Full Text Journal Articles by
Author Hardeep Kaur

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Possible prophylactic or preventive role of topical povidone iodine during accidental ocular exposure to 2019-nCoV.

Phulen Sarma, Hardeep Kaur, Bikash Medhi, Anusuya Bhattacharyya,

Graefes Arch. Clin. Exp. Ophthalmol. (Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie)
[2020, :]

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Virological and clinical cure in COVID-19 patients treated with hydroxychloroquine: A systematic review and meta-analysis.

Phulen Sarma, Hardeep Kaur, Harish Kumar, Dhruv Mahendru, Pramod Avti, Anusuya Bhattacharyya, Manisha Prajapat, Nishant Shekhar, Subodh Kumar, Rahul Singh, Ashutosh Singh, Deba Prasad Dhibar, Ajay Prakash, Bikash Medhi,

Following the demonstration of the efficacy of hydroxychloroquine against severe acute respiratory syndrome coronavirus 2 in vitro, many trials started to evaluate its efficacy in clinical settings. However, no systematic review and meta-analysis have addressed the issue of the safety and efficacy of hydroxychloroquine (HCQ) in coronavirus disease 2019. We ... Read more >>

J. Med. Virol. (Journal of medical virology)
[2020, :]

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Winter-Active Spider Fauna is Affected by Plantation Forest Type.

Kapilkumar Ingle, Hardeep Kaur, Nikolett Gallé-Szpisjak, József Bürgés, Áron Szabó, Róbert Gallé,

Plantations of non-native trees for commercial use are common practice in Europe. They are known to have severe ecological impacts on arthropod fauna by altering microclimatic conditions and reducing microhabitat diversity. However, the effect of plantation tree species on winter-active fauna is relatively unknown. Spiders are a diverse predatory arthropod ... Read more >>

Environ. Entomol. (Environmental entomology)
[2020, :]

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Bacteriological pattern and their correlation with complications in culture positive cases of acute bacterial conjunctivitis in a tertiary care hospital of upper Assam: A cross sectional study.

Anusuya Bhattacharyya, Phulen Sarma, Bhaswati Sarma, Subodh Kumar, Tapan Gogoi, Hardeep Kaur, Manish Prajapat,

Acute conjunctivitis is inflammation of conjunctiva of less than 3 to 4 weeks duration, characterized by cellular infiltration and exudation. It may also result into corneal, lid or orbital involvement which may lead to various complications.A hospital based prospective study was conducted in Assam Medical College and Hospital with 110 ... Read more >>

Medicine (Baltimore) (Medicine)
[2020, 99(7):e18570]

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Therapeutic options for the treatment of 2019-novel coronavirus: An evidence-based approach.

Phulen Sarma, Manisha Prajapat, Pramod Avti, Hardeep Kaur, Subodh Kumar, Bikash Medhi,

Indian J Pharmacol (Indian journal of pharmacology)
[2020, 52(1):1-5]

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Therapeutic options for management of Hori's nevus: A systematic review.

Harpinder Kaur, Phulen Sarma, Sukhmandeep Kaur, Hardeep Kaur, Manisha Prajapat, Saniya Mahendiratta, Subodh Kumar, Prasad Thota, Davinder Parsad, Bikash Medhi,

Hori's nevus is a pigmentation disorder reported mainly in middle-aged Asian women. There is no systematic review addressing its pharmacotherapy. The population for our systematic review was patients with a clinical/histological diagnosis of Hori's nevus (both sex, any age group). We screened five literature databases using relevant keywords. All RCTs, ... Read more >>

Dermatol Ther (Dermatologic therapy)
[2020, 33(1):e13167]

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Unresolved Recombination Intermediates Cause a RAD9-Dependent Cell Cycle Arrest in Saccharomyces cerevisiae.

Hardeep Kaur, Krishnaprasad Gn, Michael Lichten,

In Saccharomyces cerevisiae, the conserved Sgs1-Top3-Rmi1 helicase-decatenase regulates homologous recombination by limiting accumulation of recombination intermediates that are crossover precursors. In vitro studies have suggested that this may be due to dissolution of double-Holliday junction joint molecules by Sgs1-driven convergent junction migration and Top3-Rmi1 mediated strand decatenation. To ask whether ... Read more >>

Genetics (Genetics)
[2019, 213(3):805-818]

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Making Blind Children See: Impact of Correcting Moderate and Severe Visual Impairment in Schools for the Blind.

Parikshit M Gogate, Tonmoy Chottopadhyay, Hardeep Kaur, Sravanthi Narayandas, Supriya Phadke, Meena Kharat, Ashok Dhangar, Minaj Inamdar, Akshay Badkere, Rohit C Khanna,

PURPOSE:Childhood blindness and visual impairment accounts for enormous burden of blindness. This study aimed to analyze the causes of severe visual impairment and blindness in students attending schools for the blind and to identify those whose vision could be improved by optical aids. On dispensing such aids, the study also ... Read more >>

Middle East Afr J Ophthalmol (Middle East African journal of ophthalmology)
[2019, 26(4):216-222]

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Structure elaboration of isoniazid: synthesis, in silico molecular docking and antimycobacterial activity of isoniazid-pyrimidine conjugates.

Hardeep Kaur, Lovepreet Singh, Kelly Chibale, Kamaljit Singh,

Designing small molecule-based new drug candidates through structure modulation of the existing drugs has drawn considerable attention in view of inevitable emergence of resistance. A new series of isoniazid-pyrimidine conjugates were synthesized in good yields and evaluated for antitubercular activity against the H37Rv strain of Mycobacterium tuberculosis using the microplate ... Read more >>

Mol. Divers. (Molecular diversity)
[2019, :]

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A RAD9-dependent cell cycle arrest in response to unresolved recombination intermediates in Saccharomyces cerevisiae

Hardeep Kaur, GN Krishnaprasad, Michael Lichten,

Abstract In Saccharomyces cerevisiae , the conserved Sgs1-Top3-Rmi1 helicase-decatenase regulates homologous recombination by limiting accumulation of recombination intermediates that are precursors of crossovers. In vitro studies have suggested that the dissolution of double-Holliday junction joint molecules by Sgs1-driven convergent junction migration and Top3-Rmi1 mediated strand decatenation could be responsible for ... Read more >>

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Novel targets for drug discovery in celiac disease.

Rahul Soloman Singh, Ashutosh Singh, Gitika Batra, Hardeep Kaur, Bikash Medhi,

Celiac disease is a lifelong, immunological disorder induced by dietary protein-gluten, in a genetically susceptible populations, resulting in different clinical manifestations, the release of antibodies, and damage to the intestinal mucosa. The only recommended therapy for the disease is to strictly follow a gluten-free diet (GFD), which is difficult to ... Read more >>

Indian J Pharmacol (Indian journal of pharmacology)
[2019, 51(5):359-365]

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S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates.

Laura J Hunt, Emad A Ahmed, Hardeep Kaur, Jasvinder S Ahuja, Lydia Hulme, Ta-Chung Chou, Michael Lichten, Alastair S H Goldman,

We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilises Rad51-DNA filaments and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find that Srs2 activity is required for normal meiotic progression and spore viability. A significant fraction of srs2 mutant ... Read more >>

Chromosoma (Chromosoma)
[2019, 128(3):249-265]

Cited: 1 time

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Investigation of antiplasmodial efficacy of lupeol and ursolic acid isolated from Ficus benjamina leaves extract.

Amandeep Singh, Hayat Mohammad Mukhtar, Hardeep Kaur, Lakhvir Kaur,

This study emphasizes on the investigation of antiplasmodial activity of triterpenoids isolated from Ficus benjamina leaves. An unsaponified fraction of petroleum ether extract of plant leaves was subjected to silica gel column chromatography which led to the isolation of two known triterpenoids; namely ursolic acid and lupeol. These compounds were ... Read more >>

Nat. Prod. Res. (Natural product research)
[2019, :1-4]

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S. cerevisiae Srs2 helicase ensures normal recombination intermediate metabolism during meiosis and prevents accumulation of Rad51 aggregates: Supplemental Table S1-yeast strains

Laura Hunt, Emad Ahmed, Hardeep Kaur, Jasvinder Ahuja, Lydia Hulme, Ta-Chung Chou, Michael Lichten, Alastair S.H. Goldman,

We investigated the meiotic role of Srs2, a multi-functional DNA helicase/translocase that destabilizes Rad51-DNA filaments, and is thought to regulate strand invasion and prevent hyper-recombination during the mitotic cell cycle. We find that Srs2 activity is required for normal meiotic progression and spore viability. A significant fraction of srs2 mutant ... Read more >>

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Development and validation of RP-HPLC method for the determination of stigmasterol in the botanical extract of Ficus deltoidea.

Hayat Mohammad Mukhtar, Amandeep Singh, Varinder Soni, Atinderpal Singh, Hardeep Kaur,

A simple, rapid, accurate and precise RP-HPLC method was developed for the determination of stigmasterol in botanical extract of Ficus deltoidea. Separation was achieved with acetonitrile and acetic acid in water (75:25% v/v) in isocratic mode at 210 nm. Single sharp peak of standard stigmasterol was detected at retention time 3.17 min ... Read more >>

Nat. Prod. Res. (Natural product research)
[2019, 33(19):2868-2872]

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CYP2E1 activity and children with obesity: possible confounding factors.

Hardeep Kaur, Phulen Sarma, Ajay Prakash, Bikash Medhi,

Lots of factors can influence CYP2E1 activities, e.g. thyroid status, different types of anaemia (fanconi anaemia and sideroblastic anaemia), etc. Alcohol is a known inducer of CYP2E1, therefore a justifiable duration of abstinence is required before the subjects are enrolled into a study for normalization of CYP2E1 activity. In this ... Read more >>

Br J Clin Pharmacol (British journal of clinical pharmacology)
[2019, 85(2):457]

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Clientele satisfaction: An unmet need of the hour!!!

Hardeep Kaur, Gaurav Mahajan,

Med J Armed Forces India (Medical journal, Armed Forces India)
[2019, 75(3):353-354]

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Bio-analytical applications of nicking endonucleases assisted signal-amplification strategies for detection of cancer biomarkers -DNA methyl transferase and microRNA.

Sunil Mittal, Shweta Thakur, Anil Kumar Mantha, Hardeep Kaur,

The low concentrations of cancer biomarkers in the blood have limited the utility of quantitative bioassays developed for the purpose. The advent of nicking endonucleases (NEases) as signal amplification tools have greatly enhanced the detection efficiency and provided a multi-optional platform to design target specific detection methods. The present review ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2019, 124-125:233-243]

Cited: 2 times

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Interferon alpha: A rare cause of persistent pulmonary hypertension of newborn.

Hardeep Kaur, Harish Sethi, Gaurav Mahajan,

Med J Armed Forces India (Medical journal, Armed Forces India)
[2020, 76(1):115-117]

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Study of pain response in neonates during venipuncture with a view to analyse utility of topical anaesthetic agent for alleviating pain.

Hardeep Kaur, Vandana Negi, Mukti Sharma, Gaurav Mahajan,

Background:Neonates being nonverbal are unable to express their pain leading to underestimation of their pain and hence insufficient pain relief. Neonatal pain is assessed by pain scales based on the behavioural and physiological changes that occur in response to painful stimuli. This cross sectional study was conducted at a tertiary ... Read more >>

Med J Armed Forces India (Medical journal, Armed Forces India)
[2019, 75(2):140-145]

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Methods for Controlled Protein Depletion to Study Protein Function during Meiosis.

Hardeep Kaur, Jasvinder S Ahuja, Michael Lichten,

Proteins with potential roles in meiotic recombination often have essential or important functions during the mitotic cell cycle. In addition, proteins may have different functions at different times during meiosis. In such cases, it can be challenging to precisely determine protein function during meiosis using null or hypomorphic mutants. One ... Read more >>

Meth. Enzymol. (Methods in enzymology)
[2018, 601:331-357]

Cited: 3 times

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Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies.

Sunil Mittal, Hardeep Kaur, Nandini Gautam, Anil K Mantha,

Breast cancer is highly prevalent in females and accounts for second highest number of deaths, worldwide. Cumbersome, expensive and time consuming detection techniques presently available for detection of breast cancer potentiates the need for development of novel, specific and ultrasensitive devices. Biosensors are the promising and selective detection devices which ... Read more >>

Biosens Bioelectron (Biosensors & bioelectronics)
[2017, 88:217-231]

Cited: 18 times

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Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1.

Xiaoyu Xue, Alma Papusha, Koyi Choi, Jaclyn N Bonner, Sandeep Kumar, Hengyao Niu, Hardeep Kaur, Xiao-Feng Zheng, Roberto A Donnianni, Lucy Lu, Michael Lichten, Xiaolan Zhao, Grzegorz Ira, Patrick Sung,

We identified Mte1 (Mph1-associated telomere maintenance protein 1) as a multifunctional regulator of Saccharomyces cerevisiae Mph1, a member of the FANCM family of DNA motor proteins important for DNA replication fork repair and crossover suppression during homologous recombination. We show that Mte1 interacts with Mph1 and DNA species that resemble ... Read more >>

Genes Dev. (Genes & development)
[2016, 30(6):687-699]

Cited: 12 times

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Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids.

Hardeep Kaur, Jan Balzarini, Carmen de Kock, Peter J Smith, Kelly Chibale, Kamaljit Singh,

A series of hybrids comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of pyrimidine displayed the highest antiplasmodial activity [IC50 = 56 nM] against the CQ(R) (Dd2) strain, which is four-fold greater than ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2015, 101:52-62]

Cited: 2 times

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Primaquine-pyrimidine hybrids: synthesis and dual-stage antiplasmodial activity.

Hardeep Kaur, Marta Machado, Carmen de Kock, Peter Smith, Kelly Chibale, Miguel Prudêncio, Kamaljit Singh,

A series of novel pyrimidine-primaquine hybrids were synthesized and their effectiveness against the blood and liver stages of malaria parasites was evaluated. The hybrids displayed enhanced liver stage in vitro activity against P. berghei liver stage infection. ... Read more >>

Eur J Med Chem (European journal of medicinal chemistry)
[2015, 101:266-273]

Cited: 2 times

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