Full Text Journal Articles by
Author Harjeet Singh

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Oesophageal Tuberculosis: A Systematic Review Focusing on Clinical Management.

Chhagan Lal Birda, Antriksh Kumar, Pankaj Gupta, Harjeet Singh, Vishal Sharma,

Oesophageal tuberculosis, an uncommon form of extrapulmonary tuberculosis, has been reported mainly as small case series and the literature is heterogeneous. A systematic review to characterize the clinical presentation, evaluation and management of oesophageal tuberculosis was performed. Electronic databases were searched with keywords: esophagus OR esophageal AND tuberculosis. We included ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

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Utility of point-of-care urine trypsinogen dipstick test for diagnosing acute pancreatitis in an emergency unit.

Amar Simha, Atul Saroch, Ashok K Pannu, Deba P Dhibar, Navneet Sharma, Harjeet Singh, Vishal Sharma,

<b>Background:</b> A point-of-care diagnostic test for acute pancreatitis could help in early triage and management of this condition. <b>Materials & methods:</b> Urine trypsinogen dipstick test (UTDT) was performed in consecutive cases suspected to have acute pancreatitis and diagnostic accuracy calculated. <b>Results:</b> Of 187 patients, 90 were have acute pancreatitis and ... Read more >>

Biomark Med (Biomarkers in medicine)
[2021, 15(14):1271-1276]

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Prophylactic ligation of the opacified thoracic duct in minimally invasive esophagectomy - feasibility and safety.

Lunkhomba Takhellambam, Thakur Deen Yadav, Hemanth Kumar, Vikas Gupta, Cherring Tandup, Ujjwal Gorsi, Vishal Sharma, Harshal Mandhavdhare, Tanvir Samra, Harjeet Singh,

<h4>Background</h4>Chyle leak is a rare but morbid complication of esophagectomy. We assessed the feasibility of visualization and prophylactic ligation of the opacified thoracic duct (TD) after administration of 50 ml of olive oil.<h4>Methods</h4>This prospective single center study considered all patients with carcinoma of the middle and lower thirds of the ... Read more >>

Langenbecks Arch Surg (Langenbeck's archives of surgery)
[2021, 406(7):2515-2520]

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Tofacitinib in Acute Severe Ulcerative Colitis: Case Series and a Systematic Review.

Anuraag Jena, Shubhra Mishra, Anurag Sachan, Harjeet Singh, Anupam Kumar Singh, Vishal Sharma,

Inflamm Bowel Dis (Inflammatory bowel diseases)
[2021, 27(9):e101-e103]

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Surgical Management of Solid Pseudopapillary Neoplasm of Pancreas- An Experience from Tertiary Care Centre

Rohit Bhatta, Santosh Irrinki, Vikas Gupta, Thakur Deen Yadav, Yashwant Raj Sakaray, Hemanth Kumar, Ritambhra Nada, Harjeet Singh,

<h4>Background: </h4> Solid Pseudopapillary neoplasm (SPN) is uncommon and constitutes to 1-2% of pancreatic tumors. Owing to its rarity, literature is spare on its clinicopathological characteristics and surgical outcomes. <h4>Methods: </h4> Our study is a retrospective analysis of prospectively maintained data of patients with histologically proven SPN between January,2012 and ... Read more >>

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Outcome Following Percutaneous Transhepatic Biliary Drainage (PTBD) in Carcinoma Gallbladder: a Prospective Observational Study.

Vanji Nathan Subramani, Mohanasundaram Avudaiappan, Thakur Deen Yadav, Hemanth Kumar, Vishal Sharma, Harshal Mandavdhare, Ujjwal Gorsi, Harjeet Singh,

<h4>Introduction</h4>Percutaneous biliary drainage (PTBD) is required as palliation and optimization for surgery or chemotherapy in carcinoma gallbladder (GBC) but may be associated with complications. We aimed to study the outcomes, complications, and changes in quality of life in patients with GBC undergoing PTBD.<h4>Methods</h4>A prospective study from July 2018 to December ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2021, :]

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Role of Interleukin 6 in Prediction of Early Complications After Minimally Invasive Esophagectomy – A Pilot Study

Sivaraman kumarasamy, Hemanth Kumar, Vishal Sharma, Harshal Mandavdhare, Sant Ram, Harjeet Singh,

INTRODUCTION: Infectious complications following esophagectomy are associated with significant morbidity. Early prediction of these complications may mitigate significant morbidity and mortality METHODS: Patients undergoing minimally invasive esophagectomy for carcinoma esophagus between January 2019 to June 2020 were included in the study. All patients underwent standard preoperative investigations and ... Read more >>

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'Rollover' abdominal paracentesis versus standard technique: protocol of a crossover randomized comparative trial.

Vishal Sharma, Daya Krishna Jha, Manish Rohilla, Chandan K Das, Harjeet Singh, Santhosh Irrinki, Aashima Arora, Subhas C Saha, Pankaj Gupta, Harshal S Mandavdhare, Usha Dutta, Aman Sharma,

The sensitivity of single abdominal paracentesis for diagnosis of peritoneal carcinomatosis in patients with malignant ascites is 40-70%. Tumor cells shed from the peritoneum settle preferentially in certain recesses of the peritoneum. We aim to compare the standard technique of abdominal paracentesis versus a rollover technique in a randomized crossover study ... Read more >>

Future Oncol (Future oncology (London, England))
[2021, 17(26):3425-3431]

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P-selectin antibody treatment after blunt thoracic trauma prevents early pulmonary arterial thrombosis without changes in viscoelastic measurements of coagulation.

Linda M Schutzman, Rob R Rigor, Yung-Ling J Lin, An N Dang, Peter H Le, Harjeet B Singh, Bohan Yu, Peter H Wisner, Cristien C Musson, Isaiah J Clark, Joseph M Galante, Ian E Brown,

<h4>Introduction</h4>Previously, in a murine model of blunt thoracic trauma, we provided evidence of primary pulmonary thrombosis associated with increased expression of the cell adhesion molecule, P-selectin. In this study, mice are treated with P-selectin blocking antibody after injury to investigate the clinical viability of this antibody for the prevention of ... Read more >>

J Trauma Acute Care Surg (The journal of trauma and acute care surgery)
[2021, 90(6):1032-1039]

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Diverticular per oral endoscopic myotomy (DPOEM) for esophageal diverticular disease: a systematic review and meta-analysis.

Harshal S Mandavdhare, M Praveen Kumar, Dayakrishna Jha, Antriksh Kumar, Vishal Sharma, Pankaj Desai, Lada Shumkina, Pankaj Gupta, Harjeet Singh, Usha Dutta,

The traditional way to tackle Zenker's diverticulum (ZD) has been flexible endoscopic septum division (FESD). Recently, the concept of per oral endoscopic myotomy has been found useful for managing diverticular diseases of the esophagus and has been termed DPOEM. We performed a systematic review and meta-analysis to evaluate the efficacy ... Read more >>

Esophagus (Esophagus : official journal of the Japan Esophageal Society)
[2021, 18(3):436-450]

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Serial measurements of faecal calprotectin may discriminate intestinal tuberculosis and Crohn's disease in patients started on antitubercular therapy.

Vishal Sharma, Suhang Verma, Praveen Kumar-M, Harshal S Mandavdhare, Harjeet Singh, Jimil Shah, Dimple Kalsi, Amitava Dutta, Shubhra Mishra, Kaushal K Prasad, Arun K Sharma, Usha Dutta,

<h4>Background</h4>Response to antitubercular therapy (ATT) is often used to differentiate intestinal tuberculosis (ITB) from Crohn's disease. Role of non-invasive biomarkers to predict mucosal response to ATT is unclear.<h4>Materials and methods</h4>A prospective study to compare faecal calprotectin and serum C-reactive protein (CRP) levels at diagnosis, 2 and 6 months of ATT ... Read more >>

Eur J Gastroenterol Hepatol (European journal of gastroenterology & hepatology)
[2021, 33(3):334-338]

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Autologous CD33-CAR-T cells for treatment of relapsed/refractory acute myelogenous leukemia.

Francesco Paolo Tambaro, Harjeet Singh, Emily Jones, Michael Rytting, Kris M Mahadeo, Philip Thompson, Naval Daver, Courtney DiNardo, Tapan Kadia, Guillermo Garcia-Manero, Tim Chan, Rutul R Shah, William G Wierda,

Leukemia (Leukemia)
[2021, 35(11):3282-3286]

Cited: 4 times

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Anatomical Basis of Routine Caudate Lobe Resections in Hilar Cholangiocarcinoma.

Vishu Jain, Gautham Krishnamurthy, Hemanth Kumar, Daisy Sahni, Ujjwal Gorsi, Thakur Deen Yadav, Harjeet Singh,

J Gastrointest Surg (Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract)
[2021, 25(8):2114-2115]

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Per-oral Endoscopic Myotomy and Other Applications of Third Space Endoscopy: Current Status and Future Perspectives.

Harshal S Mandavdhare, Shubhra Mishra, Antriksh Kumar, Jimil Shah, Jayanta Samanta, Pankaj Gupta, Harjeet Singh, Usha Dutta,

<h4>Introduction</h4>The modification of NOTES (natural orifice transluminal endoscopic surgery) by mucosal safety flap has introduced us to the world of third space endoscopy (TSE). POEM (per-oral endoscopic myotomy) for achalasia cardia being its first vista, the realm expanded so that we can now remove en bloc a subepithelial/intramural tumor by ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, 31(5):624-636]

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Thoracoscopy-Assisted Esophagectomy vs Transhiatal Esophagectomy for Carcinoma Esophagus: a Prospective Comparison of Short-Term Outcomes.

Kunal Bikram Deo, Harjeet Singh, Vikas Gupta, Ashim Das, Ganga Ram Verma, Rajesh Gupta,

<h4>Introduction</h4>Transhiatal esophagectomy (THE) was popularized to reduce the morbidity of esophagectomy. Thoracoscopy-assisted esophagectomy (TAE) offers esophageal dissection under magnified vision. This study compares the short-term morbidity and oncological outcome following TAE and THE for esophageal carcinoma.<h4>Methodology</h4>This is a prospective comparative (January 2017-May 2018) study between TAE and THE for >cT1bN1 ... Read more >>

J Gastrointest Cancer (Journal of gastrointestinal cancer)
[2021, :]

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Outcome following Percutaneous Trans-hepatic Biliary Drainage (PTBD) in carcinoma gallbladder: A prospective observational study

Vanji Nathan Subramani, Mohanasundaram Avudaiappan, Thakur Deen Yadav, Hemanth Kumar, Vishal Sharma, Harshal Mandavdhare, Ujjwal Gorsi, Harjeet Singh,

<h4>Introduction: </h4> Percutaneous Biliary drainage (PTBD) is required as palliation and optimization for surgery or chemotherapy in carcinoma gallbladder (GBC) but may be associated with complications. We aimed to study the outcomes, complications and changes in quality of life in patients with GBC undergoing PTBD. <h4>Methods: </h4>: A prospective study ... Read more >>

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Per Oral Endoscopic Myotomy for the Management of Large Esophageal Diverticula (D-POEM): Safe and Effective Modality for Complete Septotomy.

Jayanta Samanta, Harshal S Mandavdhare, Naveen Kumar, Praveen Kumar-M, Anudeep Jafra, Rajeev Chauhan, Pankaj Gupta, K Hemanth Kumar, Harjeet Singh, Usha Dutta, Rakesh Kochhar,

With the advent of the technique of sub-mucosal tunnelling, peroral endoscopic myotomy (POEM) has been used for the treatment of esophageal diverticulum, which otherwise is a recurring problem with conventional flexible endoscopic treatment due to incompleteness of septotomy. This study reports our experience of the use of diverticular POEM (D-POEM) ... Read more >>

Dysphagia (Dysphagia)
[2021, :]

Cited: 2 times

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Adjuvant use of combination of antibiotics in acute severe ulcerative colitis: A placebo controlled randomized trial.

Shubhra Mishra, Harshal S Mandavdhare, Harjeet Singh, Arup Choudhury, Jimil Shah, Sant Ram, Dimple Kalsi, Jayanta Samanta, Kaushal K Prasad, Arun K Sharma, Usha Dutta, Vishal Sharma,

<h4>Objectives</h4>Evaluation of a combination of antibiotics as an adjuvant therapy in acute severe ulcerative colitis (ASUC).<h4>Methods</h4>Patients with ASUC were randomized to either infusions of placebo or intravenous ceftriaxone and metronidazole in addition to standard care. Primary outcome was response on day three according to Oxford's criteria. Secondary outcome measures included ... Read more >>

Expert Rev Anti Infect Ther (Expert review of anti-infective therapy)
[2021, 19(7):949-955]

Cited: 3 times

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Retrograde Myotomy as an Alternative to Antegrade Myotomy in Peroral Endoscopic Myotomy (POEM) for Achalasia Cardia - Is It Better?

Harshal S Mandavdhare, Jayanta Samanta, Anudeep Jafra, Rajeev Chauhan, Harjeet Singh, Naveen Kumar, Kimavat Hemanth Kumar, Pankaj Gupta, Usha Dutta, Rakesh Kochhar,

<h4>Background</h4>Antegrade approach myotomy is usually performed in peroral endoscopic myotomy (POEM) for achalasia cardia. This study assessed the feasibility of retrograde approach as an alternative.<h4>Methods</h4>This is a retrospective review of a prospectively maintained database of patients undergoing POEM, comparing the 2 techniques of antegrade myotomy (AM) and retrograde myotomy (RM). ... Read more >>

Surg Laparosc Endosc Percutan Tech (Surgical laparoscopy, endoscopy & percutaneous techniques)
[2021, 31(4):444-447]

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Management of gastrointestinal tuberculosis during COVID pandemic: Lessons for posterity.

Jayendra Shukla, Anuraag Jena, Harjeet Singh, Harshal S Mandavdhare, Usha Dutta, Vishal Sharma,

Dig Liver Dis (Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver)
[2021, 53(4):394-396]

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Sub-chronic and chronic toxicity evaluation of 7-methylxanthine: a new molecule for the treatment of myopia.

Harjeet Singh, Harmanpreet Singh, Nikhil Shri Sahajpal, Surinder Paul, Inderjit Kaur, Subheet Kumar Jain,

Myopia (nearsightedness) is a vision disorder with a blurring of far objects, affect millions worldwide. 7-methylxanthine (7-MX) is a molecule that is presently under clinical investigation for the treatment of myopia. In the present study, we have investigated sub-chronic and chronic toxicity of 7-MX in comparison to other clinically used ... Read more >>

Drug Chem Toxicol (Drug and chemical toxicology)
[2020, :1-12]

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Extra-hepatic biliary obstruction due to diffuse large B-cell lymphoma: an autopsy case report with unattended yet significant pathologies.

Pulkit Rastogi, Harjeet Singh, Pankaj Gupta, Amanjit Bal, Usha Dutta, Nalini Gupta,

Autopsy practice has been an invaluable tool to understand the pathobiology of various disease processes. We herein have given the description of a case of malignant extra-hepatic biliary obstruction secondary to a diffuse large B-cell lymphoma. The patient disease could only be adequately characterized at autopsy in the form of ... Read more >>

Clin J Gastroenterol (Clinical journal of gastroenterology)
[2021, 14(1):269-274]

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Role of ultrasound shear wave elastography in preoperative prediction of pancreatic fistula after pancreaticoduodenectomy.

Nakka Sushma, Pankaj Gupta, Hemanth Kumar, Vishal Sharma, Harshal Mandavdhare, Praveen Kumar-M, Ritambhra Nada, Thakur Deen Yadav, Harjeet Singh,

<h4>Background</h4>Majority of predictors of postoperative pancreatic fistula (POPF) use intraoperative variables. We aimed to study the role of preoperative ultrasound shear wave elastography (USWE) to predict POPF.<h4>Methods</h4>The consecutive patients who underwent pancreaticoduodenectomy (PD) between January 2019 to March 2020 were prospectively enrolled. All patients underwent USWE assessment at the pancreatic ... Read more >>

Pancreatology (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.])
[2020, 20(8):1764-1769]

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Novel Vitamin E TPGS based docetaxel nanovesicle formulation for its safe and effective parenteral delivery: Toxicological, pharmacokinetic and pharmacodynamic evaluation.

Amrinder Singh, Shubham Thakur, Harmanpreet Singh, Harjeet Singh, Sandeep Kaur, Satwinderjeet Kaur, Rajesh Dudi, Dilip Manikrao Mondhe, Subheet Kumar Jain,

Docetaxel (DTX) is a highly lipophilic, BCS class IV drug with poor aqueous solubility (12.7 µg/mL). Presently, only injectable formulation is available in the market which uses a large amount of surfactant (Tween 80) and dehydrated alcohol as a solubilizer. High concentrations of Tween 80 in injectable formulations are associated with ... Read more >>

J Liposome Res (Journal of liposome research)
[2021, 31(4):365-380]

Cited: 1 time

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Differentiating benign and malignant pancreatic masses: Ga-68 PSMA PET/CT as a new diagnostic avenue.

Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Vishal Sharma, Harjeet Singh, Ritambhra Nada, Amanjit Bal, Manish Rohilla, Harmandeep Singh, Surinder S Rana,

<h4>Objective</h4>Differentiation of malignant and benign pancreatic lesions on anatomical imaging is difficult in some cases with overlapping features. Prostate-specific membrane antigen (PSMA) is overexpressed during angioneogenesis in many tumors. We aimed to evaluate the PSMA expression in pancreatic lesions to differentiate these lesions and explore the performance of Ga-68 PSMA-PET/CT ... Read more >>

Eur Radiol (European radiology)
[2021, 31(4):2199-2208]

Cited: 1 time

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