Full Text Journal Articles by
Author Helena Groot

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Genetic and Bioinformatic Strategies to Improve Diagnosis in Three Inherited Bleeding Disorders in Bogotá, Colombia.

Juliana Lago, Helena Groot, Diego Navas, Paula Lago, María Gamboa, Dayana Calderón, Diana C Polanía-Villanueva,

Inherited bleeding disorders (IBDs) are the most frequent congenital diseases in the Colombian population; three of them are hemophilia A (HA), hemophilia B (HB), and von Willebrand Disease (VWD). Currently, diagnosis relies on multiple clinical laboratory assays to assign a phenotype. Due to the lack of accessibility to these tests, ... Read more >>

Genes (Basel) (Genes)
[2021, 12(11):]

Cited: 0 times

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Efficacy and Molecular Effects of a Reduced Graphene Oxide/Fe3O4 Nanocomposite in Photothermal Therapy Against Cancer.

Claudia C Barrera, Helena Groot, Watson L Vargas, Diana M Narváez,

<h4>Purpose</h4>Expanded research on the biomedical applications of graphene has shown promising results, although interactions between cells and graphene are still unclear. The current study aims to dissect the cellular and molecular effects of graphene nanocomposite in photothermal therapy against cancer, and to evaluate its efficacy.<h4>Methods</h4>In this study, a reduced graphene ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2020, 15:6421-6432]

Cited: 1 time

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Novel complexes with ONNO tetradentate coumarin schiff-base donor ligands: x-ray structures, DFT calculations, molecular dynamics and potential anticarcinogenic activity.

Paula Daniela Mestizo, Diana M Narváez, Jesús Alberto Pinzón-Ulloa, Daniela Torres Di Bello, Sebastian Franco-Ulloa, Mario A Macías, Helena Groot, Gian Pietro Miscione, Leopoldo Suescun, John J Hurtado,

The synthesis of eight novel Zn(II), Co(II), Cu(II), Ni(II) and Pt(II) complexes (2-9) derived from the ONNO tetradentate coumarin Schiff-Base donor ligands, L<sub>1</sub> and the novel L<sub>2</sub>, was performed. All compounds were characterized by analytical, spectrometry and spectroscopy techniques. Complexes 2-4 were also characterized by DFT calculations and the structures ... Read more >>

Biometals (Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine)
[2021, 34(1):119-140]

Cited: 1 time

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New peptides with immunomodulatory activity in macrophages and antibacterial activity against multiresistant Staphylococcus aureus

Laura Andrea Barrero-Guevara, Natalia Bolaños, Miguel Parra, John Mario González, Helena Groot, Carolina Muñoz-Camargo,

Staphylococcus aureus infections are a common concern world-wide due to the increasing number of bacterial strains with multiresistant properties to existing antibiotics, incrementing the need for novel molecules and therapy approaches for their treatment. This study evaluated the antibacterial and immunomodulatory activity of eight new peptides (AA, KS, NS, RN, ... Read more >>

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Tridimensional alginate disks of tunable topologies for mammalian cell encapsulation.

Alejandra Suarez-Arnedo, Diana M Narváez, Paula Sarmiento, Laura Bocanegra, Felipe Salcedo, Carolina Muñoz-Camargo, Helena Groot, Juan C Cruz,

We have developed a protocol to produce three-dimensional matrices based on alginate hydrogels for mammalian cell encapsulation. Based on the gelation properties of this polysaccharide, we implemented a calcium ion-based diffusion method where the designed hydrogels can be obtained with well-defined mechanical properties and replicable 3D topologies. The developed protocol ... Read more >>

Anal Biochem (Analytical biochemistry)
[2019, 574:31-33]

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Evaluation of the exposure to coal dust and prevalence of pneumoconiosis in underground mining in three Colombian departments

Marcela Varona, Milcíades Ibáñez-Pinilla, Leonardo Briceño, Helena Groot, Diana Narváez, Marién Palma, Diego Herrera, Gloria Morgan, Carlos Torres,

Introduction: Coal workers’ pneumoconiosis is a chronic and irreversible disease representing a public health problem. Objective: To estimate the prevalence of pneumoconiosis and its associated factors among underground coal miners in the Colombian departments of Boyacá, Cundinamarca and Norte de Santander. Materials and methods: We conducted a cross-sectional study of 476 miners ... Read more >>

Biomedica (Biomedica : revista del Instituto Nacional de Salud)
[2018, 38(4):467-478]

Cited: 0 times

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Novel BUF2-magnetite nanobioconjugates with cell-penetrating abilities.

Monica Cuellar, Javier Cifuentes, Jessica Perez, Alejandra Suarez-Arnedo, Julian A Serna, Helena Groot, Carolina Muñoz-Camargo, Juan C Cruz,

<h4>Introduction</h4>One of the major challenges of modern pharmacology is the development of systems for the delivery of therapeutic molecules in a controlled and localized manner. One strategy is to use nanostructured supports, which are well suited to carry a large number of molecules on a per mass basis. A major ... Read more >>

Int J Nanomedicine (International journal of nanomedicine)
[2018, 13:8087-8094]

Cited: 8 times

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Unveiling the Multifaceted Mechanisms of Antibacterial Activity of Buforin II and Frenatin 2.3S Peptides from Skin Micro-Organs of the Orinoco Lime Treefrog (Sphaenorhynchus lacteus).

Carolina Muñoz-Camargo, Vivian A Salazar, Laura Barrero-Guevara, Sandra Camargo, Angela Mosquera, Helena Groot, Ester Boix,

Amphibian skin is a rich source of natural compounds with diverse antimicrobial and immune defense properties. Our previous studies showed that the frog skin secretions obtained by skin micro-organs from various species of Colombian anurans have antimicrobial activities against bacteria and viruses. We purified for the first time two antimicrobial ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2018, 19(8):]

Cited: 5 times

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Effect of diabetes status and hyperglycemia on global DNA methylation and hydroxymethylation.

Jairo Arturo Pinzón-Cortés, Angelina Perna-Chaux, Nicolás Steven Rojas-Villamizar, Angélica Díaz-Basabe, Diana Carolina Polanía-Villanueva, María Fernanda Jácome, Carlos Olimpo Mendivil, Helena Groot, Valeriano López-Segura,

Type 2 diabetes mellitus (T2DM) is characterized by oxidative stress that could lead to chronic micro- and macrovascular complications. We hypothesized that some of the target organ damage is mediated by oxidative alterations in epigenetic mechanisms involving DNA methylation (5mC) and DNA hydroxymethylation (5hmC). We analyzed global DNA methylation and ... Read more >>

Endocr Connect (Endocrine connections)
[2017, 6(8):708-725]

Cited: 14 times

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Oxidative stress and repetitive element methylation changes in artisanal gold miners occupationally exposed to mercury.

Diana M Narváez, Helena Groot, Sonia M Diaz, Ruth Marien Palma, Nathalia Muñoz, Marie-Pierre Cros, Hector Hernández-Vargas,

Mercury (Hg) exposure is a public health concern due to its persistence in the environment and its high toxicity. Such toxicity has been associated with the generation of oxidative stress in occupationally exposed subjects, such as artisanal gold miners. In this study, we characterize occupational exposure to Hg by measuring ... Read more >>

Heliyon (Heliyon)
[2017, 3(9):e00400]

Cited: 3 times

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Frog skin cultures secrete anti-yellow fever compounds.

Carolina Muñoz-Camargo, Margarita Correa Méndez, Vivian Salazar, Johanna Moscoso, Diana Narváez, Maria Mercedes Torres, Franz Kaston Florez, Helena Groot, Eduardo Mitrani,

There is an urgent need to develop novel antimicrobial substances. Antimicrobial peptides (AMPs) are considered as promising candidates for future therapeutic use. Because of the re-emergence of the Flavivirus infection, and particularly the yellow fever virus (YFV), we have compared the antiviral activities from skin secretions of seven different frog ... Read more >>

J Antibiot (Tokyo) (The Journal of antibiotics)
[2016, 69(11):783-790]

Cited: 2 times

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Outlining the Ancestry Landscape of Colombian Admixed Populations.

Humberto Ossa, Juliana Aquino, Rui Pereira, Adriana Ibarra, Rafael H Ossa, Luz Adriana Pérez, Juan David Granda, Maria Claudia Lattig, Helena Groot, Elizeu Fagundes de Carvalho, Leonor Gusmão,

The ancestry of the Colombian population comprises a large number of well differentiated Native communities belonging to diverse linguistic groups. In the late fifteenth century, a process of admixture was initiated with the arrival of the Europeans, and several years later, Africans also became part of the Colombian population. Therefore, ... Read more >>

PLoS One (PloS one)
[2016, 11(10):e0164414]

Cited: 22 times

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[Real-time quantification to analyze historical Colombian samples detecting a short fragment of hypervariable region II of mitochondrial DNA].

Luz Adriana Pérez, Freddy Rodríguez, Carl Henrik Langebaek, Helena Groot,

<h4>Introduction</h4>Unlike other molecular biology studies, the analysis of ancient DNA (aDNA) requires special infrastructure and methodological conditions to guarantee the quality of the results. One of the main authenticity criteria is DNA quantification, where quantitative real-time PCR is often used given its sensitivity and specificity. Nevertheless, the implementation of these ... Read more >>

Biomedica (Biomedica : revista del Instituto Nacional de Salud)
[2016, 36(3):475-482]

Cited: 0 times

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[Determining social factors related to pesticide poisoning among rice farmers in Colombia].

Marcela E Varona, Sonia M Díaz, Leonardo Briceño, Clara I Sánchez-Infante, Carlos H Torres, Ruth M Palma, Helena Groot, Alvaro J Idrovo,

Objective Large quantities of pesticides are used in rice crops. The aim of this study is to characterize how farmers are exposed to pesticides and subsequent poisoning. Materials and Methods A multilevel (individual and community) multi-method study, which included ethnographic and survey methods, as well as measurement of pesticides in ... Read more >>

Rev Salud Publica (Bogota) (Revista de salud publica (Bogota, Colombia))
[2016, 18(4):617-629]

Cited: 3 times

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The combined expression patterns of Ikaros isoforms characterize different hematological tumor subtypes.

Carlos A Orozco, Andrés Acevedo, Lazaro Cortina, Gina E Cuellar, Mónica Duarte, Liliana Martín, Néstor M Mesa, Javier Muñoz, Carlos A Portilla, Sandra M Quijano, Guillermo Quintero, Miriam Rodriguez, Carlos E Saavedra, Helena Groot, María M Torres, Valeriano López-Segura,

A variety of genetic alterations are considered hallmarks of cancer development and progression. The Ikaros gene family, encoding for key transcription factors in hematopoietic development, provides several examples as genetic defects in these genes are associated with the development of different types of leukemia. However, the complex patterns of expression ... Read more >>

PLoS One (PloS one)
[2013, 8(12):e82411]

Cited: 4 times

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Skin micro-organs from several frog species secrete a repertoire of powerful antimicrobials in culture.

Helena Groot, Carolina Muñoz-Camargo, Johanna Moscoso, Gina Riveros, Vivian Salazar, Franz Kaston Florez, Eduardo Mitrani,

This work is an attempt to take advantage of the rich biodiversity that exists in Colombia in order to start a systematic analysis of antimicrobial substances that have emerged through amphibian evolution. For this purpose we have developed a technique to grow intact frog skin derived micro-organs (SMOs) in vitro ... Read more >>

J Antibiot (Tokyo) (The Journal of antibiotics)
[2012, 65(9):461-467]

Cited: 4 times

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[An overview of oculocutaneous albinism: TYR gene mutations in five Colombian individuals].

Diana Sanabria, Helena Groot, Julio Guzmán, María Claudia Lattig,

<h4>Introduction</h4>Oculocutaneus albinism is a pigment-related inherited disorder characterized by hypopigmentation of the skin, hair and eyes, foveal hypoplasia and low vision. To date, 230 mutations in the TYR gene have been reported as responsible for oculocutaneus albinism type 1 worldwide. TYR gene encodes the enzyme tyrosinase involved in the metabolic ... Read more >>

Biomedica (Biomedica : revista del Instituto Nacional de Salud)
[2012, 32(2):269-276]

Cited: 2 times

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[DNA damage assessment and biological monitoring of occupational exposure to organic solvents, 2006].

Carlos Humberto Torres, Marcela E Varona, Angélica Lancheros, Rosa Isabel Patiño, Helena Groot,

<h4>Introduction</h4>Exposure to solvents is one of the highest potential risks for millions of workers in the world; they can generate substantial environmental pollution leading to outbreaks of public health problems.<h4>Objective</h4>Blood levels were determined for metabolites of benzene, toluene and xylene, and polymorphisms for enzymes CYP2E1, GSTM1, GSTT1 were characterized. Damage ... Read more >>

Biomedica (Biomedica : revista del Instituto Nacional de Salud)
[2008, 28(1):126-138]

Cited: 5 times

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A human genome diversity cell line panel.

Howard M Cann, Claudia de Toma, Lucien Cazes, Marie-Fernande Legrand, Valerie Morel, Laurence Piouffre, Julia Bodmer, Walter F Bodmer, Batsheva Bonne-Tamir, Anne Cambon-Thomsen, Zhu Chen, J Chu, Carlo Carcassi, Licinio Contu, Ruofu Du, Laurent Excoffier, G B Ferrara, Jonathan S Friedlaender, Helena Groot, David Gurwitz, Trefor Jenkins, Rene J Herrera, Xiaoyi Huang, Judith Kidd, Kenneth K Kidd, Andre Langaney, Alice A Lin, S Qasim Mehdi, Peter Parham, Alberto Piazza, Maria Pia Pistillo, Yaping Qian, Qunfang Shu, Jiujin Xu, S Zhu, James L Weber, Henry T Greely, Marcus W Feldman, Gilles Thomas, Jean Dausset, L Luca Cavalli-Sforza,

Science (Science (New York, N.Y.))
[2002, 296(5566):261-262]

Cited: 565 times

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Y-chromosome evidence for differing ancient demographic histories in the Americas.

Maria-Catira Bortolini, Francisco M Salzano, Mark G Thomas, Steven Stuart, Selja P K Nasanen, Claiton H D Bau, Mara H Hutz, Zulay Layrisse, Maria L Petzl-Erler, Luiza T Tsuneto, Kim Hill, Ana M Hurtado, Dinorah Castro-de-Guerra, Maria M Torres, Helena Groot, Roman Michalski, Pagbajabyn Nymadawa, Gabriel Bedoya, Neil Bradman, Damian Labuda, Andres Ruiz-Linares,

To scrutinize the male ancestry of extant Native American populations, we examined eight biallelic and six microsatellite polymorphisms from the nonrecombining portion of the Y chromosome, in 438 individuals from 24 Native American populations (1 Na Dené and 23 South Amerinds) and in 404 Mongolians. One of the biallelic markers ... Read more >>

Am J Hum Genet (American journal of human genetics)
[2003, 73(3):524-539]

Cited: 119 times

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