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Author Hoda Daabees

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Design, synthesis of novel quinazolinone-based oxobutanonitrile derivatives as antiproliferative agents targeting human breast cancer.

Omaima Mohamed AboulWafa, Hoda Mohamed Gamal El-Din Daabees, Eman Salah Ezz-ElDien,

BACKGROUND:Breast cancer (BC) is among the leading causes of death among women worldwide. Medical interest has focused on quinazolinone derivatives approved and utilized in antitumor medications. OBJECTIVE:Novel quinazolinone-based oxobutanonitrile derivatives were designed, synthesized, and screened for in vitro anti-BC activity. METHODS:The antiproliferative activities were determined using MTT assay against MCF-7 ... Read more >>

Anticancer Agents Med Chem (Anti-cancer agents in medicinal chemistry)
[2021, :]

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Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity.

Mahmoud A Ragab, Mohamed Elagawany, Hoda Daabees, Al-Shaimaa F Ahmed, Eman M Awad, Cyrielle Billon, Bahaa Elgendy, Khaled A M Abouzid, Shaymaa E Kassab,

Nuclear Estrogen receptors (ER) are cytoplasmic proteins; translocated to the nucleus to induce transcriptional signals after getting bound to the estrogen hormone. ER activation implicated in cancer cell proliferation of female reproductive organs. Thus, the discovery of ER antagonists is a reliable strategy to combat estrogen-dependent breast cancer. Endometrial carcinoma ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 119:105554]

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New functionalized 6-thienylpyrimidine-5-carbonitriles as antiproliferative agents against human breast cancer cells.

Omaima M AboulWafa, Hoda M G Daabees, Ali Hammad, Waleed A Badawi,

6-Thienylpyrimidine-5-carbonitrile derivatives were synthesized and screened for their in vitro antiproliferative activities against two human breast cancer cell lines in comparison to 5-fluorouracil as a reference. Compounds 2, 3a-c, and 6b evolved as the most active congeners against both cell lines, while others showed selectivity for only one cell line. ... Read more >>

Arch Pharm (Weinheim) (Archiv der Pharmazie)
[2021, 354(11):e2100177]

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Febuxostat-based amides and some derived heterocycles targeting xanthine oxidase and COX inhibition. Synthesis, in vitro and in vivo biological evaluation, molecular modeling and in silico ADMET studies.

Aya Y Rashad, Shaymaa E Kassab, Hoda G Daabees, Ahmed E Abdel Moneim, Sherif A F Rostom,

Various febuxostat derivatives comprising carboxamide functionalities and different substituted heterocycles were synthesized and evaluated for their biological activities as xanthine oxidase (XO) and cyclooxygenase (COX) inhibitors. All the tested compounds exhibited variable in vitro XO inhibitory activities (IC<sub>50</sub> values 0.009-0.077 µM), among which the analog 17 has emerged as the most ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2021, 113:104948]

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A microfabricated potentiometric sensor for metoclopramide determination utilizing a graphene nanocomposite transducer layer.

Sally S El-Mosallamy, Kholoud Ahmed, Hoda G Daabees, Wael Talaat,

In the recent drug analysis arena, optimizing a green, eco-friendly, and cost-effective technique is the main target. In order to cope with green analytical chemistry principles and the trending development of miniaturized portable and handheld devices, an innovative microfabricated ion-selective electrode for the analysis of metoclopramide (MTP) was developed. The ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2020, 412(27):7505-7514]

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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.

Perihan A Elzahhar, Shrouk M Abd El Wahab, Mohamed Elagawany, Hoda Daabees, Ahmed S F Belal, Ahmed F El-Yazbi, Ali H Eid, Rana Alaaeddine, Rehab R Hegazy, Rasha M Allam, Maged W Helmy, Bahaa Elgendy, Andrea Angeli, Soad A El-Hawash, Claudiu T Supuran,

Cancer is a multifactorial disorder involving multiplicity of interrelated signaling pathways and molecular targets. To that end, a multi-target design strategy was adopted to develop some 1,2,3-triazoles hybridized with some pharmacophoric anticancer fragments, as first-in-class simultaneous inhibitors of COX-2, 15-LOX and tumor associated carbonic anhydrase enzymes. Results revealed that compounds ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2020, 200:112439]

Cited: 3 times

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2-Anilinopyrimidine derivatives: Design, synthesis, in vitro anti-proliferative activity, EGFR and ARO inhibitory activity, cell cycle analysis and molecular docking study.

Omaima M AboulWafa, Hoda M G Daabees, Waleed A Badawi,

Novel anti-proliferative agents possessing pyrimidine scaffolds were designed, synthesized and evaluated for their IC<sub>50</sub> values using MTT assay. Most compounds displayed good to excellent activity against the two tested breast cancer lines (MCF-7 and MDA-MB-231) as compared to 5-FU. The observed IC<sub>50</sub> values for active compounds ranged from 0.27 to ... Read more >>

Bioorg Chem (Bioorganic chemistry)
[2020, 99:103798]

Cited: 1 time

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Design, synthesis, biological evaluation and docking studies of new 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives as potent antioxidants and 15-lipoxygenase inhibitors.

Haydi Saher ElBordiny, Mostafa Mahmoud El-Miligy, Shaymaa Emam Kassab, Hoda Daabees, Waleed Ali Mohamed Ali, Soad Abdelhamid Mohamed El-Hawash,

New candidates of 3-(4,5-dihydro-1H-pyrazol/isoxazol-5-yl)-2-phenyl-1H-indole derivatives (4-7) were designed combining the pyrazoline/isoxazoline heterocycles and 2-phenylindole to explore its potential as 15-lipoxygenase (15-LOX) inhibitors. The design of the new derivatives was based on utilizing the antioxidant properties of pyrazoline, 2-phenylindole and the good 15-LOX inhibition properties of indolylpyrazoline. The derivatives were synthesized ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2018, 145:594-605]

Cited: 4 times

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High-performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase-5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers.

Mostafa M Baker, Tarek S Belal, Mohamed S Mahrous, Hytham M Ahmed, Hoda G Daabees,

This work presents a simple, sensitive and generic high-performance liquid chromatography with diode array detection method for the simultaneous determination of seven drugs prescribed for the treatment of erectile dysfunction and premature ejaculation. Investigated drugs include the phosphodiesterase-5 inhibitors: sildenafil, tadalafil, and vardenafil, in addition to the selective serotonin reuptake ... Read more >>

J Sep Sci (Journal of separation science)
[2016, 39(9):1656-1665]

Cited: 7 times

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Validated spectrofluorimetric determination of two pharmaceutical antihypertensive mixtures containing amlodipine besylate together with either candesartan cilexetil or telmisartan.

Tarek S Belal, Mohamed S Mahrous, Magdi M Abdel-Khalek, Hoda G Daabees, Mona M Khamis,

Amlodipine besylate (AML) is available in fixed-dose combination tablets with either candesartan cilexetil (CAN) or telmisartan (TEL). This work describes a simple, selective and sensitive spectrofluorimetric method for analysis of AML/CAN and AML/TEL binary mixtures without prior separation. The method involves measurement of the native fluorescence of AML at excitation ... Read more >>

Luminescence (Luminescence : the journal of biological and chemical luminescence)
[2014, 29(7):893-900]

Cited: 2 times

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High-performance liquid chromatographic determination of memantine in human urine following solid-phase extraction and precolumn derivatization.

Karim Michail, Hoda Daabees, Youssef Beltagy, Magdy Abd Elkhalek, Mona Khamis,

A validated HPLC-UV method is presented for the quantification of urinary memantine hydrochloride, a novel medication approved to treat moderate and advanced cases of Alzheimer's disease. The drug and amantadine hydrochloride, the internal standard, were extracted from human urine using SPE. The extract was then buffered and derivatized at room ... Read more >>

J AOAC Int (Journal of AOAC International)
[2013, 96(6):1302-1307]

Cited: 1 time

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New simple spectrophotometric method for determination of the binary mixtures (atorvastatin calcium and ezetimibe; candesartan cilexetil and hydrochlorothiazide) in tablets.

Tarek S Belal, Hoda G Daabees, Magdi M Abdel-Khalek, Mohamed S Mahrous, Mona M Khamis,

A new simple spectrophotometric method was developed for the determination of binary mixtures without prior separation. The method is based on the generation of ratio spectra of compound X by using a standard spectrum of compound Y as a divisor. The peak to trough amplitudes between two selected wavelengths in ... Read more >>

J Pharm Anal (Journal of pharmaceutical analysis)
[2013, 3(2):118-126]

Cited: 2 times

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