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Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):1974-1982]

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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Crit Care Med (Critical care medicine)
[2021, 49(11):e1063-e1143]

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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021.

Laura Evans, Andrew Rhodes, Waleed Alhazzani, Massimo Antonelli, Craig M Coopersmith, Craig French, Flávia R Machado, Lauralyn Mcintyre, Marlies Ostermann, Hallie C Prescott, Christa Schorr, Steven Simpson, W Joost Wiersinga, Fayez Alshamsi, Derek C Angus, Yaseen Arabi, Luciano Azevedo, Richard Beale, Gregory Beilman, Emilie Belley-Cote, Lisa Burry, Maurizio Cecconi, John Centofanti, Angel Coz Yataco, Jan De Waele, R Phillip Dellinger, Kent Doi, Bin Du, Elisa Estenssoro, Ricard Ferrer, Charles Gomersall, Carol Hodgson, Morten Hylander Møller, Theodore Iwashyna, Shevin Jacob, Ruth Kleinpell, Michael Klompas, Younsuck Koh, Anand Kumar, Arthur Kwizera, Suzana Lobo, Henry Masur, Steven McGloughlin, Sangeeta Mehta, Yatin Mehta, Mervyn Mer, Mark Nunnally, Simon Oczkowski, Tiffany Osborn, Elizabeth Papathanassoglou, Anders Perner, Michael Puskarich, Jason Roberts, William Schweickert, Maureen Seckel, Jonathan Sevransky, Charles L Sprung, Tobias Welte, Janice Zimmerman, Mitchell Levy,

Intensive Care Med (Intensive care medicine)
[2021, :]

Cited: 0 times

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Hepatitis C virus treatment with direct-acting antivirals induces rapid changes in the hepatic proteome.

Lauren E Ball, Bernice Agana, Susana Comte-Walters, Don C Rockey, Henry Masur, Shyam Kottilil, Eric G Meissner,

Treatment of chronic hepatitis C virus with direct-acting antivirals usually eradicates infection, but liver fibrosis does not resolve concurrently. In patients who develop cirrhosis prior to hepatitis C virus treatment, hepatic decompensation and hepatocellular carcinoma can still occur after viral elimination due to residual fibrosis. We hypothesized the liver proteome ... Read more >>

J Viral Hepat (Journal of viral hepatitis)
[2021, 28(11):1614-1623]

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Integrase Inhibitor Prescribing Disparities in the DC and Johns Hopkins HIV Cohorts.

Anne K Monroe, Matthew E Levy, Alan E Greenberg, Jeanne C Keruly, Richard D Moore, Michael A Horberg, Paige Kulie, Bernadine S Mohanraj, Princy N Kumar, Amanda D Castel, ,

Integrase inhibitors (INSTIs) are recommended by expert panels as initial therapy for people with HIV. Because there can be disparities in prescribing and uptake of novel and/or recommended therapies, this analysis assessed potential INSTI prescribing disparities using a combined data set from the Johns Hopkins HIV Clinical Cohort and the ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(8):ofab338]

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Integrase Strand Transfer Inhibitors and Weight Gain in Children and Youth With Perinatal Human Immunodeficiency Virus in the DC Cohort.

Wei Li A Koay, Sahera Dirajlal-Fargo, Matthew E Levy, Paige Kulie, Anne Monroe, Amanda D Castel, Natella Y Rakhmanina, ,

We conducted a retrospective analysis of 38 children and youth with human immunodeficiency virus (aged 0-19 years) in the United States and report an increased rate of change of BMI-for-age <i>z</i> score after initiating integrase strand transfer inhibitors (+0.19 <i>z</i> score units/year [95% confidence interval, .01-.37]; <i>P</i> = .036) for a median ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(7):ofab308]

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Characterization of HIV Risk Behaviors and Clusters Using HIV-Transmission Cluster Engine Among a Cohort of Persons Living with HIV in Washington, DC.

Brittany Wilbourn, Brittani Saafir-Callaway, Kamwing Jair, Joel O Wertheim, Oliver Laeyendeker, Jeanne A Jordan, Michael Kharfen, Amanda Castel, ,

Molecular epidemiology (ME) is one tool used to end the HIV epidemic in the United States. We combined clinical and behavioral data with HIV sequence data to identify any overlap in clusters generated from different sequence datasets; to characterize HIV transmission clusters; and to identify correlates of clustering among people ... Read more >>

AIDS Res Hum Retroviruses (AIDS research and human retroviruses)
[2021, 37(9):706-715]

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Developing Treatment Guidelines During a Pandemic Health Crisis: Lessons Learned From COVID-19.

Safia Kuriakose, Kanal Singh, Alice K Pau, Eric Daar, Rajesh Gandhi, Pablo Tebas, Laura Evans, Roy M Gulick, H Clifford Lane, Henry Masur, , Judith A Aberg, Adaora A Adimora, Jason Baker, Lisa Baumann Kreuziger, Roger Bedimo, Pamela S Belperio, Stephen V Cantrill, Craig M Coopersmith, Susan L Davis, Amy L Dzierba, John J Gallagher, David V Glidden, Birgit Grund, Erica J Hardy, Carl Hinkson, Brenna L Hughes, Steven Johnson, Marla J Keller, Arthur Y Kim, Jeffrey L Lennox, Mitchell M Levy, Jonathan Z Li, Greg S Martin, Susanna Naggie, Andrew T Pavia, Nitin Seam, Steven Q Simpson, Susan Swindells, Phyllis Tien, Alpana A Waghmare, Kevin C Wilson, Jinoos Yazdany, Philip Zachariah, Danielle M Campbell, Carly Harrison, Timothy Burgess, Joseph Francis, Virginia Sheikh, Timothy M Uyeki, Robert Walker, John T Brooks, Laura Bosque Ortiz, Richard T Davey, Laurie K Doepel, Robert W Eisinger, Alison Han, Elizabeth S Higgs, Martha C Nason, Page Crew, Andrea M Lerner, Claire Lund, Christopher Worthington,

The development of the National Institutes of Health (NIH) COVID-19 Treatment Guidelines began in March 2020 in response to a request from the White House Coronavirus Task Force. Within 4 days of the request, the NIH COVID-19 Treatment Guidelines Panel was established and the first meeting took place (virtually-as did ... Read more >>

Ann Intern Med (Annals of internal medicine)
[2021, 174(8):1151-1158]

Cited: 1 time

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Highly variable trends in rates of newly diagnosed HIV cases in U.S. hotspots, 2008-2017.

Lorena Segarra, Samuel J Simmens, Amanda D Castel, Michael Kharfen, Henry Masur, Alan E Greenberg,

The U.S. Ending the HIV Epidemic (EHE) initiative was announced in early 2019 and rapidly became a focal point for domestic HIV prevention and treatment programs. Using publicly available data from CDC, we examined historical trends in the average annual percent change (AAPC) in HIV diagnosis rates for the 57 ... Read more >>

PLoS One (PloS one)
[2021, 16(4):e0250179]

Cited: 0 times

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Pneumocystis jirovecii Disease: Basis for the Revised EORTC/MSGERC Invasive Fungal Disease Definitions in Individuals Without Human Immunodeficiency Virus.

Katrien Lagrou, Sharon Chen, Henry Masur, Claudio Viscoli, Catherine F Decker, Livio Pagano, Andreas H Groll,

<h4>Background</h4>Pneumocystis jirovecii pneumonia (PCP) causes substantive morbidity in immunocompromised patients. The EORTC/MSGERC convened an expert group to elaborate consensus definitions for Pneumocystis disease for the purpose of interventional clinical trials and epidemiological studies and evaluation of diagnostic tests.<h4>Methods</h4>Definitions were based on the triad of host factors, clinical-radiologic features, and mycologic ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(Suppl 2):S114-S120]

Cited: 1 time

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Hepatitis C Virus Relapse After Ultrashort Direct-Acting Antiviral Therapy Associates With Expression of Genes Involved With Natural Killer-Cell and CD8+ T-Cell Function.

Cody Orr, Henry Masur, Shyam Kottilil, Eric G Meissner,

To identify immunologic correlates of hepatitis C virus (HCV) relapse after direct-acting antiviral (DAA) therapy, we quantified select immune transcripts in whole blood from noncirrhotic HCV subjects treated with 4-6 weeks of DAAs. We identified specific markers of natural killer-cell and CD8<sup>+</sup> T-cell function (<i>GZMB</i>, <i>PRF1</i>, <i>NKp46</i>) with higher expression ... Read more >>

Open Forum Infect Dis (Open forum infectious diseases)
[2021, 8(4):ofab118]

Cited: 0 times

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Initiation of Low-threshold Buprenorphine in Nontreatment Seeking Patients With Opioid Use Disorder Engaged in Hepatitis C Treatment.

Kristi Hill, Laura Nussdorf, Julia D Mount, Rachel Silk, Chloe Gross, David Sternberg, Phyllis Bijole, Miriam Jones, Randy Kier, Dana Mccullough, Poonam Mathur, Shyam Kottilil, Henry Masur, Sarah Kattakuzhy, Elana S Rosenthal,

<h4>Objective</h4>The ANCHOR program offered buprenorphine treatment to people who inject drugs engaged in hepatitis C (HCV) treatment at a Washington, DC harm reduction organization. This analysis describes the program model and outcomes of the opioid care continuum at 1 year.<h4>Methods</h4>Primary outcomes were initiation of buprenorphine and retention in care, defined ... Read more >>

J Addict Med (Journal of addiction medicine)
[2021, :]

Cited: 0 times

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Infectious Diseases Society of America Position Paper: Recommended Revisions to the National Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) Sepsis Quality Measure.

Chanu Rhee, Kathleen Chiotos, Sara E Cosgrove, Emily L Heil, Sameer S Kadri, Andre C Kalil, David N Gilbert, Henry Masur, Edward J Septimus, Daniel A Sweeney, Jeffrey R Strich, Dean L Winslow, Michael Klompas,

The Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) measure has appropriately established sepsis as a national priority. However, the Infectious Diseases Society of America (IDSA and five additional endorsing societies) is concerned about SEP-1's potential to drive antibiotic overuse because it does ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2021, 72(4):541-552]

Cited: 19 times

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Retrospective-prospective study of safety and efficacy of sofosbuvir-based direct-acting antivirals in HIV/HCV-coinfected participants with decompensated liver disease pre- or post-liver transplant.

Marion G Peters, Shyam Kottilil, Norah Terrault, Dominic Amara, Jennifer Husson, Shirish Huprikar, Sander Florman, Mark S Sulkowski, Christine M Durand, Anne F Luetkemeyer, Rodney Rogers, Joshua Grab, Brandy Haydel, Emily Blumberg, Lorna Dove, Jean Emond, Kim Olthoff, Coleman Smith, Thomas Fishbein, Henry Masur, Peter G Stock,

Direct-acting antiviral (DAA) therapy has transformed the management of human immunodeficiency virus (HIV) and hepatitis C (HCV) coinfected patients with advanced liver disease. STOP-Coinfection was a multicenter prospective and retrospective, open-label study using sofosbuvir-based DAA therapy to treat HIV/HCV-coinfected participants pre- or post-liver transplant (LT). Sixty-eight participants with end-stage liver ... Read more >>

Am J Transplant (American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons)
[2021, 21(5):1780-1788]

Cited: 1 time

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Utilization of Direct Oral Anticoagulants in People Living with Human Immunodeficiency Virus: Observational Data from the District of Columbia Cohort.

Jomy M George, Safia S Kuriakose, Anne Monroe, Qingjiang Hou, Morgan Byrne, Alice K Pau, Henry Masur, Colleen Hadigan, Amanda D Castel, Michael A Horberg, ,

<h4>Background</h4>Direct oral anticoagulants (DOACs) have become first-line treatment for venous thrombotic events. DOAC prescribing trends among people living with human immunodeficiency virus (PWH) are not well described. The coadministration of DOACs with the antiretroviral (ARV) pharmacokinetic boosters ritonavir (RTV) or cobicistat (COBI) may be complicated by pharmacokinetic interactions.<h4>Methods</h4>A longitudinal cohort ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(10):e604-e613]

Cited: 1 time

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Peripheral blood correlates of virologic relapse after Sofosbuvir and Ribavirin treatment of Genotype-1 HCV infection.

Cody Orr, Wenjie Xu, Henry Masur, Shyam Kottilil, Eric G Meissner,

<h4>Background</h4>Treatment of chronic hepatitis C virus infection with direct acting antiviral therapy results in viral elimination in over 90% of cases. The duration of treatment required to achieve cure differs between individuals and relapse can occur. We asked whether cellular and transcriptional profiling of peripheral blood collected during treatment could ... Read more >>

BMC Infect Dis (BMC infectious diseases)
[2020, 20(1):929]

Cited: 2 times

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Concurrent Initiation of Hepatitis C and Opioid Use Disorder Treatment in People Who Inject Drugs.

Elana S Rosenthal, Rachel Silk, Poonam Mathur, Chloe Gross, Rahwa Eyasu, Laura Nussdorf, Kristi Hill, Christopher Brokus, Aaron D'Amore, Nadeera Sidique, Phyllis Bijole, Miriam Jones, Randy Kier, Dana McCullough, David Sternberg, Kristen Stafford, Junfeng Sun, Henry Masur, Shyamasundaran Kottilil, Sarah Kattakuzhy,

<h4>Background</h4>People who inject drugs have a high prevalence of hepatitis C virus (HCV) and significant disease associated with drug use; however, HCV treatment often occurs in absence of interventions to address opioid use disorder and drug use-related harms. The impact of concurrent initiation of opioid agonist therapy (OAT) on HCV ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(7):1715-1722]

Cited: 14 times

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Convalescent Plasma for the Treatment of COVID-19: Perspectives of the National Institutes of Health COVID-19 Treatment Guidelines Panel.

Alice K Pau, Judith Aberg, Jason Baker, Pamela S Belperio, Craig Coopersmith, Page Crew, Birgit Grund, Roy M Gulick, Carly Harrison, Arthur Kim, H Clifford Lane, Henry Masur, Virginia Sheikh, Kanal Singh, Jinoos Yazdany, Pablo Tebas, ,

Ann Intern Med (Annals of internal medicine)
[2021, 174(1):93-95]

Cited: 14 times

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Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.

J Peter Donnelly, Sharon C Chen, Carol A Kauffman, William J Steinbach, John W Baddley, Paul E Verweij, Cornelius J Clancy, John R Wingard, Shawn R Lockhart, Andreas H Groll, Tania C Sorrell, Matteo Bassetti, Hamdi Akan, Barbara D Alexander, David Andes, Elie Azoulay, Ralf Bialek, Robert W Bradsher, Stephane Bretagne, Thierry Calandra, Angela M Caliendo, Elio Castagnola, Mario Cruciani, Manuel Cuenca-Estrella, Catherine F Decker, Sujal R Desai, Brian Fisher, Thomas Harrison, Claus Peter Heussel, Henrik E Jensen, Christopher C Kibbler, Dimitrios P Kontoyiannis, Bart-Jan Kullberg, Katrien Lagrou, Frédéric Lamoth, Thomas Lehrnbecher, Jurgen Loeffler, Olivier Lortholary, Johan Maertens, Oscar Marchetti, Kieren A Marr, Henry Masur, Jacques F Meis, C Orla Morrisey, Marcio Nucci, Luis Ostrosky-Zeichner, Livio Pagano, Thomas F Patterson, John R Perfect, Zdenek Racil, Emmanuel Roilides, Marcus Ruhnke, Cornelia Schaefer Prokop, Shmuel Shoham, Monica A Slavin, David A Stevens, George R Thompson, Jose A Vazquez, Claudio Viscoli, Thomas J Walsh, Adilia Warris, L Joseph Wheat, P Lewis White, Theoklis E Zaoutis, Peter G Pappas,

<h4>Background</h4>Invasive fungal diseases (IFDs) remain important causes of morbidity and mortality. The consensus definitions of the Infectious Diseases Group of the European Organization for Research and Treatment of Cancer and the Mycoses Study Group have been of immense value to researchers who conduct clinical trials of antifungals, assess diagnostic tests, ... Read more >>

Clin Infect Dis (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America)
[2020, 71(6):1367-1376]

Cited: 200 times

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Pandemic-Related Submissions: The Challenge of Discerning Signal Amidst Noise.

Thomas P Bleck, Timothy G Buchman, R Phillip Dellinger, Clifford S Deutschman, John C Marshall, David M Maslove, Henry Masur, Margaret M Parker, Donald S Prough, Aarti Sarwal, Jonathan E Sevransky, Jean-Louis Vincent, Jerry J Zimmerman,

Crit Care Med (Critical care medicine)
[2020, 48(8):1099-1102]

Cited: 3 times

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The Effect of GS-548351 on the Pharmacokinetics of Midazolam Following Multiple Doses of ANS-6637 in Healthy Adults.

Haden T Bunn, Elana Rosenthal, Poonam Mathur, Mary McLaughlin, Michael Proschan, Arjun Vijan, Julia Aepfelbacher, Shyamasundaran Kottilil, Henry Masur, Sarah Kattakuzhy, Jomy M George,

ANS-6637, a pro-drug of GS-548351, is a selective, reversible inhibitor of aldehyde dehydrogenase isoform 2 under development as an anticraving agent for the treatment of substance use disorders. In vitro testing indicates that GS-548351 is an inhibitor and inducer of cytochrome P450 family 3, subfamily A (CYP3A). In this phase ... Read more >>

J Clin Pharmacol (Journal of clinical pharmacology)
[2020, 60(12):1598-1605]

Cited: 0 times

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Considerations for Empiric Antimicrobial Therapy in Sepsis and Septic Shock in an Era of Antimicrobial Resistance.

Jeffrey R Strich, Emily L Heil, Henry Masur,

Patients with sepsis present across a spectrum of infection sites and severity of illnesses requiring complex decision making at the bedside as to when prompt antibiotics are indicated and which regimen is warranted. Many hemodynamically stable patients with sepsis and low acuity of illness may benefit from further work up ... Read more >>

J Infect Dis (The Journal of infectious diseases)
[2020, 222(Suppl 2):S119-S131]

Cited: 3 times

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SEP-1 Has Brought Much Needed Attention to Improving Sepsis Care…But Now Is the Time to Improve SEP-1.

Chanu Rhee, Jeffrey R Strich, Michael Klompas, Donald M Yealy, Henry Masur,

Crit Care Med (Critical care medicine)
[2020, 48(6):779-782]

Cited: 0 times

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Is low-level viraemia associated with serum lipid profiles among HIV controllers?

M E Levy, A K Monroe, M A Horberg, D A Benator, A D Castel, ,

HIV Med (HIV medicine)
[2020, 21(7):e14-e16]

Cited: 0 times

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Author Correction: A cross-sectional study to characterize local HIV-1 dynamics in Washington, DC using next-generation sequencing.

Keylie M Gibson, Kamwing Jair, Amanda D Castel, Matthew L Bendall, Brittany Wilbourn, Jeanne A Jordan, Keith A Crandall, Marcos Pérez-Losada, ,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7099]

Cited: 0 times

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