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Author Honglin Niu


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DCBLD2 regulates vascular hyperplasia by modulating the platelet derived growth factor receptor-β endocytosis through Caveolin-1 in vascular smooth muscle cells.

Shuai Wang, Xiaoning Liu, Zeqi Meng, Qi Feng, Yanling Lin, Honglin Niu, Chao Yu, Yanhong Zong, Lingling Guo, Weiwei Yang, Yuehua Ma, Wenjun Zhang, Chenyang Li, Yunran Yang, Wenjuan Wang, Xurui Gao, Yaxin Hu, Chao Liu, Lei Nie,

DCBLD2 is a neuropilin-like transmembrane protein that is up-regulated during arterial remodeling in humans, rats, and mice. Activation of PDGFR-β via PDGF triggers receptor phosphorylation and endocytosis. Subsequent activation of downstream signals leads to the stimulation of phenotypic conversion of VSMCs and arterial wall proliferation, which are common pathological changes ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2022, 36(9):e22488]

Cited: 0 times

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Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress.

Tao Zhang, Yanqing Chi, Yingli Kang, Hua Lu, Honglin Niu, Wei Liu, Ying Li,

Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis mediated by coactivator PGC-1α and its downstream transcription factors NRF1 and TFAM may be a key target in maintaining mitochondrial function. Resveratrol (RESV), a natural polyphenolic antioxidant, ... Read more >>

J Cell Physiol (Journal of cellular physiology)
[2019, 234(4):5033-5043]

Cited: 28 times

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