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Author Harun Un

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Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties.

Duygu Kose, Harun Un, Rustem Anil Ugan, Zekai Halici, Elif Cadirci, Tugba Bal Tastan, Aysenur Kahramanlar,

<h4>Objectives</h4>We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) biochemically, molecularly and histopathologically.<h4>Methods</h4>A total of 40 rats were divided into 5 groups with 8 animals in each group. Group 1 (SHAM), control group; Group 2 ... Read more >>

J Pharm Pharmacol (The Journal of pharmacy and pharmacology)
[2021, :]

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A New Approach to Sepsis Treatment by Rasagiline: A Molecular, Biochemical and Histopathological Study

harun un, Rustem Anil Ugan, duygu Köse, muhammed yayla, Tugba Bal Tastan, Yasin Bayir, Zekai Halici,

<h4>Aim: </h4> We aimed to investigate the effects of rasagiline, which has a strong antioxidant, anti-apoptotic and anti-inflammatory effect, on acute lung injury that develops in the sepsis model induced with the CLP in rats. Main Methods: The rats were separated into the following six groups, Group 1: Sham, Group ... Read more >>

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Phloretin and phloridzin guard against cisplatin-induced nephrotoxicity in mice through inhibiting oxidative stress and inflammation.

Harun Un, Rustem Anil Ugan, Muhammet Ali Gurbuz, Yasin Bayir, Aysenur Kahramanlar, Gokce Kaya, Elif Cadirci, Zekai Halici,

<h4>Aim</h4>Cisplatin (Cis) is widely used chemotherapeutic and has some serious side effects as nephrotoxicity. Phloretin (PH) and Phloridzin (PZ) are known their anti-oxidant anti-inflammatory effects. We aimed to examine the protective effects of PH and PZ on cisplatin-induced nephrotoxicity.<h4>Main methods</h4>Totally, 48 Balb/C female mice were separated into eight groups (n = 6). ... Read more >>

Life Sci (Life sciences)
[2021, 266:118869]

Cited: 2 times

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Effects of soy isoflavonoids (genistein and daidzein) on endometrial receptivity.

Erdem Toktay, Jale Selli, Muhammed Ali Gurbuz, Tugba Bal Tastan, Rustem Anıl Ugan, Harun Un, Zekai Halici,

<h4>Objectives</h4>This study aimed to examine the effects of genistein and daidzein on endometrial receptivity by histopathological, immunohistochemical, and biochemical techniques.<h4>Materials and methods</h4>In this study, 72 female Sprague-Dawley rats were randomly divided into 8 groups. The endometrial receptivity model was applied to identified groups. Experimental animals were given periorally 10 mg/kg ... Read more >>

Iran J Basic Med Sci (Iranian journal of basic medical sciences)
[2020, 23(12):1603-1609]

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The Protective Roles of Butein on Indomethacin Induced Gastric Ulcer in Mice.

Rustem Anil Ugan, Harun Un,

<h4>Objective</h4>Butein is a potential agent first isolated from Rhus verniciflua that has medicinal value in East Asia and has been used in the treatment of gastritis, gastric cancer, and atherosclerosis since ancient times. The aim of our study is to show, for the first time, the anti-ulcerative effect of butein ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2020, 52(3):265-270]

Cited: 1 time

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Possible contribution of the neprilysin/ACE pathway to sepsis in mice.

Rustem Anil Ugan, Harun Un, Muhammed Ali Gurbuz, Gokce Kaya, Aysenur Kahramanlar, Zeynep Berna Aksakalli-Magden, Zekai Halici, Elif Cadirci,

<h4>Aim</h4>Omapatrilat is an antagonist of angiotensin-converting (ACE) and neprilysin-neuropeptidase (NEP) enzymes. The aim of our study is to show that omapatrilat may have beneficial effects as a treatment for polymicrobial sepsis.<h4>Main methods</h4>A cecal ligation and puncture (CLP) sepsis model was used to evaluate 10 and 20 mg/kg doses of omapatrilat in ... Read more >>

Life Sci (Life sciences)
[2020, 258:118177]

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Can aprepitant used for nausea and vomiting be good gastrointestinal complaints?

Rustem Anil Ugan, Harun Un, Duygu Kose, Elif Cadirci, Tugba Bal Tastan, Muhammed Yayla, Zekai Halici,

Aprepitant is a selective SP/NK-1 receptor antagonist and used in postoperative and chemotherapeutics induced emesis and vomiting. The aim of our study is to show aprepitant may have beneficial effects on gastrointestinal complaints in cancer patients undergoing chemotherapeutics by indomethacin-induced gastric ulcer model. A total of 48 rats were fasted ... Read more >>

Naunyn Schmiedebergs Arch Pharmacol (Naunyn-Schmiedeberg's archives of pharmacology)
[2020, 393(12):2463-2472]

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A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity.

Harun Un, Rustem Anil Ugan, Duygu Kose, Yasin Bayir, Elif Cadirci, Jale Selli, Zekai Halici,

Cisplatin is widely used chemotherapeutic drug and have some serious side effects as tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug for cisplatin treated patient to prevent nausea and vomiting. We aimed to investigate the protective effects of Aprepitant on cisplatin-induced nephrotoxicity and ... Read more >>

Eur J Pharmacol (European journal of pharmacology)
[2020, 880:173168]

Cited: 4 times

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Protective Effect of Lycopene against Reperfusion Injury in Rats with Ovarian Torsion: A Biochemical and Histopathological Evaluation.

Emsal Pinar Topdagi Yilmaz, Harun Un, Betul Gundogdu, Elif Polat, Seda Askin, Yunus Emre Topdagi, Zekai Halici,

Objective  The aim of our study was to evaluate the effect of two different doses of lycopene, an antioxidant, on experimentally induced ovarian ischemia/reperfusion (IR) injury in rat model. Materials and Methods  Twenty-four female rats were randomly divided into four groups: sham operation (group 1), 3-hour ischemia, 3-hour reperfusion (IR) ... Read more >>

J Lab Physicians (Journal of laboratory physicians)
[2020, 12(1):32-37]

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Effect of Prostaglandin E1 Analog Misoprostol in An Ovalbumin-Induced Allergic Rhinitis Model.

Zulkuf Kaya, Muhammed Yayla, Arzu Bilen, Nihal Efe Atilla, Sevilay Ozmen, Irfan Cinar, Zafer Bayraktutan, Vahit Mutlu, Harun Un, Erdem Toktay,

Objective:The aim of the present study was to demonstrate the effects of misoprostol in ovalbumin-induced allergic rhinitis (AR). The second purpose was to compare the effect profile of the combination of an antihistamine with misoprostol during treatment of AR. Materials and Methods:Twenty-five adult male rats were used and were randomly ... Read more >>

Eurasian J Med (The Eurasian journal of medicine)
[2019, 51(1):75-79]

Cited: 0 times

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The effects of Beeswax, Olive oil and Butter impregnated bandage on burn wound healing.

Yasin Bayir, Harun Un, Rustem Anil Ugan, Erol Akpinar, Elif Cadirci, Ilknur Calik, Zekai Halici,

<h4>Background</h4>Beeswax, Olive oil and Butter (BOB) are nutritive products that could support wound healing by adsorption to bandage. This study demonstrated the therapeutic effects of BOB on second degree burn.<h4>Methods</h4>Second degree burn model was created in rats. Experimental groups were assigned to Healthy, Burn, Silver Sulfadiazine (SS) and BOB. The ... Read more >>

Burns (Burns : journal of the International Society for Burn Injuries)
[2019, 45(6):1410-1417]

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Effects of Aliskiren, an RAAS inhibitor, on a carrageenan-induced pleurisy model of rats.

Yasin Bayir, Harun Un, Elif Cadirci, Erol Akpinar, Busra Diyarbakir, Ilknur Calik, Zekai Halici,

Our aim is to investigate the potentially preventive effects of Aliskiren in a carrageenan-induced lung pleurisy model and to compare the standard anti-inflammatory agents, indomethacin and dexamethasone. The pleurisy model was induced through the injection of carrageenan (0.2 ml-%2) into the pleural cavity. After the experiment, serum and lung tissues ... Read more >>

An Acad Bras Cienc (Anais da Academia Brasileira de Ciencias)
[2019, 91(1):e20180106]

Cited: 1 time

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Aliskiren - a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS.

Yasin Bayir, Elif Cadirci, Beyzagul Polat, Nurcan Kilic Baygutalp, Abdulmecit Albayrak, Emre Karakus, Harun Un, Mevlut Sait Keles, Fatma Betul Kocak Ozgeris, Erdem Toktay, Mehmet Karaca, Zekai Halici,

The aim of this study was to evaluate the effects of aliskiren, direct renin inhibitor, as an antioxidant and tissue protective agent and evaluate the molecular, biochemical, and histopathological changes in experimental ischemia and ischemia/reperfusion injury in rat ovaries. Forty-eight female rats were randomly divided into eight groups: in Group 1, only sham ... Read more >>

Gynecol Endocrinol (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology)
[2016, 32(8):675-683]

Cited: 5 times

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The Effects of Argan Oil in Second-degree Burn Wound Healing in Rats.

Umit Avsar, Zekai Halici, Erol Akpinar, Muhammed Yayla, Ummu Avsar, Un Harun, Un Harun, Atmaca Hasan Tarik, Zafer Bayraktutan,

Argan oil, produced from the kernels of the argan tree (Argania spinosa), has been shown to have antioxidant properties. To examine the effect of argan oil in second-degree burn wound healing, an in vivo experiment was conducted among 30 adult male Wistar rats divided into 5 equal groups: a sham ... Read more >>

Ostomy Wound Manage (Ostomy/wound management)
[2016, 62(3):26-34]

Cited: 5 times

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Nephroprotective potential of carnitine against glycerol and contrast-induced kidney injury in rats through modulation of oxidative stress, proinflammatory cytokines, and apoptosis.

Celalettin S Kunak, Rustem A Ugan, Elif Cadirci, Emre Karakus, Beyzagul Polat, Harun Un, Zekai Halici, Murat Saritemur, Hasan T Atmaca, Adem Karaman,

<h4>Objective</h4>Contrast media (CM) are a major cause of nephropathy in high-risk patients. The aim of this study was to examine the effects of carnitine (CAR) in advanced nephrotoxicity due to CM administration in rats with glycerol-induced renal functional disorder.<h4>Methods</h4>40 rats were divided randomly into five groups (n = 8): (1) healthy group; ... Read more >>

Br J Radiol (The British journal of radiology)
[2016, 89(1058):20140724]

Cited: 10 times

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Does bosentan protect diabetic brain alterations in rats? The role of endothelin-1 in the diabetic brain.

Recep Demir, Elif Cadirci, Erol Akpinar, Yasemin Cayir, Hasan Tarik Atmaca, Harun Un, Celalettin Semih Kunak, Muhammed Yayla, Zafer Bayraktutan, Ilknur Demir,

Diabetes mellitus (DM) is a major problem all over the world, affecting more people in recent years. Individuals with diabetes are more prone to disease than non-diabetics, especially vascular complications. The aim of this study was to examine the roles of the endothelin (ET)-1 in brain damage formed in a ... Read more >>

Basic Clin Pharmacol Toxicol (Basic & clinical pharmacology & toxicology)
[2015, 116(3):236-243]

Cited: 3 times

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The Effects of RAAS Inhibition in Rate Limiting Step by Aliskiren on Testicular Torsion Injury in Rats.

Harun Un, Yasin Bayir, Zekai Halici, Erol Akpinar, Emre Karakus, Akgun Oral, Tevfik Ziypak, Jale Selli,

<h4>Purpose</h4>Testicular torsion is a urological emergency. Failure of timely intervention for this issue leads the testicles to go into necrosis. If left untreated, it can lead to loss of the reproductive organs. The aim of this study was to examine the role of aliskiren in testicular torsion and detorsion injuries.<h4>Materials ... Read more >>

J Urol (The Journal of urology)
[2015, 194(3):828-833]

Cited: 8 times

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Tnf-α inhibition by infliximab as a new target for the prevention of glycerol-contrast-induced nephropathy.

Murat Saritemur, Harun Un, Elif Cadirci, Emre Karakus, Erol Akpinar, Zekai Halici, Rustem Anil Ugan, Adem Karaman, Hasan Tarik Atmaca,

Contrast medium-induced nephropathy (CIN) remains as a problem with high incidence and mortality rates. The aim of this study is to examine the roles of infliximab (INF) in the glycerol (GLY) and CIN model in rats. The rats were separated into five groups (n=8): Healthy, GLY, GLY+CM, GLY+CM+INF 5mg/kg intraperitoneally ... Read more >>

Environ Toxicol Pharmacol (Environmental toxicology and pharmacology)
[2015, 39(2):577-588]

Cited: 5 times

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L-carnitine alleviates sciatic nerve crush injury in rats: functional and electron microscopy assessments.

Ummü Zeynep Avsar, Umit Avsar, Ali Aydin, Muhammed Yayla, Berna Ozturkkaragoz, Harun Un, Murat Saritemur, Tolga Mercantepe,

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 ... Read more >>

Neural Regen Res (Neural regeneration research)
[2014, 9(10):1020-1024]

Cited: 3 times

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Development and validation of UFLC-MS/MS method for determination of bosentan in rat plasma.

Alptug Atila, Murat Ozturk, Yucel Kadioglu, Zekai Halici, Didar Turkan, Muhammed Yayla, Harun Un,

A rapid, simple and sensitive UFLC-MS/MS method was developed and validated for the determination of bosentan in rat plasma using etodolac as an internal standard (IS) after liquid-liquid extraction with diethyl ether-chloroform (4:1, v/v). Bosentan and IS were detected using electrospray ionization in positive ion multiple reaction monitoring mode by ... Read more >>

J Pharm Biomed Anal (Journal of pharmaceutical and biomedical analysis)
[2014, 97:33-38]

Cited: 4 times

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