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Author Henry Hsia

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A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing.

Biraja C Dash, Ocean Setia, Jolanta Gorecka, Hassan Peyvandi, Kaiti Duan, Lara Lopes, James Nie, Francois Berthiaume, Alan Dardik, Henry C Hsia,

The application of human-induced pluripotent stem cells (hiPSCs) to generate vascular smooth muscle cells (hiPSC-VSMCs) in abundance is a promising strategy for vascular regeneration. While hiPSC-VSMCs have already been utilized for tissue-engineered vascular grafts and disease modeling, there is a lack of investigations exploring their therapeutic secretory factors. The objective ... Read more >>

Cells (Cells)
[2020, 9(4):]

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Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score.

Aleksandr Voskoboinik, Alexios Hadjis, Christina Alhede, Sung Il Im, Hansu Park, Joshua Moss, Gregory M Marcus, Henry Hsia, Byron Lee, Zian Tseng, Randall Lee, Melvin Scheinman, Vasanth Vedantham, Eric Vittinghoff, Kyoung-Min Park, Edward P Gerstenfeld,

BACKGROUND:No independently validated score currently exists for risk stratification of patients with frequent premature ventricular contractions (PVCs). OBJECTIVES:The purpose of this study was to develop a risk score to predict adverse events in patients with frequent PVCs. METHODS:We analyzed consecutive patients between 2012 and 2017 undergoing 14-day continuous monitoring with ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, :]

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Safety of compression therapy for venous ulcer disease in the setting of congestive heart failure.

Robert R Attaran, Amanda Cavanaugh, Cynthia Tsay, Tariq Ahmad, Cassius I Ochoa Chaar, Scott Persing, Henry Hsia,

OBJECTIVES:Compression therapy is the mainstay of treatment for patients with venous ulcer disease. There exists a lack of certainty as to the safety of compression therapy in patients with congestive heart failure. METHODS:A retrospective review of 95 patients with the diagnosis of congestive heart failure (systolic, diastolic, or combined), who ... Read more >>

Phlebology (Phlebology)
[2020, :268355520905178]

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Induced pluripotent stem cell-derived smooth muscle cells increase angiogenesis and accelerate diabetic wound healing.

Jolanta Gorecka, Xixiang Gao, Arash Fereydooni, Biraja C Dash, Jiesi Luo, Shin Rong Lee, Ryosuke Taniguchi, Henry C Hsia, Yibing Qyang, Alan Dardik,

Aim: To assess the potential of human induced pluripotent stem cell-derived smooth muscle cells (hiPSC-SMC) to accelerate diabetic wound healing. Methods: hiPSC-SMC were embedded in 3D collagen scaffolds and cultured in vitro for 72 h; scaffolds were then applied to diabetic, nude mouse, splinted back wounds to assess in vivo healing. ... Read more >>

Regen Med (Regenerative medicine)
[2020, 15(2):1277-1293]

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Targeting Fibrotic Signaling: A Review of Current Literature and Identification of Future Therapeutic Targets to Improve Wound Healing.

Peter Theodore Hetzler, Biraja C Dash, Shangqin Guo, Henry C Hsia,

Fibrosis is a consequence of aberrant wound healing processes that can be debilitating for patients and often are associated with highly morbid disease processes. Myofibroblasts play an important role in determining an appropriate physiologic response to tissue injury or an excessive response leading to fibrosis. Specifically, "supermature" focal adhesions, α-smooth ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(6):e92-e95]

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Mapping and Ablation of Ventricular Arrhythmias in Cardiomyopathies.

Henry H Hsia, Nanqing Xiong,

Mapping and ablation of ventricular arrhythmias in patients with nonischemic cardiomyopathies remain a major challenge. The electroanatomic abnormalities are frequently inaccessible to conventional endocardial ablations. Diagnostic diligence with a thorough understanding of the potential mechanisms/substrate, coupled with detailed electroanatomic mapping, is essential. Careful procedural planning, advanced imaging, and unipolar recordings ... Read more >>

Card Electrophysiol Clin (Cardiac electrophysiology clinics)
[2019, 11(4):635-655]

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Evidence-Based Gardening: Using Palliative Approaches to Cure Complex Wounds.

Ann Hui Ching, Nicole Le, Amanda Norwich-Cavanaugh, Henry C Hsia,

Complex wounds are commonly thought to require aggressive surgical intervention to achieve healing. However, optimal healing results can often be achieved when greater emphasis is placed on optimizing patient factors prior to any surgical intervention. A retrospective review was performed of pressure ulcers and complex wound cases treated over 5 ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(4S Suppl 1):S45-S49]

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The many faces of early repolarization syndrome: A single-center case series.

Aleksandr Voskoboinik, Henry Hsia, Joshua Moss, Vasanth Vedantham, Ronn E Tanel, Akash Patel, Julianne Wojciak, Natalie Downs, Melvin M Scheinman,

BACKGROUND:Early repolarization syndrome (ERS) is a rare but increasingly recognized cause of malignant ventricular arrhythmias. OBJECTIVE:The purpose of this study was to characterize the presentations and treatments of ERS at our institution. METHODS:We performed a retrospective chart review of all patients presenting to our institution between 2008 and 2019 with ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(2):273-281]

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Can Nicotine Replacement Therapy Decrease Complications in Plastic Surgery?

Zhenzhen Xu, Amanda Norwich-Cavanaugh, Henry C Hsia,

Cigarette smoking has been well demonstrated to be associated with adverse outcomes and increased complications in surgical patients in the operative and postoperative periods. There is general agreement that smoking cessation decreases such risks; however, much debate still exists regarding the most effective modalities for risk mitigation, especially concerning modalities ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 83(4S Suppl 1):S55-S58]

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Current Status of Stem Cell Therapy for Thromboangiitis Obliterans (Buerger's Disease)

Hassan Peyvandi, Biraja Dash, Sifon Ndon, Kyle Steven Gabrick, Athena Alipour Alipour, John Persing, Henry Hsia,

Buerger's disease or Thromboangiitis Obliterans (TAO) is a nonatherosclerotic segmental vascular disease which affects small and medium arteries and veins in the upper and lower extremities. Based on pathological findings, TAO can be considered as a distinct form of vasculitis that is most prevalent in young male smokers. There is ... Read more >>

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Long-Term Corticosteroid-Sparing Immunosuppression for Cardiac Sarcoidosis.

David G Rosenthal, Purvi Parwani, Tyler O Murray, Bradley J Petek, Bryan S Benn, Teresa De Marco, Edward P Gerstenfeld, Munir Janmohamed, Liviu Klein, Byron K Lee, Joshua D Moss, Melvin M Scheinman, Henry H Hsia, Van Selby, Laura L Koth, Miguel H Pampaloni, Julie Zikherman, Vasanth Vedantham,

Background Long-term corticosteroid therapy is the standard of care for treatment of cardiac sarcoidosis (CS). The efficacy of long-term corticosteroid-sparing immunosuppression in CS is unknown. The goal of this study was to assess the efficacy of methotrexate with or without adalimumab for long-term disease suppression in CS, and to assess ... Read more >>

J Am Heart Assoc (Journal of the American Heart Association)
[2019, 8(18):e010952]

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Catheter Ablation in Scar: A Journey Into the Unknown.

Henry H Hsia, Yun Xie,

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2019, 5(8):932-934]

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Road to the Summit May Follow an Eccentric Path.

Kara S Motonaga, Henry H Hsia,

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2019, 12(8):e007691]

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Abstract 93: Does the Presence of a Pre-existing Open Wound Increase Complication Risk for Implant Procedures?

James Nie, Sina Torabi, Henry Hsia,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4 Suppl):]

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Abstract 124: The Effect of Intraoperative Temperature on Microvascular Thrombosis.

John T. Smetona, Kyle Gabrick, Jacob Dinis, Fouad Chouiari, Michael Alperovich, Marc Walker, Henry Hsia, J Grant Thomson,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4 Suppl):]

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Significance of Friction and Shear in the Prevention of Contemporary Hospital-acquired Pressure Ulcers.

Raysa Cabrejo, Sifon Ndon, Ean Saberski, Carolyn Chuang, Henry C Hsia,

Background:Hospital-acquired pressure ulcers (HAPUs) are largely preventable yet still common occurrences in hospitals. The purpose of the current study is to determine how data from the electronic medical record can be used to better understand and predict HAPU formation over the course of a hospital admission. Methods:A case-control study on ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4):e2099]

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Infusion Needle Ablation Catheter: An Evolution of Needs.

Henry H Hsia, Nanqing Xiong,

J. Am. Coll. Cardiol. (Journal of the American College of Cardiology)
[2019, 73(12):1426-1429]

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Abstract 25: Mandibular Reconstruction in the Elderly: Are Outcomes Comparable to Younger Patients?

Sina J. Torabi, Fouad Chouairi, Jacob Dinis, Henry Hsia, Michael Alperovich,

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2019, 7(4 Suppl):]

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Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.

Ajul Shah, Brandon J Sumpio, Cynthia Tsay, Matthew Swallow, Biraja Dash, Stephanie L Thorn, Albert J Sinusas, Andrew Koo, Henry C Hsia, Alexander Au,

BACKGROUND:A commonly used treatment for open wounds, negative pressure wound therapy (NPWT) has recently been used to optimize wound healing in the setting of surgically closed wounds; however, the specific mechanisms of action by which NPWT may benefit patients after surgery remain unknown. Using a swine wound healing model, the ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 82(4S Suppl 3):S222-S227]

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Clinical Value of Single-photon Emission Computed Tomography Combined With Computed Tomography for Sentinel Lymph Node Identification in Melanoma.

Andrew McGregor, Samuel Kim, Amanda Norwich-Cavanaugh, Alexander H Sun, Deena S Abbate, Henry C Hsia, Deepak Narayan,

INTRODUCTION:Melanoma is the deadliest form of skin cancer and has the ability to metastasize widely. Accurate diagnosis of sentinel lymph nodes (SLN) is crucial to its management. The gold standard for SLN identification is planar lymphoscintigraphy. Recently, single-photon emission computed tomography combined with computed tomography (SPECT/CT) has been used as ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 82(4S Suppl 3):S192-S194]

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Mouse Model of Pressure Ulcers After Spinal Cord Injury.

Suneel Kumar, Yuying Tan, Martin L Yarmush, Biraja C Dash, Henry C Hsia, Francois Berthiaume,

Pressure ulcers (PUs) are common debilitating complications of traumatic spinal cord injury (SCI) and tend to occur in soft tissues around bony prominences. There is, however, little known about the impact of SCI on skin wound healing in the context of animal models in controlled experimental settings. In this study, ... Read more >>

J Vis Exp (Journal of visualized experiments : JoVE)
[2019, (145):]

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An Algorithm for the Management of Residual Head and Neck Melanoma In Situ Using Topical Imiquimod: A Pilot Study.

Cynthia Tsay, Samuel Kim, Amanda Norwich-Cavanaugh, Henry C Hsia, Deepak Narayan,

INTRODUCTION:Melanoma in situ (MIS) is an early variant of melanoma in which the disease is limited to the epidermis. Standard therapy is currently surgical excision with at least 5-mm margins. In some instances, there are large or anatomically difficult lesions where complete excision will result in significant esthetic or functional ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2019, 82(4S Suppl 3):S199-S201]

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Impact of Acellular Dermal Matrix on Postsurgical Wound Fluid Biomarkers in Prosthetic Breast Reconstruction.

Henry C Hsia, Michael R Weaver, Jean E Schwarzbauer,

BACKGROUND:Despite the widespread practice of using biologic scaffolds for soft tissue reinforcement over prosthetic implants, the impact of acellular dermal matrix (ADM) on surgical wound fluid biomarkers over the initial postoperative period after prosthetic breast reconstruction remains poorly understood. METHODS:Patients undergoing prosthetic breast reconstruction surgery where ADM was likely to ... Read more >>

Ann Plast Surg (Annals of plastic surgery)
[2018, 81(6S Suppl 1):S89-S96]

Cited: 1 time

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Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair.

Brett A Shook, Renee R Wasko, Guillermo C Rivera-Gonzalez, Emilio Salazar-Gatzimas, Francesc López-Giráldez, Biraja C Dash, Andrés R Muñoz-Rojas, Krystal D Aultman, Rachel K Zwick, Vivian Lei, Jack L Arbiser, Kathryn Miller-Jensen, Damon A Clark, Henry C Hsia, Valerie Horsley,

During tissue repair, myofibroblasts produce extracellular matrix (ECM) molecules for tissue resilience and strength. Altered ECM deposition can lead to tissue dysfunction and disease. Identification of distinct myofibroblast subsets is necessary to develop treatments for these disorders. We analyzed profibrotic cells during mouse skin wound healing, fibrosis, and aging and ... Read more >>

Science (Science (New York, N.Y.))
[2018, 362(6417):]

Cited: 8 times

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Telehealth in Plastic Surgery: A Veterans Affairs Hospital Perspective.

Stephanie Douglas, Erik Geiger, Andrew McGregor, Amanda Norwich, Deena Abbate, Henry Hsia, Deepak Narayan,

Background:Telemedicine is a rapidly growing tool since its invention in the 1950s. Recently, it has expanded to the field of plastic surgery. In the Connecticut VA System, there is 1 plastic surgeon at a central location for the state of Connecticut and southern Massachusetts. Our aim was to pilot a ... Read more >>

Plast Reconstr Surg Glob Open (Plastic and reconstructive surgery. Global open)
[2018, 6(10):e1840]

Cited: 0 times

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