Full Text Journal Articles by
Author Ho Min Chen

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Systemic treatment of breast cancer with leptomeningeal metastases using bevacizumab, etoposide and cisplatin (BEEP regimen) significantly improves overall survival.

Tom Wei-Wu Chen, I-Shiow Jan, Dwang-Ying Chang, Ching-Hung Lin, I-Chun Chen, Ho-Min Chen, Ann-Lii Cheng, Yen-Shen Lu,

INTRODUCTION:Metastatic breast cancer (MBC) with leptomeningeal metastases (LM) has dismal survival. We aim to determine if modern systemic therapy, especially the bevacizumab, cisplatin, and etoposide (BEEP) regimen, is beneficial to MBC LM patients. METHODS:We excerpted data from a prospectively collected cytopathology database for MBC patients who were diagnosed with LM ... Read more >>

J. Neurooncol. (Journal of neuro-oncology)
[2020, :]

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Correlation of corneal pigmented arc with wide epithelial thickness map in orthokeratology-treated children using optical coherence tomography measurements.

Pei-Wei Huang, Ling Yeung, Chi-Chin Sun, Ho-Min Chen, Shu-Yen Peng, Yen-Ting Chen, Chun-Fu Liu,

PURPOSE:To determine the intensity of corneal pigmented arc in orthokeratology (ortho-k)-treated children and its correlation with wide epithelial thickness map (ETM) obtained through anterior segment optical coherent tomography (AS-OCT). METHODS:This retrospective case series reviews medical records of children who received ortho-k treatment for myopia control. Intensity of ortho-k-associated pigmented arc ... Read more >>

Cont Lens Anterior Eye (Contact lens & anterior eye : the journal of the British Contact Lens Association)
[2020, 43(3):238-243]

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Optic neuritis at the nexus of peripheral autoimmunity and central nervous system demyelination: a nationwide cohort study

Wei-Sheng Lin, Ho-Min Chen, Chih-Chao Yang, Ta-Ching Chen, Jou-Wei Lin, Wang-Tso Lee,

Abstract Background Long-term course of optic neuritis is heterogeneous and varies across populations. We aim to investigate immune-related determinants that predict conversion of optic neuritis (ON) to multiple sclerosis (MS) or neuromyelitis optica (NMO) in a nationwide cohort. Methods We conducted the population-based cohort study using data ... Read more >>

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Epidemiology of pediatric multiple sclerosis, neuromyelitis optica, and optic neuritis in Taiwan.

Wei-Sheng Lin, Hsin-Pei Wang, Ho-Min Chen, Jou-Wei Lin, Wang-Tso Lee,

BACKGROUND AND OBJECTIVE:The epidemiology of pediatric acquired demyelinating disorders remains to be clarified in many parts of Asia. We carry out this study to depict the epidemiology of pediatric multiple sclerosis (MS), neuromyelitis optica (NMO), and optic neuritis (ON) in Taiwan. METHODS:We conducted a retrospective nationwide population-based study using data ... Read more >>

J. Neurol. (Journal of neurology)
[2020, 267(4):925-932]

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Histopathologic findings after selective ophthalmic arterial injection of melphalan for retinoblastoma.

Ho-Min Chen, Sherine Jue Ong, An-Ning Chao, Kuan-Lyin Liou, Shih-Ming Jung, Ling-Yuh Kao,

PURPOSE:The aim is to describe histopathologic observations in eyes enucleated after selective ophthalmic arterial injection (SOAI) of melphalan for retinoblastoma (RB). STUDY DESIGN:This is retrospective clinical study. PATIENTS AND METHODS:Histopathologic analysis of 14 eyes (13 patients) from May 2008 through January 2015 at Chang Gung Memorial Hospital. RESULTS:The eyes after ... Read more >>

Taiwan J Ophthalmol (Taiwan journal of ophthalmology)
[2019, 9(4):262-266]

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Association between the risk of lung cancer and influenza: A population-based nested case-control study.

Ching-Fu Weng, Li-Ju Chen, Chih-Wan Lin, Ho-Min Chen, Henry Hsin-Chung Lee, Thai-Yen Ling, Fei-Yuan Hsiao,

BACKGROUND:Previous animal studies have shown that certain respiratory oncoviruses can lead to tumorigenesis, especially influenza virus. However, no clinical studies other than animal studies have been conducted to test this hypothesis. OBJECTIVE:To investigate the association between influenza and the risk of lung cancer using the Taiwan Cancer Registry Database (TCRD) ... Read more >>

Int. J. Infect. Dis. (International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases)
[2019, 88:8-13]

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Direct Comparison of Low-Dose Dabigatran and Rivaroxaban for Effectiveness and Safety in Patients with Non-Valvular Atrial Fibrillation.

Shih-Wei Meng, Ting-Tse Lin, Min-Tsun Liao, Ho-Min Chen, Chao-Lun Lai,

Background:We aimed to examine the comparative effectiveness and safety between low-dose dabigatran and rivaroxaban in atrial fibrillation (AF) patients. Methods:Using the National Health Insurance claims database in Taiwan, we conducted head-to-head comparisons among adult non-valvular AF patients prescribed with dabigatran 110 mg or rivaroxaban 15 mg between June 1, 2012 ... Read more >>

Acta Cardiol Sin (Acta Cardiologica Sinica)
[2019, 35(1):42-54]

Cited: 2 times

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Subtype-specific epidemiology of lymphoid malignancies in Taiwan compared to Japan and the United States, 2002-2012.

Bor-Sheng Ko, Li-Ju Chen, Huai-Hsuan Huang, Yao-Chun Wen, Chi-Yin Liao, Ho-Min Chen, Fei-Yuan Hsiao,

BACKGROUND:There are many unrevealed parts regarding lymphoma etiology. Previous studies suggested differences in lymphoma epidemiology among countries existed; however, some were one-center studies that were not enough to represent the whole population. OBJECTIVE:To provide epidemiological information on lymphoma within Taiwanese and to compare the data with that in Japan and ... Read more >>

Cancer Med (Cancer medicine)
[2018, 7(11):5820-5831]

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Women with Diffuse Large B Cell Lymphoma Benefit More from Rituximab-Containing Chemotherapy.

Huai-Hsuan Huang, Fei-Yuan Hsiao, Li-Ju Chen, Ho-Min Chen, Bor-Sheng Ko,

BACKGROUND:Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma. The treatment response and overall survival (OS) improved after incorporating rituximab with chemotherapies. Yet, available evidence as to whether women and men may benefit similarly from rituximab have not been adequately addressed, particularly in the real-world setting. The ... Read more >>

J Womens Health (Larchmt) (Journal of women's health (2002))
[2019, 28(2):203-211]

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Rituximab maintenance improves overall survival in follicular lymphoma: A retrospective nationwide real-world analysis from Taiwan Cancer Registry Database.

Huai-Hsuan Huang, Yao-Chun Wen, Ho-Min Chen, Fei-Yuan Hsiao, Bor-Sheng Ko,

Follicular lymphoma (FL) is the most frequent indolent lymphoma in Western countries, but it is less frequent in Asia. Several trials have demonstrated the progression-free benefit of rituximab maintenance for FL patients in Western countries. However, the overall survival (OS) benefits and effectiveness of rituximab maintenance in Asian FL patients ... Read more >>

Cancer Med (Cancer medicine)
[2018, 7(8):3582-3591]

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Dabigatran, Rivaroxaban, and Warfarin in the Oldest Adults with Atrial Fibrillation in Taiwan.

Chao-Lun Lai, Ho-Min Chen, Min-Tsun Liao, Ting-Tse Lin,

OBJECTIVES:To compare the effectiveness and safety of reduced-dose dabigatran, reduced-dose rivaroxaban, and warfarin in individuals aged 85 and older with atrial fibrillation (AF). DESIGN:Retrospective cohort study. SETTING:Taiwan National Health Insurance claims database, 2011∼2015. PARTICIPANTS:Individuals with AF aged 85 and older (mean 88.6) with incident use of oral anticoagulants between June ... Read more >>

J Am Geriatr Soc (Journal of the American Geriatrics Society)
[2018, 66(8):1567-1574]

Cited: 2 times

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High plasma interleukin-6 levels associated with poor prognosis of patients with advanced hepatocellular carcinoma.

Yu-Yun Shao, Hang Lin, Yong-Shi Li, Ying-Hui Lee, Ho-Min Chen, Ann-Lii Cheng, Chih-Hung Hsu,

Antiangiogenic therapy is crucial for advanced hepatocellular carcinoma (HCC) treatment. Interleukin (IL)-6 is an inflammatory response mediator that can promote angiogenesis. We explored its prognostic role in patients with advanced HCC.We had two patient cohorts, both comprising patients who received sorafenib-containing therapy as the first-line treatment for advanced HCC. We ... Read more >>

Jpn. J. Clin. Oncol. (Japanese journal of clinical oncology)
[2017, 47(10):949-953]

Cited: 4 times

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Irinotecan and Oxaliplatin Might Provide Equal Benefit as Adjuvant Chemotherapy for Patients with Resectable Synchronous Colon Cancer and Liver-confined Metastases: A Nationwide Database Study.

Yi-Hsin Liang, Yu-Yun Shao, Ho-Min Chen, Ann-Lii Cheng, Mei-Shu Lai, Kun-Huei Yeh,

Although irinotecan and oxaliplatin are both standard treatments for advanced colon cancer, it remains unknown whether either is effective for patients with resectable synchronous colon cancer and liver-confined metastasis (SCCLM) after curative surgery.A population-based cohort of patients diagnosed with de novo SCCLM between 2004 and 2009 was established by searching ... Read more >>

Anticancer Res. (Anticancer research)
[2017, 37(12):7095-7104]

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Prescription Patterns of Sorafenib and Outcomes of Patients with Advanced Hepatocellular Carcinoma: A National Population Study.

Li-Chun Lu, Pei-Jer Chen, Yi-Chun Yeh, Chih-Hung Hsu, Ho-Min Chen, Mei-Shu Lai, Yu-Yun Shao, Ann-Lii Cheng,

Sorafenib is the current standard treatment for advanced hepatocellular carcinoma (HCC). We analyzed national prescription patterns and treatment outcomes of patients who received sorafenib for advanced HCC.We established a nation-wide cohort of patients who started receiving treatment with sorafenib for advanced HCC between August 2012 and July 2013 from the ... Read more >>

Anticancer Res. (Anticancer research)
[2017, 37(5):2593-2599]

Cited: 6 times

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Comparative Effectiveness and Safety of Dabigatran and Rivaroxaban in Atrial Fibrillation Patients.

Chao-Lun Lai, Ho-Min Chen, Min-Tsun Liao, Ting-Tse Lin, K Arnold Chan,

We aimed to examine the comparative effectiveness and safety between dabigatran and rivaroxaban in atrial fibrillation patients.We conducted a population-based, retrospective, new-user cohort study based on the National Health Insurance claims database in Taiwan. Adult atrial fibrillation patients who initiated dabigatran (N=10 625) or rivaroxaban (N=4609) between June 1, 2012 and ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2017, 6(4):]

Cited: 5 times

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National Policies Fostering Hospice Care Increased Hospice Utilization and Reduced the Invasiveness of End-of-Life Care for Cancer Patients.

Yu-Yun Shao, Emily Han-Chung Hsiue, Chih-Hung Hsu, Chien-An Yao, Ho-Min Chen, Mei-Shu Lai, Ann-Lii Cheng,

In 2011, two national policies aiming to foster hospice services for terminal cancer patients took effect in Taiwan. The single-payer National Health Insurance of Taiwan started to reimburse full hospice services. The national hospital accreditation program, which graded all hospitals, incorporated hospice utilization in its evaluation. We assessed the impact ... Read more >>

Oncologist (The oncologist)
[2017, 22(7):843-849]

Cited: 1 time

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Cytotoxic Chemotherapy as First-Line Therapy for Advanced Non-Small-Cell Lung Cancer in Taiwan: Daily Practice.

Yi-Hsin Liang, Yu-Yun Shao, Bin-Chi Liao, Ho-Sheng Lee, James Chih-Hsin Yang, Ho-Min Chen, Chun-Ju Chiang, Ann-Lii Cheng, Mei-Shu Lai,

Cytotoxic chemotherapy is the standard first-line therapy for patients with advanced non-small cell lung cancer (NSCLC) without specific gene alterations. This study examined the prescription pattern and the survival outcome of cytotoxic chemotherapy regimens in daily practice in Taiwan.We established a population-based cohort of patients diagnosed with advanced NSCLC between ... Read more >>

J Cancer (Journal of Cancer)
[2016, 7(11):1515-1523]

Cited: 2 times

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Primary tumor site is a useful predictor of cetuximab efficacy in the third-line or salvage treatment of KRAS wild-type (exon 2 non-mutant) metastatic colorectal cancer: a nationwide cohort study.

Kuo-Hsing Chen, Yu-Yun Shao, Ho-Min Chen, Yu-Lin Lin, Zhong-Zhe Lin, Mei-Shu Lai, Ann-Lii Cheng, Kun-Huei Yeh,

Previous studies have shown left-sided colorectal cancer (LCRC) and right-sided colorectal cancer (RCRC) exhibit different molecular and clinicopathological features. We explored the association between the primary tumor site and cetuximab efficacy in KRAS wild-type colorectal cancer (CRC).This study enrolled a cohort of patients, who had received cetuximab treatment after two ... Read more >>

BMC Cancer (BMC cancer)
[2016, 16:327]

Cited: 19 times

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Key opioid prescription concerns in cancer patients: A nationwide study.

Chih-Peng Lin, Chih-Hung Hsu, Wen-Mei Fu, Ho-Min Chen, Ying-Hui Lee, Mei-Shu Lai, Yu-Yun Shao,

Opioids are crucial in cancer pain management. We examined the nationwide prescription patterns of opioids in Taiwan cancer patients to find the potential concerns.We reviewed the claims database of the National Health Insurance of Taiwan for patients diagnosed with cancer from 2003 to 2011. The use and cost of analgesics ... Read more >>

Acta Anaesthesiol Taiwan (Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists)
[2016, 54(2):51-56]

Cited: 4 times

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Risk of hip/femur fractures during the initiation period of α-adrenoceptor blocker therapy among elderly males: a self-controlled case series study.

Chao-Lun Lai, Raymond Nien-Chen Kuo, Ho-Min Chen, Ming-Fong Chen, Kinwei Arnold Chan, Mei-Shu Lai,

This study aimed to evaluate the risk of hip/femur fractures during the initiation period of α-adrenoceptor blocker therapy using the National Health Insurance claims database, Taiwan, with a self-controlled case series design.All male beneficiaries aged over 50 years as of 2007, who were incident users of α-adrenoceptor blockers and also had ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2015, 80(5):1208-1218]

Cited: 5 times

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Risk of ischemic stroke during the initiation period of α-blocker therapy among older men.

Chao-Lun Lai, Raymond Nien-Chen Kuo, Ho-Min Chen, Ming-Fong Chen, K Arnold Chan, Mei-Shu Lai,

BACKGROUND:Alpha-blockers are notorious for their first-dose effect of acute hypotension during the early initiation period. Because acute cerebral hypoperfusion may precipitate an episode of ischemic stroke, we aimed to provide a quantitative estimate of the risk of ischemic stroke during the early initiation period of α-blocker therapy, using a self-controlled ... Read more >>

CMAJ (CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne)
[2016, 188(4):255-260]

Cited: 1 time

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Young patients with colorectal cancer have increased risk of second primary cancers.

Yi-Hsin Liang, Yu-Yun Shao, Ho-Min Chen, Chiu-Lin Lai, Zhong-Zhe Lin, Raymond Nien-Chen Kuo, Ann-Lii Cheng, Kun-Huei Yeh, Mei-Shu Lai,

Because the number of long-term survivors of colorectal cancer has increased, second primary cancer has become an important issue. However, previous studies were heterogeneous in design, and few data for Asia-Pacific area were available.This was a retrospective population-based study conducted using the national database of the Taiwan Cancer Registry. Patients ... Read more >>

Jpn. J. Clin. Oncol. (Japanese journal of clinical oncology)
[2015, 45(11):1029-1035]

Cited: 4 times

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Class effect of beta-blockers in survivors of ST-elevation myocardial infarction: A nationwide cohort study using an insurance claims database.

Ting-Tse Lin, K Arnold Chan, Ho-Min Chen, Chao-Lun Lai, Mei-Shu Lai,

Beta-blockers can help reduce mortality following acute myocardial infarction (MI); however, whether beta-blockers exert a class effect remains controversial. This study identified all patients with first ST-elevation MI for the period of 2003 to 2010 from the National Health Insurance claims database, Taiwan. We compared patients prescribed carvedilol, bisoprolol, and ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:13692]

Cited: 3 times

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Type 2 diabetes mellitus is associated with increased mortality in Chinese patients receiving curative surgery for colon cancer.

Kuo-Hsing Chen, Yu-Yun Shao, Zhong-Zhe Lin, Yi-Chun Yeh, Wen-Yi Shau, Raymond Nienchen Kuo, Ho-Min Chen, Chiu-Ling Lai, Kun-Huei Yeh, Ann-Lii Cheng, Mei-Shu Lai,

BACKGROUND: We investigated the association between diabetes mellitus (DM) and the prognosis of patients with early colon cancer who had undergone curative surgery. METHODS: From three national databases of patients in Taiwan, we selected a cohort of colon cancer patients who had been newly diagnosed with stage I or stage ... Read more >>

Oncologist (The oncologist)
[2014, 19(9):951-958]

Cited: 13 times

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Clinical presentations of X-linked retinoschisis in Taiwanese patients confirmed with genetic sequencing.

Nan-Kai Wang, Laura Liu, Ho-Min Chen, Shawn Tsai, Tsong-Chi Chang, Tzu-Hsun Tsai, Chung-May Yang, An-Ning Chao, Kuan-Jen Chen, Ling-Yuh Kao, Ling Yeung, Lung-Kun Yeh, Yih-Shiou Hwang, Wei-Chi Wu, Chi-Chun Lai,

To investigate the clinical characteristics of X-linked retinoschisis (XLRS) and identify genetic mutations in Taiwanese patients with XLRS.This study included 23 affected males from 16 families with XLRS. Fundus photography, spectral domain optical coherent tomography (SD-OCT), fundus autofluorescence (FAF), and full-field electroretinograms (ERGs) were performed. The coding regions of the ... Read more >>

Mol. Vis. (Molecular vision)
[2015, 21:487-501]

Cited: 7 times

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