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Author Harumasa Yoshihara

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Clinical use of molecular targeted agents for primary small bowel adenocarcinoma: A multicenter retrospective cohort study by the Osaka Gut Forum.

Motohiro Hirao, Masato Komori, Tsutomu Nishida, Hideki Iijima, Shinjiro Yamaguchi, Ryu Ishihara, Yuichi Yasunaga, Ichizo Kobayashi, Osamu Kishida, Masahide Oshita, Hideki Hagiwara, Toshifumi Ito, Kunio Suzuki, Yoshito Hayashi, Takahiro Inoue, Masahiko Tsujii, Harumasa Yoshihara, Tetsuo Takehara,

Primary small bowel adenocarcinoma (SBA) is a rare cancer for which effective treatment strategies have not yet been established. The results of previous retrospective studies suggest that chemotherapy contributes to a longer survival time in patients with SBA. However, there are few case reports about the efficacy of molecular targeted ... Read more >>

Oncol Lett (Oncology letters)
[2017, 14(2):1628-1636]

Cited: 3 times

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S100A8 Production in CXCR2-Expressing CD11b+Gr-1high Cells Aggravates Hepatitis in Mice Fed a High-Fat and High-Cholesterol Diet.

Kaori Mukai, Takuya Miyagi, Kumiko Nishio, Yoshinobu Yokoyama, Teppei Yoshioka, Yoshinobu Saito, Satoshi Tanaka, Minoru Shigekawa, Takatoshi Nawa, Hayato Hikita, Ryotaro Sakamori, Harumasa Yoshihara, Yasuharu Imai, Naoki Hiramatsu, Tomohide Tatsumi, Tetsuo Takehara,

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a spectrum of presentations. S100A8 has been suggested to play a pivotal role as an endogenous immune-activator in inflammatory diseases. In this study, we investigated the involvement of S100A8 in the development of NAFLD. We used a diet ... Read more >>

J Immunol (Journal of immunology (Baltimore, Md. : 1950))
[2016, 196(1):395-406]

Cited: 9 times

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The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin.

Yuki Tahata, Naoki Hiramatsu, Tsugiko Oze, Naoki Morishita, Naoki Harada, Ryoko Yamada, Takayuki Yakushijin, Eiji Mita, Hideki Hagiwara, Yukinori Yamada, Toshifumi Ito, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Keiko Irishio, Michio Kato, Hayato Hikita, Ryotaro Sakamori, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>Hyperbilirubinemia, mild or moderate, is a commonly observed laboratory abnormality in chronic hepatitis C patients treated with simeprevir with pegylated interferon (Peg-IFN) plus ribavirin. In this prospective, multicenter study, we aimed to investigate the clinical features and factors associated with bilirubin increases during the therapy.<h4>Methods</h4>A total of 192 patients with ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2016, 51(3):252-259]

Cited: 7 times

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Invariant natural killer T cell deficiency leads to the development of spontaneous liver inflammation dependent on γδT cells in mice.

Kumiko Nishio, Takuya Miyagi, Tomohide Tatsumi, Kaori Mukai, Yoshinobu Yokoyama, Teppei Yoshioka, Ryotaro Sakamori, Hayato Hikita, Takahiro Kodama, Satoshi Shimizu, Minoru Shigekawa, Takatoshi Nawa, Harumasa Yoshihara, Naoki Hiramatsu, Hiroyuki Yamanaka, Ken-Ichiro Seino, Tetsuo Takehara,

<h4>Background</h4>Immune tolerance is maintained in the liver, and perturbation of tolerance can lead to immune-mediated liver diseases such as autoimmune hepatitis (AIH). Invariant natural killer T (iNKT) cells and γδT cells have been shown to maintain immune homeostasis as regulatory cells and to play pathogenic roles in immune-mediated diseases as ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2015, 50(11):1124-1133]

Cited: 5 times

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Renal dysfunction is an independent risk factor for bleeding after gastric ESD.

Teppei Yoshioka, Tsutomu Nishida, Masahiko Tsujii, Motohiko Kato, Yoshito Hayashi, Masato Komori, Harumasa Yoshihara, Takeshi Nakamura, Satoshi Egawa, Toshiyuki Yoshio, Takuya Yamada, Takamasa Yabuta, Katsumi Yamamoto, Kazuo Kinoshita, Naoki Kawai, Hideharu Ogiyama, Akihiro Nishihara, Tomoki Michida, Hideki Iijima, Ayumi Shintani, Tetsuo Takehara,

<h4>Background and study aims</h4>The number of patients with chronic kidney disease (CKD) is increasing worldwide and gastric cancer sometimes occurs with CKD. However, the safety and feasibility of endoscopic submucosal dissection (ESD) for patients with CKD are not clear. The aim of this study is to clarify the feasibility and ... Read more >>

Endosc Int Open (Endoscopy international open)
[2015, 3(1):E39-45]

Cited: 6 times

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The prospective randomized study on telaprevir at 1500 or 2250 mg with pegylated interferon plus ribavirin in Japanese patients with HCV genotype 1.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Ryoko Yamada, Naoki Harada, Naoki Morishita, Akira Yamada, Masahide Oshita, Akira Kaneko, Kunio Suzuki, Yoshiaki Inui, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>Triple therapy with telaprevir (TVR), pegylated interferon and ribavirin has improved antiviral efficacy in patients with chronic hepatitis C (CH-C). However, the severe adverse effects caused by TVR are important to resolve. In this prospective, randomized, multicenter, open-label study, the antiviral efficacy and safety in the reduced administration of TVR ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2015, 50(3):313-322]

Cited: 2 times

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Peretinoin after curative therapy of hepatitis C-related hepatocellular carcinoma: a randomized double-blind placebo-controlled study.

Kiwamu Okita, Namiki Izumi, Osamu Matsui, Katsuaki Tanaka, Shuichi Kaneko, Hisataka Moriwaki, Kenji Ikeda, Yukio Osaki, Kazushi Numata, Kohei Nakachi, Norihiro Kokudo, Kazuho Imanaka, Shuhei Nishiguchi, Takuji Okusaka, Yoichi Nishigaki, Susumu Shiomi, Masatoshi Kudo, Kenichi Ido, Yoshiyasu Karino, Norio Hayashi, Yasuo Ohashi, Masatoshi Makuuchi, Hiromitsu Kumada, ,

<h4>Background</h4>Effective prophylactic therapies have not been established for hepatocellular carcinoma recurrence. Peretinoin represents one novel option for patients with hepatitis C virus-related hepatocellular carcinoma (HCV-HCC), and it was tested in a multicenter, randomized, double-blind, placebo-controlled study.<h4>Methods</h4>Patients with curative therapy were assigned to one of the following regimens: peretinoin 600, 300 ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2015, 50(2):191-202]

Cited: 39 times

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[Bypass surgery or stent placement for biliary obstruction in patients with unresectable pancreatic cancer].

Masahiro Murakami, Junzo Shimizu, Yokoku Kim, Ho Min Kim, Yoshihito Souma, Masaki Hirota, Hirotaka Morishima, Shoki Mikata, Nobuki Matsunami, Junichi Hasegawa, Motohiro Hirao, Masato Komori, Harumasa Yoshihara, Riichiro Nezu,

The therapeutic strategy for biliary obstruction in patients with unresectable pancreatic cancer is controversial. We compared complications and prognosis between 2 groups: the B group, 8 patients who were diagnosed as having inoperable pancreatic cancer at laparotomy and underwent bypass surgery, and the S group, 7 patients who underwent endoscopic ... Read more >>

Gan To Kagaku Ryoho (Gan to kagaku ryoho. Cancer & chemotherapy)
[2013, 40(12):1705-1707]

Cited: 1 time

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Complete clogging by fungus ball: a rare complication of gastrostomy.

Shunsuke Yamamoto, Masato Komori, Harumasa Yoshihara,

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2014, 12(5):A29-30]

Cited: 0 times

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Post-treatment levels of α-fetoprotein predict incidence of hepatocellular carcinoma after interferon therapy.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Akira Yamada, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Akinori Kasahara, Toshimitsu Hamasaki, Norio Hayashi, Tetsuo Takehara, ,

<h4>Background & aims</h4>In patients with chronic hepatitis C virus (HCV) infection, lack of sustained virologic response (SVR) 24 weeks after the end of interferon therapy is a significant risk factor for hepatocellular carcinoma (HCC). Although many pretreatment factors are known to affect HCC incidence, less is known about post-treatment factors-many ... Read more >>

Clin Gastroenterol Hepatol (Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association)
[2014, 12(7):1186-1195]

Cited: 47 times

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Using early viral kinetics to predict antiviral outcome in response-guided pegylated interferon plus ribavirin therapy among patients with hepatitis C virus genotype 1.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Masanori Miyazaki, Sadaharu Iio, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Tatsuya Kanto, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>HCV kinetics during treatment demonstrated strong association with the antiviral outcome of patients treated with pegylated interferon (Peg-IFN) plus ribavirin. However, the relationship between HCV kinetics and pre-treatment factors remains unclear.<h4>Methods</h4>Of 547 patients with HCV genotype 1 treated with Peg-IFN alfa-2b plus ribavirin, 401 completed the response-guided therapy and were ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2014, 49(4):737-747]

Cited: 3 times

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Incidence of hepatocellular carcinoma in HCV-infected patients with normal alanine aminotransferase levels categorized by Japanese treatment guidelines.

Naoki Harada, Naoki Hiramatsu, Tsugiko Oze, Ryoko Yamada, Mika Kurokawa, Masanori Miyazaki, Takayuki Yakushijin, Takuya Miyagi, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Masahide Oshita, Eiji Mita, Hideki Hagiwara, Yoshiaki Inui, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Atsuo Inoue, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>This study was conducted to evaluate Japanese treatment guidelines for patients with chronic hepatitis C virus (HCV) infection and normal alanine aminotransferase (N-ALT) levels from the viewpoint of the incidence of hepatocellular carcinoma (HCC).<h4>Methods</h4>Four groups of patients with chronic HCV infection treated with pegylated interferon (Peg-IFN) plus ribavirin, and classified ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2013, 48(4):535-543]

Cited: 2 times

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Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin.

Tsugiko Oze, Naoki Hiramatsu, Changho Song, Takayuki Yakushijin, Sadaharu Iio, Yoshinobu Doi, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Masanori Miyazaki, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Norio Hayashi, Tetsuo Takehara,

<h4>Background</h4>The timing to the first undetectable hepatitis C virus (HCV) RNA level is strongly associated with sustained virologic response in pegylated interferon (Peg-IFN) plus ribavirin combination therapy for patients with chronic hepatitis C (CH-C) with genotype 1. This study was conducted to clarify the impact of drug exposure to Peg-IFN ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2012, 47(3):334-342]

Cited: 2 times

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Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case-control study.

Naoki Hiramatsu, Yuko Inoue, Tsugiko Oze, Nao Kurashige, Takayuki Yakushijin, Kiyoshi Mochizuki, Takuya Miyagi, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Masahide Oshita, Eiji Mita, Hideki Hagiwara, Yoshiaki Inui, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Norio Hayashi,

<h4>Background</h4>The antiviral effect of pegylated interferon (Peg-IFN) plus ribavirin combination therapy in chronic hepatitis C (CHC) patients with normal alanine aminotransferase (ALT) levels (N-ALT) has been reported to be equivalent to that for patients with elevated ALT levels (E-ALT). However, the actual antiviral effect in N-ALT patients remains obscure because ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2011, 46(11):1335-1343]

Cited: 6 times

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Efficacy of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Hiroyuki Fukui, Taizo Hijioka, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Eijiro Hayashi, Michio Kato, Atsushi Hosui, Takuya Miyagi, Hisashi Ishida, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,

<h4>Background</h4>It is still not known which patients with chronic hepatitis C who failed to respond to previous pegylated interferon (Peg-IFN) plus ribavirin therapy can benefit from re-treatment.<h4>Methods</h4>Seventy-four patients (HCV genotype 1, n = 56, genotype 2, n = 18) were re-treated with Peg-IFN plus ribavirin.<h4>Results</h4>On re-treatment, the sustained virologic response ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2011, 46(8):1031-1037]

Cited: 9 times

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A patient with rheumatoid arthritis treated with tocilizumab together with lamivudine prophylaxis after remission of infliximab-reactivated hepatitis B.

Hideki Tsuboi, Akira Tsujii, Akihide Nampei, Harumasa Yoshihara, Kiyoshi Kawano, Eiji Takeuchi, Kenrin Shi,

A 59-year-old woman with rheumatoid arthritis was treated quite successfully with infliximab, but her serum aminotransferase levels were markedly elevated; this was diagnosed as acute exacerbation of hepatitis B and she was treated with lamivudine, and infliximab was discontinued. The rheumatoid arthritis disease activity was uncontrollable after the discontinuation of ... Read more >>

Mod Rheumatol (Modern rheumatology)
[2011, 21(6):701-705]

Cited: 13 times

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The efficacy of extended treatment with pegylated interferon plus ribavirin in patients with HCV genotype 1 and slow virologic response in Japan.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Kazuho Imanaka, Akira Yamada, Masahide Oshita, Akira Kaneko, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Toshihiko Nagase, Yoshiaki Inui, Taizo Hijioka, Shinji Tamura, Harumasa Yoshihara, Eijiro Hayashi, Yasuharu Imai, Michio Kato, Atsushi Hosui, Takuya Miyagi, Yuichi Yoshida, Hisashi Ishida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,

<h4>Background</h4>Which patients with hepatitis C virus (HCV) genotype 1 can benefit from extended treatment with pegylated interferon (Peg-IFN) plus ribavirin is unknown, although the overall sustained virologic response (SVR) rate has been shown to improve in patients with a late virologic response (LVR), defined as detectable serum HCV RNA at ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2011, 46(7):944-952]

Cited: 10 times

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Indications and limitations for aged patients with chronic hepatitis C in pegylated interferon alfa-2b plus ribavirin combination therapy.

Tsugiko Oze, Naoki Hiramatsu, Takayuki Yakushijin, Kiyoshi Mochizuki, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Hiroyuki Fukui, Yoshiaki Inui, Taizo Hijioka, Masami Inada, Kazuhiro Kaytayama, Shinji Tamura, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Michio Kato, Takuya Miyagi, Yuichi Yoshida, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Norio Hayashi,

<h4>Background & aims</h4>This study investigated the efficacy and adverse effects of pegylated interferon (Peg-IFN) plus ribavirin therapy in aged patients with chronic hepatitis C (CH-C).<h4>Methods</h4>A total of 1040 naïve patients with CH-C (genotype 1, n=759; genotype 2, n=281), of whom 240 (23%) over 65 years old (y.o.), were treated with ... Read more >>

J Hepatol (Journal of hepatology)
[2011, 54(4):604-611]

Cited: 30 times

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Successful treatment of HCV-related cryoglobulinemic glomerulonephritis with double-filtration plasmapheresis and interferon combination therapy.

Tomoko Namba, Rie Shiba, Takeshi Yamamoto, Yasuhiro Hirai, Takuma Moriwaki, Jun Matsuda, Hiroyuki Kadoya, Masanobu Takeji, Yukinori Yamada, Harumasa Yoshihara, Atsushi Yamauchi,

A 67-year-old, hepatitis C virus (HCV)-positive woman was admitted to our hospital because of proteinuria and leg edema. Laboratory examination showed decreased serum albumin and complement activity and positive cryoglobulin. The HCV RNA genotype was 1b with high viral load. Kidney biopsy showed membranoproliferative glomerulonephritis (MPGN) with capillary deposition of ... Read more >>

Clin Exp Nephrol (Clinical and experimental nephrology)
[2010, 14(4):372-376]

Cited: 12 times

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A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis.

Kiwamu Okita, Isao Sakaida, Mitsuru Okada, Akira Kaneko, Kazuaki Chayama, Michio Kato, Michio Sata, Harumasa Yoshihara, Noriyuki Ono, Yoshikazu Murawaki,

<h4>Objectives</h4>We examined the efficacy of tolvaptan, an orally effective nonpeptide vasopressin V(2) receptor antagonist, in a Japanese clinical study in patients with intractable ascites and/or lower limb edema associated with decompensated liver cirrhosis.<h4>Methods</h4>Tolvaptan was orally administrated at titrated doses of 15, 30, and 60 mg once daily after breakfast for ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2010, 45(9):979-987]

Cited: 38 times

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Two cases of treatment with infliximab which replaced long-term home parenteral nutrition and maintained remission in patients with Crohn disease.

Narihiro Shibukawa, Riichiro Nezu, Maiko Murata, Masako Sato, Katsuhisa Noda, Masaki Hirota, Yukinori Yamada, Harumasa Yoshihara,

[Case 1] A 41-year-old man had undergone multiple bowel resections and consequently short bowel syndrome with high-output jejunostomy developed. In July 2008, he started infliximab (IFX) treatment and achieved remission and recovery from cholestatic liver damage following the cessation of home parenteral nutrition (HPN). [Case 2] A 29-year-old woman chose ... Read more >>

Nihon Shokakibyo Gakkai Zasshi (Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology)
[2010, 107(6):893-899]

Cited: 0 times

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[Investigation of simplified international diagnostic criteria for autoimmune hepatitis].

Akira Kaneko, Mitsuhiko Kubo, Ryoko Yamada, Tomoki Tanimura, Daisuke Yamaguchi, Moritoshi Yamamoto, Nobuyuki Tatsumi, Akihiro Nakama, Eiji Mita, Michio Kato, Taizo Hijioka, Masahide Oshita, Toshifumi Ito, Kazuho Imanaka, Kazuhiro Katayama, Masako Sato, Harumasa Yoshihara, Kazuo Kiriyama, Yasuharu Imai, Takeshi Kashihara, Hiroyuki Fukui, Kunio Suzuki, Shio Miyoshi, Akira Yamada, Takayuki Yakushijin, Kiyoshi Mochizuki, Naoki Hiramatsu, Tetsuo Takehara, Norio Hayashi,

The simplified international diagnostic criteria for autoimmune hepatitis (AIH), re-revised by the International AIH Group in 2008, were investigated in 114 patients with AIH from 15 centers in Japan. While applying of the criteria, we had to pay attention to anti-nuclear antibody measurement methods, and liver histology scoring. Definite and ... Read more >>

Nihon Shokakibyo Gakkai Zasshi (Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology)
[2010, 107(5):732-742]

Cited: 1 time

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Factors contributing to antiviral effect of adefovir dipivoxil therapy added to ongoing lamivudine treatment in patients with lamivudine-resistant chronic hepatitis B.

Nao Kurashige, Naoki Hiramatsu, Kazuyoshi Ohkawa, Takayuki Yakushijin, Shinichi Kiso, Tatsuya Kanto, Tetsuo Takehara, Akinori Kasahara, Yoshinori Doi, Akira Yamada, Masahide Oshita, Eiji Mita, Hideki Hagiwara, Toshihiko Nagase, Harumasa Yoshihara, Eijiro Hayashi, Yasuharu Imai, Michio Kato, Takeshi Kashihara, Norio Hayashi,

<h4>Purpose</h4>The antiviral effect of adefovir dipivoxil (ADV) added to ongoing lamivudine (LAM) treatment for LAM-resistant chronic hepatitis B (CHB) differs among patients. We investigated clinical factors affecting the response to ADV therapy in LAM-resistant CHB.<h4>Methods</h4>The subjects were 75 LAM-resistant CHB patients treated with ADV in addition to LAM. Virological response ... Read more >>

J Gastroenterol (Journal of gastroenterology)
[2009, 44(6):601-607]

Cited: 7 times

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[A case of perforating rectal ulcer with retroperitoneal emphysema treated with conservative medical management].

Hirokazu Iwata, Yoichiro Yoshida, Junichi Hasegawa, Riichiro Nezu, Narihiro Shibukawa, Harumasa Yoshihara, Kiyoshi Yoshikawa,

A 75-year-old woman complaining of sudden lower abdominal pain, fever, and bloody stool was admitted to the hospital. Abdominal CT scan showed retroperitoneal emphysema ranging from the retrorectal space to the posterior region of the kidney, and a stool-like shadow around the rectum. It suggested rectal ulcer and conservative management ... Read more >>

Nihon Shokakibyo Gakkai Zasshi (Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology)
[2009, 106(2):216-221]

Cited: 0 times

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Effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with chronic hepatitis.

Mika Kurokawa, Naoki Hiramatsu, Tsugiko Oze, Kiyoshi Mochizuki, Takayuki Yakushijin, Nao Kurashige, Yuko Inoue, Takumi Igura, Kazuho Imanaka, Akira Yamada, Masahide Oshita, Hideki Hagiwara, Eiji Mita, Toshifumi Ito, Yoshiaki Inui, Taizo Hijioka, Harumasa Yoshihara, Atsuo Inoue, Yasuharu Imai, Michio Kato, Shinichi Kiso, Tatsuya Kanto, Tetsuo Takehara, Akinori Kasahara, Norio Hayashi,

<h4>Aim</h4>The objective of this study was to elucidate the long-term effects of interferon (IFN)alpha-2b plus ribavirin combination therapy and to clarify whether this therapy can reduce the incidence of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C.<h4>Methods</h4>A total of 403 patients infected with hepatitis C virus (HCV) were enrolled ... Read more >>

Hepatol Res (Hepatology research : the official journal of the Japan Society of Hepatology)
[2009, 39(5):432-438]

Cited: 24 times

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