Full Text Journal Articles by
Author Herbert Y Lin

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Fluid assessment in dialysis patients by point-of-care magnetic relaxometry.

Lina A Colucci, Kristin M Corapi, Matthew Li, Xavier Vela Parada, Andrew S Allegretti, Herbert Y Lin, Dennis A Ausiello, Matthew S Rosen, Michael J Cima,

Magnetic resonance imaging (MRI) is a powerful diagnostic tool, but its use is restricted to the scanner suite. Here, we demonstrate that a bedside nuclear magnetic resonance (NMR) sensor can assess fluid status changes in individuals at a fraction of the time and cost compared to MRI. Our study recruited ... Read more >>

Sci Transl Med (Science translational medicine)
[2019, 11(502):]

Cited: 1 time

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Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.

Yining Li, Jérôme Fortin, Luisina Ongaro, Xiang Zhou, Ulrich Boehm, Alan Schneyer, Daniel J Bernard, Herbert Y Lin,

Inhibins are gonadal hormones that act on pituitary gonadotrope cells to suppress FSH synthesis and secretion. Inhibin A and B are heterodimers of the inhibin ⍺-subunit disulfide-linked to one of two inhibin β-subunits. Homodimers or heterodimers of the inhibin β-subunits form the activins, which stimulate FSH production. Activins signal through ... Read more >>

Endocrinology (Endocrinology)
[2018, 159(12):4077-4091]

Cited: 2 times

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RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism.

Wenjing Liu, Binbin Chen, Yang Wang, Chenling Meng, Huihui Huang, Xiao-Ru Huang, Jinzhong Qin, Shrikant R Mulay, Hans-Joachim Anders, Andong Qiu, Baoxue Yang, Gordon J Freeman, Hua Jenny Lu, Herbert Y Lin, Zhi-Hua Zheng, Hui-Yao Lan, Yu Huang, Yin Xia,

Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is a type of programed necrosis, which is executed by mixed lineage kinase domain-like protein (MLKL) upon its binding to the plasma membrane. Emerging evidence indicates that necroptosis plays a critical role in the development of ... Read more >>

Proc. Natl. Acad. Sci. U.S.A. (Proceedings of the National Academy of Sciences of the United States of America)
[2018, 115(7):E1475-E1484]

Cited: 10 times

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Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway.

Jiangfeng Liu, Weiling Wang, Ming Liu, Limin Su, Hong Zhou, Yin Xia, Jianhua Ran, Herbert Y Lin, Baoxue Yang,

Autosomal dominant polycystic kidney disease (ADPKD) is a monogenetic disease that still lacks effective therapy. Repulsive guidance molecule b (RGMb), a co-receptor for bone morphogenetic proteins (BMPs) and a ligand for neogenin, is expressed in renal tubular epithelial cells. Previous studies showed that RGMb plays negative roles in several types ... Read more >>

Cell. Signal. (Cellular signalling)
[2016, 28(12):1842-1851]

Cited: 0 times

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Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice.

Antonella Nai, Aude Rubio, Alessandro Campanella, Ophélie Gourbeyre, Irene Artuso, Jessica Bordini, Aurélie Gineste, Chloé Latour, Céline Besson-Fournier, Herbert Y Lin, Hélène Coppin, Marie-Paule Roth, Clara Camaschella, Laura Silvestri, Delphine Meynard,

Hepcidin, the main regulator of iron homeostasis, is repressed when erythropoiesis is acutely stimulated by erythropoietin (EPO) to favor iron supply to maturing erythroblasts. Erythroferrone (ERFE) has been identified as the erythroid regulator that inhibits hepcidin in stress erythropoiesis. A powerful hepcidin inhibitor is the serine protease matriptase-2, encoded by ... Read more >>

Blood (Blood)
[2016, 127(19):2327-2336]

Cited: 37 times

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Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice.

Chenling Meng, Wenjing Liu, Huihui Huang, Yang Wang, Binbin Chen, Gordon J Freeman, Alan Schneyer, Herbert Y Lin, Yin Xia,

Bone morphogenetic protein (BMP) signaling plays an important role in spermatogenesis and follicle development. Our previous studies have shown that repulsive guidance molecule b (RGMb, also known as Dragon) is a coreceptor that enhances BMP2 and BMP4 signaling in several cell types and that RGMb is expressed in spermatocytes and ... Read more >>

Biol. Reprod. (Biology of reproduction)
[2016, 94(4):78]

Cited: 1 time

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Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease.

Benedikt Schaefer, David Haschka, Armin Finkenstedt, Britt-Sabina Petersen, Igor Theurl, Benjamin Henninger, Andreas R Janecke, Chia-Yu Wang, Herbert Y Lin, Lothar Veits, Wolfgang Vogel, Günter Weiss, Andre Franke, Heinz Zoller,

Liver disease due to alpha-1-antitrypsin deficiency (A1ATD) is associated with hepatic iron overload in a subgroup of patients. The underlying cause for this association is unknown. The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin (A1AT) on the expression of ... Read more >>

Hum. Mol. Genet. (Human molecular genetics)
[2015, 24(21):6254-6263]

Cited: 6 times

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Hepcidin regulation in prostate and its disruption in prostate cancer.

Lia Tesfay, Kathryn A Clausen, Jin Woo Kim, Poornima Hegde, Xiaohong Wang, Lance D Miller, Zhiyong Deng, Nicole Blanchette, Tara Arvedson, Cindy K Miranti, Jodie L Babitt, Herbert Y Lin, Donna M Peehl, Frank M Torti, Suzy V Torti,

Hepcidin is a circulating peptide hormone made by the liver that is a central regulator of systemic iron uptake and recycling. Here, we report that prostate epithelial cells also synthesize hepcidin, and that synthesis and secretion of hepcidin are markedly increased in prostate cancer cells and tissue. Prostatic hepcidin functions ... Read more >>

Cancer Res. (Cancer research)
[2015, 75(11):2254-2263]

Cited: 51 times

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Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys.

Anthony E Samir, Andrew S Allegretti, Qingli Zhu, Manish Dhyani, Arash Anvari, Dorothy A Sullivan, Caitlin A Trottier, Sarah Dougherty, Winfred W Williams, Jodie L Babitt, Julia Wenger, Ravi I Thadhani, Herbert Y Lin,

There currently is a need for a non-invasive measure of renal fibrosis. We aim to explore whether shear wave elastography (SWE)-derived estimates of tissue stiffness may serve as a non-invasive biomarker that can distinguish normal and abnormal renal parenchymal tissue.Participants with CKD (by estimated GFR) and healthy volunteers underwent SWE. ... Read more >>

BMC Nephrol (BMC nephrology)
[2015, 16:119]

Cited: 23 times

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Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.

Martina Pauk, Lovorka Grgurevic, Jelena Brkljacic, Vera Kufner, Tatjana Bordukalo-Niksic, Kristina Grabusic, Genadij Razdorov, Dunja Rogic, Marijan Zuvic, Hermann Oppermann, Jodie L Babitt, Herbert Y Lin, Sinisa Volarevic, Slobodan Vukicevic,

Iron overload accelerates bone loss in mice lacking the bone morphogenetic protein 6 (Bmp6) gene, which is the key endogenous regulator of hepcidin, iron homeostasis gene. We investigated involvement of other BMPs in preventing haemochromatosis and subsequent osteopenia in Bmp6-/- mice.Iron-treated wild-type (WT) and Bmp6-/- mice were analysed for hepcidin ... Read more >>

Int Orthop (International orthopaedics)
[2015, 39(1):161-172]

Cited: 11 times

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Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-α, and IL-1β.

Yueshui Zhao, Xiaoqiu Xiao, Stuart J Frank, Herbert Y Lin, Yin Xia,

During inflammation, the liver becomes resistant to growth hormone (GH) actions, leading to downregulation of the GH target gene IGF-I and activation of catabolism. Proinflammatory cytokines IL-6, TNF-α, and IL-1β are critically involved in the pathogenesis of hepatic GH resistance. However, the mechanisms used by endogenous IL-6, TNF-α, and IL-1β ... Read more >>

Am. J. Physiol. Endocrinol. Metab. (American journal of physiology. Endocrinology and metabolism)
[2014, 307(2):E186-98]

Cited: 14 times

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The role of TMPRSS6/matriptase-2 in iron regulation and anemia.

Chia-Yu Wang, Delphine Meynard, Herbert Y Lin,

Matriptase-2, encoded by the TMPRSS6 gene, is a member of the type II transmembrane serine protease family. Matriptase-2 has structural and enzymatic similarities to matriptase-1, which has been implicated in cancer progression. Matriptase-2 was later established to be essential in iron homeostasis based on the phenotypes of iron-refractory iron deficiency ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2014, 5:114]

Cited: 19 times

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Inflammation regulates TMPRSS6 expression via STAT5.

Delphine Meynard, Chia Chi Sun, Qifang Wu, Wenjie Chen, Shanzhuo Chen, Caroline N Nelson, Michael J Waters, Jodie L Babitt, Herbert Y Lin,

TMPRSS6 is a regulated gene, with a crucial role in the regulation of iron homeostasis by inhibiting hepcidin expression. The main regulator of iron homeostasis, the antimicrobial peptide hepcidin, which also has a role in immunity, is directly upregulated by inflammation. In this study, we analyzed whether inflammation is also ... Read more >>

PLoS ONE (PloS one)
[2013, 8(12):e82127]

Cited: 10 times

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Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity.

Ingo Hilgendorf, Igor Theurl, Louisa M S Gerhardt, Clinton S Robbins, Georg F Weber, Ayelet Gonen, Yoshiko Iwamoto, Norbert Degousee, Tobias A W Holderried, Carla Winter, Andreas Zirlik, Herbert Y Lin, Galina K Sukhova, Jagdish Butany, Barry B Rubin, Joseph L Witztum, Peter Libby, Matthias Nahrendorf, Ralph Weissleder, Filip K Swirski,

Atherosclerotic lesions grow via the accumulation of leukocytes and oxidized lipoproteins in the vessel wall. Leukocytes can attenuate or augment atherosclerosis through the release of cytokines, chemokines, and other mediators. Deciphering how leukocytes develop, oppose, and complement each other's function and shape the course of disease can illuminate our understanding ... Read more >>

Circulation (Circulation)
[2014, 129(16):1677-1687]

Cited: 50 times

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The liver: conductor of systemic iron balance.

Delphine Meynard, Jodie L Babitt, Herbert Y Lin,

Iron is a micronutrient essential for almost all organisms: bacteria, plants, and animals. It is a metal that exists in multiple redox states, including the divalent ferrous (Fe(2+)) and the trivalent ferric (Fe(3+)) species. The multiple oxidation states of iron make it excellent for electron transfer, allowing iron to be ... Read more >>

Blood (Blood)
[2014, 123(2):168-176]

Cited: 52 times

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Differential regulation of myeloid leukemias by the bone marrow microenvironment.

Daniela S Krause, Keertik Fulzele, André Catic, Chia Chi Sun, David Dombkowski, Michael P Hurley, Sanon Lezeau, Eyal Attar, Joy Y Wu, Herbert Y Lin, Paola Divieti-Pajevic, Robert P Hasserjian, Ernestina Schipani, Richard A Van Etten, David T Scadden,

Like their normal hematopoietic stem cell counterparts, leukemia stem cells (LSCs) in chronic myelogenous leukemia (CML) and acute myeloid leukemia (AML) are presumed to reside in specific niches in the bone marrow microenvironment (BMM) and may be the cause of relapse following chemotherapy. Targeting the niche is a new strategy ... Read more >>

Nat. Med. (Nature medicine)
[2013, 19(11):1513-1517]

Cited: 117 times

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BuMPing iron with modified heparins.

Jodie L Babitt, Herbert Y Lin,

In this issue of Blood, Poli et al demonstrate that heparin analogs engineered to minimize their anticoagulant properties can potently downregulate hepcidin production in vitro and in vivo, and may potentially be used to treat the anemia of inflammation. ... Read more >>

Blood (Blood)
[2014, 123(10):1440-1441]

Cited: 0 times

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Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells.

Wenjing Liu, Xiaoling Li, Yueshui Zhao, Xiao-Ming Meng, Chao Wan, Baoxue Yang, Hui-Yao Lan, Herbert Y Lin, Yin Xia,

Dragon is one of the three members of the repulsive guidance molecule (RGM) family, i.e. RGMa, RGMb (Dragon), and RGMc (hemojuvelin). We previously identified the RGM members as bone morphogenetic protein (BMP) co-receptors that enhance BMP signaling. Our previous studies found that Dragon is highly expressed in the tubular epithelial ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2013, 288(44):31528-31539]

Cited: 11 times

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Local proliferation dominates lesional macrophage accumulation in atherosclerosis.

Clinton S Robbins, Ingo Hilgendorf, Georg F Weber, Igor Theurl, Yoshiko Iwamoto, Jose-Luiz Figueiredo, Rostic Gorbatov, Galina K Sukhova, Louisa M S Gerhardt, David Smyth, Caleb C J Zavitz, Eric A Shikatani, Michael Parsons, Nico van Rooijen, Herbert Y Lin, Mansoor Husain, Peter Libby, Matthias Nahrendorf, Ralph Weissleder, Filip K Swirski,

During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall. The observation that circulating monocytes give rise to lesional macrophages has reinforced the concept that monocyte infiltration dictates macrophage buildup. Recent work has indicated, however, that macrophage accumulation does not depend on monocyte recruitment in ... Read more >>

Nat. Med. (Nature medicine)
[2013, 19(9):1166-1172]

Cited: 393 times

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A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.

Chia Chi Sun, Valentina Vaja, Shanzhuo Chen, Igor Theurl, Aaron Stepanek, Diane E Brown, Maria D Cappellini, Guenter Weiss, Charles C Hong, Herbert Y Lin, Jodie L Babitt,

Anemia is a common complication of chronic kidney disease (CKD) that negatively impacts the quality of life and is associated with numerous adverse outcomes. Excess levels of the iron regulatory hormone hepcidin are thought to contribute to anemia in CKD patients by decreasing iron availability from the diet and from ... Read more >>

Nephrol. Dial. Transplant. (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association)
[2013, 28(7):1733-1743]

Cited: 30 times

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Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans.

Orlando M Gutiérrez, Chia Chi Sun, Wenjie Chen, Jodie L Babitt, Herbert Y Lin,

Am. J. Nephrol. (American journal of nephrology)
[2012, 36(4):332-3; author reply 333]

Cited: 7 times

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Mechanisms of anemia in CKD.

Jodie L Babitt, Herbert Y Lin,

Anemia is a common feature of CKD associated with poor outcomes. The current management of patients with anemia in CKD is controversial, with recent clinical trials demonstrating increased morbidity and mortality related to erythropoiesis stimulating agents. Here, we examine recent insights into the molecular mechanisms underlying anemia of CKD. These ... Read more >>

J. Am. Soc. Nephrol. (Journal of the American Society of Nephrology : JASN)
[2012, 23(10):1631-1634]

Cited: 171 times

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Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs).

Qifang Wu, Chia Chi Sun, Herbert Y Lin, Jodie L Babitt,

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor beta superfamily that exert their effects via type I and type II serine threonine kinase receptors and the SMAD intracellular signaling pathway to regulate diverse biologic processes. Recently, we discovered that the repulsive guidance molecule (RGM) family, including RGMA, ... Read more >>

PLoS ONE (PloS one)
[2012, 7(9):e46307]

Cited: 30 times

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Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent.

Xinggang Wu, Lai-Ming Yung, Wai-Hang Cheng, Paul B Yu, Jodie L Babitt, Herbert Y Lin, Yin Xia,

Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages. Hepcidin is synthesized mainly in the liver, where hepcidin is regulated by iron loading, inflammation and hypoxia. Recently, we have demonstrated that bone morphogenetic protein (BMP)-hemojuvelin ... Read more >>

PLoS ONE (PloS one)
[2012, 7(9):e44622]

Cited: 20 times

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A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum.

Wenjie Chen, Chia Chi Sun, Shanzhuo Chen, Delphine Meynard, Jodie L Babitt, Herbert Y Lin,

Hemojuvelin is a critical regulator of hepcidin expression and can be cleaved by proteases to form soluble hemojuvelin. Soluble hemojuvelin has been recently identified in human serum but the presence and quantity of soluble hemojuvelin in mouse serum is unknown. We developed a two-site enzyme-linked immunosorbent assay using a monoclonal ... Read more >>

Haematologica (Haematologica)
[2013, 98(2):296-304]

Cited: 11 times

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