Full Text Journal Articles by
Author Helen Mactier

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Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.

Chris Gale, Maria A Quigley, Anna Placzek, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk,

BACKGROUND:Babies differ from older children with regard to their exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, data describing the effect of SARS-CoV-2 in this group are scarce, and guidance is variable. We aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who ... Read more >>

Lancet Child Adolesc Health (The Lancet. Child & adolescent health)
[2020, :]

Cited: 0 times

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Perspective from the chair of the BAPM Working Group on perinatal management of extreme preterm birth before 27 weeks of gestation.

Helen Mactier,

Arch Dis Child Educ Pract Ed (Archives of disease in childhood. Education and practice edition)
[2020, :]

Cited: 0 times

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Prenatal opioid exposure - Increasing evidence of harm.

Helen Mactier, Ruth Hamilton,

Prenatal opioid exposure adversely impacts upon fetal growth and places the newborn at risk of neonatal opioid withdrawal. The severity and duration of opioid withdrawal cannot be predicted in the individual baby and may be contributed to by other drugs including benzodiazepines and alcohol as well as cigarette smoking. Mitigating ... Read more >>

Early Hum Dev (Early human development)
[2020, 150:105188]

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Time to standardise neonatal pulse oximetry.

Cliodhna Godden, Emily Mullan, Helen Mactier, Richard Boulton, Martin Shaw, Andrew Brunton, Stephen Dacombe, Ruth Hamilton,

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, :]

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National active surveillance to understand and inform neonatal care in COVID-19.

Chris Gale, Marian Knight, Shamez Ladhani, Elizabeth S Draper, Don Sharkey, Cora Doherty, Helen Mactier, Jennifer J Kurinczuk, ,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(4):346-347]

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Recommendations in the face of uncertainty: should extremely preterm infants receive chest compressions and/or epinephrine in the delivery room?

Dominic Wilkinson, Neil Marlow, Dean Hayden, Helen Mactier,

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(3):240-241]

Cited: 0 times

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Perinatal management of extreme preterm birth before 27 weeks of gestation: a framework for practice.

Helen Mactier, Sarah Elizabeth Bates, Tracey Johnston, Caroline Lee-Davey, Neil Marlow, Kate Mulley, Lucy K Smith, Meekai To, Dominic Wilkinson, ,

Arch. Dis. Child. Fetal Neonatal Ed. (Archives of disease in childhood. Fetal and neonatal edition)
[2020, 105(3):232-239]

Cited: 1 time

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Accommodation outcomes for children of drug-misusing women.

Jennifer Mitchell, Helen Mactier,

Children of drug-misusing women are a vulnerable group. Data describing the pattern of accommodation placements are lacking. We investigated 10- to 12-year accommodation outcomes of children born to drug-misusing mothers at a single maternity hospital. 94% of mothers were prescribed maintenance methadone during pregnancy and at least 87% poly-drug used.Data ... Read more >>

Arch Dis Child (Archives of disease in childhood)
[2019, :]

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Controlled Trial of Two Incremental Milk-Feeding Rates in Preterm Infants.

Jon Dorling, Jane Abbott, Janet Berrington, Beth Bosiak, Ursula Bowler, Elaine Boyle, Nicholas Embleton, Oliver Hewer, Samantha Johnson, Edmund Juszczak, Alison Leaf, Louise Linsell, Kenny McCormick, William McGuire, Omar Omar, Christopher Partlett, Mehali Patel, Tracy Roberts, Ben Stenson, John Townend, ,

BACKGROUND:Observational data have shown that slow advancement of enteral feeding volumes in preterm infants is associated with a reduced risk of necrotizing enterocolitis but an increased risk of late-onset sepsis. However, data from randomized trials are limited. METHODS:We randomly assigned very preterm or very-low-birth-weight infants to daily milk increments of ... Read more >>

N. Engl. J. Med. (The New England journal of medicine)
[2019, 381(15):1434-1443]

Cited: 4 times

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Early versus Delayed Fortification of Human Milk in Preterm Infants: A Systematic Review.

Wesam Alyahya, Judith Simpson, Ada L Garcia, Helen Mactier, Christine A Edwards,

Expressed breast milk (EBM) is commonly supplemented with commercially prepared human milk fortifier to meet the additional nutritional needs of preterm infants. The optimal milk intake at which to introduce fortification is unknown. The objective of this systematic review was to compare the effect of early fortification (EF) versus that ... Read more >>

Neonatology (Neonatology)
[2020, 117(1):24-32]

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Results from capnography studies in adults may not apply to neonates.

Robert Tinnion, Helen Mactier, Colin Morley, Charles Roehr, Allan Jackson, Stephen Wardle, ,

BMJ (BMJ (Clinical research ed.))
[2019, 364:l1338]

Cited: 0 times

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Surfactant replacement therapy for respiratory distress syndrome in preterm infants: United Kingdom national consensus.

Sujoy Banerjee, Ramon Fernandez, Grenville F Fox, Kevin C W Goss, Helen Mactier, Peter Reynolds, David G Sweet, Charles C Roehr,

Pediatr Res (Pediatric research)
[2019, 86(1):12-14]

Cited: 3 times

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Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial.

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BACKGROUND:Infections acquired in hospital are an important cause of morbidity and mortality in very preterm infants. Several small trials have suggested that supplementing the enteral diet of very preterm infants with lactoferrin, an antimicrobial protein processed from cow's milk, prevents infections and associated complications. The aim of this large randomised ... Read more >>

Lancet (Lancet (London, England))
[2019, 393(10170):423-433]

Cited: 9 times

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Childhood neurodevelopment after prescription of maintenance methadone for opioid dependency in pregnancy: a systematic review and meta-analysis.

Victoria J Monnelly, Ruth Hamilton, Francesca M Chappell, Helen Mactier, James P Boardman,

AIM:To systematically review and meta-analyse studies of neurodevelopmental outcome of children born to mothers prescribed methadone in pregnancy. METHOD:MEDLINE, Embase, and PsycINFO were searched for studies published from 1975 to 2017 reporting neurodevelopmental outcomes in children with prenatal methadone exposure. RESULTS:Forty-one studies were identified (2283 participants). Eight studies were amenable ... Read more >>

Dev Med Child Neurol (Developmental medicine and child neurology)
[2019, 61(7):750-760]

Cited: 4 times

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Prenatal methadone exposure is associated with altered neonatal brain development.

Victoria J Monnelly, Devasuda Anblagan, Alan Quigley, Manuel Blesa Cabez, E Sarah Cooper, Helen Mactier, Scott I Semple, Mark E Bastin, James P Boardman,

Methadone is used for medication-assisted treatment of heroin addiction during pregnancy. The neurodevelopmental outcome of children with prenatal methadone exposure can be sub-optimal. We tested the hypothesis that brain development is altered among newborn infants whose mothers were prescribed methadone. 20 methadone-exposed neonates born after 37 weeks' postmenstrual age (PMA) and ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2018, 18:9-14]

Cited: 15 times

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Increased DNA Methylation of ABCB1, CYP2D6, and OPRM1 Genes in Newborn Infants of Methadone-Maintained Opioid-Dependent Mothers.

Poppy McLaughlin, Helen Mactier, Cheryl Gillis, Tamas Hickish, Anton Parker, Wei-Jun Liang, M David Osselton,

OBJECTIVE:To investigate whether in utero opioid exposure, which has been linked to adverse neurodevelopmental and social outcomes, is associated with altered DNA methylation of opioid-related genes at birth. STUDY DESIGN:Observational cohort study of 21 healthy methadone-maintained opioid-dependent mother-infant dyads consecutively delivered at >36 weeks of gestation, and 2 comparator groups: ... Read more >>

J Pediatr (The Journal of pediatrics)
[2017, 190:180-184.e1]

Cited: 7 times

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Determining the pattern and prevalence of alcohol consumption in pregnancy by measuring biomarkers in meconium.

Carolyn Abernethy, Karen E McCall, Gail Cooper, Donata Favretto, Fabio Vaiano, Elisabetta Bertol, Helen Mactier,

To investigate the feasibility of determining the pattern and prevalence of alcohol consumption in pregnancy by measuring ethanol biomarkers in meconium.Population-based observational study.Inner-city maternity unit in Scotland, UK.Random sample of singleton infants delivered after 36 completed weeks' gestation.Fatty acid ethyl esters (FAEEs) and ethyl glucuronide (EtG) in meconium were measured ... Read more >>

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2018, 103(3):F216-F220]

Cited: 3 times

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Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers.

Helen Mactier, Poppy McLaughlin, Cheryl Gillis, Michael David Osselton,

Background Neonatal abstinence syndrome (NAS) in infants of methadone-maintained opioid-dependent (MMOD) mothers cannot be predicted in individual cases. We investigated whether variation in infant genotype is associated with severity of NAS. Methods This is a pilot observational cohort study of 21 MMOD mothers and their newborns. Infant buccal swabs were obtained soon ... Read more >>

Am J Perinatol (American journal of perinatology)
[2017, 34(9):918-921]

Cited: 2 times

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Commentary on Gibson et al. (2017): Gestational age and the severity of neonatal abstinence syndrome.

Helen Mactier,

Addiction (Addiction (Abingdon, England))
[2017, 112(4):717-718]

Cited: 0 times

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A novel, simultaneous extraction of FAEE and EtG from meconium and analysis by LC-MS/MS.

Fabio Vaiano, Donata Favretto, Diego Palumbo, Gail Cooper, Helen Mactier, Francesco P Busardò, Francesco Mari, Elisabetta Bertol,

Fatty acid ethyl esters (FAEEs) and ethyl-glucuronide (EtG) in meconium have been widely studied as biomarkers of maternal alcohol consumption during pregnancy. Many analytical approaches have been proposed for their analysis, mostly consisting of separated extraction procedures requiring the use of two meconium aliquots. This study aimed to validate a ... Read more >>

Anal Bioanal Chem (Analytical and bioanalytical chemistry)
[2016, 408(10):2587-2594]

Cited: 3 times

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Should pregnant women with unknown HIV status be offered rapid HIV testing in labour?

Jonathan Downie, Helen Mactier, Ruth M Bland,

Arch Dis Child Fetal Neonatal Ed (Archives of disease in childhood. Fetal and neonatal edition)
[2016, 101(1):F79-84]

Cited: 0 times

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Reply to letter from Drs. Jones, Heil and O'Grady.

Helen Mactier, Laura McGlone,

Early Hum Dev (Early human development)
[2015, 91(3):245]

Cited: 0 times

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Infants of opioid-dependent mothers: neurodevelopment at six months.

Laura McGlone, Helen Mactier,

The aim of this study is to describe infant neurodevelopment in 81 infants of methadone-prescribed opioid-dependent mothers.Griffith MD scores at six months.Scores were lower in all domains compared to controls (p<0.001). Poly-drug exposed infants and those treated for neonatal abstinence syndrome performed significantly poorer (p=0.002 and p=0.008 respectively).Infants of methadone-maintained ... Read more >>

Early Hum. Dev. (Early human development)
[2015, 91(1):19-21]

Cited: 16 times

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Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy.

Laura McGlone, Ruth Hamilton, Daphne L McCulloch, Jane R MacKinnon, Michael Bradnam, Helen Mactier,

BACKGROUND: Flash visual evoked potentials (VEPs) were abnormal in a cohort of 100 neonates exposed to maintenance methadone in utero. This prospective cohort study now describes clinical visual and electrophysiological outcomes at 6 months. METHODS: Visual assessment included modified Atkinson test battery; strabismus, nystagmus, reduced visual acuity, delayed visual maturation ... Read more >>

Br J Ophthalmol (The British journal of ophthalmology)
[2014, 98(2):238-245]

Cited: 20 times

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Neonatal and longer term management following substance misuse in pregnancy.

Helen Mactier,

Substance misuse in pregnancy is not a new problem, but although impaired foetal growth and the risk of developing neonatal abstinence syndrome are widely appreciated, relatively little attention has been paid to longer term consequences for the infant. Available evidence indicates that prenatal exposure to opioids and other drugs of ... Read more >>

Early Hum Dev (Early human development)
[2013, 89(11):887-892]

Cited: 7 times

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