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Author Hongwei Ling

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Glycemic variability indices determined by self-monitoring of blood glucose are associated with β-cell function in Chinese patients with type 2 diabetes.

Yusheng Zhang, Jiao Dai, Xiao Han, Yue Zhao, Hui Zhang, Xuan Liu, Wei Li, Hongwei Ling, Xiaoyan Zhou, Changjiang Ying,

INTRODUCTION:Glycemic control plays an important role in diabetes management, and self-monitoring of blood glucose (SMBG) is critical to achieving good glycemic control. However, there are few studies about the relationship between SMBG-estimated glycemic indices and β-cell function. Here we investigated the association between glucose variation indices estimated by SMBG and ... Read more >>

Diabetes Res. Clin. Pract. (Diabetes research and clinical practice)
[2020, 164:108152]

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Predictive factors associated with glycaemic response to exenatide in Chinese patients with type 2 diabetes mellitus.

Tao Wang, Fan Zhang, Xiaotong Wang, Xizhi Li, Hongwei Ling, Dongmei Lv, Xiaoxing Yin, Qian Lu,

WHAT IS KNOWN AND OBJECTIVE:Exenatide is widely used in the treatment of type 2 diabetes mellitus (T2DM) because of its established effect on lowering glucose and promotion of weight loss. However, therapeutic response to exenatide varies considerably among patients with T2DM. The purpose of this study was to determine which ... Read more >>

J Clin Pharm Ther (Journal of clinical pharmacy and therapeutics)
[2020, :]

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Glucose fluctuation increased mesangial cell apoptosis related to AKT signal pathway.

Changjiang Ying, Shanshan Wang, Yan Lu, Lei Chen, Yizhen Mao, Hongwei Ling, Xingbo Cheng, Xiaoyan Zhou,

Introduction:Blood glucose fluctuation is an important factor for the development of diabetic complications. Glucose fluctuation aggravated the renal injury in diabetic nephropathy. In the present study, our aim was to investigate the effects of blood glucose fluctuation on the glomerular mesangal cells and its related mechanism. Material and methods:Mesangial cells ... Read more >>

Arch Med Sci (Archives of medical science : AMS)
[2019, 15(3):730-737]

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Zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating AKT signalling-pathway.

Changjiang Ying, Lei Chen, Shanshan Wang, Yizhen Mao, Hongwei Ling, Wei Li, Xiaoyan Zhou,

Oxidative stress is a critical factor in the pathophysiology of diabetic kidney disease. Previous study shows that hyperglycaemia aggravates renal injury through oxidative stress in diabetic model, and antioxidants have beneficial effect on diabetic kidney disease. However, the role of antioxidants in the progression of diabetic kidney disease is poorly ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2017, 90:796-805]

Cited: 4 times

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Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats.

Changjiang Ying, Yizhen Mao, Lei Chen, Shanshan Wang, Hongwei Ling, Wei Li, Xiaoyan Zhou,

Diabetic nephropathy (DN) is one of the most severe diabetic complication and it is becoming become a worldwide epidemic, accounting for approximately one-third of all case of end-stage renal disease. However, the underlying mechanism and strategy to alleviate renal injury remain unclear. In the present study, we assessed the protective ... Read more >>

Int. J. Biol. Macromol. (International journal of biological macromolecules)
[2017, 105(Pt 3):1587-1594]

Cited: 4 times

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Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.

Changjiang Ying, Ting Liu, Hongwei Ling, Mingyue Cheng, Xiaoyan Zhou, Shanshan Wang, Yizhen Mao, Lei Chen, Runze Zhang, Wei Li,

To study the effect of blood glucose variability on cardiac fibrosis and its mechanism in a model of diabetic cardiomyopathy.A total of 45 Sprague Dawley rats were randomly divided into three groups: control, control diabetes mellitus and fluctuated blood glucose groups. Fluctuated blood glucose was induced by daily subcutaneous insulin ... Read more >>

Diab Vasc Dis Res (Diabetes & vascular disease research)
[2017, 14(4):327-335]

Cited: 4 times

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Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats.

Changjiang Ying, Xiaoyan Zhou, Zhenzhen Chang, Hongwei Ling, Xingbo Cheng, Wei Li,

Blood glucose fluctuation is associated with diabetic nephropathy. However, the mechanism by which blood glucose fluctuation accelerates renal injury is not fully understood. The aim of the present study was to assess the effects of blood glucose fluctuation on diabetic nephropathy in rats and investigate its underlying mechanism. Diabetes in ... Read more >>

Endocrine (Endocrine)
[2016, 53(1):81-96]

Cited: 7 times

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