Full Text Journal Articles by
Author Helen Wedegaertner


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The α-Arrestin ARRDC3 Is an Emerging Multifunctional Adaptor Protein in Cancer.

Helen Wedegaertner, Wen-An Pan, Carlos C Gonzalez, David J Gonzalez, JoAnn Trejo,

<b><i>Significance:</i></b> Adaptor proteins control the spatiotemporal dynamics of cellular signaling. Dysregulation of adaptor protein function can cause aberrant cell signaling and promote cancer. The arrestin family of adaptor proteins are known to regulate signaling by the superfamily of G protein-coupled receptors (GPCRs). The GPCRs are highly druggable and implicated in ... Read more >>

Antioxid Redox Signal (Antioxidants & redox signaling)
[2022, :]

Cited: 0 times

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α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis.

Aleena K S Arakaki, Wen-An Pan, Helen Wedegaertner, Ivette Roca-Mercado, Logan Chinn, Taranjit S Gujral, JoAnn Trejo,

The α-arrestin domain containing protein 3 (ARRDC3) is a tumor suppressor in triple-negative breast carcinoma (TNBC), a highly metastatic subtype of breast cancer that lacks targeted therapies. Thus, understanding the mechanisms and targets of ARRDC3 in TNBC is important. ARRDC3 regulates trafficking of protease-activated receptor 1 (PAR1, also known as ... Read more >>

J Cell Sci (Journal of cell science)
[2021, 134(8):]

Cited: 3 times

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Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC.

Victoria J Gennaro, Helen Wedegaertner, Steven B McMahon, Steven B McMahon,

<h4>Background</h4>The oncoprotein MYC has the dual capacity to drive cell cycle progression or induce apoptosis, depending on the cellular context. BAG1 was previously identified as a transcriptional target of MYC that functions as a critical determinant of this cell fate decision. The BAG1 protein is expressed as multiple isoforms, each ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):258]

Cited: 4 times

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