Full Text Journal Articles by
Author Hideki Tsumura

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Similar responsiveness between C57BL/6N and C57BL/6J mouse substrains to superovulation.

Miyuki Shindo, Hideki Tsumura, Kenji Miyado, Woojin Kang, Natsuko Kawano, Tomoko Yoshida, Maki Fukami, Mami Miyado,

Superovulation is a method for the drug-induced release of multiple eggs and useful for <i>in vitro</i> fertilization. Thus, its high efficiency largely reduces the number of mice used per experiment. We compared the responsivity to superovulation between C57BL/6N (B6N) and C57BL/6J (B6J) substrains. The average number of ovulated eggs was ... Read more >>

MicroPubl Biol (microPublication biology)
[2021, 2021:]

Cited: 0 times

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Relationships between Slc1a5 and Osteoclastogenesis.

Hideki Tsumura, Miyuki Shindo, Morihiro Ito, Arisa Igarashi, Kazue Takeda, Kenji Matsumoto, Takashi Ohkura, Kenji Miyado, Fumihiro Sugiyama, Akihiro Umezawa, Yasuhiko Ito,

<i>Slc1a5</i> (<i>ASCT2</i>) encodes a small neutral amino-acid exchanger and is the most well-studied glutamine transporter in cancer cells. To investigate the role of <i>Slc1a5</i> in osteoclastogenesis, we developed <i>Slc1a5</i>-deficient mice by using a conventional gene-targeting approach. The <i>Slc1a</i>5<sup>-/-</sup> mice showed no obvious abnormalities in growth. Glutamine uptake was assessed in ... Read more >>

Comp Med (Comparative medicine)
[2021, 71(4):285-294]

Cited: 0 times

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Relationship between insomnia with alcohol drinking before sleep (Ne-Zake) or in the morning (Mukae-Zake) among Japanese farmers.

Rie Sato, Takashi Hisamatsu, Hideki Tsumura, Mari Fukuda, Kaori Taniguchi, Haruo Takeshita, Hideyuki Kanda,

<h4>Background</h4>Ne-Zake is the drinking of alcohol before sleeping for helping to fall asleep and sleep well, and Mukae-Zake is the drinking of alcohol in the morning for "calming down" or "curing hangovers".<h4>Objective</h4>We sought to examine the relationship of insomnia with Ne-Zake and Mukae-Zake among healthy middle-aged Japanese farmers.<h4>Methods</h4>In a cross-sectional ... Read more >>

Alcohol (Alcohol (Fayetteville, N.Y.))
[2021, 93:57-62]

Cited: 0 times

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Loss of the branched-chain amino acid transporter CD98hc alters the development of colonic macrophages in mice.

Philipp Wuggenig, Berna Kaya, Hassan Melhem, C Korcan Ayata, , Petr Hruz, A Emre Sayan, Hideki Tsumura, Morihiro Ito, Julien Roux, Jan Hendrik Niess,

Comprehensive development is critical for gut macrophages being essential for the intestinal immune system. However, the underlying mechanisms of macrophage development in the colon remain elusive. To investigate the function of branched-chain amino acids in the development of gut macrophages, an inducible knock-out mouse model for the branched-chain amino acid ... Read more >>

Commun Biol (Communications biology)
[2020, 3(1):130]

Cited: 7 times

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Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.

Seiji Ogawa, Mitsutoshi Yamada, Akihiro Nakamura, Tohru Sugawara, Akari Nakamura, Shoko Miyajima, Yuichirou Harada, Reina Ooka, Ryuichiro Okawa, Jun Miyauchi, Hideki Tsumura, Yasunori Yoshimura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, Akihiro Umezawa, Toshio Hamatani,

Zygotic genome activation (ZGA) begins after fertilization and is essential for establishing pluripotency and genome stability. However, it is unclear how ZGA genes prevent mitotic errors. Here we show that knockout of the ZGA gene Zscan5b, which encodes a SCAN domain with C2H2 zinc fingers, causes a high incidence of ... Read more >>

Stem Cell Reports (Stem cell reports)
[2019, 12(6):1366-1379]

Cited: 2 times

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At-risk Internet addiction and related factors among junior high school teachers-based on a nationwide cross-sectional study in Japan.

Ayumi Iwaibara, Mari Fukuda, Hideki Tsumura, Hideyuki Kanda,

<h4>Background</h4>School teachers have a possibility toward at-risk Internet addiction (IA) due to increased opportunities to use the Internet, along with the spread of the Internet in recent years. Burnout syndrome (BOS) is found to be one of the symptoms related to unhealthy mental health, especially among teachers. This study aims ... Read more >>

Environ Health Prev Med (Environmental health and preventive medicine)
[2019, 24(1):3]

Cited: 3 times

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Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones.

Yuko Katoh-Fukui, Takashi Baba, Tetsuya Sato, Hiroyuki Otake, Yuko Nagakui-Noguchi, Miyuki Shindo, Mikita Suyama, Yasuyuki Ohkawa, Hideki Tsumura, Ken-Ichirou Morohashi, Maki Fukami,

A set of key developmental genes is essential for skeletal growth from multipotent progenitor cells at weaning. Polycomb group proteins, which regulate such genes contributes to the cell lineage commitment and subsequent differentiation via epigenetic chromatin modification and remodeling. However, it is unclear which cell lineage and gene sets are ... Read more >>

Bone (Bone)
[2019, 120:219-231]

Cited: 1 time

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Bcl-2-associated athanogene 3 (BAG3) is an enhancer of small heat shock protein turnover via activation of autophagy in the heart.

Yui Inomata, Shouta Nagasaka, Kazuki Miyate, Yuta Goto, Chizuru Hino, Chihiro Toukairin, Rieko Higashio, Kinji Ishida, Tomoyuki Saino, Masamichi Hirose, Hideki Tsumura, Atsushi Sanbe,

Bcl-2-associated athanogene 3 (BAG3) is strongly expressed in both cardiac and skeletal muscle. A recent study showed that BAG3 may play a protective role in muscles. Little is known, however, regarding the detailed role of BAG3 in cardiac muscle. To better understand the functional role of cardiac BAG3 in the ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2018, 496(4):1141-1147]

Cited: 6 times

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Prevalence and Risk Factors of Internet Addiction Among Employed Adults in Japan.

Hideki Tsumura, Hideyuki Kanda, Nagisa Sugaya, Satoshi Tsuboi, Kenzo Takahashi,

<h4>Background</h4>The prevalence of Internet addiction (IA) among employed adults has not been reported using a large sample. To clarify the actual status of addictive Internet use among employed adults, this study aimed to evaluate the prevalence and the risk factors of IA and at-risk IA among employed adults in Japan.<h4>Methods</h4>This ... Read more >>

J Epidemiol (Journal of epidemiology)
[2018, 28(4):202-206]

Cited: 5 times

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Slc3a2 Mediates Branched-Chain Amino-Acid-Dependent Maintenance of Regulatory T Cells.

Kayo Ikeda, Makoto Kinoshita, Hisako Kayama, Shushi Nagamori, Pornparn Kongpracha, Eiji Umemoto, Ryu Okumura, Takashi Kurakawa, Mari Murakami, Norihisa Mikami, Yasunori Shintani, Satoko Ueno, Ayatoshi Andou, Morihiro Ito, Hideki Tsumura, Koji Yasutomo, Keiichi Ozono, Seiji Takashima, Shimon Sakaguchi, Yoshikatsu Kanai, Kiyoshi Takeda,

Foxp3<sup>+</sup> regulatory T (Treg) cells, which suppress immune responses, are highly proliferative in vivo. However, it remains unclear how the active replication of Treg cells is maintained in vivo. Here, we show that branched-chain amino acids (BCAAs), including isoleucine, are required for maintenance of the proliferative state of Treg cells via the ... Read more >>

Cell Rep (Cell reports)
[2017, 21(7):1824-1838]

Cited: 28 times

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Post-event Processing Predicts Impaired Cortisol Recovery Following Social Stressor: The Moderating Role of Social Anxiety.

Shunta Maeda, Tomoya Sato, Hironori Shimada, Hideki Tsumura,

There is growing evidence that individuals with social anxiety show impaired cortisol recovery after experiencing social evaluative stressors. Yet, little is known regarding the cognitive processes underlying such impaired cortisol recovery. The present study examined the effect of post-event processing (PEP), referred to as repetitive thinking about social situations, on ... Read more >>

Front Psychol (Frontiers in psychology)
[2017, 8:1919]

Cited: 2 times

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Neuregulin-1 type III knockout mice exhibit delayed migration of Schwann cell precursors.

Yuki Miyamoto, Tomohiro Torii, Akito Tanoue, Kazuko Kawahara, Miyuki Arai, Hideki Tsumura, Toru Ogata, Motoshi Nagao, Nobuo Terada, Masahiro Yamamoto, Shou Takashima, Junji Yamauchi,

In an embryonic developmental stage of the peripheral nervous system (PNS), Schwann cell precursors migrate along neuronal axons to their final destinations. After birth, they eventually wrap around individual axons to form myelin sheaths, which insulate axons to increase the nerve conduction velocity. Some growth factors and adhesion molecules are ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2017, 486(2):506-513]

Cited: 6 times

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Impaired CD98 signaling protects against graft-versus-host disease by increasing regulatory T cells.

Yoshiaki Nishio, Masayuki Fujino, Songjie Cai, Yuya Kitajima, Taro Saito, Hideki Tsumura, Morihiro Ito, Yasuhiko Ito, Yukitoshi Nagahara, Xiao-Kang Li,

Graft-versus-host disease (GvHD) is a major barrier to the broader use of allogenic hematopoietic stem cell transplantation for non-malignant clinical applications. A murine model of C57BL/6 to B6D2F1 acute GvHD was employed with T lymphocytes harboring a deletion of the CD98 heavy chain (CD98hc(-/-)) as donor cells. The CD98hc(-/-) resulted ... Read more >>

Transpl Immunol (Transplant immunology)
[2016, 35:34-39]

Cited: 3 times

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CD98 Heavy Chain Is a Potent Positive Regulator of CD4+ T Cell Proliferation and Interferon-γ Production In Vivo.

Takeshi Kurihara, Hideki Arimochi, Zaied Ahmed Bhuyan, Chieko Ishifune, Hideki Tsumura, Morihiro Ito, Yasuhiko Ito, Akiko Kitamura, Yoichi Maekawa, Koji Yasutomo,

Upon their recognition of antigens presented by the MHC, T cell proliferation is vital for clonal expansion and the acquisition of effector functions, which are essential for mounting adaptive immune responses. The CD98 heavy chain (CD98hc, Slc3a2) plays a crucial role in the proliferation of both CD4+ and CD8+ T ... Read more >>

PLoS One (PloS one)
[2015, 10(10):e0139692]

Cited: 2 times

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Neurophysiological modulation of rapid emotional face processing is associated with impulsivity traits.

Takahiro Soshi, Takamasa Noda, Kumiko Ando, Kanako Nakazawa, Hideki Tsumura, Takayuki Okada,

<h4>Background</h4>Sensori-perceptual processing of emotional stimuli under attentive conditions effectively prevents response disinhibition. This is observed saliently in low-impulsive people, because of their high sensitivity to warning signals, such as emotional faces. Results from human neurophysiological studies have been used to develop a dual detector model for early sensori-perceptual processing. A ... Read more >>

BMC Neurosci (BMC neuroscience)
[2015, 16:87]

Cited: 2 times

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Conditional deletion of CD98hc inhibits osteoclast development.

Hideki Tsumura, Morihiro Ito, Masamichi Takami, Miyuki Arai, Xiao-Kang Li, Toshio Hamatani, Arisa Igarashi, Shuji Takada, Kenji Miyado, Akihiro Umezawa, Yasuhiko Ito,

The CD98 heavy chain (CD98hc) regulates virus-induced cell fusion and monocyte fusion, and is involved in amino acid transportation. Here, we examined the role that CD98hc plays in the formation of osteoclasts using CD98hc<sup>flox/flox</sup>LysM-cre peritoneal macrophages (CD98hc-defect macrophages). Peritoneal macrophages were stimulated with co-cultured with osteoblasts in the presence of ... Read more >>

Biochem Biophys Rep (Biochemistry and biophysics reports)
[2016, 5:203-210]

Cited: 1 time

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Data supporting Arf6 regulation of Schwann cell differentiation and myelination.

Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, Junji Yamauchi,

The data is related to the research article entitled "Arf6 mediates Schwann cell differentiation and myelination" [1]. To further investigate the role of Arf6 in promoting myelination by Schwann cells in vivo, we have characterized an another line (#2) of small-hairpin (sh)RNA transgenic mice targeting Arf6. The number of transgenes ... Read more >>

Data Brief (Data in brief)
[2015, 5:388-395]

Cited: 1 time

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Stress-induced cortisol is associated with generation of non-negative interpretations during cognitive reappraisal.

Hideki Tsumura, Jun Sensaki, Hironori Shimada,

<h4>Background</h4>Enhanced processing of emotional stimuli after stress exposure is reported to be associated with stress-induced cortisol. Because enhanced emotional information processing could make cognitive emotion regulation more difficult, it was hypothesized that stress-induced cortisol would be associated with non-negative interpretation generation associated with the cognitive reappraisal processes.<h4>Methods</h4>A total of 36 ... Read more >>

Biopsychosoc Med (BioPsychoSocial medicine)
[2015, 9:23]

Cited: 3 times

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Impulsivity is Associated with Early Sensory Inhibition in Neurophysiological Processing of Affective Sounds.

Takahiro Soshi, Takamasa Noda, Kumiko Ando, Kanako Nakazawa, Hideki Tsumura, Takayuki Okada,

Impulsivity is widely related to socially problematic behaviors and psychiatric illness. Previous studies have investigated the relationship between response inhibition and impulsivity. However, no study has intensively examined how impulsivity correlates with automatic sensory processing before the drive for response inhibition to sensory inputs. Sensory gating (SG) is an automatic ... Read more >>

Front Psychiatry (Frontiers in psychiatry)
[2015, 6:141]

Cited: 1 time

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Arf6 mediates Schwann cell differentiation and myelination.

Tomohiro Torii, Yuki Miyamoto, Masahiro Yamamoto, Katsuya Ohbuchi, Hideki Tsumura, Kazuko Kawahara, Akito Tanoue, Hiroyuki Sakagami, Junji Yamauchi,

During development of the peripheral nervous system (PNS), Schwann cells wrap neuronal axons, becoming the myelin sheaths that help axonal functions. While the intercellular signals controlling the myelination process between Schwann cells and peripheral neurons are well studied, the transduction of these signals in Schwann cells still remains elusive. Here, ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2015, 465(3):450-457]

Cited: 5 times

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Partial rescue of mucopolysaccharidosis type VII mice with a lifelong engraftment of allogeneic stem cells in utero.

Norimasa Ihara, Umezawa Akihiro, Naoko Onami, Hideki Tsumura, Eisuke Inoue, Satoshi Hayashi, Haruhiko Sago, Shuki Mizutani,

In utero hematopoietic cell transplantation (IUHCT) has been performed in Mucopolysaccharidosis Type VII (MPSVII) mice, but a lifelong engraftment of allogeneic donor cells has not been achieved. In this study, we sought to confirm a lifelong engraftment of allogeneic donor cells immunologically matched to the mother and to achieve partial ... Read more >>

Congenit Anom (Kyoto) (Congenital anomalies)
[2015, 55(1):55-64]

Cited: 1 time

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In vivo knockdown of ErbB3 in mice inhibits Schwann cell precursor migration.

Tomohiro Torii, Yuki Miyamoto, Shuji Takada, Hideki Tsumura, Miyuki Arai, Kazuaki Nakamura, Katsuya Ohbuchi, Masahiro Yamamoto, Akito Tanoue, Junji Yamauchi,

The myelin sheath insulates neuronal axons and markedly increases the nerve conduction velocity. In the peripheral nervous system (PNS), Schwann cell precursors migrate along embryonic neuronal axons to their final destinations, where they eventually wrap around individual axons to form the myelin sheath after birth. ErbB2 and ErbB3 tyrosine kinase ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2014, 452(3):782-788]

Cited: 7 times

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CD98hc regulates the development of experimental colitis by controlling effector and regulatory CD4(+) T cells.

Zaied Ahmed Bhuyan, Hideki Arimochi, Jun Nishida, Keiko Kataoka, Takeshi Kurihara, Chieko Ishifune, Hideki Tsumura, Morihiro Ito, Yasuhiko Ito, Akiko Kitamura, Koji Yasutomo,

CD4(+) T cell activation is controlled by signaling through the T cell receptor in addition to various co-receptors, and is also affected by their interactions with effector and regulatory T cells in the microenvironment. Inflammatory bowel diseases (IBD) are caused by the persistent activation and expansion of auto-aggressive CD4(+) T ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2014, 444(4):628-633]

Cited: 2 times

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Post-error action control is neurobehaviorally modulated under conditions of constant speeded response.

Takahiro Soshi, Kumiko Ando, Takamasa Noda, Kanako Nakazawa, Hideki Tsumura, Takayuki Okada,

Post-error slowing (PES) is an error recovery strategy that contributes to action control, and occurs after errors in order to prevent future behavioral flaws. Error recovery often malfunctions in clinical populations, but the relationship between behavioral traits and recovery from error is unclear in healthy populations. The present study investigated ... Read more >>

Front Hum Neurosci (Frontiers in human neuroscience)
[2014, 8:1072]

Cited: 4 times

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Effects of distraction on negative behaviors and salivary α-amylase under mildly stressful medical procedures for brief inpatient children.

Hideki Tsumura, Hironori Shimada, Hiroshi Morimoto, Chihiro Hinuma, Yoshiko Kawano,

Inconsistent results have been reported on the effects of distraction on negative emotions during medical procedures in infants. These differing results may be attributable to the fact that the effects are apparent under a mildly stressful medical procedure. A total of 17 infants, 18 preschoolers, and 15 school-aged children who ... Read more >>

J Health Psychol (Journal of health psychology)
[2014, 19(8):1079-1088]

Cited: 2 times

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