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Author Henry Hsia

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Does the Presence of a Preexisting Open Wound Increase Complication Risk for Implant Procedures?

James Nie, Sina Torabi, Henry C Hsia,

<h4>Abstract</h4>Despite limited evidence, a common belief in surgical practice is that patients should not undergo elective surgery until any open wounds heal because of the risk of seeding infection to the new surgical site. To our knowledge, this is the first study to analyze postoperative complication rates for implants placed ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2021, :]

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Integrin β3 Targeting Biomaterial Preferentially Promotes Secretion of bFGF and Proliferation of iPSC-Derived Vascular Smooth Muscle Cells

Biraja Dash, Kaiti Duan, Themis Kyriakides, Henry Hsia,

Human-induced pluripotent stem cell-derived-vascular smooth muscle cells (hiPSC-VSMC) have been shown to promote angiogenesis and wound healing. However, there is a paucity of research on how the extracellular matrix (ECM) microenvironment may impact the hiPSC-VSMC’s function. In this study, our objective was to understand the effect of specific ECM ligand-integrin ... Read more >>

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Prelamination of Vascularized Tensor Fascia Lata for Complex Abdominal Wall Reconstruction.

Amanda Norwich-Cavanaugh, Samuel Kim, Gauri Panse, Ean Saberski, Henry C Hsia, Deepak Narayan,

<h4>Abstract</h4>There are 2 to 5 million laparotomies performed in the United States annually. Of these, 250,000 to 350,000 will undergo a ventral hernia repair. Repairs are often complicated by recurrence and infection. These risks are significantly increased in previously infected repairs, with reported recurrence rates varying from 17% to 28% ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2021, :]

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Fibronectin Induced Human Pluripotent Stem Cell-derived Vascular Smooth Muscle Cells Enhance Endothelial Network Formation Via Fibroblast Growth Factor

Kaiti Duan, Biraja Dash, Henry C. Hsia,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2020, 8(9 Suppl):]

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Complex Re-Entrant Arrhythmias Involving the His-Purkinje System: A Structured Approach to Diagnosis and Management.

Aleksandr Voskoboinik, Edward P Gerstenfeld, Joshua D Moss, Henry Hsia, Jeffrey Goldberger, Babak Nazer, Thomas Dewland, David Singh, Nitish Badhwar, Patrick J Tchou, John N Meriwether, William Sauer, Asaf Danon, Bernard Belhassen, Melvin M Scheinman,

<h4>Objectives</h4>This study sought to characterize the presentations, electrophysiological features and diagnostic maneuvers for a series of unique arrhythmias involving the HPS.<h4>Background</h4>By virtue of its unique anatomy and ion channel composition, the His-Purkinje system (HPS) is prone to a variety of arrhythmic perturbations.<h4>Methods</h4>The authors present a collaborative multicenter case series of ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2020, 6(12):1488-1498]

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An in situ collagen-HA hydrogel system promotes survival and preserves the proangiogenic secretion of hiPSC-derived vascular smooth muscle cells.

Biraja C Dash, Kaiti Duan, Hao Xing, Themis R Kyriakides, Henry C Hsia,

Human-induced pluripotent stem cell-derived vascular smooth muscle cells (hiPSC-VSMCs) with proangiogenic properties have huge therapeutic potential. While hiPSC-VSMCs have already been utilized for wound healing using a biomimetic collagen scaffold, an in situ forming hydrogel mimicking the native environment of skin offers the promise of hiPSC-VSMC mediated repair and regeneration. ... Read more >>

Biotechnol Bioeng (Biotechnology and bioengineering)
[2020, :]

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An In situ Collagen-HA Hydrogel System Promotes Survival and Preserves the Proangiogenic Secretion of hiPSC-derived Vascular Smooth Muscle Cells

Biraja Dash, Kaiti Duan, Hao Xing, Themis Kyriakides, Henry Hsia,

Human induced pluripotent stem cell-derived vascular smooth muscle cells (hiPSC-VSMCs) with proangiogenic properties have huge therapeutic potential. While hiPSC-VSMCs have already been utilized for wound healing using a biomimetic collagen scaffold, an in situ forming hydrogel mimicking the native environment of skin offers the promise of hiPSC-VSMC mediated repair and ... Read more >>

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Self-Assembled Nanomaterials for Chronic Skin Wound Healing.

Hwan June Kang, Nuozhou Chen, Biraja C Dash, Henry C Hsia, François Berthiaume,

Significance: Chronic wounds are one of the major burdens of the U.S. health care system with an annual cost of $31.7 billion and affecting an estimated 2.4-4.5 million people. Several underlying molecular and cellular pathophysiological mechanisms, including poor vascularization, excessive extracellular matrix (ECM) degradation by proteases, decreased growth factor activity, ... Read more >>

Adv Wound Care (New Rochelle) (Advances in wound care)
[2020, :]

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A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing.

Biraja C Dash, Ocean Setia, Jolanta Gorecka, Hassan Peyvandi, Kaiti Duan, Lara Lopes, James Nie, Francois Berthiaume, Alan Dardik, Henry C Hsia,

The application of human-induced pluripotent stem cells (hiPSCs) to generate vascular smooth muscle cells (hiPSC-VSMCs) in abundance is a promising strategy for vascular regeneration. While hiPSC-VSMCs have already been utilized for tissue-engineered vascular grafts and disease modeling, there is a lack of investigations exploring their therapeutic secretory factors. The objective ... Read more >>

Cells (Cells)
[2020, 9(4):]

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Abstract 104: Bio-functional Collagen Matrix Scaffold Composition Differentially Promotes Paracrine Activity In Human Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells.

Kaiti Duan, Biraja Dash, Henry C. Hsia,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2020, 8(4 Suppl):]

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Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score.

Aleksandr Voskoboinik, Alexios Hadjis, Christina Alhede, Sung Il Im, Hansu Park, Joshua Moss, Gregory M Marcus, Henry Hsia, Byron Lee, Zian Tseng, Randall Lee, Melvin Scheinman, Vasanth Vedantham, Eric Vittinghoff, Kyoung-Min Park, Edward P Gerstenfeld,

BACKGROUND:No independently validated score currently exists for risk stratification of patients with frequent premature ventricular complexes (PVCs). OBJECTIVES:The purpose of this study was to develop a risk score to predict adverse events in patients with frequent PVCs. METHODS:We analyzed consecutive patients between 2012 and 2017 undergoing 14-day continuous monitoring with ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(7):1066-1074]

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Safety of compression therapy for venous ulcer disease in the setting of congestive heart failure.

Robert R Attaran, Amanda Cavanaugh, Cynthia Tsay, Tariq Ahmad, Cassius I Ochoa Chaar, Scott Persing, Henry Hsia,

OBJECTIVES:Compression therapy is the mainstay of treatment for patients with venous ulcer disease. There exists a lack of certainty as to the safety of compression therapy in patients with congestive heart failure. METHODS:A retrospective review of 95 patients with the diagnosis of congestive heart failure (systolic, diastolic, or combined), who ... Read more >>

Phlebology (Phlebology)
[2020, 35(8):556-560]

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Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.

Peter Theodore Hetzler, Biraja C Dash, Shangqin Guo, Henry C Hsia,

Fibrosis is a consequence of aberrant wound healing processes that can be debilitating for patients and often are associated with highly morbid disease processes. Myofibroblasts play an important role in determining an appropriate physiologic response to tissue injury or an excessive response leading to fibrosis. Specifically, "supermature" focal adhesions, α-smooth ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(6):e92-e95]

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Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.

Jolanta Gorecka, Xixiang Gao, Arash Fereydooni, Biraja C Dash, Jiesi Luo, Shin Rong Lee, Ryosuke Taniguchi, Henry C Hsia, Yibing Qyang, Alan Dardik,

<b>Aim:</b> To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. <b>Methods:</b> hiPSC-SMC were embedded in 3D collagen scaffolds and cultured <i>in vitro</i> for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess <i>in vivo</i> healing. ... Read more >>

Regen Med (Regenerative medicine)
[2020, 15(2):1277-1293]

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Mapping and Ablation of Ventricular Arrhythmias in Cardiomyopathies.

Henry H Hsia, Nanqing Xiong,

Mapping and ablation of ventricular arrhythmias in patients with nonischemic cardiomyopathies remain a major challenge. The electroanatomic abnormalities are frequently inaccessible to conventional endocardial ablations. Diagnostic diligence with a thorough understanding of the potential mechanisms/substrate, coupled with detailed electroanatomic mapping, is essential. Careful procedural planning, advanced imaging, and unipolar recordings ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2019, 11(4):635-655]

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The many faces of early repolarization syndrome: A single-center case series.

Aleksandr Voskoboinik, Henry Hsia, Joshua Moss, Vasanth Vedantham, Ronn E Tanel, Akash Patel, Julianne Wojciak, Natalie Downs, Melvin M Scheinman,

<h4>Background</h4>Early repolarization syndrome (ERS) is a rare but increasingly recognized cause of malignant ventricular arrhythmias.<h4>Objective</h4>The purpose of this study was to characterize the presentations and treatments of ERS at our institution.<h4>Methods</h4>We performed a retrospective chart review of all patients presenting to our institution between 2008 and 2019 with ERS. Exclusion ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(2):273-281]

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Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.

Ann Hui Ching, Nicole Le, Amanda Norwich-Cavanaugh, Henry C Hsia,

Complex wounds are commonly thought to require aggressive surgical intervention to achieve healing. However, optimal healing results can often be achieved when greater emphasis is placed on optimizing patient factors prior to any surgical intervention. A retrospective review was performed of pressure ulcers and complex wound cases treated over 5 ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(4S Suppl 1):S45-S49]

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Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery?

Zhenzhen Xu, Amanda Norwich-Cavanaugh, Henry C Hsia,

Cigarette smoking has been well demonstrated to be associated with adverse outcomes and increased complications in surgical patients in the operative and postoperative periods. There is general agreement that smoking cessation decreases such risks; however, much debate still exists regarding the most effective modalities for risk mitigation, especially concerning modalities ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(4S Suppl 1):S55-S58]

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Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease)

Hassan Peyvandi, Biraja Dash, Sifon Ndon, Kyle Steven Gabrick, Athena Alipour Alipour, John Persing, Henry Hsia,

Buerger's disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is ... Read more >>

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Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

David G Rosenthal, Purvi Parwani, Tyler O Murray, Bradley J Petek, Bryan S Benn, Teresa De Marco, Edward P Gerstenfeld, Munir Janmohamed, Liviu Klein, Byron K Lee, Joshua D Moss, Melvin M Scheinman, Henry H Hsia, Van Selby, Laura L Koth, Miguel H Pampaloni, Julie Zikherman, Vasanth Vedantham,

Background Long-term corticosteroid therapy is the standard of care for treatment of cardiac sarcoidosis (CS). The efficacy of long-term corticosteroid-sparing immunosuppression in CS is unknown. The goal of this study was to assess the efficacy of methotrexate with or without adalimumab for long-term disease suppression in CS, and to assess ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(18):e010952]

Cited: 1 time

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Catheter Ablation in Scar: A Journey Into the Unknown.

Henry H Hsia, Yun Xie,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(8):932-934]

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Road to the Summit May Follow an Eccentric Path.

Kara S Motonaga, Henry H Hsia,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2019, 12(8):e007691]

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Abstract 124: The Effect of Intraoperative Temperature on Microvascular Thrombosis.

John T. Smetona, Kyle Gabrick, Jacob Dinis, Fouad Chouiari, Michael Alperovich, Marc Walker, Henry Hsia, J Grant Thomson,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4 Suppl):]

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Significance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure Ulcers.

Raysa Cabrejo, Sifon Ndon, Ean Saberski, Carolyn Chuang, Henry C Hsia,

<h4>Background</h4>Hospital-acquired pressure ulcers (HAPUs) are largely preventable yet still common occurrences in hospitals. The purpose of the current study is to determine how data from the electronic medical record can be used to better understand and predict HAPU formation over the course of a hospital admission.<h4>Methods</h4>A case-control study on HAPUs ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4):e2099]

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Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.

Ajul Shah, Brandon J Sumpio, Cynthia Tsay, Matthew Swallow, Biraja Dash, Stephanie L Thorn, Albert J Sinusas, Andrew Koo, Henry C Hsia, Alexander Au,

<h4>Background</h4>A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been used to optimize wound healing in the setting of surgically closed wounds; however, the specific mechanisms of action by which NPWT may benefit patients after surgery remain unknown. Using a swine wound healing model, the ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 82(4S Suppl 3):S222-S227]

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