Full Text Journal Articles by
Author Helmut Friess

Advertisement

Find full text journal articles






Morphology Matters: A Critical Reappraisal of the Clinical Relevance of Morphologic Criteria From the 2019 WHO Classification in a Large Colorectal Cancer Cohort Comprising 1004 Cases.

Moritz Jesinghaus, Maxime Schmitt, Corinna Lang, Marianne Reiser, Alexander Scheiter, Björn Konukiewitz, Katja Steiger, Miguel Silva, Markus Tschurtschenthaler, Sebastian Lange, Sebastian Foersch, Karl F Becker, Dieter Saur, Helmut Friess, Kathrin Halfter, Jutta Engel, Melanie Boxberg, Nicole Pfarr, Dirk Wilhelm, Wilko Weichert,

The 2019 World Health Organization (WHO) classification of colorectal carcinoma (CRC) profoundly reclassified CRC subtypes and introduces tumor budding as a second major grading criterion, while condensing conventional grade into a 2-tiered system. So far it remains largely unexplored how these parameters interact with each other and whether they truly ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2021, 45(7):969-978]

Cited: 0 times

View full text PDF listing >>



Impact of the COVID-19 Pandemic on Surgical Oncology in Europe: Results of a European Survey.

Christian Stöss, Marcella Steffani, Ilaria Pergolini, Daniel Hartmann, Dejan Radenkovic, Alexander Novotny, Helmut Friess, Michael W Müller,

<h4>Background</h4>The first COVID-19 pandemic wave hit most of the health-care systems worldwide. The present survey aimed to provide a European overview on the COVID-19 impact on surgical oncology.<h4>Methods</h4>This anonymous online survey was accessible from April 24 to May 11, 2020, for surgeons (n = 298) who were contacted by the ... Read more >>

Dig Surg (Digestive surgery)
[2021, :1-7]

Cited: 0 times

View full text PDF listing >>



Advertisement

[Effects of the first COVID-19 wave on visceral surgery : A retrospective comparison of case numbers from a university hospital and a primary care hospital].

Marcella Steffani, Constanze Merz, Christian Stöß, Lars Landau, Norbert Hüser, Daniel Hartmann, Helmut Friess, Jörg Theisen, Alexander Novotny,

<h4>Background</h4>During the first wave of the COVID-19 pandemic, the downregulation of all elective interventions during the period from 15 March 2020 to 15 May 2020 in Germany led to a decrease in operations. The impact on the number of specific operations in visceral surgery is so far unknown.<h4>Methods</h4>This retrospective study included ... Read more >>

Chirurg (Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen)
[2021, 92(6):559-566]

Cited: 0 times

View full text PDF listing >>



Effective operating room (OR) utilization by performing low-complex surgical procedures during the 2020 corona pandemic.

Thomas Vogel, Dina Schippers, Balqees Aldarweesh, Ilaria Pergolini, Martina Stollreiter, Klaus Wagner, Dirk Wilhelm, Helmut Friess, Michael Kranzfelder,

<h4>Purpose</h4>The SARS-CoV-2 pandemic has almost stopped all elective surgical treatment throughout the world. As operating room (OR) capacities are reduced everywhere to ensure availability of intensive care capacities, especially low-complex surgical procedures are often postponed. These include totally implantable central-venous access ports which are important for the oncologic treatment of ... Read more >>

Int J Comput Assist Radiol Surg (International journal of computer assisted radiology and surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



INR and not bilirubin levels predict postoperative morbidity in patients with malignant obstructive jaundice.

Florian Scheufele, Lena Aichinger, Carsten Jäger, Ihsan Ekin Demir, Stephan Schorn, Elke Demir, Mine Sargut, Helmut Friess, Güralp O Ceyhan,

<h4>Background</h4>There are no established predictors for deciding between upfront surgery and PBD in pancreatic head malignancy. Once PBD is present, the ideal drainage-time remains elusive. The aim was, to identify predictors in jaundiced patients and ideal PBD-duration.<h4>Methods</h4>Analysis of 304 patients with pancreatic head malignancy (56% with PBD, n = 170) undergoing pancreaticoduodenectomy ... Read more >>

Am J Surg (American journal of surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Prediction of Tumor Cellularity in Resectable PDAC from Preoperative Computed Tomography Imaging.

Friederike Jungmann, Georgios A Kaissis, Sebastian Ziegelmayer, Felix Harder, Clara Schilling, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Rebekka Schirren, Ishan Ekin Demir, Helmut Friess, Markus R Makowski, Rickmer F Braren, Fabian K Lohöfer,

<h4>Background</h4>PDAC remains a tumor entity with poor prognosis and a 5-year survival rate below 10%. Recent research has revealed invasive biomarkers, such as distinct molecular subtypes, predictive for therapy response and patient survival. Non-invasive prediction of individual patient outcome however remains an unresolved task.<h4>Methods</h4>Discrete cellularity regions of PDAC resection specimen ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(9):]

Cited: 0 times

View full text PDF listing >>



Crohn's disease: a population-based study of surgery in the age of biological therapy.

Christian Stöss, Maximilian Berlet, Stefan Reischl, Ulrich Nitsche, Marie-Christin Weber, Helmut Friess, Dirk Wilhelm, Philipp-Alexander Neumann,

<h4>Purpose</h4>Despite primary conservative therapy for Crohn's disease, a considerable proportion of patients ultimately needs to undergo surgery. Presumably, due to the increased use of biologics, the number of surgeries might have decreased. This study aimed to delineate current case numbers and trends in surgery in the era of biological therapy ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Retrospective study of prognosis of patients with multiple colorectal carcinomas: synchronous versus metachronous makes the difference.

Christoph Barz, Christian Stöss, Philipp-Alexander Neumann, Dirk Wilhelm, Klaus-Peter Janssen, Helmut Friess, Ulrich Nitsche,

<h4>Purpose</h4>Little is known about difference between synchronous colorectal cancer (SCRC) and metachronous colorectal cancer (MCRC) despite the relevance for this selected patient group. The aim of this retrospective review was to analyze patients with SCRC and MCRC.<h4>Methods</h4>All patients who underwent surgery for SCRC and MCRC between 1982 and 2019 were ... Read more >>

Int J Colorectal Dis (International journal of colorectal disease)
[2021, 36(7):1487-1498]

Cited: 0 times

View full text PDF listing >>



Acute Appendicitis: Trends in Surgical Treatment.

Christian Stöß, Ulrich Nitsche, Philipp-Alexander Neumann, Victoria Kehl, Dirk Wilhelm, Reinhard Busse, Helmut Friess, Ulrike Nimptsch,

<h4>Background</h4>Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity.<h4>Methods</h4>Data from diagnosis-related group statistics were ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(14):244-249]

Cited: 0 times

View full text PDF listing >>



Acute Appendicitis: Trends in Surgical Treatment—A Population-Based Study of Over 800 000 Patients.

Christian Stöß, Ulrich Nitsche, Philipp-Alexander Neumann, Victoria Kehl, Dirk Wilhelm, Reinhard Busse, Helmut Friess, Ulrike Nimptsch,

<h4>Background</h4>Appendectomy is the gold standard for treatment of acute appendicitis. However, recent studies favor primary antibiotic therapy. The aim of this observational study was to explore changes in the numbers of operations for acute appendicitis in the period 2010-2017, paying special attention to disease severity.<h4>Methods</h4>Data from diagnosis-related group statistics were ... Read more >>

Dtsch Arztebl Int (Deutsches Arzteblatt international)
[2021, 118(Forthcoming):]

Cited: 0 times

View full text PDF listing >>



Stroma composition and proliferative activity are related to therapy response in neoadjuvant treated pancreatic ductal adenocarcinoma.

Lena Haeberle, Andrea Cacciato Insilla, Anne-Christine Kapp, Katja Steiger, Anna Melissa Schlitter, Björn Konukiewitz, Ihsan Ekin Demir, Helmut Friess, Irene Esposito,

<h4>Background</h4>Tumor regression grading (TRG) based on histopathology is the main tool to assess therapy effects after neoadjuvant therapy (NAT) of pancreatic ductal adenocarcinoma (PDAC). However, reliable markers to distinguish therapy effects from pre-existing tumor features are lacking. The aim of this study was the characterization of PDAC after NAT, focusing ... Read more >>

Histol Histopathol (Histology and histopathology)
[2021, :18332]

Cited: 0 times

View full text PDF listing >>



PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer.

Lucia Liotta, Sebastian Lange, H Carlo Maurer, Kenneth P Olive, Rickmer Braren, Nicole Pfarr, Sebastian Burger, Alexander Muckenhuber, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Helmut Friess, Roland Schmid, Hana Algül, Philipp J Jost, Juliane Ramser, Christine Fischer, Anne S Quante, Maximilian Reichert, Michael Quante,

BACKGROUNDPancreatic cancer is one of the deadliest cancers, with low long-term survival rates. Despite recent advances in treatment, it is important to identify and screen high-risk individuals for cancer prevention. Familial pancreatic cancer (FPC) accounts for 4%-10% of pancreatic cancers. Several germline mutations are related to an increased risk and ... Read more >>

JCI Insight (JCI insight)
[2021, 6(8):]

Cited: 0 times

View full text PDF listing >>



Novel Histologic Categorization Based on Lauren Histotypes Conveys Prognostic Information for Gastroesophageal Junction Cancers-Analysis from a Large Single Center Cohort in Germany.

Rebekka Schirren, Alexander Novotny, Julia Slotta-Huspenina, Helmut Friess, Daniel Reim,

Adenocarcinoma of the gastroesophageal junction (AEG) ranks among the most common cancers in the Western world with increasing incidence. However, the prognostic influence and applicability of the Lauren classification was not examined in detail before. The purpose of this analysis was to analyze the oncologic outcomes of GE-junction cancer related ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(6):]

Cited: 0 times

View full text PDF listing >>



A Simple Classification Of Pancreatic Duct Size and Texture Predicts Postoperative Pancreatic Fistula: A classification of the International Study Group of Pancreatic Surgery (ISGPS).

Fabian Schuh, André L Mihaljevic, Pascal Probst, Maxwell T Trudeau, Philip C Müller, Giovanni Marchegiani, Marc G Besselink, Faik Uzunoglu, Jakob R Izbicki, Massimo Falconi, Carlos Fernandez-Del Castillo, Mustapha Adham, Kaspar Z'graggen, Helmut Friess, Jens Werner, Jürgen Weitz, Oliver Strobel, Thilo Hackert, Dejan Radenkovic, Dezső Kelemen, Christopher Wolfgang, Y I Miao, Shailesh V Shrikhande, Keith D Lillemoe, Christos Dervenis, Claudio Bassi, John P Neoptolemos, Markus K Diener, Charles M Vollmer, Markus W Büchler,

<h4>Objective</h4>The aim of this study was to develop a classification system for pancreas-associated risk factors in pancreatoduodenectomy (PD).<h4>Summary background data</h4>Postoperative pancreatic fistula (POPF) is the most relevant PD-associated complication. A simple standardized surgical reporting system based on pancreas- associated risk factors is lacking.<h4>Methods</h4>A systematic literature search was conducted to identify ... Read more >>

Ann Surg (Annals of surgery)
[2021, :]

Cited: 0 times

View full text PDF listing >>



Effects of COVID-19 Pandemic on the Treatment of Pancreatic Cancer: A Perspective from Central Europe.

Ilaria Pergolini, I Ekin Demir, Christian Stöss, Klaus Emmanuel, Robert Rosenberg, Helmut Friess, Alexander Novotny,

<h4>Background</h4>This survey aimed to register changes determined by the COVID-19 pandemic on pancreatic surgery in a specific geographic area (Germany, Austria, and Switzerland) to evaluate the impact of the pandemic and obtain interesting cues for the future.<h4>Methods</h4>An online survey was designed using Google Forms focusing on the local impact of ... Read more >>

Dig Surg (Digestive surgery)
[2021, 38(2):158-165]

Cited: 0 times

View full text PDF listing >>



A novel tissue inhibitor of metalloproteinases-1/liver/cachexia score predicts prognosis of gastrointestinal cancer patients.

Olga Prokopchuk, Chris D Hermann, Benjamin Schoeps, Ulrich Nitsche, Oleksii L Prokopchuk, Percy Knolle, Helmut Friess, Marc E Martignoni, Achim Krüger,

<h4>Background</h4>Cachexia, a devastating syndrome in cancer patients, critically determines survival and life quality. It is characterized by impaired homeostasis of multiple organs including the liver, involves tissue wasting, and is conventionally diagnosed and classified by weight loss (WL). However, recent studies pointed at the problem that WL is not sufficient ... Read more >>

J Cachexia Sarcopenia Muscle (Journal of cachexia, sarcopenia and muscle)
[2021, 12(2):378-392]

Cited: 1 time

View full text PDF listing >>



Guidelines on Pancreatic Cystic Neoplasms: Major Inconsistencies With Available Evidence and Clinical Practice- Results From an International Survey.

Giovanni Marchegiani, Roberto Salvia, ,

Gastroenterology (Gastroenterology)
[2021, 160(7):2234-2238]

Cited: 0 times

View full text PDF listing >>



Ac2-26-Nanoparticles Induce Resolution of Intestinal Inflammation and Anastomotic Healing via Inhibition of NF-κB Signaling in a Model of Perioperative Colitis.

Stefan Reischl, Jong Hyun Lee, Joseph Raphael Elias Miltschitzky, Vincent Vieregge, Robert Leon Walter, Vanessa Twardy, Atsuko Kasajima, Helmut Friess, Nazila Kamaly, Philipp-Alexander Neumann,

<h4>Background</h4>Although in most patients with inflammatory bowel diseases, conservative therapy is successful, a significant proportion of patients still require surgery once in their lifetime. Development of a safe perioperative treatment to dampen colitis activity without disturbance of anastomotic healing is an urgent and unmet medical need. Annexin A1 (ANXA1) has ... Read more >>

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, :]

Cited: 1 time

View full text PDF listing >>



[Reconstruction following gastrectomy].

Marie-Christin Weber, Maximilian Berlet, Alexander Novotny, Helmut Friess, Daniel Reim,

Minimally invasive surgical techniques with respect to the treatment of gastric cancer have progressed rapidly over the last few years. Especially in Asia, where the incidence of gastric cancer is ten times higher than in Europe, surgery for gastric cancer is steadily evolving, especially regarding laparoscopic and robot-assisted procedures. This ... Read more >>

Chirurg (Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen)
[2021, 92(6):506-514]

Cited: 0 times

View full text PDF listing >>



Significance of Lauren Classification in Patients Undergoing Neoadjuvant/Perioperative Chemotherapy for Locally Advanced Gastric or Gastroesophageal Junction Cancers-Analysis from a Large Single Center Cohort in Germany.

Rebekka Schirren, Alexander Novotny, Christian Oesterlin, Julia Slotta-Huspenina, Helmut Friess, Daniel Reim,

<h4>Background</h4>the purpose of this analysis was to analyze the outcomes of multimodal treatment that are related to Lauren histotypes in gastro-esophageal cancer (GEC).<h4>Methods</h4>patients with GEC between 1986 and 2013 were analyzed. Uni- and multivariate regression analysis were performed to identify predictors for overall survival. Lauren histotype stratified overall survival (OS)-rates ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

Cited: 1 time

View full text PDF listing >>



Surgical oncology in the age of multimodality therapy for cancer of the upper and lower gastrointestinal tract.

Philipp-Alexander Neumann, Maximilian Wolfgang Berlet, Helmut Friess,

<h4>Introduction</h4>To date, all efforts to fight gastrointestinal cancer, regardless of its origin and entity, have resulted in complex therapeutic regimens involving a combination of systemic therapy, radiation therapy and surgery. It is generally accepted across all disciplines that not one, but the combination and the proper timing of all modalities ... Read more >>

Expert Rev Anticancer Ther (Expert review of anticancer therapy)
[2021, 21(5):511-522]

Cited: 0 times

View full text PDF listing >>



Patterns and Relevance of Langerhans Islet Invasion in Pancreatic Cancer.

Ruediger Goess, Ayse Ceren Mutgan, Umut Çalışan, Yusuf Ceyhun Erdoğan, Lei Ren, Carsten Jäger, Okan Safak, Pavel Stupakov, Rouzanna Istvanffy, Helmut Friess, Güralp O Ceyhan, Ihsan Ekin Demir,

<b>Background</b>: Pancreatic cancer-associated diabetes mellitus (PC-DM) is present in most patients with pancreatic cancer, but its pathogenesis remains poorly understood. Therefore, we aimed to characterize tumor infiltration in Langerhans islets in pancreatic cancer and determine its clinical relevance.<h4>Methods</h4>Langerhans islet invasion was systematically analyzed in 68 patientswith pancreatic ductal adenocarcinoma (PDAC) ... Read more >>

Cancers (Basel) (Cancers)
[2021, 13(2):]

Cited: 0 times

View full text PDF listing >>



Repeated resection for recurrent intrahepatic cholangiocarcinoma: A retrospective German multicentre study.

Fabian Bartsch, Johannes Eberhard, Felix Rückert, Moritz Schmelzle, Nadja Lehwald-Tywuschik, Stefan Fichtner-Feigl, Jochen Gaedcke, Karl J Oldhafer, Felix Oldhafer, Markus Diener, Arianeb Mehrabi, Utz Settmacher, Thomas Becker, Tobias Keck, Helmut Friess, Benjamin Strücker, Sabine Opitz, Johannes Lemke, Andreas Schnitzbauer, Hauke Lang, ,

<h4>Background</h4>Tumour recurrence is common after resection of intrahepatic cholangiocarcinoma (ICC). Repeated resection is a potential curative treatment, but outcomes are not well-defined thus far. The aim of this retrospective multicentre cohort study was to show the feasibility and survival of repeated resection of ICC recurrence.<h4>Methods</h4>Data were collected from 18 German ... Read more >>

Liver Int (Liver international : official journal of the International Association for the Study of the Liver)
[2021, 41(1):180-191]

Cited: 1 time

View full text PDF listing >>



Risk of colectomy after conservative treatment of diverticulitis of the left hemicolon complicated by abdominal or pelvic abscess: protocol of a systematic review and meta-analysis.

Maximilian Sohn, Ayman Agha, Igors Iesalnieks, Anna Tiefes, Alfred Hochrein, Helmut Friess, Dirk Wilhelm, Stephan Schorn,

<h4>Introduction</h4>Acute diverticulitis of the sigmoid colon is increasingly treated by a non-operative approach. The need for colectomy after recovery from a flare of acute diverticulitis of the left colon, complicated diverticular abscess is still controversial. The primary aim of this study is to assess the risk of interval emergency surgery ... Read more >>

BMJ Open (BMJ open)
[2020, 10(12):e042350]

Cited: 0 times

View full text PDF listing >>



Anastomotic leakage following resection of the esophagus – Introduction of an endoscopic scoring system

Jeannine Bachmann, Marcus Feith, Christoph Schlag, Mohamed Abdelhafez, Marc Martignoni, Helmut Friess,

<h4>Background: </h4> Malignant tumors of the esophagus are the sixth leading cause of cancer-related deaths worldwide. Postoperative leakage of the esophago-gastrostomy leads to mediastinal sepsis, which is still associated with a high morbidity and mortality rate. The aim of this study was to describe the endoscopic view of the different ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0638 s