Full Text Journal Articles by
Author Harshal S Mandavdhare

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Oral Fluconazole Therapy in Patients With Active Ulcerative Colitis Who Have Detectable Candida in the Stool: A Double-Blind Randomized Placebo-controlled Trial.

Anuraag Jena, Usha Dutta, Jimil Shah, Vishal Sharma, Kaushal K Prasad, Rudramurthy M Shivaprakash, Harshal S Mandavdhare, Jayanta Samanta, Pankaj Sharma, Priyanka Popli, Arun K Sharma, Saroj K Sinha, Arunaloke Chakrabarti, Rakesh Kochhar,

<h4>Background</h4>There is an emerging role of fungal dysbiosis in the pathogenesis of inflammatory bowel disease. Prevalence of Candida in patients with active ulcerative colitis (UC) and the effect of fluconazole therapy in reducing disease activity of UC are not known.<h4>Patients and methods</h4>All consecutive consenting patients with active UC defined as ... Read more >>

J Clin Gastroenterol (Journal of clinical gastroenterology)
[2021, :]

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Peroral endoscopic myotomy (POEM) for esophageal diverticula.

Jayanta Samanta, Zaheer Nabi, Jahnvi Dhar, Harshal S Mandavdhare,

Esophageal diverticula (ED) are uncommon, mostly seen in elderly and can present with a multitude of symptoms. Of the three types of ED, epiphrenic and mid-esophageal diverticulum are still rare. These are often associated with esophageal motility disorder, which contributes to its development. The key step in the management of ... Read more >>

Minerva Gastroenterol (Torino) (Minerva gastroenterology)
[2021, :]

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TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India.

Narinder Grover, Prateek Bhatia, Antriksh Kumar, Minu Singh, Deepesh Lad, Harshal S Mandavdhare, Jayanta Samanta, Kaushal K Prasad, Usha Dutta, Vishal Sharma,

<h4>Background</h4>Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-15 (NUDT15) have been implicated as the predominant cause of thiopurine induced leukopenia in the Western countries and East Asia respectively. Exact role of these polymorphisms in South Asian population with inflammatory bowel disease (IBD) is uncertain.<h4>Methods</h4>We included consecutive patients with IBD who ... Read more >>

BMC Gastroenterol (BMC gastroenterology)
[2021, 21(1):327]

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'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial.

Vishal Sharma, Daya Krishna Jha, Manish Rohilla, Chandan K Das, Harjeet Singh, Santhosh Irrinki, Aashima Arora, Subhas C Saha, Pankaj Gupta, Harshal S Mandavdhare, Usha Dutta, Aman Sharma,

The sensitivity of single abdominal paracentesis for diagnosis of peritoneal carcinomatosis in patients with malignant ascites is 40-70%. Tumor cells shed from the peritoneum settle preferentially in certain recesses of the peritoneum. We aim to compare the standard technique of abdominal paracentesis versus a rollover technique in a randomized crossover study ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, 17(26):3425-3431]

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Per-oral Endoscopic Myotomy and Other Applications of Third Space Endoscopy: Current Status and Future Perspectives.

Harshal S Mandavdhare, Shubhra Mishra, Antriksh Kumar, Jimil Shah, Jayanta Samanta, Pankaj Gupta, Harjeet Singh, Usha Dutta,

<h4>Introduction</h4>The modification of NOTES (natural orifice transluminal endoscopic surgery) by mucosal safety flap has introduced us to the world of third space endoscopy (TSE). POEM (per-oral endoscopic myotomy) for achalasia cardia being its first vista, the realm expanded so that we can now remove en bloc a subepithelial/intramural tumor by ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, 31(5):624-636]

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Submucosal dissection of the septum or submucosal tunneling endoscopic septum division: should we wander the free path or follow the tunnel?

Harshal S Mandavdhare,

Endoscopy (Endoscopy)
[2021, 53(4):455]

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Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis.

Harshal S Mandavdhare, M Praveen Kumar, Dayakrishna Jha, Antriksh Kumar, Vishal Sharma, Pankaj Desai, Lada Shumkina, Pankaj Gupta, Harjeet Singh, Usha Dutta,

The traditional way to tackle Zenker's diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the efficacy ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, 18(3):436-450]

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Serial measurements of faecal calprotectin may discriminate intestinal tuberculosis and Crohn's disease in patients started on antitubercular therapy.

Vishal Sharma, Suhang Verma, Praveen Kumar-M, Harshal S Mandavdhare, Harjeet Singh, Jimil Shah, Dimple Kalsi, Amitava Dutta, Shubhra Mishra, Kaushal K Prasad, Arun K Sharma, Usha Dutta,

<h4>Background</h4>Response to antitubercular therapy (ATT) is often used to differentiate intestinal tuberculosis (ITB) from Crohn's disease. Role of non-invasive biomarkers to predict mucosal response to ATT is unclear.<h4>Materials and methods</h4>A prospective study to compare faecal calprotectin and serum C-reactive protein (CRP) levels at diagnosis, 2 and 6 months of ATT ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(3):334-338]

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Cost concerns, not the guidelines, drive clinical care of IBD during COVID pandemic in a resource limited setting.

Vishal Sharma, Jayendra Shukla, Vikas Suri, Anuraag Jena, Anirudh Mukerjee, Harshal S Mandavdhare, Ashish Bhalla, Usha Dutta,

Expert Rev Gastroenterol Hepatol (Expert review of gastroenterology & hepatology)
[2021, 15(4):465-466]

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Per Oral Endoscopic Myotomy for the Management of Large Esophageal Diverticula (D-POEM): Safe and Effective Modality for Complete Septotomy.

Jayanta Samanta, Harshal S Mandavdhare, Naveen Kumar, Praveen Kumar-M, Anudeep Jafra, Rajeev Chauhan, Pankaj Gupta, K Hemanth Kumar, Harjeet Singh, Usha Dutta, Rakesh Kochhar,

With the advent of the technique of sub-mucosal tunnelling, peroral endoscopic myotomy (POEM) has been used for the treatment of esophageal diverticulum, which otherwise is a recurring problem with conventional flexible endoscopic treatment due to incompleteness of septotomy. This study reports our experience of the use of diverticular POEM (D-POEM) ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

Cited: 2 times

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Retrograde Myotomy as an Alternative to Antegrade Myotomy in Peroral Endoscopic Myotomy (POEM) for Achalasia Cardia - Is It Better?

Harshal S Mandavdhare, Jayanta Samanta, Anudeep Jafra, Rajeev Chauhan, Harjeet Singh, Naveen Kumar, Kimavat Hemanth Kumar, Pankaj Gupta, Usha Dutta, Rakesh Kochhar,

<h4>Background</h4>Antegrade approach myotomy is usually performed in peroral endoscopic myotomy (POEM) for achalasia cardia. This study assessed the feasibility of retrograde approach as an alternative.<h4>Methods</h4>This is a retrospective review of a prospectively maintained database of patients undergoing POEM, comparing the 2 techniques of antegrade myotomy (AM) and retrograde myotomy (RM). ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, 31(4):444-447]

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Adjuvant use of combination of antibiotics in acute severe ulcerative colitis: A placebo controlled randomized trial.

Shubhra Mishra, Harshal S Mandavdhare, Harjeet Singh, Arup Choudhury, Jimil Shah, Sant Ram, Dimple Kalsi, Jayanta Samanta, Kaushal K Prasad, Arun K Sharma, Usha Dutta, Vishal Sharma,

<h4>Objectives</h4>Evaluation of a combination of antibiotics as an adjuvant therapy in acute severe ulcerative colitis (ASUC).<h4>Methods</h4>Patients with ASUC were randomized to either infusions of placebo or intravenous ceftriaxone and metronidazole in addition to standard care. Primary outcome was response on day three according to Oxford's criteria. Secondary outcome measures included ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2021, 19(7):949-955]

Cited: 3 times

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Management of gastrointestinal tuberculosis during COVID pandemic: Lessons for posterity.

Jayendra Shukla, Anuraag Jena, Harjeet Singh, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma,

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(4):394-396]

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Mandatory preprocedure testing for SARS-CoV-2 for all-comers may not be required for resuming endoscopic services amidst the ongoing COVID-19 pandemic.

Soumya Jagannath, Ashish Agarwal, Deepak Gunjan, Samir Mohindra, Vishal Sharma, Sudipta Dhar Chowdhury, Sanjeev Sachdeva, Vivek A Saraswat, Rakesh Kochhar, Anoop Saraya, ,

Gut (Gut)
[2021, 70(9):1805-1806]

Cited: 1 time

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Transversal Incision and Longitudinal Septostomy: "One Size Does Not Fit all".

Harshal S Mandavdhare,

Dig Dis (Digestive diseases (Basel, Switzerland))
[2021, 39(4):415-416]

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Xpert MTB/RIF for diagnosis of tubercular liver abscess. A case series.

Roshan Agarwala, Sahajal Dhooria, Niranjan S Khaire, Shubhra Mishra, Samman Verma, Jimil Shah, Harshal S Mandavdhare, Savita Kumari, Usha Dutta, Vishal Sharma,

Hepatic involvement is an infrequent manifestation of abdominal tuberculosis and could occur in form of granulomatous hepatitis, nodular involvement or abscess formation. Tubercular liver abscess (TLA) is uncommon, and diagnosing this entity is a challenge. Xpert MTB/RIF (Cepheid, Sunnyvale, CA, USA) assay has been widely used for diagnosing pulmonary tuberculosis ... Read more >>

Infez Med (Le infezioni in medicina)
[2020, 28(3):420-424]

Cited: 1 time

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Diagnostic accuracy of the Xpert MTB/RIF assay for abdominal tuberculosis: a systematic review and meta-analysis.

Vishal Sharma, Hariom Soni, Praveen Kumar-M, Saurabh Dawra, Shubhra Mishra, Harshal S Mandavdhare, Harjeet Singh, Usha Dutta,

<h4>Background</h4>We performed a meta-analysis to determine diagnostic accuracy of Xpert MTB/RIF for diagnosis of abdominal (intestinal or peritoneal) tuberculosis (TB) in various tissues (intestinal, omental/peritoneal tissue or ascitic fluid).<h4>Methods</h4>Electronic databases were searched for observational studies on use of Xpert MTB/RIF in ascitic fluid, peritoneal, or omental tissue for diagnosis of ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2021, 19(2):253-265]

Cited: 4 times

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Erodes and bleeds, fistulises and obstructs: Bouveret's syndrome.

Rinkal B Kakadiya, Uttam Thakur, Lileshwar Kaman, Harshal S Mandavdhare,

One of the rare complications of cholelithiasis is gallstone ileus which occurs in <5% of patients. Among them, <3% develop Bouveret's syndrome: gastric outlet obstruction by a large gallstone in the pylorus or duodenum. One large review of 128 patients showed it to present at a mean age of 74.1 ± 11.1 ... Read more >>

Trop Doct (Tropical doctor)
[2020, 50(4):383-385]

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FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study.

Abhi K Singh, Rajender Kumar, Pankaj Gupta, Praveen Kumar-M, Shubhra Mishra, Harshal S Mandavdhare, Harjeet Singh, Kaushal K Prasad, Usha Dutta, Vishal Sharma,

<h4>Background</h4>Ileocecal thickening (ICT) on imaging could result from diverse etiologies but may also be clinically insignificant.<h4>Aim</h4>Evaluation of role of combined 2-deoxy-2-fluorine-18-fluoro-D-glucose(<sup>18</sup>F-FDG)-positron emission tomography and computed tomographic enterography (PET-CTE) for determination of clinical significance of suspected ICT.<h4>Methods</h4>This prospective study enrolled consecutive patients with suspected ICT on ultrasound. Patients were evaluated with ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2021, 66(5):1620-1630]

Cited: 0 times

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Coronavirus Disease (COVID-19) and the Liver: A comprehensive systematic review and meta-analysis

Praveen Kumar-M, Shubhra Mishra, Daya Krishna Jha, Jayendra Shukla, Arup Choudhury, Ritin Mohindra, Harshal Mandavdhare, Usha Dutta, Vishal Sharma,

<h4>Background: </h4> Liver function derangements have been reported in coronavirus disease (COVID-19) but reported rates are variable. <h4>Methods: </h4>: We searched Pubmed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR) ... Read more >>

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Coronavirus disease (COVID-19) and the liver: a comprehensive systematic review and meta-analysis.

Praveen Kumar-M, Shubhra Mishra, Daya Krishna Jha, Jayendra Shukla, Arup Choudhury, Ritin Mohindra, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma,

<h4>Background</h4>Liver function derangements have been reported in coronavirus disease (COVID-19), but reported rates are variable.<h4>Methods</h4>We searched PubMed and Embase with terms COVID and SARS-COV-2 from December 1, 2019 till April 5, 2020. We estimated overall prevalence, stratified prevalence based on severity, estimated risk ratio (RR), and estimated standardized mean difference ... Read more >>

Hepatol Int (Hepatology international)
[2020, 14(5):711-722]

Cited: 31 times

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Per oral endoscopic myotomy with fundoplication is a technically feasible NOTES for achalasia cardia.

Harshal S Mandavdhare, Jayanta Samanta, Prerna Varma, Praveen Kumar-M, Pankaj Gupta, Harjeet Singh, Usha Dutta, Rakesh Kochhar,

<b>Background:</b> Per-oral endoscopic myotomy (POEM) has become the standard of care for the endoscopic management of achalasia but its major long-term adverse effect has been the development of reflux-associated symptoms and sequelae.<b>Aim:</b> This study was conducted to assess the feasibility and reproducibility of the technique of POEM with fundoplication (POEM + F), ... Read more >>

Minim Invasive Ther Allied Technol (Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy)
[2020, :1-6]

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Antibiotics for prophylaxis of spontaneous bacterial peritonitis: systematic review & Bayesian network meta-analysis.

Hariom Soni, Praveen Kumar-M, Vishal Sharma, Balaji L Bellam, Shubhra Mishra, Dhruv Mahendru, Harshal S Mandavdhare, Bikash Medhi, Usha Dutta, Virendra Singh,

<h4>Background</h4>Various antibiotic regimens are used for primary and secondary prevention of spontaneous bacterial peritonitis (SBP). A systematic review and network meta-analysis to compare various antibiotics regimens for primary and secondary prevention of SBP were done.<h4>Methods</h4>We did a comprehensive literature search using various databases (i.e. MEDLINE via Ovid and PubMed, Embase, ... Read more >>

Hepatol Int (Hepatology international)
[2020, 14(3):399-413]

Cited: 2 times

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Defining 'Satisfactory Response' to Therapy in Abdominal Tuberculosis: A Work in Progress.

Vishal Sharma, Harjeet Singh, Harshal S Mandavdhare,

Abdominal tuberculosis is difficult to diagnose due to low sensitivity of microbiological tests and the low histological yield. Satisfactory response to therapy has long been used a criteria for the diagnosis of abdominal tuberculosis. However, the appropriate definitions of response to therapy in abdominal tuberculosis have remained unclear. Recent evidence ... Read more >>

Infect Disord Drug Targets (Infectious disorders drug targets)
[2020, 20(2):111-114]

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Risk of hepatitis with various reintroduction regimens of anti-tubercular therapy: a systematic review and network meta-analysis.

Hariom Soni, Praveen Kumar-M, Shubhra Mishra, Balaji L Bellam, Harjeet Singh, Harshal S Mandavdhare, Bikash Medhi, Usha Dutta, Vishal Sharma,

<b>Objective</b>: To compare risk of hepatotoxicity between various regimens for reintroduction of antitubercular therapy (ATT) in patients with previous episode of ATT hepatitis.<b>Methods</b>: We searched various databases (PubMed, Embase, CENTRAL, Scopus, WoS and LILACS) for studies comparing ATT reintroduction regimens using terms 'drug-induced liver injury' and 'antitubercular drugs' AND 'reintroduction'. ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2020, 18(2):171-179]

Cited: 1 time

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