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Author Henrik Hellquist

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High-grade Transformation/Dedifferentiation in Salivary Gland Carcinomas: Occurrence Across Subtypes and Clinical Significance.

Alena Skalova, Ilmo Leivo, Henrik Hellquist, Abbas Agaimy, Roderick H W Simpson, Göran Stenman, Vincent Vander Poorten, Justin A Bishop, Alessandro Franchi, Juan C Hernandez-Prera, David Slouka, Stefan M Willems, Kerry D Olsen, Alfio Ferlito,

High-grade transformation (HGT) or dedifferentiation has been described in a variety of salivary gland carcinomas, including acinic cell carcinoma, secretory carcinoma, adenoid cystic carcinoma, epithelial-myoepithelial carcinoma, polymorphous adenocarcinoma, low-grade mucoepidermoid carcinoma, and hyalinizing clear cell carcinoma. High-grade (HG) transformed tumors are composed of a conventional low-grade component characterized by specific ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):107-118]

Cited: 0 times

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Emerging Entities and New Diagnostic Markers for Head and Neck Soft Tissue and Bone Tumors.

Alessandro Franchi, Lester D R Thompson, Juan C Hernandez-Prera, Abbas Agaimy, Michelle D Williams, Lauge H Mikkelsen, Justin A Bishop, Stefan M Willems, Henrik Hellquist, Alfio Ferlito,

Bone and soft tissue tumors of the head and neck are relatively uncommon tumors that often represent a diagnostic challenge because of the wide range of entities that must be considered in the differential diagnosis. Over the past few years, classification of bone and soft tissue tumors has evolved primarily ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2021, 28(3):139-149]

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Developing Classifications of Laryngeal Dysplasia: The Historical Basis.

Henrik Hellquist, Alfio Ferlito, Antti A Mäkitie, Lester D R Thompson, Justin A Bishop, Abbas Agaimy, Juan C Hernandez-Prera, Douglas R Gnepp, Stefan M Willems, Pieter J Slootweg, Alessandra Rinaldo,

During the last 60 years numerous significant attempts have been made to achieve a widely acceptable terminology and histological grading for laryngeal squamous intraepithelial lesions. While dysplasia was included in the pathology of the uterine cervix already in 1953, the term dysplasia was accepted in laryngeal pathology first after the Toronto ... Read more >>

Adv Ther (Advances in therapy)
[2020, 37(6):2667-2677]

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Sinonasal Undifferentiated Carcinoma (SNUC): From an Entity to Morphologic Pattern and Back Again-A Historical Perspective.

Abbas Agaimy, Alessandro Franchi, Valerie J Lund, Alena Skálová, Justin A Bishop, Asterios Triantafyllou, Simon Andreasen, Douglas R Gnepp, Henrik Hellquist, Lester D R Thompson, Alessandra Rinaldo, Alfio Ferlito,

Since the first description of sinonasal undifferentiated carcinoma (SNUC) as a distinctive highly aggressive sinonasal neoplasm with probable origin from the sinonasal mucosa (Schneiderian epithelium), SNUC has been the subject of ongoing study and controversy. In particular, the SNUC category gradually became a "wastebasket" for any undifferentiated or unclassifiable sinonasal ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2020, 27(2):51-60]

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Update on Neuroendocrine Carcinomas of the Larynx.

Carolina Strosberg, Alfio Ferlito, Asterios Triantafyllou, Douglas R Gnepp, Justin A Bishop, Henrik Hellquist, Primoz Strojan, Stefan M Willems, Göran Stenman, Alessandra Rinaldo, Juan C Hernandez-Prera,

<h4>Objectives</h4>Laryngeal neuroendocrine carcinomas are heterogeneous neoplasms characterized by neuroendocrine differentiation. Their prognoses are dependent on tumor type, therefore different classifications have been developed. Moreover, other tumors have overlapping pathologic features posing a range of diagnostic possibilities.<h4>Methods</h4>A review of the literature was performed to comprehensively understand the classification and diagnosis of ... Read more >>

Am J Clin Pathol (American journal of clinical pathology)
[2019, 152(6):686-700]

Cited: 1 time

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An evidence-based analysis of the management of N0 neck in patients with cancer of the parotid gland.

Jose Guilherme Vartanian, Joao Gonçalves Filho, Luiz Paulo Kowalski, Jatin P Shah, Carlos Suárez, Alessandra Rinaldo, Remco De Bree, Juan P Rodrigo, Marc Hamoir, Robert P Takes, Antti A Mäkitie, Peter Zbären, Simon Andreasen, Vincent Vander Poorten, Alvaro Sanabria, Henrik Hellquist, K Thomas Robbins, Carsten C Bödeker, Carl Silver, Alfio Ferlito,

<b>Introduction</b>: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. <b>Areas covered</b>: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2019, 19(10):899-908]

Cited: 1 time

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Well-differentiated Neuroendocrine Carcinoma of the Larynx: Confusion of Terminology and Uncertainty of Early Studies.

Jennifer L Hunt, Leon Barnes, Asterios Triantafyllou, Douglas R Gnepp, Kenneth O Devaney, Göran Stenman, Gyorgy B Halmos, Justin A Bishop, Alena Skálová, Stefan M Willems, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito,

Well-differentiated neuroendocrine carcinoma (also known as "carcinoid") of the larynx is an exceedingly rare tumor that has an epithelial origin. These tumors are malignant and have a low, but definite, risk of metastasis. Although it can be challenging, this tumor should be differentiated from moderately differentiated neuroendocrine carcinoma (also known ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2019, 26(4):246-250]

Cited: 1 time

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Some Considerations on the WHO Histological Classification of Laryngeal Neoplasms.

Alfio Ferlito, Kenneth O Devaney, Jennifer L Hunt, Henrik Hellquist,

A new edition of the World Health Organization (WHO) Histological classification of tumours of the hypopharynx, larynx, trachea and parapharyngeal space was published in 2017. We have considered this classification regarding laryngeal neoplasms and discuss the grounds for said revision. Many of the laryngeal neoplasms described in the literature and ... Read more >>

Adv Ther (Advances in therapy)
[2019, 36(7):1511-1517]

Cited: 0 times

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Lymphomas of the head and neck region: an update.

José Cabeçadas, Daniel Martinez, Simon Andreasen, Lauge Hjorth Mikkelsen, Ricardo Molina-Urra, Diane Hall, Primož Strojan, Henrik Hellquist, Francesco Bandello, Alessandra Rinaldo, Antonio Cardesa, Alfio Ferlito,

The field of haematopathology is rapidly evolving and for the non-specialized pathologist receiving a specimen with the possibility of a lymphoid malignancy may be a daunting experience. The coincidence of the publication, in 2017, of the WHO monographies on head and neck and haematopoietic and lymphoid tumours prompted us to ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2019, 474(6):649-665]

Cited: 4 times

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Preoperative diagnostic of parotid gland neoplasms: fine-needle aspiration cytology or core needle biopsy?

Peter Zbären, Asterios Triantafyllou, Kenneth O Devaney, Vincent Vander Poorten, Henrik Hellquist, Alessandra Rinaldo, Alfio Ferlito,

A preoperative cytologic or histologic diagnosis of parotid gland neoplasms is mandatory to decide which surgical procedure would be appropriate. Open biopsies are contraindicated because of the risk of recurrence secondary to tumour cell seeding; furthermore a subsequent curative parotid surgery can be complicated by a previous open biopsy. While ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2018, 275(11):2609-2613]

Cited: 2 times

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Biphenotypic sinonasal sarcoma: demographics, clinicopathological characteristics, molecular features, and prognosis of a recently described entity.

Simon Andreasen, Justin A Bishop, Henrik Hellquist, Jennifer Hunt, Katalin Kiss, Alessandra Rinaldo, Alena Skálová, Stefan M Willems, Michelle Williams, Alfio Ferlito,

Biphenotypic sinonasal sarcoma (BSNS) is a recently recognized type of sarcoma arising exclusively in the sinonasal tract displaying unique clinical course, histopathology, and genetics. Due to its rarity, only case series and case reports are available. In order to provide an overview of the current understanding of this disease, we ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2018, 473(5):615-626]

Cited: 4 times

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Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.

Vincent Vander Poorten, Asterios Triantafyllou, Alena Skálová, Göran Stenman, Justin A Bishop, Esther Hauben, Jennifer L Hunt, Henrik Hellquist, Simon Feys, Remco De Bree, Antti A Mäkitie, Miquel Quer, Primož Strojan, Orlando Guntinas-Lichius, Alessandra Rinaldo, Alfio Ferlito,

Although relatively rare, polymorphous adenocarcinoma (PAC) is likely the second most common malignancy of the minor salivary glands (MiSG). The diagnosis is mainly based on an incisional biopsy. The optimal treatment comprises wide surgical excision, often with adjuvant radiotherapy. In general, PAC has a good prognosis. Previously, PAC was referred to ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2018, 275(7):1681-1695]

Cited: 3 times

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The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.

Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito,

Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2018, 42(2):e11-e27]

Cited: 21 times

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Newly Described Entities in Salivary Gland Pathology.

Alena Skálová, Douglas R Gnepp, James S Lewis, Jennifer L Hunt, Justin A Bishop, Henrik Hellquist, Alessandra Rinaldo, Vincent Vander Poorten, Alfio Ferlito,

Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2017, 41(8):e33-e47]

Cited: 10 times

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Differential Diagnosis in Neuroendocrine Neoplasms of the Larynx.

Jennifer L Hunt, Alfio Ferlito, Henrik Hellquist, Alessandra Rinaldo, Alena Skálová, Pieter J Slootweg, Stefan M Willems, Antonio Cardesa,

The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis and treatment are also different among these tumor ... Read more >>

Adv Anat Pathol (Advances in anatomic pathology)
[2017, 24(3):161-168]

Cited: 5 times

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How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?

Fernando López, Michelle D Williams, Alena Skálová, Henrik Hellquist, Carlos Suárez, Iain J Nixon, Juan P Rodrigo, Antonio Cardesa, Primož Strojan, Miquel Quer, Jennifer L Hunt, Alessandra Rinaldo, Alfio Ferlito,

Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. ... Read more >>

Adv Ther (Advances in therapy)
[2017, 34(4):813-825]

Cited: 0 times

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NUT midline carcinoma of the larynx: an international series and review of the literature.

Henrik Hellquist, Christopher A French, Justin A Bishop, Andrés Coca-Pelaz, Evan J Propst, António Paiva Correia, Bo-Yee Ngan, Ronald Grant, Nicole A Cipriani, David Vokes, Rui Henrique, Fernando Pardal, Jose Ramon Vizcaino, Alessandra Rinaldo, Alfio Ferlito,

<h4>Aims</h4>NUT midline carcinoma (NMC) is a rare undifferentiated and aggressive carcinoma that locates characteristically to the midline of the head and neck, and mediastinum. NMC is characterized by chromosomal rearrangements of the gene NUT, at 15q14. The BRD4 gene on 19q13 is the most common translocation partner forming a fusion ... Read more >>

Histopathology (Histopathology)
[2017, 70(6):861-868]

Cited: 10 times

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Salivary gland hybrid tumour revisited: could they represent high-grade transformation in a low-grade neoplasm?

Henrik Hellquist, Alena Skalova, Bahram Azadeh,

Salivary gland hybrid tumour, first described in 1996, is a very rare neoplasm for which exact morphological criteria have not been universally agreed upon. In contrast, the concept of high-grade transformation (HGT) in salivary neoplasms has been widely accepted during the last decade, and the number of reported cases is ... Read more >>

Virchows Arch (Virchows Archiv : an international journal of pathology)
[2016, 469(6):643-650]

Cited: 3 times

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High grade transformation of salivary gland acinic cell carcinoma with emphasis on histological diagnosis and clinical implications.

Danielle Bury, Mugtaba Dafalla, Shabada Ahmed, Henrik Hellquist,

Acinic cell carcinoma (ACC) is commonly thought of as a low grade malignant salivary neoplasm, and possibly has the best prognosis of all salivary malignancies with a 10-year survival of almost 90%. High grade transformation (HGT) in these tumours is a relatively rare event but is increasingly being reported. HGT ... Read more >>

Pathol Res Pract (Pathology, research and practice)
[2016, 212(11):1059-1063]

Cited: 1 time

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Cervical lymph node metastasis in adenoid cystic carcinoma of oral cavity and oropharynx: A collective international review.

Carlos Suárez, Leon Barnes, Carl E Silver, Juan P Rodrigo, Jatin P Shah, Asterios Triantafyllou, Alessandra Rinaldo, Antonio Cardesa, Karen T Pitman, Luiz P Kowalski, K Thomas Robbins, Henrik Hellquist, Jesus E Medina, Remco de Bree, Robert P Takes, Andrés Coca-Pelaz, Patrick J Bradley, Douglas R Gnepp, Afshin Teymoortash, Primož Strojan, William M Mendenhall, Jean Anderson Eloy, Justin A Bishop, Kenneth O Devaney, Lester D R Thompson, Marc Hamoir, Pieter J Slootweg, Vincent Vander Poorten, Michelle D Williams, Bruce M Wenig, Alena Skálová, Alfio Ferlito,

The purpose of this study was to suggest general guidelines in the management of the N0 neck of oral cavity and oropharyngeal adenoid cystic carcinoma (AdCC) in order to improve the survival of these patients and/or reduce the risk of neck recurrences. The incidence of cervical node metastasis at diagnosis ... Read more >>

Auris Nasus Larynx (Auris, nasus, larynx)
[2016, 43(5):477-484]

Cited: 4 times

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Cervical Lymph Node Metastasis in High-Grade Transformation of Head and Neck Adenoid Cystic Carcinoma: A Collective International Review.

Henrik Hellquist, Alena Skálová, Leon Barnes, Antonio Cardesa, Lester D R Thompson, Asterios Triantafyllou, Michelle D Williams, Kenneth O Devaney, Douglas R Gnepp, Justin A Bishop, Bruce M Wenig, Carlos Suárez, Juan P Rodrigo, Andrés Coca-Pelaz, Primož Strojan, Jatin P Shah, Marc Hamoir, Patrick J Bradley, Carl E Silver, Pieter J Slootweg, Vincent Vander Poorten, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Jean Anderson Eloy, Robert P Takes, Alessandra Rinaldo, Alfio Ferlito,

Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor ... Read more >>

Adv Ther (Advances in therapy)
[2016, 33(3):357-368]

Cited: 18 times

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Cervical Lymph Node Metastasis in Adenoid Cystic Carcinoma of the Larynx: A Collective International Review.

Andrés Coca-Pelaz, Leon Barnes, Alessandra Rinaldo, Antonio Cardesa, Jatin P Shah, Juan P Rodrigo, Carlos Suárez, Jean Anderson Eloy, Justin A Bishop, Kenneth O Devaney, Lester D R Thompson, Bruce M Wenig, Primož Strojan, Marc Hamoir, Patrick J Bradley, Douglas R Gnepp, Carl E Silver, Pieter J Slootweg, Asterios Triantafyllou, Vincent Vander Poorten, Michelle D Williams, Alena Skálová, Henrik Hellquist, Afshin Teymoortash, Jesus E Medina, K Thomas Robbins, Karen T Pitman, Luiz P Kowalski, Remco de Bree, William M Mendenhall, Robert P Takes, Alfio Ferlito,

Adenoid cystic carcinoma (AdCC) of the head and neck is a well-recognized pathologic entity that rarely occurs in the larynx. Although the 5-year locoregional control rates are high, distant metastasis has a tendency to appear more than 5 years post treatment. Because AdCC of the larynx is uncommon, it is difficult ... Read more >>

Adv Ther (Advances in therapy)
[2016, 33(4):553-579]

Cited: 2 times

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Neuroendocrine neoplasms of the sinonasal region.

Diana Bell, Ehab Y Hanna, Randal S Weber, Franco DeMonte, Asterios Triantafyllou, James S Lewis, Antonio Cardesa, Pieter J Slootweg, Göran Stenman, Douglas R Gnepp, Kenneth O Devaney, Juan P Rodrigo, Alessandra Rinaldo, Bruce M Wenig, William H Westra, Justin A Bishop, Henrik Hellquist, Jennifer L Hunt, Kimihide Kusafuka, Bayardo Perez-Ordoñez, Michelle D Williams, Robert P Takes, Alfio Ferlito,

Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis ... Read more >>

Head Neck (Head & neck)
[2016, 38 Suppl 1:E2259-66]

Cited: 20 times

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European position paper on endoscopic management of tumours of the nose, paranasal sinuses and skull base.

Valerie J Lund, Heinz Stammberger, Piero Nicolai, Paolo Castelnuovo, Tim Beal, Alfred Beham, Manuel Bernal-Sprekelsen, Hannes Braun, Paola Cappabianca, Ricardo Carrau, Luigi Cavallo, George Clarici, Wolfwang Draf, Felice Esposito, Juan Fernandez-Miranda, Wytske Fokkens, Paul Gardner, Verena Gellner, Henrik Hellquist, Phillipe Hermann, Werner Hosemann, David Howard, Nick Jones, Mark Jorissen, Amin Kassam, Daniel Kelly, Senta Kurschel-Lackner, Samuel Leong, Nancy McLaughlin, Roberto Maroldi, Amir Minovi, Michael Mokry, Metin Onerci, Yew Kwang Ong, Daniel Prevedello, Hesham Saleh, Dharambir S Sehti, Daniel Simmen, Carl Snyderman, Auturo Solares, Magaret Spittle, Aldo Stamm, Peter Tomazic, Matteo Trimarchi, Frank Unger, Peter-John Wormald, Adam Zanation, ,

Tumours affecting the nose, paranasal sinuses and adjacent skull base are fortunately rare. However, they pose significant problems of management due their late presentation and juxtaposition to important anatomical structures such eye and brain. The increasing application of endonasal endoscopic techniques to their excision offers potentially similar scales of resection ... Read more >>

Rhinol Suppl (Rhinology. Supplement)
[2010, 22:1-143]

Cited: 130 times

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Multifocal multi-site Warthin tumour.

Jennifer M Hilton, John S Phillips, Henrik B Hellquist, Don J Premachandra,

The unique case of a 55-year-old man with multifocal adenolymphoma (Warthin's tumour) of both parotid glands, the neck and post-nasal space is presented. Warthin tumour is almost exclusively a parotid tumour but is known to be bilateral in 7-10% of cases and multifocal in 2% of cases. Most extraglandular Warthin ... Read more >>

Eur Arch Otorhinolaryngol (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery)
[2008, 265(12):1573-1575]

Cited: 11 times

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