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Author Henrik Bjarke Vaegter

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Preliminary validity and test-retest reliability of two depression questionnaires compared with a diagnostic interview in 99 patients with chronic pain seeking specialist pain treatment.

Thuy Vy Kha, Elsebeth Stenager, Huong Hoang, Karin Bruun-Plesner, Kira Søndberg Fuglsang, Birgitte Søgaard la Cour, Gitte Handberg, Henrik Bjarke Vaegter,

Objectives Depression symptomatology is highly prevalent in patients with chronic pain, but accurate identification of major depression may be challenged due to time constraints and diagnostic interviews are therefore not routinely performed in clinical practice. Assessment of depression may be facilitated through the use of full-length depression screening questionnaires with ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2020, :]

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Power of Words: Influence of Preexercise Information on Hypoalgesia after Exercise-Randomized Controlled Trial.

Henrik Bjarke Vaegter, Peter Thinggaard, Casper Høj Madsen, Monika Hasenbring, Jonas Bloch Thorlund,

PURPOSE:Exercise increases pressure pain thresholds (PPT) in pain-free individuals, known as exercise-induced hypoalgesia (EIH). Positive pre-exercise information can elicit higher EIH responses, but the effect of positive versus negative pre-exercise information on EIH is unknown. The primary aim of this randomized controlled trial (RCT) was to compare EIH at the ... Read more >>

Med Sci Sports Exerc (Medicine and science in sports and exercise)
[2020, :]

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Testosterone replacement therapy of opioid-induced male hypogonadism improved body composition but not pain perception: a double-blind, randomized, and placebo-controlled trial.

Dorte Glintborg, Henrik Bjarke Vaegter, Louise Lehmann Christensen, Emma Bendix, Thomas Graven-Nielsen, Per Grünwald Andersen, Marianne Andersen,

Background:Hypogonadism is prevalent during opioid treatment, but the effect of testosterone replacement treatment (TRT) on body composition, pain perception, and adrenal function is unclear. Purpose:To measure changes in body composition, pain perception, quality of life, and adrenal function after TRT or placebo in opioid-treated men with chronic non-malignant pain. Methods:Double-blind, ... Read more >>

Eur. J. Endocrinol. (European journal of endocrinology)
[2020, 182(6):539-548]

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Alterations in pronociceptive and antinociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pronociceptive and antinociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions, alterations are well-established, but in populations with low back pain (LBP), there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to ... Read more >>

Pain (Pain)
[2020, 161(3):464-475]

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Low-Dose Naltrexone for the Treatment of Fibromyalgia: Investigation of Dose-Response Relationships.

Karin Bruun-Plesner, Morten Rune Blichfeldt-Eckhardt, Henrik Bjarke Vaegter, Joergen T Lauridsen, Kirstine Amris, Palle Toft,

OBJECTIVE:This study explores dose-response relationships when treating fibromyalgia with low-dose naltrexone. DESIGN:A single-blinded clinical trial was carried out using the "up-and-down" method. SUBJECTS:Subjects included women with a diagnosis of fibromyalgia aged 18-60 years who had been referred to treatment at a public pain clinic at a Danish university hospital. METHODS:The test ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2020, :]

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Multiple physical symptoms and individual characteristics - A cross-sectional study of the general population.

Sanne Rasmussen, Cecilie Thit Jensen, Marianne Rosendal, Henrik Bjarke Vægter, Jens Søndergaard, Dorte Ejg Jarbøl,

OBJECTIVE:Multiple physical symptoms not attributable to known organic disease are common in all medical fields and associated with major personal and social consequences. This study investigated multiple physical symptoms according to the construct of bodily distress syndrome (BDS) and associated individual characteristics in the general adult population. METHODS:A nationwide, population-based ... Read more >>

J Psychosom Res (Journal of psychosomatic research)
[2020, 131:109941]

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Improvements in clinical pain and experimental pain sensitivity after cognitive functional therapy in patients with severe persistent low back pain.

Henrik Bjarke Vaegter, Kaper Ussing, Jannick Vaaben Johansen, Irene Stegemejer, Thorvaldur Skuli Palsson, Peter O'Sullivan, Peter Kent,

Introduction:Multidisciplinary care is recommended for disabling persistent low back pain (pLBP) nonresponsive to primary care. Cognitive functional therapy (CFT) is a physiotherapy-led individualised intervention targeting psychological, physical, and lifestyle barriers to recovery, to self-manage pLBP. Objectives:This pilot study investigated clinical outcomes and pain thresholds after a 12-week CFT pathway in ... Read more >>

Pain Rep (Pain reports)
[2020, 5(1):e802]

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Alterations in pro-nociceptive and anti-nociceptive mechanisms in patients with low back pain: a systematic review with meta-analysis.

Megan E McPhee, Henrik Bjarke Vaegter, Thomas Graven-Nielsen,

Altered pro-nociceptive and anti-nociceptive mechanisms are often implicated in painful conditions and have been increasingly studied over the past decade. For some painful conditions alterations are well-established, but in low back pain (LBP) populations there remains considerable debate whether these mechanisms are altered. The present systematic review aimed to address ... Read more >>

Pain (Pain)
[2019, :]

Cited: 0 times

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Assessing Endogenous Pain Inhibition: Test-Retest Reliability of Exercise-Induced Hypoalgesia in Local and Remote Body Parts After Aerobic Cycling.

Stefan Gomolka, Henrik Bjarke Vaegter, Jo Nijs, Mira Meeus, Hannah Gajsar, Monika I Hasenbring, Christina Titze,

OBJECTIVE:Acute exercise can trigger a hypoalgesic response (exercise-induced hypoalgesia [EIH]) in healthy subjects. Despite promising application possibilities of EIH in the clinical context, its reliability has not been sufficiently examined. This study therefore investigated the between-session and within-subject test-retest reliability of EIH at local and remote body parts after aerobic ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2019, 20(11):2272-2282]

Cited: 1 time

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Walking increases pain tolerance in humans an experimental cross-over study.

Jens-Christian Trojel Hviid, Jonas Bloch Thorlund, Henrik Bjarke Vaegter,

Background and aims Exercise is commonly used as treatment for chronic pain with positive long-term effects on pain and pain-related disability. In pain-free subjects, hypoalgesia following an acute bout of exercise compared with a control condition has consistently been demonstrated also known as exercise-induced hypoalgesia (EIH). Walking exercise, a low ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2019, :]

Cited: 0 times

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Cause-specific mortality of patients with severe chronic pain referred to a multidisciplinary pain clinic: a cohort register-linkage study.

Henrik Bjarke Vaegter, Martine Støten, Siv Laine Silseth, Annette Erlangsen, Gitte Handberg, Stine Sondergaard, Elsebeth Stenager,

Background and aims Almost 20% of the adult population suffers from chronic pain. Chronic pain may be linked to an elevated mortality; however, results from previous studies are inconsistent. Some studies find similar mortality levels in chronic pain patients and pain-free controls while other studies show elevated mortality levels among ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2019, 19(1):93-99]

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Assessment of CPM reliability: quantification of the within-subject reliability of 10 different protocols.

Henrik Bjarke Vaegter, Kristian Kjær Petersen, Carsten Dahl Mørch, Yosuke Imai, Lars Arendt-Nielsen,

Background and aims Conditioned Pain Modulation (CPM) is a well-established phenomenon and several protocols have shown acceptable between-subject reliability [based on intraclass correlation coefficient (ICC) values] in pain-free controls. Recently, it was recommended that future CPM test-retest reliability studies should explicitly report CPM reliability based on CPM responders and non-responders ... Read more >>

Scand J Pain (Scandinavian journal of pain)
[2018, 18(4):729-737]

Cited: 1 time

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Exercise-Induced Hypoalgesia After Isometric Wall Squat Exercise: A Test-Retest Reliabilty Study.

Henrik Bjarke Vaegter, Kristian Damgaard Lyng, Fredrik Wannebo Yttereng, Mads Holst Christensen, Mathias Brandhøj Sørensen, Thomas Graven-Nielsen,

Background:Isometric exercises decrease pressure pain sensitivity in exercising and nonexercising muscles known as exercise-induced hypoalgesia (EIH). No studies have assessed the test-retest reliability of EIH after isometric exercise. This study investigated the EIH on pressure pain thresholds (PPTs) after an isometric wall squat exercise. The relative and absolute test-retest reliability ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2019, 20(1):129-137]

Cited: 1 time

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Systemic Exercise-Induced Hypoalgesia Following Isometric Exercise Reduces Conditioned Pain Modulation.

Ali Alsouhibani, Henrik Bjarke Vaegter, Marie Hoeger Bement,

Objective:Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This study investigated the effects of acute isometric exercise on CPM. In addition, the ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2019, 20(1):180-190]

Cited: 2 times

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Test-Retest Reliabilty of Exercise-Induced Hypoalgesia After Aerobic Exercise.

Henrik Bjarke Vaegter, Daniel Bandholtz Dørge, Kristian Sonne Schmidt, Anders Haagen Jensen, Thomas Graven-Nielsen,

Objective:Exercise increases pressure pain thresholds (PPTs) in exercising and nonexercising muscles, known as exercise-induced hypoalgesia (EIH). No studies have investigated the test-retest reliability of change in PPTs after aerobic exercise. Primary objectives were to compare the effect on PPTs after an incremental bicycling exercise compared with quiet rest and to ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2018, 19(11):2212-2222]

Cited: 2 times

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Hypoalgesia after bicycling at lactate threshold is reliable between sessions.

Henrik Bjarke Vaegter, Louise Kathrine Bjerregaard, Mia-Maja Redin, Sara Hartung Rasmussen, Thomas Graven-Nielsen,

PURPOSE:Exercise decreases pain sensitivity known as exercise-induced hypoalgesia (EIH). However, the consistency of EIH after an acute exercise protocol based on subjective ratings of perceived exertion has been questioned. Objectives were to compare the effect on pressure pain thresholds (PPTs) after bicycling with work-rate at the lactate threshold compared with ... Read more >>

Eur. J. Appl. Physiol. (European journal of applied physiology)
[2019, 119(1):91-102]

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Pain-Related Acceptance as a Mediator in the Fear Avoidance Model of Chronic Pain: A Preliminary Study.

Sophie Lykkegaard Ravn, Maria Louison Vang, Henrik Bjarke Vaegter, Tonny Elmose Andersen,

Objective:The fear avoidance model has served as a popular, heuristic model in explaining the transition from acute to chronic pain. In addition, the significance of pain-related acceptance in chronic pain development and adjustment is underlined in a vast number of empirical studies. The objective of the current preliminary study was ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2018, 19(9):1764-1771]

Cited: 0 times

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The role of posttraumatic stress symptoms on chronic pain outcomes in chronic pain patients referred to rehabilitation.

Sophie Lykkegaard Ravn, Henrik Bjarke Vaegter, Thomas Cardel, Tonny Elmose Andersen,

Posttraumatic stress symptoms (PTSS) are highly prevalent in chronic pain patients and may affect pain symptomatology negatively, but there is still a great need to explore exactly how this occurs. Therefore, this study investigated differences in pain intensity, pain-related disability, and psychological distress between chronic pain patients not exposed to ... Read more >>

J Pain Res (Journal of pain research)
[2018, 11:527-536]

Cited: 1 time

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Symptoms of Fibromyalgia According to the 2016 Revised Fibromyalgia Criteria in Chronic Pain Patients Referred to Multidisciplinary Pain Rehabilitation: Influence on Clinical and Experimental Pain Sensitivity.

Karin Bruun Plesner, Henrik Bjarke Vaegter,

Fibromyalgia (FM) is a condition with chronic widespread pain and signs of generalized pain hypersensitivity. FM has previously been classified according to the American College of Rheumatology-1990 criteria, where the presence of hypersensitivity is estimated by a tender point examination. Because of the limitations of these classification criteria, new diagnostic ... Read more >>

J Pain (The journal of pain : official journal of the American Pain Society)
[2018, 19(7):777-786]

Cited: 0 times

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An updated view on the reliability of different protocols for the assessment of conditioned pain modulation.

Kristian Kjær Petersen, Henrik Bjarke Vaegter, Lars Arendt-Nielsen,

Pain (Pain)
[2017, 158(5):988]

Cited: 3 times

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Isometric Back Exercise Has Different Effect on Pressure Pain Thresholds in Healthy Men and Women.

Hannah Gajsar, Christina Titze, Monika Ilona Hasenbring, Henrik Bjarke Vaegter,

Objective:Isometric exercises produce an acute decrease in the pain sensitivity, known as exercise-induced hypoalgesia (EIH). Existing EIH paradigms use exercises at the extremities with more pronounced EIH at local compared to remote body sites, indicating local inhibition in addition to central inhibitory mechanisms. So far the results on EIH in ... Read more >>

Pain Med (Pain medicine (Malden, Mass.))
[2017, 18(5):917-923]

Cited: 3 times

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Facilitated Pronociceptive Pain Mechanisms in Radiating Back Pain Compared With Localized Back Pain.

Henrik Bjarke Vaegter, Thorvaldur Skuli Palsson, Thomas Graven-Nielsen,

Facilitated pain mechanisms and impaired pain inhibition are often found in chronic pain patients. This study compared clinical pain profiles, pain sensitivity, as well as pronociceptive and antinociceptive mechanisms in patients with localized low back pain (n = 18), localized neck pain (n = 17), low back and radiating leg pain (n = 18), or neck ... Read more >>

J Pain (The journal of pain : official journal of the American Pain Society)
[2017, 18(8):973-983]

Cited: 4 times

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Exercising non-painful muscles can induce hypoalgesia in individuals with chronic pain.

Henrik Bjarke Vaegter,

Scand J Pain (Scandinavian journal of pain)
[2017, 15:60-61]

Cited: 0 times

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A 13-Weeks Mindfulness Based Pain Management Program Improves Psychological Distress in Patients with Chronic Pain Compared with Waiting List Controls.

Tonny Elmose Andersen, Henrik Bjarke Vægter,

BACKGROUND:Eradication of pain is seldom an option in chronic pain management. Hence, mindfulness meditation has become popular in pain management. OBJECTIVE:This pilot study compared the effect of a 13-weeks cognitive behavioural therapy program with integrated mindfulness meditation (CBTm) in patients with chronic non-malignant pain with a control condition. It was ... Read more >>

Clin Pract Epidemiol Ment Health (Clinical practice and epidemiology in mental health : CP & EMH)
[2016, 12:49-58]

Cited: 2 times

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Acetaminophen for Chronic Pain: A Systematic Review on Efficacy.

Zandra Nymand Ennis, Dorthe Dideriksen, Henrik Bjarke Vaegter, Gitte Handberg, Anton Pottegård,

Acetaminophen (paracetamol) is the most commonly used analgesic worldwide and recommended as first-line treatment in all pain conditions by WHO. We performed a systematic literature review to evaluate the efficacy of acetaminophen when used for chronic pain conditions. Applying three broad search strategies for acetaminophen use in chronic pain in ... Read more >>

Basic Clin. Pharmacol. Toxicol. (Basic & clinical pharmacology & toxicology)
[2016, 118(3):184-189]

Cited: 13 times

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