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Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells.

Jiaqi Lu, Lili Gu, Qin Li, Ningzi Wu, Hongxing Li, Xinyue Zhang,

<h4>Context</h4>Andrographolide (Andro) has a neuroprotective effect and a potential for treating Alzheimer's disease (AD), but the mechanism has not been elucidated.<h4>Objective</h4>The efficacy of Andro on p62-mediated Kelch-like ECH-associated protein 1(Keap1)-Nuclear factor E2 related factor 2 (Nrf2) pathways in the aluminium maltolate (Al(mal)<sub>3</sub>)-induced neurotoxicity in PC12 cell was explored.<h4>Materials and methods</h4>PC12 ... Read more >>

Pharm Biol (Pharmaceutical biology)
[2021, 59(1):232-241]

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Vascular smooth muscle cell-specific miRNA-214 knockout inhibits angiotensin II-induced hypertension through upregulation of Smad7.

Youyou Li, Hongxing Li, Wenjuan Xing, Jianwei Li, Ruikai Du, Dengchao Cao, Yinbo Wang, Xueyi Yang, Guohui Zhong, Yinlong Zhao, Weijia Sun, Caizhi Liu, Xingcheng Gao, Yeheng Li, Zizhong Liu, Xiaoyan Jin, Dingsheng Zhao, Yingjun Tan, Yanqing Wang, Shujuan Liu, Min Yuan, Jinping Song, Yan-Zhong Chang, Feng Gao, Shukuan Ling, Yingxian Li,

Vascular remodeling is a prominent trait during the development of hypertension, attributable to the phenotypic transition of vascular smooth muscle cells (VSMCs). Increasing studies demonstrate that microRNA plays an important role in this process. Here, we surprisingly found that smooth muscle cell-specific miR-214 knockout (miR-214 cKO) significantly alleviates angiotensin II ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(11):e21947]

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Spin-dependent Schottky barriers and vacancy-induced spin-selective ohmic contacts in magnetic vdW heterostructures.

Hongxing Li, Yuan-Kai Xu, Zi-Peng Cheng, Bin-Guang He, Wei-Bing Zhang,

2D ferromagnets, such as CrX<sub>3</sub> (X = Cl, Br and I), have been attracting extensive attention since they provide novel platforms to fundamental physics and device applications. Integrating CrX<sub>3</sub> with other electrodes and substrates is an essential step to their device realization. Therefore, it is important to understand the interfacial ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2020, 22(17):9460-9466]

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Production of xylitol by Saccharomyces cerevisiae using waste xylose mother liquor and corncob residues.

Yao He, Hongxing Li, Liyuan Chen, Liyuan Zheng, Chunhui Ye, Jin Hou, Xiaoming Bao, Weifeng Liu, Yu Shen,

Exorbitant outputs of waste xylose mother liquor (WXML) and corncob residue from commercial-scale production of xylitol create environmental problems. To reduce the wastes, a Saccharomyces cerevisiae strain tolerant to WXML was conferred with abilities to express the genes of xylose reductase, a xylose-specific transporter and enzymes of the pentose phosphate ... Read more >>

Microb Biotechnol (Microbial biotechnology)
[2021, 14(5):2059-2071]

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Delay-Dependent Switching Approaches for Stability Analysis of Two Additive Time-Varying Delay Neural Networks.

Xiaoyu Zhang, Degang Wang, Kaoru Ota, Mianxiong Dong, Hongxing Li,

This article analyzes the exponentially stable problem of neural networks (NNs) with two additive time-varying delay components. Disparate from the previous solutions on this similar model, switching ideas, that divide the time-varying delay intervals and treat the small intervals as switching signals, are introduced to transfer the studied problem into ... Read more >>

IEEE Trans Neural Netw Learn Syst (IEEE transactions on neural networks and learning systems)
[2021, PP:]

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A novel TLE6 mutation, c.541+1G>A, identified using whole-exome sequencing in a Chinese family with female infertility.

Bin Mao, Xueling Jia, Hongfang Liu, Xiaojuan Xu, Xiaodong Zhao, Yue Yuan, Hongxing Li, Xiaoling Ma, Lili Zhang,

<h4>Background</h4>Oocytes have a lot of maternal RNAs and proteins, which are used by the early embryo before zygotic genome activation. Transducin-like enhancer of split 6 (TLE6) is a component of a subcortical maternal complex which plays a critical role in early embryonic development.<h4>Methods</h4>The patient had been diagnosed with primary infertility ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2021, 9(8):e1743]

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Effect of thickness and stacking order on Raman spectrum of layered CrCl3.

Zi-Peng Cheng, Bin-Guang He, Hongxing Li, Wei-Bing Zhang,

Layer- and stacking-dependent physical properties discovered in van der Waals materials have attracted a lot of attention recently. In this work, we have investigated the Raman spectrum of layered magnetic CrCl<sub>3</sub>with different atomic thickness and stacking order from first principles. Our study indicates Raman shift of<i>R</i>3̄and<i>C</i>2/<i>m</i>phase is near degenerate except ... Read more >>

J Phys Condens Matter (Journal of physics. Condensed matter : an Institute of Physics journal)
[2021, 33(35):]

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Hybridization Chain Reaction-Amplified Electrochemical DNA-Based Sensors Enable Calibration-Free Measurements of Nucleic Acids Directly in Whole Blood.

Shaoguang Li, Hongxing Li, Xun Li, Man Zhu, Hui Li, Fan Xia,

Hybridization chain reaction (HCR) amplification strategy has been extensively explored for the application of electrochemical DNA-based sensors. Despite the enhancement in its sensitivity using the HCR, such sensor platform exhibited significant sensor-to-sensor variations in current due to variations in probe counts and lengths. To circumvent this, we are developing here ... Read more >>

Anal Chem (Analytical chemistry)
[2021, 93(23):8354-8361]

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Risk factors for the occurrence and recurrence of acute cerebellar ataxia: a retrospective observational study.

Zhongxian Zhu, Weiwei Jiang, Wei Li, Jie Zhang, Xiaofeng Lv, Changgui Lu, Huan Chen, Hongxing Li, Hua Xie, Jie Tang, Chunxia Du, Guanglin Chen, Qiming Geng, Weibing Tang,

<h4>Objective</h4>There is little evidence to support a correlation between abdominal surgery and acute cerebellar ataxia (ACA). We reviewed the records of children with ACA treated at our institution to analyze risk factors for ACA.<h4>Methods</h4>Clinical data of 442 children with ACA treated at Children's Hospital of Nanjing Medical University between November ... Read more >>

Neurol Sci (Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology)
[2021, :]

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Size-dependent melting thermodynamics of nanorods in theory and experiment.

Xinru Song, Hongxing Li, Zixiang Cui, Yongqiang Xue, Jianhua Zhang, Xing Yu, Rong Zhang,

Compared with other morphological nanomaterials, nanorods have many unique properties that are closely related to their thermal stability. However, current studies on melting thermodynamic theory of nanorods are still not perfect, and the mechanism and the quantitative regularities of the effect of size of nanorods on melting thermodynamics still remain ... Read more >>

Phys Chem Chem Phys (Physical chemistry chemical physics : PCCP)
[2019, 21(48):26549-26556]

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Identification of a five-gene signature in association with overall survival for hepatocellular carcinoma.

Lei Yang, Weilong Yin, Xuechen Liu, Fangcun Li, Li Ma, Dong Wang, Hongxing Li,

<h4>Background</h4>Hepatocellular carcinoma (HCC) is considered to be a malignant tumor with a high incidence and a high mortality. Accurate prognostic models are urgently needed. The present study was aimed at screening the critical genes for prognosis of HCC.<h4>Methods</h4>The GSE25097, GSE14520, GSE36376 and GSE76427 datasets were obtained from Gene Expression Omnibus ... Read more >>

PeerJ (PeerJ)
[2021, 9:e11273]

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Effects of Judet Quadricepsplasty in the Treatment of Post-traumatic Extension Contracture of the Knee.

Yong Luo, Hongxing Li, Lin Mei, Xinzhan Mao,

<h4>Objective</h4>To investigate the clinical outcomes and the affecting factors of Judet's quadricepsplasty on the stiffness of post-traumatic knee flexion.<h4>Methods</h4>A retrospective survey was analyzed from June 2015 to October 2018. A total of 15 patients (eight males, seven females; mean age, 48.27 years) with extension contracture of the knee were treated by ... Read more >>

Orthop Surg (Orthopaedic surgery)
[2021, 13(4):1284-1289]

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m6A demethylase ALKBH5 suppresses proliferation and migration of enteric neural crest cells by regulating TAGLN in Hirschsprung's disease.

Binyu Wang, Xiang Fang, Xinhe Sun, Chunxia Du, Lingling Zhou, Xiurui Lv, Yuhan Li, Hongxing Li, Weibing Tang,

<h4>Objectives</h4>This study aims to investigate the role of demethylase ALKBH5 mediated demethylation of TAGLN mRNA in the occurrence of Hirschsprung's disease (HSCR), and to clarify how ALKBH5 reduces the m<sup>6</sup>A level of TAGLN mRNA and inhibits its degradation, thereby inhibiting the proliferation and migration of neural crest cells, and potentially ... Read more >>

Life Sci (Life sciences)
[2021, 278:119577]

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Peptide Derived from AHNAK Inhibits Cell Migration and Proliferation in Hirschsprung's Disease by Targeting the ERK1/2 Pathway.

Yuhan Li, Xiurui Lv, Huan Chen, Zhengke Zhi, Zhonghong Wei, Binyu Wang, LingLing Zhou, Hongxing Li, Weibing Tang,

Hirschsprung's disease (HSCR) is characterized by the lack of ganglion cells in the distal part of the digestive tract. It occurs due to migration disorders of enteric neural crest cells (ENCCs) from 5 to 12 weeks of embryonic development. More and more studies show that HSCR is a result of ... Read more >>

J Proteome Res (Journal of proteome research)
[2021, 20(5):2308-2318]

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Chromosomal analysis for embryos from balanced chromosomal rearrangement carriers using next generation sequencing.

Xiaoling Ma, Xiaojuan Xu, Bin Mao, Hongfang Liu, Hongxing Li, Kun Liu, Dexiao Song, Shilong Xue, Naihui Wang,

We aimed to use next generation sequencing (NGS) to investigate chromosomal abnormalities in blastocyst trophectoderm (TE) samples, and reproductive outcomes with the different types of chromosomal rearrangements (CR) and for each sex of CR carrier. A total of 1189 blastocyst TE samples were evaluated using NGS to detect chromosomal unbalanced ... Read more >>

Mol Reprod Dev (Molecular reproduction and development)
[2021, 88(5):362-370]

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All-Scale Hierarchical Structure Contributing to Ultralow Thermal Conductivity of Zintl Phase CaAg0.2Zn0.4Sb.

Jie Chen, Wenhua Xue, Chen Chen, Hongxing Li, Canying Cai, Qian Zhang, Yumei Wang,

TiNiSi-type Zintl phase CaAgSb can transform into LiGaGe-type Zintl phase CaAg <i><sub>x</sub></i> Zn<sub>(1-</sub> <i><sub>x</sub></i> <sub>)/2</sub>Sb when some of the Ag atoms are substituted by Zn atoms, leading to an ultralow thermal conductivity of ≈0.4 W m<sup>-1</sup> K<sup>-1</sup> in the whole measured temperature range of CaAg<sub>0.2</sub>Zn<sub>0.4</sub>Sb. The microstructure is then investigated ... Read more >>

Adv Sci (Weinh) (Advanced science (Weinheim, Baden-Wurttemberg, Germany))
[2021, 8(11):2100109]

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Enhanced Photoelectrochemical Water Oxidation Performance in Bilayer TiO2 /α-Fe2 O3 Nanorod Arrays Photoanode with Cu : NiOx as Hole Transport Layer and Co-Pi as Cocatalyst.

Hongxing Li, Meisong Yin, Xianglin Li, Rong Mo,

Efficient charge transfer and excellent surface water oxidation kinetics are key factors in determining the photoelectrochemical (PEC) water splitting performance in photoelectrodes. Herein, a bilayer TiO<sub>2</sub> /α-Fe<sub>2</sub> O<sub>3</sub> nanorod (NR) arrays photoanode was prepared with deposited Cu-doped NiO<sub>x</sub> (Cu : NiO<sub>x</sub> ) hole transport layer (HTL) and Co-Pi oxygen evolution reaction (OER) ... Read more >>

ChemSusChem (ChemSusChem)
[2021, 14(11):2331-2340]

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Effects of Diet Induced Weight Reduction on Cartilage Pathology and Inflammatory Mediators in the Joint Tissues.

Antonia RuJia Sun, Xiaoxin Wu, Ross Crawford, Hongxing Li, Lin Mei, Yong Luo, Yin Xiao, Xinzhan Mao, Indira Prasadam,

Obesogenic diets contribute to the pathology of osteoarthritis (OA) by altering systemic and local metabolic inflammation. Yet, it remains unclear how quickly and reproducibly the body responds to weight loss strategies and improve OA. In this study we tested whether switching obese diet to a normal chow diet can mitigate ... Read more >>

Front Med (Lausanne) (Frontiers in medicine)
[2021, 8:628843]

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[Progress in studies on production of chemicals from xylose by Saccharomyces cerevisiae].

Ming Wang, Tao Luan, Jianzhi Zhao, Hongxing Li, Xiaoming Bao,

Effective utilization of xylose is a basis for economic production of biofuels or chemicals from lignocellulose biomass. Over the past 30 years, through metabolic engineering, evolutionary engineering and other strategies, the metabolic capacity of xylose of the traditional ethanol-producing microorganism Saccharomyces cerevisiae has been significantly improved. In recent years, the ... Read more >>

Sheng Wu Gong Cheng Xue Bao (Sheng wu gong cheng xue bao = Chinese journal of biotechnology)
[2021, 37(3):1042-1057]

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Engineering the ligand states by surface functionalization: a new way to enhance the ferromagnetism of CrI3.

Hongxing Li, Zi-Peng Cheng, Bin-Guang He, Wei-Bing Zhang,

The newly discovered 2D magnetic materials provide new opportunities for basic physics research and device applications. However, their low Curie temperature (TC) is a common weakness. In this paper, by combining magnetic Hamiltonian, Wannier functions and first-principles calculations, we systematically study the magnetic properties of monolayer CrI3 functionalized with halogens. ... Read more >>

Nanoscale (Nanoscale)
[2021, 13(9):4821-4827]

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Multibody dynamic modeling and controlling for unmanned bicycle system.

Yongli Zhang, Guoliang Zhao, Hongxing Li,

The accurate mathematical model of the dynamic multi-rigid-body mechanical system of unmanned bicycle is established by using the Kane method, and the derivation is presented in detail. And then, the stability of the unmanned bicycle system is analyzed based on the obtained model. In addition, the influence factors to the ... Read more >>

ISA Trans (ISA transactions)
[2021, :]

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Probing N-Glycan Functions in Human Interleukin-17A Based on Chemically Synthesized Homogeneous Glycoforms.

Hongxing Li, Jun Zhang, Chuanjing An, Suwei Dong,

<i>N</i>-Glycosylation represents an essential type of posttranslational modification for proteins. However, deciphering the functions of <i>N</i>-glycosylation remains a challenge due to the lack of analytical and biochemical methods to accurately differentiate the protein glycoforms with various intact glycans. Here we report our synthesis and evaluation of homogeneously glycosylated interleukin-17A (IL-17A), ... Read more >>

J Am Chem Soc (Journal of the American Chemical Society)
[2021, 143(7):2846-2856]

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Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways.

Shuping Sun, Jiahao Zhang, Hongxing Li, Yunyan Du, Shengli Li, Anqi Li, Xiaoguo Suo, Yang Wang, Qi Sun,

<h4>Ethnopharmacological relevance</h4>Chloranthus serratus is a traditional Chinese medicine for treating arthritis and bruises.<h4>Aim of the study</h4>To investigate the dose-effect relationship and molecular mechanisms of the water extract of C. serratus roots (WECR) in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.<h4>Materials and methods</h4>The cell viability was detected by CCK-8 method. One-step method, DCFH-DA fluorescence probe ... Read more >>

J Ethnopharmacol (Journal of ethnopharmacology)
[2021, 271:113880]

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lncRNA-RMST Functioned as a SOX2 Transcription Co-Regulator to Regulate miR-1251 in the Progression of Hirschsprung's Disease

Lingling Zhou, Zhengke Zhi, Pingfa Chen, Chunxia Du, Binyu Wang, Xiang Fang, Weibing Tang, Hongxing Li,

<h4>Background: </h4> Hirschsprung’s disease (HSCR) is a congenital colon disease characterized by the lack of ganglion cells which is closely related to impaired migration and proliferation of enteric neural crest cells (ENCCs). Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) have been authenticated as an important class of regulators of biological ... Read more >>

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Multiple 'omics'-analysis reveals the role of prostaglandin E2 in Hirschsprung's disease.

Weibing Tang, Minjian Chen, Xuejiang Guo, Kun Zhou, Zechao Wen, Fengli Liu, Xiang Liu, Xiaohua Mao, Xiaowei He, Weiyue Hu, Xian Sun, Junwei Tang, Hongxing Li, Richard Allen White, Wei Lv, Pin Wang, Bo Hang, Rongli Sun, Xinru Wang, Yankai Xia,

The etiology and pathogenesis of Hirschsprung's disease (HSCR) remain largely unknown. We examined colon tissues from three independent populations with a combined analysis of metabolomics, transcriptomics and proteomics to understand HSCR pathogenesis, according to which mouse model was used to examine prostaglandin E2 (PGE2) induced clinical presentation of HSCR. SH-SY5Y ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2021, 164:390-398]

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