Full Text Journal Articles by
Author He Huang

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The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer.

Ting Deng, Qidan Huang, Ting Wan, Xiaoling Luo, Yanling Feng, He Huang, Jihong Liu,

<h4>Objective</h4>To estimate the impact of lymph node dissection on survival in patients with apparent early-stage epithelial ovarian cancer (EOC).<h4>Methods</h4>We conducted a retrospective review of patients with clinical stage I-II EOC. All patients underwent primary surgery at Sun Yat-sen University Cancer Center between January 2003 and December 2015. Demographic features and ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e40]

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Plasmonically enabled two-dimensional material-based optoelectronic devices.

Hao Wang, Shasha Li, Ruoqi Ai, He Huang, Lei Shao, Jianfang Wang,

Two-dimensional (2D) materials, such as graphene, transition metal dichalcogenides, black phosphorus and hexagonal boron nitride, have been intensively investigated as building blocks for optoelectronic devices in the past few years. Very recently, significant efforts have been devoted to the improvement of the optoelectronic performances of 2D materials, which are restricted ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(15):8095-8108]

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Clinical risk score for predicting invasive fungal disease after allogeneic hematopoietic stem cell transplantation: Analysis of the China Assessment of Antifungal Therapy in Hematological Diseases (CAESAR) study.

Yuqian Sun, Jiong Hu, He Huang, Jing Chen, Jianyong Li, Jun Ma, Juan Li, Yingmin Liang, Jianmin Wang, Yan Li, Kang Yu, Jianda Hu, Jie Jin, Chun Wang, Depei Wu, Yang Xiao, Xiaojun Huang,

<h4>Background and objective</h4>Invasive fungal disease (IFD) is associated with a high mortality for patients with hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). This study aimed not only to develop a proven/probable IFD risk-scoring model but to identify high-risk populations that would benefit from anti-fungal prophylaxis.<h4>Methods</h4>Data from the China ... Read more >>

Transpl Infect Dis (Transplant infectious disease : an official journal of the Transplantation Society)
[2021, :e13611]

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VHH212 nanobody targeting the hypoxia-inducible factor 1α suppresses angiogenesis and potentiates gemcitabine therapy in pancreatic cancer in vivo.

Guangbo Kang, Min Hu, He Ren, Jiewen Wang, Xin Cheng, Ruowei Li, Bo Yuan, Yasmine Balan, Zixuan Bai, He Huang,

<h4>Objective</h4>We aimed to develop a novel anti-HIF-1α intrabody to decrease gemcitabine resistance in pancreatic cancer patients.<h4>Methods</h4>Surface plasmon resonance and glutathione S-transferase pull-down assays were conducted to identify the binding affinity and specificity of anti-HIF-1α VHH212 [a single-domain antibody (nanobody)]. Molecular dynamics simulation was used to determine the protein-protein interactions between ... Read more >>

Cancer Biol Med (Cancer biology & medicine)
[2021, :]

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Metal-organic frameworks coupling simultaneous saccharication and fermentation for enhanced butyric acid production from rice straw under visible light by Clostridium tyrobutyricum CtΔack::cat1.

Tingting Liu, Matthew Jay Malkmes, Liying Zhu, He Huang, Ling Jiang,

Here, Metal-Organic Frameworks (MOFs) coupling simultaneous saccharification and fermentation for butyric acid production using rice straw was constructed. Clostridium tyrobutyricum Δack::cat1, with deleted ack gene and overexpressed cat1 gene, was used as the butyric-acid-fermentation strain. MOFs was employed as a photocatalyst to improve butyric acid production, as well as a ... Read more >>

Bioresour Technol (Bioresource technology)
[2021, 332:125117]

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CRISPR/Cas-mediated non-viral genome specific targeted CAR T cells achieve high safety and efficacy in relapsed/refractory B-cell non-Hodgkin lymphoma

He Huang, Jiqin Zhang, Yongxian Hu, Jiaxuan Yang, Wei Li, Mingming Zhang, Yue Tian, Guoqing Wei, Linjie Zhang, Kui Zhao, Binghe Tan, Jiazhen Cui, Yalei Qi, Yi Li, Qiliang Tian, Qingcan Wang, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu,

In recent years, chimeric antigen receptor (CAR) T cell therapy has shown great promise in treating hematological malignancies. However, CAR T cell therapy currently has several limitations. Here we successfully developed a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPR/Cas9. Based on the optimized protocol, ... Read more >>

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Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor.

Danni Rao, Heng Li, Xuelian Ren, Yaoliang Sun, Cuiyun Wen, Mingyue Zheng, He Huang, Wei Tang, Shilin Xu,

ZAP-70 (zeta-chain associated protein kinase 70 kDa) signaling pathway and its functions have been involved in the development and adaptive immune signaling of T cell. It thus represents a promising target for autoimmune diseases. Although reversible ZAP-70 kinase domain inhibitors have been developed, they are either weak or nonselective. We report ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2021, 219:113393]

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Remediation of Soil in a Deserted Arsenic Plant Site Using Synthesised MgAlFe-LDHs.

Kai Zhong, Chaolan Zhang, Siwei Ren, He Huang, Qun Rong, Yongxin Zhou,

Layered double hydroxides (LDHs) are promising soil contamination amendment agents for its efficient absorbing abilities. However, the application of LDHs in remediation of heavy metal contaminated soil are to be developed. In this study, we synthesized MgAlFe-LDHs by introducing Fe<sup>3+</sup> into interlayer of the MgAl-LDHs using co-precipitation method. X-ray diffraction ... Read more >>

Bull Environ Contam Toxicol (Bulletin of environmental contamination and toxicology)
[2021, :]

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CTRP4 binds to the interleukin-6 Receptor and ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation

Lulu Cao, Wei Chen, Daxiang Na, He Huang, Qi Li, Xiaoxin Zhu, Lu Wang,

CTRP4, a secreted protein, plays an important role in protecting against sepsis and energy metabolism; however, its physiological functions in autoimmune disease remain unknown. In this study, we demonstrate that Th17 cell-associated experimental autoimmune encephalomyelitis was greatly exacerbated in Ctrp4 −/− mice because of increased Th17 cell infiltration. In vitro ... Read more >>

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miR‑541‑3p inhibits the viability and migration of vascular smooth muscle cells via targeting STIM1.

Zhiyu Lv, Dengliang Yi, Chi Zhang, Yujie Xie, He Huang, Zhongcai Fan, Xing Liu,

The transformation of vascular smooth muscle cells (VSMCs) into the proliferative migratory phenotype in the plaque area contributes to stable plaque formation and facilitates the pathogenesis of atherosclerosis. Stromal interaction molecule 1 (STIM1) has been identified to promote the proliferation of VSMCs, suggesting that STIM1 may be a potent target for the ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2021, 23(5):]

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Rationale and Design of the ADIDAS Study: Association Between Dapagliflozin-Induced Improvement and Anemia in Heart Failure Patients.

Jianping Zeng, Yunlong Zhu, Wenjiao Zhao, Mingxing Wu, Haobo Huang, He Huang, ChunFeng Wu, XiaoLin Zhou, ShengHua Zhou, ChengMing Wang, Kai Yin, FangHua Xu, ZhiQiang Cai, Xinyang Li, Huiheng Cheng, Youwen Xie, Zhuqing Tan, Xiaoyong Hu, Dexiang Liao, Yingchun Wang,

<h4>Background</h4>Heart failure (HF) is one of the most serious health concerns worldwide. Anemia is a highly prevalent comorbidity and outcome predictor in HF patients. Sodium glucose co-transport 2 (SGLT2) inhibitors have been demonstrated to reduce the risk of cardiovascular death and HF hospitalization in HF patients.<h4>Purpose</h4>This investigator-initiated, interventional, prospective, double-blind, ... Read more >>

Cardiovasc Drugs Ther (Cardiovascular drugs and therapy)
[2021, :]

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Identification of a 5-Gene-Based Scoring System by WGCNA and LASSO to Predict Prognosis for Rectal Cancer Patients.

He Huang, Shilei Xu, Aidong Chen, Fen Li, Jiezhong Wu, Xusheng Tu, Kunpeng Hu,

<h4>Background</h4>Although accumulating evidence suggested that a molecular signature panel may be more effective for the prognosis prediction than routine clinical characteristics, current studies mainly focused on colorectal or colon cancers. No reports specifically focused on the signature panel for rectal cancers (RC). Our present study was aimed at developing a ... Read more >>

Anal Cell Pathol (Amst) (Analytical cellular pathology (Amsterdam))
[2021, 2021:6697407]

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A Potential Combination Therapy of Berberine Hydrochloride With Antibiotics Against Multidrug-Resistant Acinetobacter baumannii.

Xiaobo Li, Yanqing Song, Lina Wang, Guangbo Kang, Ping Wang, Huabing Yin, He Huang,

Multidrug-resistant (MDR) <i>Acinetobacter baumannii</i> strains can cause severe infections in intensive care units, and are rapidly developing resistance to the last-resort of existing antibiotics, posing a major global threat to health care system. Berberine hydrochloride (BBH), a kind of isoquinoline alkaloids extracted from Berberis and other plants, has been widely ... Read more >>

Front Cell Infect Microbiol (Frontiers in cellular and infection microbiology)
[2021, 11:660431]

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Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Update: Genetic Pathogenesis.

Weiran Li, He Huang, Minglong Cai, Tao Yuan, Yujun Sheng,

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by the inflammation of small and medium vessels and presence of proteinase 3-ANCA or myeloperoxidase-ANCA in the circulation. AAV comprises three clinical subtypes: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic GPA (EGPA). Although the pathogenesis of AAV is still unclear, ... Read more >>

Front Immunol (Frontiers in immunology)
[2021, 12:624848]

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Rethinking Capital Structure Decision and Corporate Social Responsibility in Response to COVID-19

He Huang, April Ye,

COVID-19 has severely constricted the global economic activities. This paper examines the joint effect of capital structure and corporate social responsibility (CSR) activities on firm risk during COVID-19. We find that firms having excessive debt beyond the optimal level experienced high firm risk during the pandemic and the effect is ... Read more >>

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Automatic lumen detection and magnetic alignment control for magnetic-assisted capsule colonoscope system optimization.

Sheng-Yang Yen, Hao-En Huang, Gi-Shih Lien, Chih-Wen Liu, Chia-Feng Chu, Wei-Ming Huang, Fat-Moon Suk,

We developed a magnetic-assisted capsule colonoscope system with integration of computer vision-based object detection and an alignment control scheme. Two convolutional neural network models A and B for lumen identification were trained on an endoscopic dataset of 9080 images. In the lumen alignment experiment, models C and D used a ... Read more >>

Sci Rep (Scientific reports)
[2021, 11(1):6460]

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Biotechnological production of lipid and terpenoid from thraustochytrids.

Fei Du, Yu-Zhou Wang, Ying-Shuang Xu, Tian-Qiong Shi, Wen-Zheng Liu, Xiao-Man Sun, He Huang,

As fungus-like protists, thraustochytrids have been increasingly studied for their faster growth rates and high lipid content. In the 1990s, thraustochytrids were used as docosahexaenoic acid (DHA) producers for the first time. Thraustochytrids genera, such as Thraustochytrium, Schizochytrium, and Aurantiochytrium have been developed and patented as industrial strains for DHA ... Read more >>

Biotechnol Adv (Biotechnology advances)
[2021, 48:107725]

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Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua.

Bo Hu, He Huang, Songzhu Hu, Miaomiao Ren, Qi Wei, Xiangrui Tian, Mohammed Esmail Abdalla Elzaki, Chris Bass, Jianya Su, Subba Reddy Palli,

The evolution of insect resistance to insecticides is frequently associated with overexpression of one or more cytochrome P450 enzyme genes. Although overexpression of CYP450 genes is a well-known mechanism of insecticide resistance, the underlying regulatory mechanisms are poorly understood. Here we uncovered the mechanisms of overexpression of the P450 gene, ... Read more >>

PLoS Genet (PLoS genetics)
[2021, 17(3):e1009403]

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How Do We Manage Hematopoietic Cell Transplant during the SARS-CoV-2 Pandemic?

Haowen Xiao, Yi Luo, Jimin Shi, Aiyun Jin, Mohamad Mohty, Arnon Nagler, Robert Peter Gale, He Huang,

Patients receiving a hematopoietic cell transplant are thought to be at increased risk of infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and coronavirus infectious disease 2019. Transplant activities at our center continue, and notably, no patient has been infected with SARS-CoV-2. Indeed, social distancing, masking, and education for patients ... Read more >>

Acta Haematol (Acta haematologica)
[2021, :1-7]

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Developing GDi-CRISPR System for Multi-copy Integration in Saccharomyces cerevisiae.

Zi-Xu Zhang, Yu-Zhou Wang, Ying-Shuang Xu, Xiao-Man Sun, He Huang,

In recent years, Saccharomyces cerevisiae has been widely used in the production of biofuels and value-added chemicals. To stably express the target products, it is necessary to integrate multiple target genes into the chromosome of S. cerevisiae. CRISPR multi-copy integration technology relying on delta sites has been developed, but it ... Read more >>

Appl Biochem Biotechnol (Applied biochemistry and biotechnology)
[2021, :]

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Establishment and evaluation of an indirect ELISA for detection of antibodies to goat Klebsiella pneumonia.

Ruichang Chen, Hongqi Shang, Xiangyun Niu, Jin Huang, Yongqiang Miao, Zhou Sha, Liting Qin, He Huang, Duo Peng, Ruiliang Zhu,

<h4>Background</h4>Klebsiella pneumonia, a Gram-negative bacterium belonging to the genus Enterobacter, causes many human and livestock diseases. Notably, infected goats may develop pneumonia, septicemia, which can lead to occasional death, resulting in great economic losses in goat-farming industry. However, there are little systematic methods for detection of goat Klebsiella pneumoniae in ... Read more >>

BMC Vet Res (BMC veterinary research)
[2021, 17(1):107]

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An Insight of the First Community Infected COVID-19 Patient in Beijing by Imported Case: Role of Deep Learning-Assisted CT Diagnosis.

Da Sheng Li, Da Wei Wang, Na Na Wang, Hai Wang Xu, He Huang, Jian Ping Dong, Chen Xia,

In the era of coronavirus disease 2019 (COVID-19) pandemic, imported COVID-19 cases pose great challenges to many countries. Chest CT examination is considered to be complementary to nucleic acid test for COVID-19 detection and diagnosis. We report the first community infected COVID-19 patient by an imported case in Beijing, which ... Read more >>

Chin Med Sci J (Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih)
[2021, 36(1):66-71]

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ITGB2 as a Novel Biomarker Correlating With Prognosis and Immune Infiltrates in Ovarian Cancer

chanyuan li, Ting Wan, Ting Deng, Junya Cao, He Huang, Jihong Liu,

<h4>Background: </h4> Epithelial ovarian cancer is nowadays one of the malignancies in women, this study aimed to identify novel biomarkers to predict prognosis and immunotherapy efficacy. <h4>Methods:</h4> The differentially expressed genes (DEGs) obtained from online database Gene Expression Omnibus (GEO)were screened via GEO2R and Venn diagram software, gene enrichment was ... Read more >>

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Electrophotocatalytic C-H Heterofunctionalization of Arenes.

He Huang, Tristan H Lambert,

The electrophotocatalytic heterofunctionalization of arenes is described. Using 2,3-dichloro-5,6-dicyanoquinone (DDQ) under a mild electrochemical potential with visible-light irradiation, arenes undergo oxidant-free hydroxylation, alkoxylation, and amination with high chemoselectivity. In addition to batch reactions, an electrophotocatalytic recirculating flow process is demonstrated, enabling the conversion of benzene to phenol on a gram ... Read more >>

Angew Chem Int Ed Engl (Angewandte Chemie (International ed. in English))
[2021, :]

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Effectiveness of Sequential Chemoradiation vs Concurrent Chemoradiation or Radiation Alone in Adjuvant Treatment After Hysterectomy for Cervical Cancer: The STARS Phase 3 Randomized Clinical Trial.

He Huang, Yan-Ling Feng, Ting Wan, Yan-Na Zhang, Xin-Ping Cao, Yong-Wen Huang, Ying Xiong, Xin Huang, Min Zheng, Yan-Fang Li, Jun-Dong Li, Guan-Di Chen, Hu Li, Yi-Le Chen, Li-Guo Ma, Hong-Ying Yang, Li Li, Shu-Zhong Yao, Wei-Jun Ye, Hua Tu, Qi-Dan Huang, Li-Zhi Liang, Fu-Yuan Liu, Qing Liu, Ji-Hong Liu,

<h4>Importance</h4>There is no current consensus on the role of chemotherapy in addition to radiation for postoperative adjuvant treatment of patients with early-stage cervical cancer with adverse pathological factors.<h4>Objective</h4>To evaluate the clinical benefits of sequential chemoradiation (SCRT) and concurrent chemoradiation (CCRT) compared with radiation alone (RT) as a postoperative adjuvant treatment ... Read more >>

JAMA Oncol (JAMA oncology)
[2021, 7(3):361-369]

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