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Author Hongwu Meng

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The miR-455-3p/HDAC2 axis plays a pivotal role in the progression and reversal of liver fibrosis and is regulated by epigenetics.

Hongmei You, Ling Wang, Fangtian Bu, Hongwu Meng, Xueyin Pan, Juanjuan Li, Yafei Zhang, Ao Wang, Nana Yin, Cheng Huang, Jun Li,

Histone deacetylases (HDACs), especially HDAC2, play a role in alleviating liver fibrosis; however, the specific upstream regulation mechanism is unknown. Herein, TargetScan was used to predict the potential upstream targets of HDAC2, and the role of miR-455-3p was explored. The dual luciferase reporter assay showed that miR-455-3p binds to the ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21700]

Cited: 0 times

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Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis.

Hongwu Meng, Ling Wang, Hongmei You, Cheng Huang, Jun Li,

Alcoholic hepatitis (AH) is a widely prevalent liver-related disease that results from long-term alcohol consumption. However, there is still a lack of effective treatment. Previous studies have reported that circular RNAs (circRNAs) are related to the development of various diseases. However, the function of circRNAs and their roles in AH ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2019, 862:172642]

Cited: 1 time

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