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Author Hiroyuki Fukui

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Patho-Pharmacological Research of Anti-allergic Natural Products Targeting Antihistamine-Sensitive and -Insensitive Allergic Mechanisms.

Hiroyuki Fukui, Hiroyuki Mizuguchi, Yoshiaki Kitamura, Noriaki Takeda,

Histamine H<sub>1</sub> receptor (H1R) has a special up-regulation mechanism by the stimulation of H1R, mediated by protein kinase C-delta (PKCδ) signaling and H1R gene expression, resulting increase in H1R signaling. Increase in H1R mRNA in nasal mucosa was induced after the provocation of nasal hypersensitivity model rats and suppressed by ... Read more >>

Curr Top Behav Neurosci (Current topics in behavioral neurosciences)
[2021, :]

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Molecular Signaling and Transcriptional Regulation of Histamine H1 Receptor Gene.

Hiroyuki Mizuguchi, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui,

Histamine-activated histamine H<sub>1</sub> receptor (H1R) signaling regulates many gene expressions, mainly through the protein kinase C (PKC)/extracellular signal-regulated kinases (ERK) signaling. Involvement of other signaling, including NF-κB, Wnt, RUNX-2, and Rho A signaling was also demonstrated. In addition, cAMP production through the activation of H1R signaling was reported. H1R gene ... Read more >>

Curr Top Behav Neurosci (Current topics in behavioral neurosciences)
[2021, :]

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Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct-acting anti-virals.

Yuki Tahata, Ryotaro Sakamori, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Hideki Hagiwara, Yasuharu Imai, Naoki Hiramatsu, Shinji Tamura, Keiji Yamamoto, Masahide Oshita, Kazuyoshi Ohkawa, Taizo Hijioka, Hiroyuki Fukui, Toshifumi Ito, Yoshinori Doi, Yukinori Yamada, Takayuki Yakushijin, Yuichi Yoshida, Tomohide Tatsumi, Tetsuo Takehara, ,

<h4>Background</h4>Several factors associated with hepatocellular carcinoma (HCC) occurrence after sustained virological response (SVR) in patients with hepatitis C have been reported. However, few validation studies have been performed in the era of direct-acting anti-virals (DAAs).<h4>Aims</h4>To develop a prediction model for HCC occurrence after DAA-mediated SVR and validate its usefulness.<h4>Methods</h4>We analysed ... Read more >>

Aliment Pharmacol Ther (Alimentary pharmacology & therapeutics)
[2021, :]

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Effects of narrow-band UVB on nasal symptom and upregulation of histamine H1 receptor mRNA in allergic rhinitis model rats.

Seiichiro Kamimura, Yoshiaki Kitamura, Tatsuya Fujii, Kentaro Okamoto, Nanae Sanada, Natsuki Okajima, Tomoharu Wakugawa, Hiroyuki Fukui, Hiroyuki Mizuguchi, Noriaki Takeda,

<h4>Background</h4>Phototherapy with narrow-band ultraviolet B (narrow-band UVB) is clinically effective treatment for atopic dermatitis. In the present study, we examined the effects of intranasal irradiation with narrow-band UVB on nasal symptom, upregulation of histamine H<sub>1</sub> receptor (H1R) gene expression and induction of DNA damage in the nasal mucosa of allergic ... Read more >>

Laryngoscope Investig Otolaryngol (Laryngoscope investigative otolaryngology)
[2021, 6(1):34-41]

Cited: 0 times

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Exacerbation of immune thrombocytopenia triggered by COVID-19 in patients with systemic lupus erythematosus.

Yasushi Kondo, Yuko Kaneko, Tatsuhiro Oshige, Hiroyuki Fukui, Shuntaro Saito, Mikio Okayama, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Koichi Fukunaga, Tsutomu Takeuchi,

Ann Rheum Dis (Annals of the rheumatic diseases)
[2021, 80(5):e77]

Cited: 7 times

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Psychologic stress and disease activity in patients with inflammatory bowel disease: A multicenter cross-sectional study.

Manabu Araki, Shinichiro Shinzaki, Takuya Yamada, Shoko Arimitsu, Masato Komori, Narihiro Shibukawa, Akira Mukai, Sachiko Nakajima, Kazuo Kinoshita, Shinji Kitamura, Yoko Murayama, Hiroyuki Ogawa, Yuichi Yasunaga, Masahide Oshita, Hiroyuki Fukui, Eiji Masuda, Masahiko Tsujii, Shoichiro Kawai, Satoshi Hiyama, Takahiro Inoue, Hitoshi Tanimukai, Hideki Iijima, Tetsuo Takehara,

BACKGROUND AND AIMS:Psychologic stress can affect the pathogenesis of inflammatory bowel disease (IBD), but the precise contribution of psychologic stress to IBD remains unclear. We investigated the association of psychologic stress with disease activity in patients with IBD, especially in terms of mental state and sleep condition. METHODS:This was a ... Read more >>

PLoS One (PloS one)
[2020, 15(5):e0233365]

Cited: 2 times

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Elucidation of Inverse Agonist Activity of Bilastine.

Hiroyuki Mizuguchi, Tomoharu Wakugawa, Hisato Sadakata, Seiichiro Kamimura, Mai Takemoto, Tomomi Nakagawa, Masami Yabumoto, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui,

H<sub>1</sub>-antihistamines antagonize histamine and prevent it from binding to the histamine H<sub>1</sub> receptor (H1R). Some of them also act as inverse agonists, which are more potent than pure antagonists because they suppress the constitutive H1R activity. Bilastine is a non-sedative antihistamine which is one of the most satisfy the requirements ... Read more >>

Pharmaceutics (Pharmaceutics)
[2020, 12(6):]

Cited: 2 times

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Reversible cerebral vasoconstriction syndrome: the importance of follow-up imaging within 2 weeks

Kiyomitsu Fukaguchi, Tadahiro Goto, Hiroyuki Fukui, Ichiro Sekine, Hiroshi Yamagami,

<h4>Background: </h4> In patients with thunderclap headache, reversible cerebral vasoconstriction syndrome (RCVS) should be considered as a differential diagnosis. However, RCVS diagnosis in the emergency department (ED) remains challenging. This study described the clinical features of RCVS, determined the factors related to RCVS diagnosis, and suggested treatment strategies for its ... Read more >>

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Effects of corticosteroid on mRNA levels of histamine H1 receptor in nasal mucosa of healthy participants and HeLa cells.

Yoshiaki Kitamura, Seiichiro Kamimura, Tatsuya Fujii, Hiroyuki Mizuguchi, Keisuke Naito, Eiji Kondo, Kazunori Matsuda, Takahiro Azuma, Go Sato, Hiroyuki Fukui, Noriaki Takeda,

The purpose of this study is to examine the effect of intranasal corticosteroid (INCS) administration on histamine H1 receptor (H1R) gene expression in the nasal mucosa of healthy participants and the effects of dexamethasone on basal and histamine-induced H1R mRNA expression, and histamine-induced phosphorylation of extracellular signal-regulated kinase (ERK) in ... Read more >>

J Med Invest (The journal of medical investigation : JMI)
[2020, 67(3.4):311-314]

Cited: 0 times

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Reversible cerebral vasoconstriction syndrome: the importance of follow-up imaging within 2 weeks.

Kiyomitsu Fukaguchi, Tadahiro Goto, Hiroyuki Fukui, Ichiro Sekine, Hiroshi Yamagami,

<h4>Aim</h4>In patients with thunderclap headaches, reversible cerebral vasoconstriction syndrome (RCVS) should be considered as a differential diagnosis. However, RCVS diagnosis in the emergency department (ED) remains challenging. This report describes the clinical features and factors related to RCVS diagnosis and suggests diagnostic strategies for its management.<h4>Methods</h4>We retrospectively reviewed the medical ... Read more >>

Acute Med Surg (Acute medicine & surgery)
[2020, 7(1):e559]

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Identification of pyrogallol from Awa-tea as an anti-allergic compound that suppresses nasal symptoms and IL-9 gene expression.

Tomohiro Nakano, Mitsuhiro Ikeda, Tomoharu Wakugawa, Yoshiki Kashiwada, Osamu Kaminuma, Noriko Kitamura, Masam Yabumoto, Hiromichi Fujino, Yoshiaki Kitamura, Hiroyuki Fukui, Noriaki Takeda, Hiroyuki Mizuguchi,

As the expression level of allergic disease sensitive genes are correlated with the severity of allergic symptoms, suppression of these gene expressions could be promising therapeutics. We demonstrated that protein kinase Cδ / heat shock protein 90-mediated H1R gene expression signaling and nuclear factor of activated T-cells (NFAT)-mediated IL-9 gene expression signaling ... Read more >>

J Med Invest (The journal of medical investigation : JMI)
[2020, 67(3.4):289-297]

Cited: 1 time

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Impact of non-pharmaceutical interventions for the COVID-19 pandemic on emergency department patient trends in Japan: a retrospective analysis.

Ichiro Sekine, Haruki Uojima, Hiroshi Koyama, Tadashi Kamio, Morihiko Sato, Tadatsugu Yamamoto, Kiyomitsu Fukaguchi, Hiroyuki Fukui, Hiroshi Yamagami,

<h4>Aim</h4>The coronavirus disease (COVID-19) pandemic massively impacted emergency department (ED) visits. The unavailability of specific therapies or vaccines has made non-pharmaceutical interventions (NPIs) an alternative strategy for COVID-19. We assessed the impact of NPIs (nationwide school closures and state of emergency) on ED visits during the COVID-19 pandemic in Japan.<h4>Methods</h4>This ... Read more >>

Acute Med Surg (Acute medicine & surgery)
[2020, 7(1):e603]

Cited: 1 time

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Predictive factors of anemia during sofosbuvir and ribavirin therapy for genotype 2 chronic hepatitis C patients.

Ayako Urabe, Ryotaro Sakamori, Yuki Tahata, Ryoko Yamada, Yasuharu Imai, Hideki Hagiwara, Shinji Tamura, Hiroyuki Fukui, Yukinori Yamada, Akira Kaneko, Taizo Hijioka, Takahiro Kodama, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara,

<h4>Aim</h4>Sofosbuvir (SOF) and ribavirin (RBV) combination therapy has improved the sustained virologic response (SVR) rate and shortened the treatment duration for patients with chronic hepatitis C virus (HCV) genotype 2 infection. Ribavirin-induced hemolytic anemia is one of the most troublesome side-effects of SOF/RBV therapy; however, factors associated with this condition ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2019, 49(8):853-859]

Cited: 0 times

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Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response.

Ryoko Yamada, Naoki Hiramatsu, Tsugiko Oze, Ayako Urabe, Yuki Tahata, Naoki Morishita, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Takayuki Yakushijin, Akira Yamada, Hideki Hagiwara, Eiji Mita, Masahide Oshita, Toshifumi Itoh, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Atsuo Inoue, Yasuharu Imai, Tomohide Tatsumi, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,

<h4>Aim</h4>In patients with chronic hepatitis C, hepatocellular carcinoma (HCC) occurs at a certain frequency, even if a sustained virologic response (SVR) is achieved by antiviral treatment. Old age, liver fibrosis, and high post-treatment α-fetoprotein (AFP) level are typical risk factors of post-SVR HCC. We examined whether the frequencies and factors ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2019, 49(5):570-578]

Cited: 7 times

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Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats.

Tatsuya Fujii, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Kentaro Okamoto, Nanae Sanada, Takuya Yamada, Manabu Sugiyama, Shotaro Michinaga, Mika Kitayama, Hiroyuki Fukui, Noriaki Takeda,

Narrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/cm<sup>2</sup> of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H<sub>1</sub> receptor (H1R) gene expression without induction of apoptosis in HeLa cells. However, the effect of NB-UVB irradiation on nasal symptoms is ... Read more >>

J Pharmacol Sci (Journal of pharmacological sciences)
[2018, 138(1):54-62]

Cited: 1 time

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Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis.

Rezwanul Islam, Hiroyuki Mizuguchi, Aurpita Shaha, Kohei Nishida, Masami Yabumoto, Hisashi Ikeda, Hiromichi Fujino, Yoshiaki Kitamura, Hiroyuki Fukui, Noriaki Takeda,

As expression level of allergic disease-sensitive genes are correlated with allergic symptom severity, suppression of these gene expressions could be good therapeutics. We have demonstrated that PKCδ signaling and NFAT signaling, involve in histamine H<sub>1</sub> receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. ... Read more >>

J Med Invest (The journal of medical investigation : JMI)
[2018, 65(3.4):242-250]

Cited: 3 times

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Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H1 Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis.

Aurpita Shaha, Hiroyuki Mizuguchi, Yoshiaki Kitamura, Hiromichi Fujino, Masami Yabumoto, Noriaki Takeda, Hiroyuki Fukui,

The significant correlation between nasal symptom scores and level of histamine H<sub>1</sub> receptor (H1R) mRNA in nasal mucosa was observed in patients with pollinosis, suggesting that H1R gene is an allergic disease sensitive gene. We demonstrated that H1R and interleukin (IL)-9 gene are the allergic rhinitis (AR)-sensitive genes and protein ... Read more >>

Biol Pharm Bull (Biological & pharmaceutical bulletin)
[2018, 41(9):1440-1447]

Cited: 4 times

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Ca2+ -dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells.

Shigeru Hishinuma, Hiroshi Komazaki, Hayato Tsukamoto, Hirokazu Hatahara, Hiroyuki Fukui, Masaru Shoji,

G<sub>q/11</sub> protein-coupled human histamine H<sub>1</sub> receptors in Chinese hamster ovary cells stimulated with histamine undergo clathrin-dependent endocytosis followed by proteasome/lysosome-mediated down-regulation. In this study, we evaluated the effects of a sustained increase in intracellular Ca<sup>2+</sup> concentrations induced by a receptor-bypassed stimulation with ionomycin, a Ca<sup>2+</sup> ionophore, on the endocytosis and ... Read more >>

J Neurochem (Journal of neurochemistry)
[2018, 144(1):68-80]

Cited: 1 time

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Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease.

Manabu Araki, Shinichiro Shinzaki, Takuya Yamada, Shoko Arimitsu, Masato Komori, Narihiro Shibukawa, Akira Mukai, Sachiko Nakajima, Kazuo Kinoshita, Shinji Kitamura, Yoko Murayama, Hiroyuki Ogawa, Yuichi Yasunaga, Masahide Oshita, Hiroyuki Fukui, Eiji Masuda, Masahiko Tsujii, Satoshi Hiyama, Takahiro Inoue, Hideki Iijima, Tetsuo Takehara,

<h4>Background</h4>Environmental factors are suggested to affect the pathogenesis of several diseases, including inflammatory bowel disease (IBD). The seasonality of disease onset and exacerbation in IBD, however, are not well established. We herein aimed to clarify the disease seasonality and to investigate the underlying characteristics in IBD patients exhibiting seasonality of ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2017, 52(11):1149-1157]

Cited: 8 times

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Protein kinase C-δ signaling regulates glucagon secretion from pancreatic islets.

Kiyotake Yamamoto, Hiroyuki Mizuguchi, Natsumi Tokashiki, Makoto Kobayashi, Motoyuki Tamaki, Youichi Sato, Hiroyuki Fukui, Aiko Yamauchi,

Accumulating evidence supports the "glucagonocentric hypothesis", in which antecedent α-cell failure and inhibition of glucagon secretion are responsible for diabetes progression. Protein kinase C (PKC) is involved in glucagon secretion from α-cells, although which PKC isozyme is involved and the mechanism underlying this PKC-regulated glucagon secretion remains unknown. Here, the ... Read more >>

J Med Invest (The journal of medical investigation : JMI)
[2017, 64(1.2):122-128]

Cited: 5 times

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Histamine H1 Receptor Gene Expression and Drug Action of Antihistamines.

Hiroyuki Fukui, Hiroyuki Mizuguchi, Hisao Nemoto, Yoshiaki Kitamura, Yoshiki Kashiwada, Noriaki Takeda,

The upregulation mechanism of histamine H<sub>1</sub> receptor through the activation of protein kinase C-δ (PKCδ) and the receptor gene expression was discovered. Levels of histamine H<sub>1</sub> receptor mRNA and IL-4 mRNA in nasal mucosa were elevated by the provocation of nasal hypersensitivity model rats. Pretreatment with antihistamines suppressed the elevation ... Read more >>

Handb Exp Pharmacol (Handbook of experimental pharmacology)
[2017, 241:161-169]

Cited: 1 time

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Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na.

Shigeru Hishinuma, Kiyoe Kosaka, Chizuru Akatsu, Yoshihiro Uesawa, Hiroyuki Fukui, Masaru Shoji,

The affinity of ligands for G-protein-coupled receptors (GPCRs) is allosterically regulated by Na<sup>+</sup> via a highly conserved aspartate residue (Asp<sup>2.50</sup>) in the second transmembrane domain of GPCRs. In the present study, we examined the Na<sup>+</sup>-mediated regulation of the affinity of ligands for G<sub>q/11</sub>-protein-coupled human histamine H<sub>1</sub> receptors in Chinese hamster ... Read more >>

Biochem Pharmacol (Biochemical pharmacology)
[2017, 128:46-54]

Cited: 5 times

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Anti-bacterial and anti-inflammatory effects of ethanol extract from Houttuynia cordata poultice.

Yasuko Sekita, Keiji Murakami, Hiromichi Yumoto, Hiroyuki Mizuguchi, Takashi Amoh, Satoshi Ogino, Takashi Matsuo, Yoichiro Miyake, Hiroyuki Fukui, Yoshiki Kashiwada,

Houttuynia cordata (HC) has been commonly used as many traditional remedies in local areas of Japan. Although many pharmacological activities of HC have been reported, the mechanism underlying the effect of HC remains unknown. We conducted the interview survey in Japan to verify how HC was actually used. The interview ... Read more >>

Biosci Biotechnol Biochem (Bioscience, biotechnology, and biochemistry)
[2016, 80(6):1205-1213]

Cited: 11 times

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[Molecular pharmacology of (-)maackiain, from Kujin, an anti-allergic Kampo medicine].

Hiroyuki Fukui, Hiroyuki Mizuguchi, Yoshiki Kashiwada, Hisao Nemoto, Yoshiaki Kitamura, Noriaki Takeda,

Nihon Yakurigaku Zasshi (Nihon yakurigaku zasshi. Folia pharmacologica Japonica)
[2016, 147(3):148-151]

Cited: 0 times

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Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.

Hiroyuki Mizuguchi, Asish K Das, Kazutaka Maeyama, Shrabanti Dev, Masum Shahriar, Yoshiaki Kitamura, Noriaki Takeda, Hiroyuki Fukui,

Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. The H1R gene is upregulated in patients with pollinosis, and its expression level is correlated with the severity of nasal symptoms. Here, we show that antihistamine suppressed upregulation of histidine decarboxylase (HDC) mRNA ... Read more >>

J Pharmacol Sci (Journal of pharmacological sciences)
[2016, 130(4):212-218]

Cited: 2 times

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