Full Text Journal Articles by
Author Homa Ahmadzia

Advertisement

Find full text journal articles






Pharmacoethics and Pregnancy: Overcoming the drug orphan stigma

Jamil Kazma, Johannes van den Anker (NO FURTHER ASSIGNMENTS), Homa Ahmadzia,

There is paucity of evidence to support clinical decision making and counseling related to medication use in pregnancy. Despite multiple efforts from legislative bodies and advocacy groups, the inclusion of pregnant women in clinical drug trials assessing efficacy and safety remains scarce. Pregnancy can be complicated by multiple co-morbidities that ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Normative placental structure in pregnancy using quantitative Magnetic Resonance Imaging.

Nickie Andescavage, Kushal Kapse, Yuan-Chiao Lu, Scott D Barnett, Marni Jacobs, Alexis C Gimovsky, Homa Ahmadzia, Jessica Quistorff, Catherine Lopez, Nicole Reinholdt Andersen, Dorothy Bulas, Catherine Limperopoulos,

<h4>Introduction</h4>To characterize normative morphometric, textural and microstructural placental development by applying advanced and quantitative magnetic resonance imaging (qMRI) techniques to the in-vivo placenta.<h4>Methods</h4>We enrolled 195 women with uncomplicated, healthy singleton pregnancies in a prospective observational study. Women underwent MRI between 16- and 40-weeks' gestation. Morphometric and textural metrics of placental ... Read more >>

Placenta (Placenta)
[2021, 112:172-179]

Cited: 0 times

View full text PDF listing >>



Advertisement

Obstetric hemorrhage risk assessment tool predicts composite maternal morbidity.

Emer L Colalillo, Andrew D Sparks, Jaclyn M Phillips, Chinelo L Onyilofor, Homa K Ahmadzia,

Obstetric hemorrhage is one of the leading preventable causes of maternal mortality in the United States. Although hemorrhage risk-prediction models exist, there remains a gap in literature describing if these risk-prediction tools can identify composite maternal morbidity. We investigate how well an established obstetric hemorrhage risk-assessment tool predicts composite hemorrhage-associated ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):14709]

Cited: 0 times

View full text PDF listing >>



Outcomes of cesarean delivery in obstetric patients with SARS-CoV-2 infection.

Allison Lankford, Jeffrey Berger, Ivy Benjenk, Amanda Jackson, Homa Ahmadzia, Michael Mazzeffi,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Low- and middle-income country abstract representation at the Society for Maternal Fetal Medicine Annual Pregnancy Meeting.

Jamil M Kazma, Monica Saleeb, Savita Potarazu, Elizabeth Stringer, Homa K Ahmadzia, Alexis C Gimovsky,

Int J Gynaecol Obstet (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics)
[2021, 154(3):568-569]

Cited: 0 times

View full text PDF listing >>



Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging.

Nickie Andescavage, Wonsang You, Marni Jacobs, Kushal Kapse, Jessica Quistorff, Dorothy Bulas, Homa Ahmadzia, Alexis Gimovsky, Ahmet Baschat, Catherine Limperopoulos,

<h4>Introduction</h4>Gross and microstructural changes in placental development can influence placental function and adversely impact fetal growth and well-being; however, there is a paucity of invivo tools available to reliably interrogate in vivo placental microstructural development. The objective of this study is to characterize invivo placental microstructural diffusion and perfusion in ... Read more >>

Placenta (Placenta)
[2020, 93:113-118]

Cited: 0 times

View full text PDF listing >>



Developing a model for predicting venous thromboembolism in obese pregnant women in a national study.

Julia Ellis-Kahana, Andrew D Sparks, Alexis C Gimovsky, Andra H James, Homa K Ahmadzia,

<h4>Introduction</h4>Venous thromboembolism (VTE) in pregnancy and postpartum is a leading cause of maternal morbidity and mortality in developed countries, where obesity is a known risk for this complication. Current guidelines vary in which patients qualify for VTE prophylaxis, precluding a uniform approach for management. We sought to derive a risk ... Read more >>

Thromb Res (Thrombosis research)
[2020, 191:42-49]

Cited: 1 time

View full text PDF listing >>



Population pharmacokinetics and pharmacodynamics of Tranexamic acid in women undergoing caesarean delivery.

Shuhui Li, Homa K Ahmadzia, Dong Guo, Elyes Dahmane, Adam Miszta, Naomi L C Luban, Jeffrey S Berger, Andra H James, Alisa S Wolberg, John N van den Anker, Jogarao V S Gobburu,

<h4>Aims</h4>The population pharmacokinetics (PK) and pharmacodynamics (PD) of tranexamic acid (TXA) have not been studied to prevent postpartum haemorrhage (PPH) in pregnant women. It is unclear which TXA dose assures sufficient PPH prevention. This study investigated population PK/PD of TXA in pregnant women who underwent caesarean delivery to determine the ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2021, 87(9):3531-3541]

Cited: 1 time

View full text PDF listing >>



Expanding Access to Fetal Telecardiology During the COVID-19 Pandemic.

Bryanna N Schwartz, Jennifer H Klein, Megan B Barbosa, Sheri L Hamersley, Kimberly W Hickey, Homa K Ahmadzia, Richard E Broth, Thomas L Pinckert, Craig A Sable, Mary T Donofrio, Anita Krishnan,

<b><i>Background:</i></b> This study aims to describe one center's experience in expanding a fetal telecardiology program through collaborative work with maternal fetal medicine (MFM) clinics with the goal of safely reaching mothers during the COVID-19 pandemic. We sought to define the extent of fetal telehealth conversion at a large fetal cardiac ... Read more >>

Telemed J E Health (Telemedicine journal and e-health : the official journal of the American Telemedicine Association)
[2021, :]

Cited: 1 time

View full text PDF listing >>



Optimal use of intravenous tranexamic acid for hemorrhage prevention in pregnant women.

Homa K Ahmadzia, Naomi L C Luban, Shuhui Li, Dong Guo, Adam Miszta, Jogarao V S Gobburu, Jeffrey S Berger, Andra H James, Alisa S Wolberg, John van den Anker,

<h4>Background</h4>Every 2 minutes, there is a pregnancy-related death worldwide, with one-third caused by severe postpartum hemorrhage. Although international trials demonstrated the efficacy of 1000 mg tranexamic acid in treating postpartum hemorrhage, to the best of our knowledge, there are no dose-finding studies of tranexamic acid on pregnant women for postpartum ... Read more >>

Am J Obstet Gynecol (American journal of obstetrics and gynecology)
[2021, 225(1):85.e1-85.e11]

Cited: 3 times

View full text PDF listing >>



Tranexamic acid for the prevention of postpartum hemorrhage: a cost-effectiveness analysis

Wayde Dazelle, Megan Ebner, Jamil Kazma, Homa Ahmadzia,

<h4>Objectives: </h4> To estimate the cost-effectiveness of alternative risk-dictated strategies utilizing prophylactic tranexamic acid (TXA) for the prevention of postpartum hemorrhage (PPH). Study Design: We constructed a microsimulation-based Markov decision-analytic model estimating the cost-effectiveness of three alternative risk-dictated strategies for TXA prophylaxis versus the status quo (no TXA) in a ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Application of a plasmin generation assay to define pharmacodynamic effects of tranexamic acid in women undergoing cesarean delivery.

Adam Miszta, Homa K Ahmadzia, Naomi L C Luban, Shuhui Li, Dong Guo, Lori A Holle, Jeffrey S Berger, Andra H James, Jogarao V S Gobburu, John van den Anker, Bas de Laat, Alisa S Wolberg,

Essentials Tranexamic acid (TXA) is an antifibrinolytic drug used to reduce bleeding. Assaying plasmin generation (PG) in plasma detects clinically relevant TXA levels in vitro and ex vivo. 3.1-16.2 µg/mL TXA half-maximally inhibits PG in plasma from women undergoing cesarean delivery. PG velocity shows the strongest dose-relationship at low TXA concentrations ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2021, 19(1):221-232]

Cited: 3 times

View full text PDF listing >>



"Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendation from the women's SSC of the ISTH": Response to comment from Kitchen et al.

Emmanuel J Favaloro, Ariunzaya Amgalan, Terrence Allen, Maha Othman, Homa K Ahmadzia,

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, 18(9):2420-2422]

Cited: 1 time

View full text PDF listing >>



Risks associated with cesarean delivery during prolonged second stage of labor.

Alexis C Gimovsky, Amelie Pham, Homa K Ahmadzia, Andrew D Sparks, Scott M Petersen,

<h4>Background</h4>Data regarding maternal and fetal morbidities are limited to surgical morbidity per each additional hour in the second stage of labor.<h4>Objective</h4>This study aimed to quantify perinatal morbidities associated with cesarean delivery by duration of the second stage of labor.<h4>Study design</h4>Our work is a retrospective cohort study of cesarean deliveries during ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2021, 3(1):100276]

Cited: 0 times

View full text PDF listing >>



Systematic review of viscoelastic testing (TEG/ROTEM) in obstetrics and recommendations from the women's SSC of the ISTH.

Ariunzaya Amgalan, Terrence Allen, Maha Othman, Homa K Ahmadzia,

Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) are point-of-care viscoelastic devices that use whole blood samples to assess coagulation and fibrinolysis. These devices have been studied extensively in cardiac surgery, but there is limited robust evidence supporting its use in obstetrics. The hesitancy toward its routine use in obstetrics may be ... Read more >>

J Thromb Haemost (Journal of thrombosis and haemostasis : JTH)
[2020, 18(8):1813-1838]

Cited: 3 times

View full text PDF listing >>



Feasibility of QSM in the human placenta.

Zungho Zun, Kushal Kapse, Jessica Quistorff, Nickie Andescavage, Alexis C Gimovsky, Homa Ahmadzia, Catherine Limperopoulos,

<h4>Purpose</h4>Quantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function of the human placenta is oxygen transfer to the developing fetus, which remains difficult to study in utero. The purpose of this study is to investigate the feasibility of ... Read more >>

Magn Reson Med (Magnetic resonance in medicine)
[2021, 85(3):1272-1281]

Cited: 0 times

View full text PDF listing >>



National trends in tranexamic acid use in the peripartum period, 2015-2019.

Homa K Ahmadzia, Elaine B Hynds, Richard L Amdur, Alexis C Gimovsky, Andra H James, Naomi L C Luban,

<h4>Background</h4>The purpose of this study was to measure trends in the use of tranexamic acid (TXA) during delivery in the United States and to evaluate demographic data and morbidity outcomes among these patients.<h4>Methods</h4>This retrospective cohort study includes data from 19 hospitals in the Universal Health Services network. We compared rates ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(3):746-752]

Cited: 0 times

View full text PDF listing >>



The association of maternal hypertensive disorders with neonatal congenital heart disease: analysis of a United States cohort.

Laura Sanapo, Mary T Donofrio, Homa K Ahmadzia, Alexis C Gimovsky, Mohamed A Mohamed,

<h4>Objective</h4>To examine the association of any type of maternal hypertensive disorders of pregnancy (HDP) and neonatal congenital heart diseases (CHD).<h4>Study design</h4>We compared the prevalence of CHD between neonates born to mothers with HDP to those delivered to mothers without HDP among 24,525,889 hospital records of living infants, from a national ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(11):1617-1624]

Cited: 0 times

View full text PDF listing >>



Hemorrhage Risk Assessment on Admission: Utility for Prediction of Maternal Morbidity.

Homa K Ahmadzia, Jaclyn M Phillips, Rose Kleiman, Alexis C Gimovsky, Susan Bathgate, Naomi L C Luban, Richard L Amdur,

<h4>Objective</h4>Hemorrhage is a major cause of maternal morbidity and mortality prompting creation of innovative risk assessment tools to identify patients at highest risk. We aimed to investigate the association of hemorrhage risk assessment with maternal morbidity and to evaluate maternal outcomes after implementation of the risk assessment across hospital sites.<h4>Study ... Read more >>

Am J Perinatol (American journal of perinatology)
[2021, 38(11):1126-1133]

Cited: 1 time

View full text PDF listing >>



Blood type association with bleeding outcomes at delivery in a large multi-center study.

Najeebah A Bade, Jamil M Kazma, Richard L Amdur, Julia Ellis-Kahana, Homa K Ahmadzia,

Postpartum hemorrhage is a leading cause of maternal death globally. Recent studies have associated Type-O group to increased risk of bleeding. We aimed to determine if women with Type-O blood are at higher risk of PPH. This is a retrospective cohort analysis of a multi-center database included women admitted to ... Read more >>

J Thromb Thrombolysis (Journal of thrombosis and thrombolysis)
[2020, 50(2):439-445]

Cited: 0 times

View full text PDF listing >>



A national update on rates of postpartum haemorrhage and related interventions.

Homa K Ahmadzia, Chad A Grotegut, Andra H James,

<h4>Background</h4>Postpartum haemorrhage (PPH) is still a leading cause of maternal morbidity in the US. We aimed to reassess national trends in severe and non-severe PPH using recent data.<h4>Material and methods</h4>We performed a cross-sectional study using the 2001-2012 Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project. Delivery-related hospitalisations with ... Read more >>

Blood Transfus (Blood transfusion = Trasfusione del sangue)
[2020, 18(4):247-253]

Cited: 1 time

View full text PDF listing >>



Fetal acute cerebral vasoreactivity to maternal hyperoxia in low-risk pregnancies: a cross-sectional study.

Laura Sanapo, Tareq Al-Shargabi, Homa K Ahmadzia, David N Schidlow, Mary T Donofrio, Laura Hitchings, Alfred Khoury, G Larry Maxwell, Robin Baker, Dorothy I Bulas, Luis M Gomez, Adre J du Plessis,

<h4>Objective</h4>To establish whether fetal cerebral vasoreactivity (CVR<sub>O2</sub> ), following maternal hyperoxia, is predicted by fetal cerebral and uteroplacental Doppler pulsatility indices (PI) at baseline, fetal pulmonary vasoreactivity to oxygen (PVR<sub>O2</sub> ), gestational age (GA), or sex.<h4>Methods</h4>Pulsatility index of middle (MCA), anterior (ACA), posterior cerebral (PCA), umbilical (UA), uterine (UtA), and ... Read more >>

Prenat Diagn (Prenatal diagnosis)
[2020, 40(7):813-824]

Cited: 0 times

View full text PDF listing >>



Anatomical and physiological alterations of pregnancy.

Jamil M Kazma, John van den Anker, Karel Allegaert, André Dallmann, André Dallmann, Homa K Ahmadzia,

The extensive metabolic demands of pregnancy require specific physiological and anatomical changes. These changes affect almost all organ systems, including the cardiovascular, respiratory, renal, gastrointestinal, and hematologic system. The placenta adds another layer of complexity. These changes make it challenging for clinicians to understand presenting signs and symptoms, or to ... Read more >>

J Pharmacokinet Pharmacodyn (Journal of pharmacokinetics and pharmacodynamics)
[2020, 47(4):271-285]

Cited: 8 times

View full text PDF listing >>



Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States.

Homa K Ahmadzia, Najma Khorrami, Jené A Carter, Juliana Stone, Richard L Amdur,

<h4>Objective</h4>To compare rates of adverse pregnancy outcomes for HIV, tuberculosis, and malaria-infected patients in the United States with those of uninfected patients.<h4>Study design</h4>A nationally representative sample of 24,149,664 singleton live births were identified using pregnancy hospitalizations that resulted in delivery between 1998-2000 and 2009-2011 in this retrospective cohort study. Maternal ... Read more >>

J Perinatol (Journal of perinatology : official journal of the California Perinatal Association)
[2020, 40(2):240-247]

Cited: 0 times

View full text PDF listing >>



Outcomes of women age 40 or more undergoing repeat cesarean or trial of labor after cesarean.

Homa Ahmadzia, Kathryn Denny, Susanne Bathgate, Charles Macri, Scott C Quinlan, Alexis C Gimovsky,

<h4>Aim</h4>Despite the increasing trend in delayed childbirth and the known associated complications in advancing maternal age, limited information exists regarding outcomes in very advanced maternal age by delivery type. This study aims to evaluate maternal and neonatal outcomes in women age 40 or more undergoing cesarean delivery or trial of ... Read more >>

J Matern Fetal Neonatal Med (The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians)
[2021, 34(22):3750-3755]

Cited: 1 time

View full text PDF listing >>



Advertisement


Disclaimer

1.0141 s