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Author Hirokazu Takahashi

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Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan.

Yumie Kobayashi, Satoko Ohfuji, Kyoko Kondo, Wakaba Fukushima, Satoshi Sasaki, Noriko Kamata, Hirokazu Yamagami, Yasuhiro Fujiwara, Yasuo Suzuki, Yoshio Hirota, ,

<h4>Background</h4>Dietary fatty acids can affect chronic intestinal inflammation and have been reported to be associated with the development of ulcerative colitis (UC), mainly in Europe and the United States. The association of dietary intake of fatty acids and the risk for UC was investigated in Japan, where dietary habits lead ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(5):617-628]

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Relationship between NAFLD and Periodontal Disease from the View of Clinical and Basic Research, and Immunological Response

Masahiro Hatasa, Sumiko Yoshida, Hirokazu Takahashi, Kenichi Tanaka, Yoshihito Kubotsu, Yujin Ohsugi, Takaharu Katagiri, Takanori Iwata, Sayaka Katagiri,

Periodontal disease is an inflammatory disease caused by pathogenic oral microorganisms that leads to the destruction of alveolar bone and connective tissues around the teeth. Although many studies have shown that periodontal disease is a risk factor for systemic diseases, such as type 2 diabetes and cardiovascular diseases, the relationship ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2021, 22(7):]

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Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease.

Michihiro Iwaki, Takaomi Kessoku, Anna Ozaki, Yuki Kasai, Takashi Kobayashi, Asako Nogami, Yasushi Honda, Yuji Ogawa, Kento Imajo, Masato Yoneda, Ayako Maeda, Yoshiki Tanaka, Shunji Nakajima, Hiroshi Ohno, Haruki Usuda, Miwa Kawanaka, Takumi Kawaguchi, Takuji Torimura, Masayoshi Kage, Hideyuki Hyogo, Hirokazu Takahashi, Yuichiro Eguchi, Shinichi Aishima, Koichiro Wada, Noritoshi Kobayashi, Yoshio Sumida, Satoru Saito, Atsushi Nakajima,

<h4>Background and aim</h4>Gut microbiota composition is associated with the pathogenesis of non-alcoholic fatty liver disease. However, the association between gut microbiota composition and non-alcoholic fatty liver disease in non-obese patients remains unclear. We compared clinical parameters and gut microbiota profiles of healthy controls and non-obese and obese patients with non-alcoholic ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, :]

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TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients.

Hitoe Mori, Hirokazu Takahashi, Keiichiro Mine, Ken Higashimoto, Kanako Inoue, Motoyasu Kojima, Shigetaka Kuroki, Takahisa Eguchi, Yasuhiro Ono, Sadataka Inuzuka, Hidenobu Soejima, Seiho Nagafuchi, Keizo Anzai,

Accumulating evidence has suggested that viral infection causes type 1 diabetes due to direct β-cell damage and the triggering of autoimmune reactivity to β cells. Here, we elucidated that the tyrosine kinase 2 <i>(Tyk2</i>) gene, encoding an interferon receptor signaling molecule, is responsible for virus-induced diabetes in mice, and its ... Read more >>

Genes (Basel) (Genes)
[2021, 12(3):]

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The epidemiology of NAFLD and lean NAFLD in Japan: a meta-analysis with individual and forecasting analysis, 1995-2040.

Takanori Ito, Masatoshi Ishigami, Biyao Zou, Taku Tanaka, Hirokazu Takahashi, Masayuki Kurosaki, Mayumi Maeda, Khin Naing Thin, Kenichi Tanaka, Yuka Takahashi, Yoshito Itoh, Kentaro Oniki, Yuya Seko, Junji Saruwatari, Miwa Kawanaka, Masanori Atsukawa, Hideyuki Hyogo, Masafumi Ono, Eiichi Ogawa, Scott D Barnett, Christopher D Stave, Ramsey C Cheung, Mitsuhiro Fujishiro, Yuichiro Eguchi, Hidenori Toyoda, Mindie H Nguyen,

<h4>Background</h4>NAFLD is increasing in Asia including Japan, despite its lower obesity rate than the West. However, NAFLD can occur in lean people, but data are limited. We aimed to investigate the epidemiology of NAFLD in Japan with a focus on lean NAFLD.<h4>Methods</h4>We searched PubMed, Cochrane Library, EMBASE, Web of Science, ... Read more >>

Hepatol Int (Hepatology international)
[2021, :]

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Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.

Pasquale Nigro, Roeland J W Middelbeek, Christiano R R Alves, Susana Rovira-Llopis, Krithika Ramachandran, Leslie A Rowland, Andreas B Møller, Hirokazu Takahashi, Ana B Alves-Wagner, Maria Vamvini, Nathan S Makarewicz, Brent G Albertson, Michael F Hirshman, Laurie J Goodyear,

Recent studies demonstrate that adaptations to white adipose tissue are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal white adipose tissue (iWAT) in male mice including decreasing fat mass, improving mitochondrial function, inducing beiging and stimulating the ... Read more >>

Diabetes (Diabetes)
[2021, :]

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Correction to: Discovery of a Novel Gene Conferring Tellurite Tolerance through Tellurite Reduction to Escherichia coli Transformant in Marine Sediment Metagenomic Library.

Madison Pascual Munar, Hirokazu Takahashi, Yoshiko Okamura,

Mar Biotechnol (NY) (Marine biotechnology (New York, N.Y.))
[2021, 23(1):156]

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Analysis of the Shape of the T-wave in Congenital Long-QT Syndrome Type 3 by Geometric Morphometrics

Hitoshi Horigome, Yasuhiro Ishikawa, Hirokazu Takahashi, Masao Yoshinaga, Naokata Sumitomo,

The characteristic shape of the T-wave in congenital long -QT syndrome type 3 (LQTS3) is considered a late-onset T-wave. We analyzed the difference in the shapes of T-waves between LQTS3 cases and normal subjects using generalized Procrustes analysis (GPA). The J and Q points of V5 in the ECGs of ... Read more >>

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Prediction of Nonalcoholic Fatty Liver Disease Using Noninvasive and Non-Imaging Procedures in Japanese Health Checkup Examinees.

Kenichiro Murayama, Michiaki Okada, Kenichi Tanaka, Chika Inadomi, Wataru Yoshioka, Yoshihito Kubotsu, Tomomi Yada, Hiroshi Isoda, Takuya Kuwashiro, Satoshi Oeda, Takumi Akiyama, Noriko Oza, Hideyuki Hyogo, Masafumi Ono, Takumi Kawaguchi, Takuji Torimura, Keizo Anzai, Yuichiro Eguchi, Hirokazu Takahashi,

Access to imaging is limited for diagnosing nonalcoholic fatty liver disease (NAFLD) in general populations. This study evaluated the diagnostic performance of noninvasive and nonimaging indexes to predict NAFLD in the general Japanese population. Health checkup examinees without hepatitis virus infection or habitual alcohol drinking were included. Fatty liver was ... Read more >>

Diagnostics (Basel) (Diagnostics (Basel, Switzerland))
[2021, 11(1):]

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The first-round results of a population-based cohort study of HPV testing in Japanese cervical cancer screening: baseline characteristics, screening results, and referral rate.

Kanako Kono, Tohru Morisada, Kumiko Saika, Eiko Saitoh Aoki, Etsuko Miyagi, Kiyoshi Ito, Hirokazu Takahashi, Tomio Nakayama, Hiroshi Saito, Daisuke Aoki,

<h4>Objective</h4>In 2013, a cohort study aimed to clarify the positive and negative effects of introducing the human papillomavirus (HPV) testing for population-based cervical cancer screening has been launched in Japan. This study included four screenings during the subsequent 7-year follow-up period. We aim to describe the results of the first ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e29]

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Improvement of fatty acid productivity of thraustochytrid, Aurantiochytrium sp. by genome editing.

Kenshi Watanabe, Charose Marie Ting Perez, Tomoki Kitahori, Kosuke Hata, Masato Aoi, Hirokazu Takahashi, Tetsushi Sakuma, Yoshiko Okamura, Yutaka Nakashimada, Takashi Yamamoto, Keisuke Matsuyama, Shinzo Mayuzumi, Tsunehiro Aki,

Thraustochytrid strains belonging to the genus Aurantiochytrium accumulate significant amounts of lipids including polyunsaturated fatty acids and carotenoids and, therefore, are expected to be used for industrial production of various valuable materials. Although various efforts such as chemical mutagenesis and homologous gene recombination have been made to improve lipid productivity ... Read more >>

J Biosci Bioeng (Journal of bioscience and bioengineering)
[2021, 131(4):373-380]

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Eradication of hepatitis C virus with direct-acting antivirals improves glycemic control in diabetes: A multicenter study.

Hirokazu Takahashi, Takashi Nakahara, Tomomi Kogiso, Kento Imajo, Takaomi Kessoku, Takumi Kawaguchi, Tatsuya Ide, Miwa Kawanaka, Hideyuki Hyogo, Hideki Fujii, Masafumi Ono, Yoshihiro Kamada, Yoshio Sumida, Keizo Anzai, Masahito Shimizu, Takuji Torimura, Atsushi Nakajima, Katsutoshi Tokushige, Kazuaki Chayama, Yuichiro Eguchi, ,

<h4>Background and aim</h4>Hepatitis C virus (HCV) infection causes insulin resistance and diabetes as extrahepatic manifestations. We aimed to analyze the effect of HCV eradication by direct-acting antiviral (DAA) agents on glucose tolerance.<h4>Methods</h4>The hemoglobin A1c (HbA1c) of 272 patients with HCV infection who achieved a sustained virologic response (SVR) was analyzed ... Read more >>

JGH Open (JGH open : an open access journal of gastroenterology and hepatology)
[2021, 5(2):228-234]

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Direct Comparison of US and MR Elastography for Staging Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.

Kento Imajo, Yasushi Honda, Takashi Kobayashi, Koki Nagai, Anna Ozaki, Michihiro Iwaki, Takaomi Kessoku, Yuji Ogawa, Hirokazu Takahashi, Yusuke Saigusa, Masato Yoneda, Hiroyuki Kirikoshi, Daisuke Utsunomiya, Shinichi Aishima, Satoru Saito, Atsushi Nakajima,

<h4>Background & aims</h4>As alternatives to the expensive liver biopsy for assessing liver fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD), we directly compared the diagnostic abilities of magnetic resonance elastography (MRE), vibration-controlled transient elastography (VCTE), and two-dimensional shear wave elastography (2D-SWE).<h4>Methods</h4>Overall, 231 patients with biopsy-proven NAFLD were included. ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2020, :]

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HCC risk post-SVR with DAAs in East Asians: findings from the REAL-C cohort.

Yasuhito Tanaka, Eiichi Ogawa, Chung-Feng Huang, Hidenori Toyoda, Dae Won Jun, Cheng-Hao Tseng, Yao-Chun Hsu, Masaru Enomoto, Hirokazu Takahashi, Norihiro Furusyo, Ming-Lun Yeh, Etsuko Iio, Satoshi Yasuda, Carla Pui-Mei Lam, Dong Hyun Lee, Hiroaki Haga, Eileen L Yoon, Sang Bong Ahn, Grace Wong, Makoto Nakamuta, Hideyuki Nomura, Pei-Chien Tsai, Jang Han Jung, Do Seon Song, Hansen Dang, Mayumi Maeda, Linda Henry, Ramsey Cheung, Man-Fung Yuen, Yoshiyuki Ueno, Yuichiro Eguchi, Akihiro Tamori, Ming-Lung Yu, Jun Hayashi, Mindie H Nguyen, ,

<h4>Background</h4>Despite HCV cure, patients remain at risk for HCC, but risk factor data for HCC following SVR are limited for Asian patients.<h4>Methods</h4>To address this gap, we analyzed 5814 patients (5646 SVR, 168 non-SVR) from the Real-World Evidence from the Asia Liver Consortium for HCV (REAL-C) who did not have HCC ... Read more >>

Hepatol Int (Hepatology international)
[2020, 14(6):1023-1033]

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MAFLD identifies patients with significant hepatic fibrosis better than NAFLD.

Sakura Yamamura, Mohammed Eslam, Takumi Kawaguchi, Tsubasa Tsutsumi, Dan Nakano, Shinobu Yoshinaga, Hirokazu Takahashi, Keizo Anzai, Jacob George, Takuji Torimura,

<h4>Background & aims</h4>Diagnostic criteria for metabolic associated fatty liver disease (MAFLD) have been proposed, but not validated. We aimed to compare the diagnostic accuracy of the MAFLD definition vs the existing NAFLD criteria to identify patients with significant fibrosis and to characterize the impact of mild alcohol intake.<h4>Methods</h4>We enrolled 765 ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2020, 40(12):3018-3030]

Cited: 3 times

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Hepatitis C Virus Cure Rates Are Reduced in Patients With Active but Not Inactive Hepatocellular Carcinoma: A Practice Implication.

Eiichi Ogawa, Hidenori Toyoda, Etsuko Iio, Dae Won Jun, Chung-Feng Huang, Masaru Enomoto, Yao-Chun Hsu, Hiroaki Haga, Shinji Iwane, Grace Wong, Dong Hyun Lee, Toshifumi Tada, Chen-Hua Liu, Wan-Long Chuang, Jun Hayashi, Ramsey Cheung, Satoshi Yasuda, Cheng-Hao Tseng, Hirokazu Takahashi, Sally Tran, Yee Hui Yeo, Linda Henry, Scott D Barnett, Hideyuki Nomura, Makoto Nakamuta, Chia-Yen Dai, Jee-Fu Huang, Hwai-I Yang, Mei-Hsuan Lee, Mi Jung Jun, Jia-Horng Kao, Yuichiro Eguchi, Yoshiyuki Ueno, Akihiro Tamori, Norihiro Furusyo, Ming-Lung Yu, Yasuhito Tanaka, Mindie H Nguyen, ,

<h4>Background</h4>Cure rates of hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) for patients with active and inactive hepatocellular carcinoma (HCC) may differ, but well-controlled studies are limited. We aimed to evaluate DAA outcomes in a large East Asian HCV/HCC population compared with HCV/non-HCC patients.<h4>Methods</h4>Using data from the Real-World Evidence ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(11):2840-2848]

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Porphyromonas gingivalis impairs glucose uptake in skeletal muscle associated with altering gut microbiota.

Kazuki Watanabe, Sayaka Katagiri, Hirokazu Takahashi, Naoki Sasaki, Shogo Maekawa, Rina Komazaki, Masahiro Hatasa, Yoichiro Kitajima, Yusuke Maruyama, Takahiko Shiba, Keiji Komatsu, Yujin Ohsugi, Kenichi Tanaka, Ayumi Matsuzawa, Tomomitsu Hirota, Haruka Tohara, Yuichiro Eguchi, Keizo Anzai, Atsuhiko Hattori, Takanori Iwata,

Skeletal muscles have a high metabolic capacity, which play key roles in glucose metabolism. Although periodontal disease increases the risk of metabolic syndrome, the relationship between periodontal bacterial infection and skeletal muscle metabolic dysfunction is unclear. We found that anti-Porphyromonas gingivalis (Pg) antibody titers positively correlated with intramuscular adipose tissue ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(2):e21171]

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Convolutional neural network with autoencoder-assisted multiclass labelling for seizure detection based on scalp electroencephalography.

Hirokazu Takahashi, Ali Emami, Takashi Shinozaki, Naoto Kunii, Takeshi Matsuo, Kensuke Kawai,

<h4>Objective</h4>In long-term video-monitoring, automatic seizure detection holds great promise as a means to reduce the workload of the epileptologist. A convolutional neural network (CNN) designed to process images of EEG plots demonstrated high performance for seizure detection, but still has room for reducing the false-positive alarm rate.<h4>Methods</h4>We combined a CNN ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2020, 125:104016]

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FIB-4 First in Diagnostic Algorithm of MAFLD at the Era of “Global Metabodemic “

Yoshio Sumida, Masashi Yoneda, Katsutoshi Tokushige, Miwa Kawanaka, Hideki Fujii, Masato Yoneda, Kento Imajo, Hirokazu Takahashi, Yuichiro Eguchi, Masafumi Ono, Yuichi Nozaki, Hideyuki Hyogo, Masahiro Koseki, Yuichi Yoshida, Takumi Kawaguchi, Yoshihiro Kamada, Takeshi Okanoue, Atsushi Nakajima,

The prevalence of obesity or metabolic syndrome is increasing worldwide (&ldquo;Globally metabodemic&rdquo;). Approximately 25% of adult general population is suffering from nonalcoholic fatty liver disease (NAFLD) which has become serious health problem. Hepatic fibrosis is the most significant determinant of all cause and liver -related mortality in NAFLD. Noninvasive test ... Read more >>

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Glucagon-Like Peptide-1 Receptor Agonist Prevented the Progression of Hepatocellular Carcinoma in a Mouse Model of Nonalcoholic Steatohepatitis.

Motoyasu Kojima, Hirokazu Takahashi, Takuya Kuwashiro, Kenichi Tanaka, Hitoe Mori, Iwata Ozaki, Yoichiro Kitajima, Yayoi Matsuda, Kenji Ashida, Yuichiro Eguchi, Keizo Anzai,

Glucagon-like peptide-1 (GLP-1) receptor agonists are used to treat diabetes, but their effects on nonalcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) remain unclear. In this study, mice with streptozotocin- and high-fat diet-induced diabetes and NASH were subcutaneously treated with liraglutide or saline (control) for 14 weeks. Glycemic ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 21(16):]

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Genetic Susceptibility of the Host in Virus-Induced Diabetes.

Keiichiro Mine, Yasunobu Yoshikai, Hirokazu Takahashi, Hitoe Mori, Keizo Anzai, Seiho Nagafuchi,

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of ... Read more >>

Microorganisms (Microorganisms)
[2020, 8(8):]

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Patient-reported outcomes in patients with non-alcoholic fatty liver disease: A narrative review of Chronic Liver Disease Questionnaire-non-alcoholic fatty liver disease/non-alcoholic steatohepatitis.

Sakura Yamamura, Dan Nakano, Ryuki Hashida, Tsubasa Tsutsumi, Takumi Kawaguchi, Michiaki Okada, Hiroshi Isoda, Hirokazu Takahashi, Hiroo Matsuse, Yuichiro Eguchi, Yoshio Sumida, Atsushi Nakajima, Lynn Gerber, Zobair M Younossi, Takuji Torimura,

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and one of the leading causes of hepatocellular carcinoma and liver transplantation. Moreover, patients with NAFLD frequently complain of non-specific symptoms including fatigue, abdominal discomfort, as well as anxiety, and NAFLD is reported to affect patient-reported outcomes (PROs). ... Read more >>

J Gastroenterol Hepatol (Journal of gastroenterology and hepatology)
[2021, 36(3):629-636]

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Metabolomic/lipidomic-based analysis of plasma to diagnose hepatocellular ballooning in patients with non-alcoholic fatty liver disease: A multicenter study.

Yuji Ogawa, Takashi Kobayashi, Yasushi Honda, Takaomi Kessoku, Wataru Tomeno, Kento Imajo, Takashi Nakahara, Satoshi Oeda, Yuko Nagaoki, Yuichiro Amano, Tatsuya Ando, Megumi Hirayama, Osamu Isono, Hidenori Kamiguchi, Hiroshi Nagabukuro, Shinji Ogawa, Yoshinori Satomi, Yusuke Saigusa, Hirokazu Takahashi, Hideyuki Hyogo, Masato Yoneda, Satoru Saito, Takeharu Yamanaka, Shinichi Aishima, Yuichiro Eguchi, Masayoshi Kage, Kazuaki Chayama, Atsushi Nakajima,

AIM:Liver biopsy is still required for the diagnosis of hepatocellular ballooning and inflammation, which are important histological features of non-alcoholic steatohepatitis. We undertook this multicenter, cross-sectional study to identify novel blood markers for the diagnosis of hepatocellular ballooning. METHODS:We enrolled 176 patients, of whom 132 were proven by liver biopsy ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2020, 50(8):955-965]

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Surveillance of Hepatocellular Carcinoma in Nonalcoholic Fatty Liver Disease

Yoshio Sumida, Masashi Yoneda, Yuya Seko, Hiroshi Ishiba, Tasuku Hara, Hidenori Toyoda, Satoshi Yasuda, Takashi Kumada, Hideki Hayashi, Takashi Kobayashi, Kento Imajo, Masato Yoneda, Toshifumi Tada, Takumi Kawaguchi, Yuichiro Eguchi, Oeda Satoshi, Hirokazu Takahashi, Eiichi Tomita, Takeshi Okanoue, Atsushi Nakajima, Japan Study Group of NAFLD (JSG-NAFLD),

Nonalcoholic fatty liver disease (NAFLD) is becoming the leading cause of hepatocellular carcinoma (HCC), liver-related mortality, and liver transplantation. There is reasonable epidemiological cohort data to recommend surveillance of patients with NAFLD based upon the incidence of HCC. The American Gastroenterology Association (AGA) expert review published in 2020 recommend that ... Read more >>

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FIB-4 index-based surveillance for advanced liver fibrosis in diabetes patients.

Nozomi Kawata, Hirokazu Takahashi, Shinji Iwane, Kanako Inoue, Motoyasu Kojima, Michiko Kohno, Kenichi Tanaka, Hitoe Mori, Hiroshi Isoda, Satoshi Oeda, Yayoi Matsuda, Yoshiaki Egashira, Jyunichi Nojiri, Hiroyuki Irie, Yuichiro Eguchi, Keizo Anzai,

Liver fibrosis is associated with lifestyle-related diseases, including diabetes. The identification of diabetic patients with severe liver fibrosis is important, but a simple and reliable diagnostic procedure remains to be determined. We conducted an observational study to evaluate the performance of a FIB-4 index-based screening strategy for the diagnosis of ... Read more >>

Diabetol Int (Diabetology international)
[2021, 12(1):118-125]

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