Gao,

<i>Fusobacterium nucleatum caused drug-resistant</i> around tumor sites often leads to the failure of chemotherapy during colorectal cancer (CRC) treatment. Multifunctional cationic quaternary ammonium materials have been widely used as broad-spectrum antibacterial agents in antibacterial and anticancer fields. Herein, we design a smart supramolecular quaternary ammonium nanoparticle, namely quaternary ammonium [email protected][5]A ... Read more >>

J Mater Chem B (Journal of materials chemistry. B)
[2021, 9(46):9594-9605]

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MicroRNA-378 regulates adipogenic differentiation in bovine intramuscular preadipocytes by targeting CaMKK2.

Dongwei Li, Heng Wang, Yongmin Li, Changqing Qu, Yunhai Zhang, Hongyu Liu, Xiaorong Zhang,

Intramuscular fat, as one of the most important palatability attribute of beef carcase, is the primary determinant of beef quality. The research of adipogenesis mechanism would provide new insight into intramuscular fatty deposition. Here, the role of microRNA-378 was investigated during bovine adipogenic differentiation. It was revealed that miR-378 expression ... Read more >>

Adipocyte (Adipocyte)
[2021, 10(1):483-492]

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Effect of black soldier fly (Hermetia illucens) larvae meal on lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei.

Yongkang Chen, Shuyan Chi, Shuang Zhang, Xiaohui Dong, Qihui Yang, Hongyu Liu, Beiping Tan, Shiwei Xie,

The present study investigated the effect of black soldier fly (Hermetia illucens) larvae meal (BSF) on hemolymph biochemical indicators, muscle metabolites as well as the lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei. Four diets were formulated in which the control diet contained 25% fishmeal (FM) and 10% ... Read more >>

Br J Nutr (The British journal of nutrition)
[2021, :1-39]

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Prolonging photoperiod promotes testosterone synthesis of Leydig cells by directly targeting local melatonin system in rooster testes†.

Gaoqing Xu, Zhiyu Yuan, Jiani Hou, Jing Zhao, Hongyu Liu, Wenfa Lu, Jun Wang,

The study investigated the effects of prolonging photoperiod on the synthesis of testosterone and melatonin in roosters, and the effect of melatonin on testosterone synthesis in rooster Leydig cells as well as its molecular mechanisms. We randomly divided one hundred and twenty 20-week-old roosters into three groups and provided 6, ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, 105(5):1317-1329]

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Epigallocatechin 3-gallate improves the quality of bull semen cryopreservation.

Zhiqiang Li, Hongtao Wang, Chongshan Yuan, Ping Lu, Yan Zhou, Wenfa Lu, Jing Zhao, Hongyu Liu, Jun Wang,

To determine the effects of epigallocatechin-3-gallate (EGCG) on the cryopreservation of bovine semen, epigallocatechin-3-gallate dissolved with double distilled water to 0.2, 0.4, 0.6 and 0.8 mg/ml were added to the cryopreservation diluent of the bull semen. Then, we used computer-assisted analysis of semen kinematic parameters, staining method to detect membrane function, ... Read more >>

Andrologia (Andrologia)
[2021, :e14310]

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Discriminating BTX Molecules by the Nonselective Metal Oxide Sensor-Based Smart Sensing System.

Hongyu Liu, Gang Meng, Zanhong Deng, Kazuki Nagashima, Shimao Wang, Tiantian Dai, Liang Li, Takeshi Yanagida, Xiaodong Fang,

Discriminating structurally similar volatile organic compounds (VOCs) molecules, such as benzene, toluene, and three xylene isomers (BTX), remains a significant challenge, especially, for metal oxide semiconductor (MOS) sensors, in which selectivity is a long-standing challenge. Recent progress indicates that temperature modulation of a single MOS sensor offers a powerful route ... Read more >>

ACS Sens (ACS sensors)
[2021, 6(11):4167-4175]

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Exploring the efficacy of tumor electric field therapy against glioblastoma: An in vivo and in vitro study.

Hao Wu, Lin Yang, Hanjie Liu, Dan Zhou, Dikang Chen, Xiaoque Zheng, Hui Yang, Chong Li, Jiusheng Chang, Anhua Wu, Zhifei Wang, Nianjun Ren, Shengqing Lv, Yuyang Liu, Muyuan Jia, Jian Lu, Hongyu Liu, Guochen Sun, Zhixiong Liu, Jialin Liu, Ling Chen,

<h4>Aims</h4>Tumor electric fields therapy (TTFields) is emerging as a novel anti-cancer physiotherapy. Despite recent breakthroughs of TTFields in glioma treatment, the average survival time for glioblastoma patients with TTFields is <2 years, even when used in conjugation with traditional anti-cancer therapies. To optimize TTFields-afforded efficacy against glioblastoma, we investigated the cancer ... Read more >>

CNS Neurosci Ther (CNS neuroscience & therapeutics)
[2021, 27(12):1587-1604]

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Upfront Brain Treatments Followed by Lung Surgery Improves Survival for Stage IV Non-small Cell Lung Cancer Patients With Brain Metastases: A Large Cohort Analysis.

Xiaopeng He, Shen Yin, Hongyu Liu, Rong Lu, Kemp Kernstine, David E Gerber, Yang Xie, Donghan M Yang,

<b>Background:</b> Current treatment guidelines for stage IV non-small cell lung cancer (NSCLC) with brain metastases recommend brain treatments, including surgical resection and radiotherapy (RT), in addition to resection of the primary lung tumor. Here, we investigate the less-studied impact of treatment sequence on the overall survival. <b>Methods:</b> The National Cancer ... Read more >>

Front Surg (Frontiers in surgery)
[2021, 8:649531]

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The 'hand as foot' teaching method of uterine prolapse.

Mengjie Tang, Hongyu Liu, Leilei Zhang,

In the course of clinical teaching, due to the lack of understanding of the relationship between the position of the uterus, the cervix, the vagina, many students even know the score generally, but it is difficult to clearly remember this important knowledge point. The application of this teaching method in ... Read more >>

Asian J Surg (Asian journal of surgery)
[2021, :]

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Conceptus interferon gamma is essential for establishment of pregnancy in the pig.

Destiny N Johns, Caroline G Lucas, Caroline A Pfeiffer, Paula R Chen, Ashley E Meyer, Shelbi D Perry, Lee D Spate, Raissa F Cecil, Melissa A Fudge, Melissa S Samuel, Christine M Spinka, Hongyu Liu, Matthew C Lucy, Kevin D Wells, Randall S Prather, Thomas E Spencer, Rodney D Geisert,

Establishment and maintenance of pregnancy in the pig is a complex process that relies on conceptus regulation of the maternal proinflammatory response to endometrial attachment. Following elongation, pig conceptuses secrete interferon gamma (IFNG) during attachment to the endometrial luminal epithelium. The objective here was to determine if conceptus production of ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, :]

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Uterine glands impact embryo survival and stromal cell decidualization in mice.

Pramod Dhakal, Harriet C Fitzgerald, Andrew M Kelleher, Hongyu Liu, Thomas E Spencer,

Uterine glands are essential for the establishment of pregnancy and have critical roles in endometrial receptivity to blastocyst implantation, stromal cell decidualization, and placentation. Uterine gland dysfunction is considered a major contributing factor to pregnancy loss, however our understanding of how glands impact embryo survival and stromal cell decidualization is incomplete. ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(10):e21938]

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A commentary on "The role of rapid intraoperative parathyroid hormone (ioPTH) assay in determining outcome of parathyroidectomy in primary hyperparathyroidism: A systematic review and meta-analysis" (Int J Surg 2021; 92:106042).

Hongyu Liu, Chong Zhang,

Int J Surg (International journal of surgery (London, England))
[2021, 94:106129]

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microRNA-10b promotes the apoptosis of bovine ovarian granulosa cells by targeting plasminogen activator inhibitor-1.

Lewei Guo, Qixuan Huang, Jing Zhao, Hongyu Liu, Wenfa Lu, Jun Wang,

Granulosa cells (GCs) are essential somatic cells in the ovaries, and apoptosis of GCs causes follicular atresia. microRNA-10b (miR-10b) is pivotal for cell apoptosis. However, currently, little is known about the role of miR-10b in bovine ovarian GCs (BGCs). In this study, the effect of miR-10b on the apoptosis of ... Read more >>

Theriogenology (Theriogenology)
[2021, 176:206-216]

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SCReadCounts: estimation of cell-level SNVs expression from scRNA-seq data.

N M Prashant, Nawaf Alomran, Yu Chen, Hongyu Liu, Pavlos Bousounis, Mercedeh Movassagh, Nathan Edwards, Anelia Horvath,

<h4>Background</h4>Recent studies have demonstrated the utility of scRNA-seq SNVs to distinguish tumor from normal cells, characterize intra-tumoral heterogeneity, and define mutation-associated expression signatures. In addition to cancer studies, SNVs from single cells have been useful in studies of transcriptional burst kinetics, allelic expression, chromosome X inactivation, ploidy estimations, and haplotype ... Read more >>

BMC Genomics (BMC genomics)
[2021, 22(1):689]

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Lung microbiota: Unexploited treasure hidden in the immune microenvironment of lung cancer.

Ruifeng Shi, Yongwen Li, Hongyu Liu, Jun Chen,

Thorac Cancer (Thoracic cancer)
[2021, 12(21):2964-2966]

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Untargeted LC-MS-based metabonomic analysis of the effect of photoperiod on the testes of broiler roosters.

Lewei Guo, Qingyu Zhu, Hongyu Liu, Jing Zhao, Wenfa Lu, Jun Wang,

Photoperiod is an important factor that stimulates the reproductive performance of broiler breeder roosters. However, the mechanism by which photoperiod affects the reproductive performance of broiler breeder roosters has not been fully studied. To study the effects of different photoperiods on the reproductive performance of broiler breeder roosters, 120 Arbor ... Read more >>

J Anim Physiol Anim Nutr (Berl) (Journal of animal physiology and animal nutrition)
[2021, :]

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Prediction Model for Lung Cancer in High-Risk Nodules Being Considered for Resection: Development and Validation in a Chinese Population.

Chunqiu Xia, Minghui Liu, Xin Li, Hongbing Zhang, Xuanguang Li, Di Wu, Dian Ren, Yu Hua, Ming Dong, Hongyu Liu, Jun Chen,

<h4>Background</h4>Determining benign and malignant nodules before surgery is very difficult when managing patients with pulmonary nodules, which further makes it difficult to choose an appropriate treatment. This study aimed to develop a lung cancer risk prediction model for predicting the nature of the nodule in patients' lungs and deciding whether ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:700179]

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Improved SNV Discovery in Barcode-Stratified scRNA-seq Alignments.

Prashant N M, Hongyu Liu, Christian Dillard, Helen Ibeawuchi, Turkey Alsaeedy, Hang Chan, Anelia Dafinova Horvath,

Currently, the detection of single nucleotide variants (SNVs) from 10 x Genomics single-cell RNA sequencing data (scRNA-seq) is typically performed on the pooled sequencing reads across all cells in a sample. Here, we assess the gaining of information regarding SNV assessments from individual cell scRNA-seq data, wherein the alignments are ... Read more >>

Genes (Basel) (Genes)
[2021, 12(10):]

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Association of IGF-1 and IGFBP-3 levels with gastric cancer: A systematic review and meta-analysis.

Hongyu Liu, Huxia Gu, Emad H Kutbi, Shing Cheng Tan, Teck Yew Low, Chong Zhang,

<h4>Purpose</h4>Many studies have investigated the association between serum IGF-1 and IGFBP levels with gastric cancer (GC), but the results remained inconclusive. In this work, we performed a systematic review and meta-analysis to examine the precise association of serum levels of IGF-1 and IGFBP with GC.<h4>Methods</h4>A comprehensive systematic search was carried ... Read more >>

Int J Clin Pract (International journal of clinical practice)
[2021, 75(11):e14764]

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Dietary supplementation of β-conglycinin, with or without sodium butyrate on the growth, immune response and intestinal health of hybrid grouper.

Bin Yin, Hongyu Liu, Beiping Tan, Xiaohui Dong, Shuyan Chi, Qihui Yang, Shuang Zhang,

We investigated the effects of low and high doses of β-conglycinin and the ameliorative effects of sodium butyrate (based on high-dose β-conglycinin) on the growth performance, serum immunity, distal intestinal histopathology, and gene, protein expression related to intestinal health in hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂). The results revealed ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):17298]

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Author Correction: Optimum protein requirement of juvenile orange-spotted grouper (Epinephelus coioides).

Xiaobo Yan, Junjiang Yang, Xiaohui Dong, Beiping Tan, Shuang Zhang, Shuyan Chi, QihuiYang, Hongyu Liu, Yuanzhi Yang,

Sci Rep (Scientific reports)
[2021, 11(1):17938]

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