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Author Heekyong Bae

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Multi-omics: Differential expression of IFN-γ results in distinctive mechanistic features linking chronic inflammation, gut dysbiosis, and autoimmune diseases.

Heekyong R Bae, Patrick S C Leung, Deborah L Hodge, John M Fenimore, Seon-Min Jeon, Vishal Thovarai, Amiran Dzutsev, Andrew A Welcher, Michael Boedigheimer, Michael A Damore, Myung-Sook Choi, Richard A Fravell, Giorgio Trinchieri, M Eric Gershwin, Howard A Young,

Low grade, chronic inflammation is a critical risk factor for immunologic dysfunction including autoimmune diseases. However, the multiplicity of complex mechanisms and lack of relevant murine models limit our understanding of the precise role of chronic inflammation. To address these hurdles, we took advantage of multi-omics data and a unique ... Read more >>

J. Autoimmun. (Journal of Autoimmunity)
[2020, 111:102436]

Cited: 0 times

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Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

Ashley V Menk, Nicole E Scharping, Rebecca S Moreci, Xue Zeng, Cliff Guy, Sonia Salvatore, Heekyong Bae, Jianxin Xie, Howard A Young, Stacy Gelhaus Wendell, Greg M Delgoffe,

To fulfill bioenergetic demands of activation, T cells perform aerobic glycolysis, a process common to highly proliferative cells in which glucose is fermented into lactate rather than oxidized in mitochondria. However, the signaling events that initiate aerobic glycolysis in T cells remain unclear. We show T cell activation rapidly induces glycolysis independent of transcription, ... Read more >>

Cell Rep (Cell Reports)
[2018, 22(6):1509-1521]

Cited: 26 times

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The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity.

Heekyong R Bae, Deborah L Hodge, Guo-Xiang Yang, Patrick S C Leung, Sathi Babu Chodisetti, Julio C Valencia, Michael Sanford, John M Fenimore, Ziaur S M Rahman, Koichi Tsuneyama, Gary L Norman, M Eric Gershwin, Howard A Young,

We have reported on a murine model of autoimmune cholangitis, generated by altering the AU-rich element (ARE) by deletion of the interferon gamma (IFN-γ) 3' untranslated region (coined ARE-Del-/- ), that has striking similarities to human primary biliary cholangitis (PBC) with female predominance. Previously, we suggested that the sex bias ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2018, 67(4):1408-1419]

Cited: 4 times

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Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance.

Heekyong R Bae, Patrick S C Leung, Koichi Tsuneyama, Julio C Valencia, Deborah L Hodge, Seohyun Kim, Tim Back, Megan Karwan, Anand S Merchant, Nobuyuki Baba, Dechun Feng, Ogyi Park, Bin Gao, Guo-Xiang Yang, M Eric Gershwin, Howard A Young,

UNLABELLED:In most autoimmune diseases the serologic hallmarks of disease precede clinical pathology by years. Therefore, the use of animal models in defining early disease events becomes critical. We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNγ) characterized by prolonged and chronic expression of IFNγ through deletion ... Read more >>

Hepatology (Hepatology (Baltimore, Md.))
[2016, 64(4):1189-1201]

Cited: 23 times

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The ATP-competitive mTOR inhibitor INK128 enhances in vitro and in vivo radiosensitivity of pancreatic carcinoma cells.

Thomas J Hayman, Amy Wahba, Barbara H Rath, Heekyong Bae, Tamalee Kramp, Uma T Shankavaram, Kevin Camphausen, Philip J Tofilon,

PURPOSE:Radiotherapy remains a primary treatment modality for pancreatic carcinoma, a tumor characterized by aberrant mTOR activity. Given the regulatory role of mTOR in gene translation, in this study, we defined the effects of the clinically relevant, ATP-competitive mTOR inhibitor, INK128 on the radiosensitivity of pancreatic carcinoma cell lines. EXPERIMENTAL DESIGN:Clonogenic ... Read more >>

Clin. Cancer Res. (Clinical cancer research : an official journal of the American Association for Cancer Research)
[2014, 20(1):110-119]

Cited: 21 times

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Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.

Heekyong Bae, Jun-Lin Guan,

Autophagy is a lysosomal bulk degradation process for intracellular protein and organelles. FIP200 (200 kDa FAK-family interacting protein) is an essential component of mammalian autophagy that is implicated in breast cancer in recent studies. Here we show that inactivation of FIP200 resulted in deficient repair of DNA damage induced by ... Read more >>

Mol. Cancer Res. (Molecular cancer research : MCR)
[2011, 9(9):1232-1241]

Cited: 43 times

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Hematopoietic cell kinase associates with the 40S ribosomal subunit and mediates the ribotoxic stress response to deoxynivalenol in mononuclear phagocytes.

Heekyong Bae, Jennifer S Gray, Maoxiang Li, Laura Vines, Joon Kim, James J Pestka,

The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck). Here we elucidated critical linkages that exist among the ribosome and these kinases during the course of ... Read more >>

Toxicol. Sci. (Toxicological sciences : an official journal of the Society of Toxicology)
[2010, 115(2):444-452]

Cited: 26 times

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