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Author Hongen Chen

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Low-Density Lipoprotein Cholesterol/High-Density Lipoprotein Cholesterol Ratio and Carotid Intima-Media Thickness: A Cohort Study in China.

Pei Qin, Jing Shi, Liming Cao, Xue Li, Yanmei Lou, Changyi Wang, Jianping Ma, Li Wang, Xiaolin Peng, Hongen Chen, Shan Xu, Ping Zhao, Dongsheng Hu, Fulan Hu,

Low-density lipoprotein cholesterol to high-density lipoprotein cholesterol (LDL-C/HDL-C) ratio may carry additional information and has been suggested as a better predictor for atherosclerosis progression and cardiovascular disease (CVD) than LDL-C and HDL-C alone. Therefore, we aim to explore the association between LDL-C/HDL-C ratio and high carotid intima-media thickness (CIMT) risk ... Read more >>

Lipids (Lipids)
[2020, :]

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Association of TG/HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China.

Yanyan Zhang, Pei Qin, Yanmei Lou, Ping Zhao, Xue Li, Ranran Qie, Xiaoyan Wu, Minghui Han, Shengbing Huang, Yang Zhao, Dechen Liu, Yuying Wu, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Dan Zhao, Shan Xu, Li Wang, Xinping Luo, Ming Zhang, Dongsheng Hu, Fulan Hu,

BACKGROUND:The association of ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-C ratio) change trajectory with risk of type 2 diabetes mellitus (T2DM) remains unknown. The aim of this study was to evaluate the association between risk of T2DM and TG/HDL-C ratio change trajectory. METHODS:A total of 18,444 participants aged 18-80 years ... Read more >>

J Diabetes (Journal of diabetes)
[2020, :]

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Dose-response association of the ZJU index and fatty liver disease risk: A large cohort in China.

Xue Li, Pei Qin, Liming Cao, Yanmei Lou, Jing Shi, Ping Zhao, Changyi Wang, Jianping Ma, Shan Xu, Xiaolin Peng, Hongen Chen, Dan Zhao, Fulan Hu, Yashuang Zhao,

AIMS:To investigate the sex-specific association between the ZJU index and risk of fatty liver disease in a large Chinese cohort. METHODS:Totally 28,729 adults without fatty liver disease at baseline and who completed at least one follow-up of annual examinations between 2009 and 2016 were included in this study. Cox proportional ... Read more >>

J. Gastroenterol. Hepatol. (Journal of gastroenterology and hepatology)
[2020, :]

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High MTHFR promoter methylation levels in men confer protection against ischemic stroke.

Shan Xu, Qianping Shi, Bo Li, Liyuan Han, Guodong Xu, Xiaolin Peng, Hongen Chen, Shuhong Dai, Wancheng Ma, Changyi Wang, Jianping Ma,

The MTHFR gene encodes methylenetetrahydrofolate reductase required for the metabolism of homocysteine (Hcy) - a previously reported independent risk factor for ischemic stroke (IS). In this study, we first aimed to clarify the association between DNA methylation levels in the MTHFR promoter and the risk of IS, followed by the ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):477-486]

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Sex-Specific Association of Serum Uric Acid Level and Change in Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large Cohort Study in China.

Yanmei Lou, Pei Qin, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Li Wang, Dechen Liu, Yang Li, Ping Zhao, Dezhu Han, Dongsheng Hu, Fulan Hu,

Background:Conflicting findings have been reported regarding the sex-specific association between serum uric acid (SUA) level and type 2 diabetes mellitus (T2DM) risk, and no study has explored the association between the change in hyperuricemia status and T2DM risk. The study was aimed at exploring the sex-specific association of baseline SUA ... Read more >>

J Diabetes Res (Journal of diabetes research)
[2020, 2020:9637365]

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The contribution of plasma uric acid to the risk of stroke in hypertensive populations.

Jing Shi, Guanyun Yan, Liming Cao, Xue Li, Yiwei Zhang, Suhua Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Hongen Chen, Fulan Hu, Ran Wang,

BACKGROUND:There is limited available evidence of a relationship between uric acid (UA) level and stroke in hypertensive populations worldwide. We aimed to estimate the relationship between UA level and stroke in Chinese hypertensive populations. METHODS:A total of 4 710 essentially hypertensive Chinese patients, including 307 with stroke, were recruited consecutively ... Read more >>

Cardiovasc J Afr (Cardiovascular journal of Africa)
[2020, 31:1-6]

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Dose-response associations between serum creatinine and type 2 diabetes mellitus risk: A Chinese cohort study and meta-analysis of cohort studies.

Pei Qin, Yanmei Lou, Liming Cao, Jing Shi, Gang Tian, Dechen Liu, Qionggui Zhou, Chunmei Guo, Quanman Li, Yang Zhao, Feiyan Liu, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Ming Zhang, Dongsheng Hu, Fulan Hu,

BACKGROUND:This study aims to investigate the association between serum creatinine and risk of type 2 diabetes mellitus (T2DM) based on a cohort analysis and meta-analysis of cohort studies. METHODS:We enrolled 41 439 participants aged ≥18 years without T2DM at baseline, who had ≥2 health examinations based on an ongoing prospective cohort in ... Read more >>

J Diabetes (Journal of diabetes)
[2020, 12(8):594-604]

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Baseline serum albumin and its dynamic change is associated with type 2 diabetes risk: A large cohort study in China.

Fulan Hu, Yanmei Lou, Jing Shi, Liming Cao, Changyi Wang, Jianping Ma, Xiaolin Peng, Shan Xu, Hongen Chen, Dan Zhao, Yang Zhao, Chunmei Guo, Dechen Liu, Qionggui Zhou, Quanman Li, Feiyan Liu, Gang Tian, Xiaoyan Wu, Ranran Qie, Minghui Han, Shengbing Huang, Ping Zhao, Ming Zhang, Dongsheng Hu, Pei Qin,

BACKGROUND:The study aimed to investigate the associations of baseline serum albumin level and its dynamic change with type 2 diabetes mellitus (T2DM) risk in a large Chinese cohort study. METHODS:This cohort study included 30 442 adults without T2DM at first entry, who completed at least one follow-up of annual examinations between ... Read more >>

Diabetes Metab Res Rev (Diabetes/metabolism research and reviews)
[2020, 36(5):e3296]

Cited: 1 time

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Significant Association of Methylenetetrahydrofolate dehydrogenase 1 Promoter Hypomethylation with Stroke in a Chinese Population with Primary Hypertension.

Changyi Wang, Guodong Xu, Qi Wen, Xiaolin Peng, Hongen Chen, Jingwen Zhang, Shan Xu, Chunhui Zhang, Min Zhang, Jianping Ma, Zhaohui Hui, Jianhang Du, Guifu Wu, Min Ma,

OBJECTIVE:Hypertension and hyperhomocysteinemia are both stroke risk factors. Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) plays a vital role in one-carbon metabolism via encoding a protein with three distinct enzymatic activities (methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formate-tetrahydrofolate ligase). We aimed to elucidate the association between MTHFD1 promoter methylation and stroke in a Chinese ... Read more >>

Ann. Clin. Lab. Sci. (Annals of clinical and laboratory science)
[2019, 49(1):112-118]

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CBS promoter hypermethylation increases the risk of hypertension and stroke.

Changyi Wang, Guodong Xu, Qi Wen, Xiaolin Peng, Hongen Chen, Jingwen Zhang, Shan Xu, Chunhui Zhang, Min Zhang, Jianping Ma, Zhaohui Hui, Guifu Wu, Min Ma,

OBJECTIVES:Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the development of hypertension and stroke. METHODS:Using quantitative methylation-specific PCR, we determined the Cystathionine ... Read more >>

Clinics (Sao Paulo) (Clinics (Sao Paulo, Brazil))
[2019, 74:e630]

Cited: 4 times

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Comparison of coronary heart disease risk assessments among individuals with metabolic syndrome using three diagnostic definitions: a cross-sectional study from China.

Juan Zhou, Qin Gao, Jun Wang, Min Zhang, Jianping Ma, Changyi Wang, Hongen Chen, Xiaolin Peng, Liping Hao,

OBJECTIVE:Metabolic syndrome (MetS) is a notable risk factor of coronary heart disease (CHD). However, there are differences in the methods used to define MetS. The purpose of this study was to determine which MetS definition most fully reflects the 10-year probability of CHD based on the Framingham risk algorithm. DESIGN:Cross-sectional ... Read more >>

BMJ Open (BMJ open)
[2018, 8(10):e022974]

Cited: 1 time

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Association of Plasma 7-Ketocholesterol With Cardiovascular Outcomes and Total Mortality in Patients With Coronary Artery Disease.

Jiayi Song, Duan Wang, Hongen Chen, Xiuwei Huang, Yuan Zhong, Nan Jiang, Chaogang Chen, Min Xia,

7-Ketocholesterol (7-KC), a form of cholesterol oxidation product, plays an essential role in the atherogenesis in animal models.We sought to determine the association of circulating 7-KC with clinical cardiovascular outcomes and total mortality in patients with stable coronary artery disease.We measured the plasma 7-KC levels by high-performance liquid chromatography in ... Read more >>

Circ. Res. (Circulation research)
[2017, 120(10):1622-1631]

Cited: 4 times

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Retinol-Binding Protein-Dependent Cholesterol Uptake Regulates Macrophage Foam Cell Formation and Promotes Atherosclerosis.

Yan Liu, Yuan Zhong, Hongen Chen, Duan Wang, Min Wang, Jing-Song Ou, Min Xia,

BACKGROUND:Retinol-binding protein 4 (RBP4) is an adipokine that plays decisive roles in glucose metabolism and insulin sensitivity. Elevated circulating RBP4 levels were reported to be associated with increased risk for cardiovascular disease, but the precise role of RBP4 in atherosclerotic diseases and its mechanisms of action remain elusive. METHODS:Serum RBP4 ... Read more >>

Circulation (Circulation)
[2017, 135(14):1339-1354]

Cited: 10 times

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Association of Serum Retinoic Acid With Risk of Mortality in Patients With Coronary Artery Disease.

Yan Liu, Hongen Chen, Di Mu, Di Li, Yuan Zhong, Nan Jiang, Yuan Zhang, Min Xia,

Retinoic acid (RA) and its mediated nuclear receptor signaling have broad protective effects on vascular systems. Whether circulating levels of RA are associated with mortality in patients with coronary artery disease is still unknown.To evaluate the association of circulating RA with the risk of mortality.We measured serum RA concentrations in ... Read more >>

Circ. Res. (Circulation research)
[2016, 119(4):557-563]

Cited: 5 times

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Retinol-Binding Protein 4 Induces Hepatic Mitochondrial Dysfunction and Promotes Hepatic Steatosis.

Yan Liu, Di Mu, Hongen Chen, Di Li, Jiayi Song, Yuan Zhong, Min Xia,

Elevated serum retinol-binding protein 4 (RBP4) has been implicated in insulin resistant and nonalcoholic fatty liver disease (NAFLD) subjects; however, the molecular mechanism of RBP4 in NAFLD remains obscure.Hepatic RBP4 mRNA level and its association with lipid accumulation were examined in NAFLD patients and mouse model. Furthermore, human RBP4 overexpressing ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2016, 101(11):4338-4348]

Cited: 10 times

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Circulating Retinoic Acid Levels and the Development of Metabolic Syndrome.

Yan Liu, Hongen Chen, Di Mu, Jiahua Fan, Jiayi Song, Yuan Zhong, Di Li, Min Xia,

In this prospective study, we evaluated the association of retinoic acid (RA) with the metabolic syndrome (MetS) in the Chinese population.A total of 1042 nondiabetic adults from the population-based Nutrition and Health of Aging Population were prospectively followed up for 4 years. Serum RA concentrations was determined and its relationship ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2016, 101(4):1686-1692]

Cited: 5 times

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N-methylnicotinamide protects against endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice.

Nan Jiang, Min Wang, Jiayi Song, Yan Liu, Hongen Chen, Di Mu, Min Xia,

Epidemiological studies have demonstrated that N-methylnicotinamide (MNA) may exert antithrombotic and anti-inflammatory effects on the endothelium. However, the exact role of MNA in endothelial function remains uncertain.Apolipoprotein E-deficient (apoE(-/-) ) mice fed with a high-fat, high-cholesterol diet (HCD) and human umbilical vein endothelial cells (HUVECs) were used to explore the ... Read more >>

Mol Nutr Food Res (Molecular nutrition & food research)
[2016, 60(7):1625-1636]

Cited: 2 times

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Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice.

Wenjing Zhou, Jiacheng Lin, Hongen Chen, Jingjing Wang, Yan Liu, Min Xia,

It has been suggested that retinoic acid (RA) has a potential role in the prevention of atherosclerotic CVD. In the present study, we used J774A.1 cell lines and primary peritoneal macrophages to investigate the protective effects of RA on foam cell formation and atherogenesis in apoE-deficient (apoE- / -) mice. ... Read more >>

Br. J. Nutr. (The British journal of nutrition)
[2015, 114(4):509-518]

Cited: 13 times

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PGC-1β suppresses saturated fatty acid-induced macrophage inflammation by inhibiting TAK1 activation.

Hongen Chen, Yan Liu, Di Li, Jiayi Song, Min Xia,

Inflammation of infiltrated macrophages in adipose tissue is a key contributor to the initiation of adipose insulin resistance. These macrophages are exposed to high local concentrations of free fatty acids (FFAs) and can be proinflammatory activated by saturated fatty acids (SFAs). However, the regulatory mechanisms on SFA-induced macrophage inflammation are ... Read more >>

IUBMB Life (IUBMB life)
[2016, 68(2):145-155]

Cited: 5 times

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Association of serum retinoic acid with hepatic steatosis and liver injury in nonalcoholic fatty liver disease.

Yan Liu, Hongen Chen, Jingjing Wang, Wenjing Zhou, Ruifang Sun, Min Xia,

BACKGROUND: Retinoic acid (RA), an active metabolite of vitamin A (retinol), has been implicated in the regulation of lipid metabolism and hepatic steatosis in animal models. However, the relation between RA and liver histology in patients with nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) is unknown. OBJECTIVE: This ... Read more >>

Am. J. Clin. Nutr. (The American journal of clinical nutrition)
[2015, 102(1):130-137]

Cited: 16 times

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Circulating retinol binding protein 4 is associated with coronary lesion severity of patients with coronary artery disease.

Yan Liu, Duan Wang, Hongen Chen, Min Xia,

OBJECTIVES: This study was to examine the association between plasma retinol binding protein 4 (RBP4) levels and the complexity of angiographic coronary lesion in patients with coronary artery disease (CAD). METHODS AND RESULTS: A cross-sectional and prospective study was carried out in Guangzhou Chinese population. 672 persons were evaluated by ... Read more >>

Atherosclerosis (Atherosclerosis)
[2015, 238(1):45-51]

Cited: 9 times

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Retinol binding protein 4 induces mitochondrial dysfunction and vascular oxidative damage.

Jingjing Wang, Hongen Chen, Yan Liu, Wenjing Zhou, Ruifang Sun, Min Xia,

Mitochondrial dysfunction has been implicated in cardiovascular diseases. Elevation of serum retinol binding protein 4 (RBP4) in patients has been linked to cardiovascular disease. However, the role of RBP4 on mitochondrial oxidative stress and vascular oxidative damage is not well demonstrated. Therefore, we evaluated the impact of RBP4 on the ... Read more >>

Atherosclerosis (Atherosclerosis)
[2015, 240(2):335-344]

Cited: 9 times

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Elevated retinol binding protein 4 induces apolipoprotein B production and associates with hypertriglyceridemia.

Yan Liu, Hongen Chen, Jingjing Wang, Wenjing Zhou, Ruifang Sun, Min Xia,

A high level of retinol binding protein 4 (RBP4) is reported to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between serum RBP4 and metabolic phenotypes is scarce. In the present study, we aimed to evaluate serum RBP4 distribution and its association with ... Read more >>

J Clin Endocrinol Metab (The Journal of clinical endocrinology and metabolism)
[2015, 100(5):E720-8]

Cited: 0 times

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Mathematical modelling of schistosomiasis japonica: comparison of control strategies in the People's Republic of China.

Gail M Williams, Adrian C Sleigh, Yuesheng Li, Zheng Feng, George M Davis, Hongen Chen, Allen G P Ross, Robert Bergquist, Donald P McManus,

We present the first mathematical model on the transmission dynamics of Schistosoma japonicum. The work extends Barbour's classic model of schistosome transmission. It allows for the mammalian host heterogeneity characteristic of the S. japonicum life cycle, and solves the problem of under-specification of Barbour's model by the use of Chinese ... Read more >>

Acta Trop. (Acta tropica)
[2002, 82(2):253-262]

Cited: 72 times

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