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Author Hideki Tokunaga

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Docetaxel and carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix: a phase II study.

Muneaki Shimada, Shinya Sato, Tadahiro Shoji, Shoji Nagao, Hideki Tokunaga, Kotaro Sueoka, Kazuhiro Takehara, Keiichiro Nakamura, Satoshi Yamaguchi, Junzo Kigawa,

<h4>Background</h4>This phase II study evaluated the efficacy and safety of docetaxel/carboplatin chemotherapy for treating patients with stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix.<h4>Methods</h4>A total of 50 patients with International Federation of Gynecology and Obstetrics stage IVB or recurrent non-squamous cell carcinoma of the uterine cervix were ... Read more >>

Int J Clin Oncol (International journal of clinical oncology)
[2021, :]

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Prospective evaluation of sentinel node navigation surgery in Japanese patients with low-risk endometrial cancer-safety and occurrence of lymphedema.

Hitoshi Niikura, Asami Toki, Tomoyuki Nagai, Satoshi Okamoto, Shogo Shigeta, Hideki Tokunaga, Muneaki Shimada, Mika Watanabe, Nobuo Yaegashi,

<h4>Objective</h4>The present study aimed to clarify the occurrence rate of lymphedema and prognosis in patients with endometrial cancer according to sentinel lymph node biopsy alone with intraoperative histopathological examination.<h4>Methods</h4>The study included 45 consecutive patients with endometrial cancer treated at Tohoku University Hospital between October 2014 and August 2017. All patients ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2021, 51(4):584-589]

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Correction to: Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade.

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase,

Eur Radiol (European radiology)
[2021, 31(3):1780-1781]

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The validity of the subsequent pregnancy index score for fertility-sparing trachelectomy in early-stage cervical cancer.

Takashi Iwata, Hiroko Machida, Koji Matsuo, Kaoru Okugawa, Tsuyoshi Saito, Kyoko Tanaka, Kenichiro Morishige, Hiroaki Kobayashi, Kiyoshi Yoshino, Hideki Tokunaga, Tomoaki Ikeda, Makio Shozu, Nobuo Yaegashi, Takayuki Enomoto, Mikio Mikami,

<h4>Objective</h4>To evaluate timing and a prediction model for pregnancy in early-stage cervical cancer patients who underwent fertility-sparing trachelectomy.<h4>Design</h4>Retrospective cohort.<h4>Setting</h4>Academic multicenter.<h4>Patient(s)</h4>Women ages <45 years with clinical stage I-II cervical cancer were enrolled between 2009 and 2013 (n = 393).<h4>Intervention(s)</h4>Planned fertility-sparing trachelectomy.<h4>Main outcome measure(s)</h4>Cumulative incidences and clinicopathological characteristics of those who developed ... Read more >>

Fertil Steril (Fertility and sterility)
[2021, :]

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The 2020 Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer.

Hideki Tokunaga, Mikio Mikami, Satoru Nagase, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Toyomi Satoh, Yasuyuki Hirashima, Noriomi Matsumura, Yoshihito Yokoyama, Kei Kawana, Satoru Kyo, Daisuke Aoki, Hidetaka Katabuchi,

The fifth edition of the Japan Society of Gynecologic Oncology guidelines for the treatment of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer was published in 2020. The guidelines contain 6 chapters-namely, (1) overview of the guidelines; (2) epithelial ovarian cancer, fallopian tube cancer, and primary peritoneal cancer; (3) ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e49]

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Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2).

Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda,

Identification of the population frequencies of definitely pathogenic germline variants in two major hereditary breast and ovarian cancer syndrome (HBOC) genes, BRCA1/2, is essential to estimate the number of HBOC patients. In addition, the identification of moderately penetrant HBOC gene variants that contribute to increasing the risk of breast and ... Read more >>

PLoS One (PloS one)
[2021, 16(1):e0236907]

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Phase 2 single-arm study on the safety of maintenance niraparib in Japanese patients with platinum-sensitive relapsed ovarian cancer.

Kazuhiro Takehara, Takashi Matsumoto, Junzo Hamanishi, Kosei Hasegawa, Motoki Matsuura, Kiyonori Miura, Shoji Nagao, Hidekatsu Nakai, Naotake Tanaka, Hideki Tokunaga, Kimio Ushijima, Hidemichi Watari, Yoshihito Yokoyama, Yoichi Kase, Shuuji Sumino, Ajit Suri, Hiroaki Itamochi, Nobuhiro Takeshima,

<h4>Objective</h4>The primary objective of this study was to evaluate the safety of niraparib 300 mg/day in Japanese patients with platinum-sensitive, relapsed ovarian cancer in a maintenance setting.<h4>Methods</h4>Phase 2, multicenter, open-label, single-arm study enrolled Japanese patients with platinum-sensitive, relapsed ovarian cancer who had received ≥2 platinum-based regimens. The primary endpoint (incidence ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e21]

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Lymphadenectomy issues in endometrial cancer.

Yosuke Konno, Hiroshi Asano, Ayumi Shikama, Daisuke Aoki, Michihiro Tanikawa, Akinori Oki, Koji Horie, Akira Mitsuhashi, Akira Kikuchi, Hideki Tokunaga, Yasuhisa Terao, Toyomi Satoh, Kimio Ushijima, Mitsuya Ishikawa, Nobuo Yaegashi, Hidemichi Watari,

<h4>Objectives</h4>This review aims to introduce preoperative scoring systems to predict lymph node metastasis (LNM) and ongoing clinical trials to investigate the therapeutic role of lymphadenectomy for endometrial cancer.<h4>Methods</h4>We summarized previous reports on the preoperative prediction models for LNM and evaluated their validity to omit lymphadenectomy in our recent cohorts. Next, ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(2):e25]

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Impact of Histopathological Risk Factors on the Treatment of Stage IB-IIB Uterine Cervical Cancer.

Muneaki Shimada, Hideki Tokunaga, Junzo Kigawa, Nobuo Yaegashi,

In the past decade, the incidence of adenocarcinoma of the uterine cervix gradually increased. Recent literature revealed that the molecular pathogenesis differs by histological subtype, and the histological subtype should be considered in deciding treatments for patients with uterine cervical cancer. However, no treatment based on histological type or genomic ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2020, 252(4):339-351]

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background: </h4> The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT). <h4>Methods: </h4> Patients with persistent cervical cancer treated with definitive RT/CCRT at ... Read more >>

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Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.

Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa, Takafumi Toita, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

<h4>Background</h4>The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definitive radiotherapy (RT)/ concurrent chemoradiotherapy (CCRT).<h4>Methods</h4>Patients with persistent cervical cancer treated with definitive RT/CCRT at 35 institutions from 2005 to ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):1169]

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Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes in a 3,552 Japanese whole-genome sequence dataset (3.5KJPNv2)

Hideki Tokunaga, Keita Iida, Atsushi Hozawa, Soichi Ogishima, Yoh Watanabe, Shogo Shigeta, Muneaki Shimada, Yumi Yamaguchi-Kabata, Shu Tadaka, Fumiki Katsuoka, Shin Ito, Kazuki Kumada, Yohei Hamanaka, Nobuo Fuse, Kengo Kinoshita, Masayuki Yamamoto, Nobuo Yaegashi, Jun Yasuda,

Identification of pathogenic germline variants yet no clinical evidence in BRCA genes has become important in patient care of hereditary breast and ovarian cancer syndrome (HBOC). Computational scoring and prospective cohort studies may help to identify such pathogenic variants. We annotated the variants in the BRCA1 and BRCA2 genes from ... Read more >>

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MicroRNA Let-7c Contributes to Paclitaxel Resistance via Aurora-B in Endometrial Serous Carcinoma.

Izumi Sato, Masumi Ishibashi, Hideki Tokunaga, Shogo Shigeta, Shoko Sakurada, Muneaki Shimada, Satoru Nagase, Yoh Watanabe, Nobuo Yaegashi,

The incidence of endometrial cancer has rapidly risen over recent years. Paclitaxel, a key drug for endometrial cancer treatment, inhibits microtubule depolymerization and induces apoptosis in cancer cells. Endometrial serous carcinoma (ESC) accounts for < 10% of all endometrial carcinomas, but its aggressive nature makes it responsible for close to ... Read more >>

Tohoku J Exp Med (The Tohoku journal of experimental medicine)
[2020, 251(4):263-272]

Cited: 1 time

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Gaussian mixture model-based cluster analysis of apparent diffusion coefficient values: a novel approach to evaluate uterine endometrioid carcinoma grade.

Sakiko Kageyama, Naoko Mori, Shunji Mugikura, Hideki Tokunaga, Kei Takase,

<h4>Objectives</h4>The purpose of our study was to perform Gaussian mixture model (GMM)-based cluster analysis of the apparent diffusion coefficient (ADC) data of patients with endometrioid carcinoma, and to evaluate the relationship between histological grade and the ratios of the different clusters in each patient.<h4>Methods</h4>This retrospective study enrolled 122 patients (training: ... Read more >>

Eur Radiol (European radiology)
[2021, 31(1):55-64]

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Potential of Tyrosine Kinase Receptor TIE-1 as Novel Therapeutic Target in High-PI3K-Expressing Ovarian Cancer.

Xuewei Zhang, Masumi Ishibashi, Kazuyuki Kitatani, Shogo Shigeta, Hideki Tokunaga, Masafumi Toyoshima, Muneaki Shimada, Nobuo Yaegashi,

Tyrosine kinase receptor TIE-1 plays a critical role in angiogenesis and blood-vessel stability. In recent years, increased TIE-1 expression has been observed in many types of cancers; however, the biological significance and underlying mechanisms remain unknown. Thus, in the present study, we investigated the tumor biological functions of TIE-1 in ... Read more >>

Cancers (Basel) (Cancers)
[2020, 12(6):]

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Cervical cancer screening rates before and after the Great East Japan Earthquake in the Miyagi Prefecture, Japan.

Yasuhiro Miki, Toru Tase, Hideki Tokunaga, Nobuo Yaegashi, Kiyoshi Ito,

After disasters, issues pertaining to women's health such as irregular periods and bleeding are well surveyed. However, the management of women's health, especially changes in the rate of health checkups, has not been investigated. In the present study, we focused on the change in the cervical cancer screening rates (CCS-Rs) ... Read more >>

PLoS One (PloS one)
[2020, 15(3):e0229924]

Cited: 1 time

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Perioperative treatments for stage IB-IIB uterine cervical cancer.

Muneaki Shimada, Hideki Tokunaga, Hiroaki Kobayashi, Mitsuya Ishikawa, Nobuo Yaegashi,

Japan Society of Gynecologic Oncology guidelines recommended either radical hysterectomy-based approach or the definitive radiotherapy including concurrent chemoradiotherapy as primary treatment for patients with not only stage IB1/IIA1, but also stages IB2, IIA2 and IIB. Based on pathological findings of surgical specimens, patients who underwent radical hysterectomy are divided into ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2020, 50(2):99-103]

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Correlation of World Health Organization 2010 Classification for Gastroenteropancreatic Neuroendocrine Neoplasms with the Prognosis of Ovarian Neuroendocrine Neoplasms: Kansai Clinical Oncology Group-Protocol Review Committee/Intergroup Study.

Kentaro Kai, Kaei Nasu, Haruto Nishida, Tsutomu Daa, Ayumi Shikama, Takaya Shiozaki, Masamitsu Kurakazu, Mitsutake Yano, Yuko Imamura, Hideki Tokunaga, Kazuto Tasaki, Yasushi Iida, Yuki Yamada, Hiroyuki Morisawa, Satoshi Nakagawa, Etsuko Fujimoto, Tomohiko Tsuruta, Harunobu Matsumoto, Atsushi Arakawa, Michiko Nonaka, Hirokuni Takano, Takashi Ushiwaka, Taisuke Mori, Kimihiko Ito, Takashi Motohashi, Norihiro Teramoto, Takashi Yamada,

<h4>Background</h4>In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for ovarian NENs (O-NENs) and correlates with prognosis.<h4>Methods</h4>Sixty-eight patients diagnosed with carcinoid, ... Read more >>

Neuroendocrinology (Neuroendocrinology)
[2021, 111(4):320-329]

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Clinical status and prognostic factors in Japanese patients with uterine leiomyosarcoma.

Kazuhiro Takehara, Natsumi Yamashita, Reiko Watanabe, Norihiro Teramoto, Hitoshi Tsuda, Takashi Motohashi, Kenichi Harano, Toru Nakanishi, Hideki Tokunaga, Nobuyuki Susumu, Yutaka Ueda, Yoshihito Yokoyama, Toshiaki Saito,

OBJECTIVE:Uterine leiomyosarcoma (uLMS) is a rare gynecologic malignancy for which the currently available treatments do not consistently provide long-term disease control. This study aimed to reveal the current clinical status of uLMS to support future clinical trials. METHODS:This study enrolled patients with uLMS treated at 53 Japanese institutions from 2000 ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 157(1):115-120]

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Survival outcome and perioperative complication related to neoadjuvant chemotherapy with carboplatin and paclitaxel for advanced ovarian cancer: A systematic review and meta-analysis.

Hiroko Machida, Hideki Tokunaga, Koji Matsuo, Noriomi Matsumura, Yoichi Kobayashi, Tsutomu Tabata, Masanori Kaneuchi, Satoru Nagase, Mikio Mikami,

<h4>Objective</h4>To compare the effectiveness and safety of neoadjuvant chemotherapy with carboplatin/paclitaxel followed by interval debulking surgery (NACT-IDS) to primary debulking surgery plus postoperative chemotherapy (PDS) for advanced ovarian cancer.<h4>Methods</h4>A comprehensive systematic review and meta-analysis were conducted by an Expert Panel of the Japan Society of Gynecologic Oncology Ovarian Cancer Committee. ... Read more >>

Eur J Surg Oncol (European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology)
[2020, 46(5):868-875]

Cited: 2 times

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Fertility-sparing trachelectomy for early-stage cervical cancer: A proposal of an ideal candidate.

Hiroko Machida, Takashi Iwata, Kaoru Okugawa, Koji Matsuo, Tsuyoshi Saito, Kyoko Tanaka, Kenichiro Morishige, Hiroaki Kobayashi, Kiyoshi Yoshino, Hideki Tokunaga, Tomoaki Ikeda, Makio Shozu, Nobuo Yaegashi, Takayuki Enomoto, Mikio Mikami,

<h4>Objective</h4>To propose an ideal patient candidate with early-stage cervical cancer for undergoing fertility-sparing trachelectomy.<h4>Methods</h4>This nationwide, multicenter, retrospective study was conducted by the Japan Society of Obstetrics and Gynecology involving women aged <45 years with clinical stage I-II cervical cancer who had planned fertility-sparing trachelectomy and pelvic lymphadenectomy between 2009 and 2013 ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2020, 156(2):341-348]

Cited: 2 times

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Clinical and reproductive outcomes of fertility-sparing surgery in stage I epithelial ovarian cancer.

Takafumi Watanabe, Shu Soeda, Hiroshi Nishiyama, Yuichiroh Kiko, Hideki Tokunaga, Shogo Shigeta, Nobuo Yaegashi, Hidekazu Yamada, Tsuyoshi Ohta, Satoru Nagase, Tadahiro Shoji, Masahiro Kagabu, Tsukasa Baba, Dai Shimizu, Naoki Sato, Yukihiro Terada, Masayuki Futagami, Yoshihito Yokoyama, Keiya Fujimori,

The aim of the present study was to evaluate the oncologic safety and reproductive outcome in patients with stage I epithelial ovarian cancer (EOC) treated with fertility-sparing surgery (FSS). Women aged ≤40 years with stage I EOC who had undergone FSS between 2000 and 2010 were retrospectively reviewed. Survival was ... Read more >>

Mol Clin Oncol (Molecular and clinical oncology)
[2020, 12(1):44-50]

Cited: 2 times

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Analysis of the relapse patterns and risk factors of endometrial cancer following postoperative adjuvant chemotherapy in a phase III randomized clinical trial.

Hiroyuki Nomura, Daisuke Aoki, Nobuyuki Susumu, Mika Mizuno, Hidekatsu Nakai, Masahide Arai, Shin Nishio, Hideki Tokunaga, Toru Nakanishi, Yoh Watanabe, Nobuo Yaegashi, Yoshihito Yokoyama, Kazuhiro Takehara,

<h4>Objective</h4>This study was to analyze patterns and risk factors of relapse after postoperative adjuvant chemotherapy for endometrial cancer.<h4>Methods</h4>Among patients enrolled in a randomized phase III trial (JGOG2043) investigating the efficacy of adjuvant chemotherapy for endometrial cancer at a high risk of progression, the recurrent patients were studied. Clinical information were ... Read more >>

Gynecol Oncol (Gynecologic oncology)
[2019, 155(3):413-419]

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Clinicopathologic features, treatment, prognosis and prognostic factors of neuroendocrine carcinoma of the endometrium: a retrospective analysis of 42 cases from the Kansai Clinical Oncology Group/Intergroup study in Japan.

Harunobu Matsumoto, Mototsugu Shimokawa, Kaei Nasu, Ayumi Shikama, Takaya Shiozaki, Masayuki Futagami, Kentaro Kai, Hiroaki Nagano, Taisuke Mori, Mitsutake Yano, Norihiro Sugino, Etsuko Fujimoto, Norihito Yoshioka, Satoshi Nakagawa, Muneaki Shimada, Hideki Tokunaga, Yuki Yamada, Tomohiko Tsuruta, Kazuto Tasaki, Ryutaro Nishikawa, Shiho Kuji, Takashi Motohashi, Kimihiko Ito, Takashi Yamada, Norihiro Teramoto,

<h4>Objective</h4>We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2019, 30(6):e103]

Cited: 2 times

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Sentinel node navigation surgery in cervical and endometrial cancer: a review.

Hitoshi Niikura, Keita Tsuji, Hideki Tokunaga, Muneaki Shimada, Mitsuya Ishikawa, Nobuo Yaegashi,

Pelvic lymphadenectomy is generally performed to treat early-stage cervical cancer, and pelvic ± para-aortic lymphadenectomy is performed in patients with endometrial cancer confined to the uterus. However, systematic lymphadenectomy is frequently associated with sequelae including lymphocele, lymphedema and cellulitis. The sentinel lymph node concept has been recently applied in the ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2019, 49(6):495-500]

Cited: 2 times

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