Full Text Journal Articles by
Author Helen S Hammer


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Characterization of hepatic zonation in mice by mass-spectrometric and antibody-based proteomics approaches.

Simon Kling, Benedikt Lang, Helen S Hammer, Wael Naboulsi, Heike Sprenger, Falko Frenzel, Oliver Pötz, Michael Schwarz, Albert Braeuning, Markus F Templin,

Periportal and perivenous hepatocytes show zonal heterogeneity in metabolism and signaling. Here, hepatic zonation in mouse liver was analyzed by non-targeted mass spectrometry (MS) and by the antibody-based DigiWest technique, yielding a comprehensive overview of protein expression in periportal and perivenous hepatocytes. Targeted immunoaffinity-based proteomics were used to substantiate findings ... Read more >>

Biol Chem (Biological chemistry)
[2021, :]

Cited: 0 times

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Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.

Lisa Goedtke, Heike Sprenger, Ute Hofmann, Felix F Schmidt, Helen S Hammer, Ulrich M Zanger, Oliver Poetz, Albrecht Seidel, Albert Braeuning, Stefanie Hessel-Pras,

Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants produced by incomplete combustion of organic matter. They induce their own metabolism by upregulating xenobiotic-metabolizing enzymes such as cytochrome P450 monooxygenase 1A1 (CYP1A1) by activating the aryl hydrocarbon receptor (AHR). However, previous studies showed that individual PAHs may also interact with the constitutive ... Read more >>

Int J Mol Sci (International journal of molecular sciences)
[2020, 22(1):]

Cited: 0 times

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Propiconazole is an activator of AHR and causes concentration additive effects with an established AHR ligand.

Constanze Knebel, Juliane Kebben, Ivano Eberini, Luca Palazzolo, Helen S Hammer, Roderich D Süssmuth, Tanja Heise, Stefanie Hessel-Pras, Alfonso Lampen, Albert Braeuning, Philip Marx-Stoelting,

Consumers are exposed to pesticide residues and other food contaminants via the diet. Both can exert adverse effects on different target organs via the activation of nuclear receptor pathways. Hepatotoxic effects of the widely used triazole fungicide propiconazole (Pi) are generally attributed to the activation of the constitutive androstane receptor ... Read more >>

Arch Toxicol (Archives of toxicology)
[2018, 92(12):3471-3486]

Cited: 3 times

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Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates.

Frederik Weiß, Helen S Hammer, Kathrin Klein, Hannes Planatscher, Ulrich M Zanger, Agneta Norén, Christine Wegler, Per Artursson, Thomas O Joos, Oliver Poetz,

The quantification of drug metabolizing enzymes and transporters has recently been revolutionized on the basis of targeted proteomic approaches. Isotope-labeled peptides are used as standards for the quantification of the corresponding proteins in enzymatically fragmented samples. However, hurdles in these approaches are low throughput and tedious sample prefractionation steps prior ... Read more >>

Drug Metab Dispos (Drug metabolism and disposition: the biological fate of chemicals)
[2018, 46(4):387-396]

Cited: 6 times

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Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

Christine Wegler, Fabienne Z Gaugaz, Tommy B Andersson, Jacek R Wiśniewski, Diana Busch, Christian Gröer, Stefan Oswald, Agneta Norén, Frederik Weiss, Helen S Hammer, Thomas O Joos, Oliver Poetz, Brahim Achour, Amin Rostami-Hodjegan, Evita van de Steeg, Heleen M Wortelboer, Per Artursson,

Many different methods are used for mass-spectrometry-based protein quantification in pharmacokinetics and systems pharmacology. It has not been established to what extent the results from these various methods are comparable. Here, we compared six different mass spectrometry-based proteomics methods by measuring the expression of clinically relevant drug transporters and metabolizing ... Read more >>

Mol Pharm (Molecular pharmaceutics)
[2017, 14(9):3142-3151]

Cited: 35 times

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