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Interventional occlusion of left atrial appendage in patients with atrial fibrillation. Gender-related outcomes in the German LAARGE Registry.

Caroline Kleinecke, Thorsten Lewalter, Horst Sievert, Volker Geist, Uwe Zeymer, Harald Mudra, Sven Pleger, Matthias Hochadel, Jochen Senges, Johannes Brachmann,

<h4>Introduction</h4>Gender-based differences in atrial fibrillation have been identified, but limited data exist for patients undergoing left atrial appendage occluder (LAAO) implantation. This study reports gender-related periprocedural and 1-year outcomes of the prospective, multicenter German left atrial appendage occlusion registry (LAARGE).<h4>Methods</h4>LAARGE enrolled 641 patients who were scheduled for LAAO implantation from ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, :]

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Contralateral Stenosis and Echolucent Plaque Morphology are Associated with Elevated Stroke Risk in Patients Treated with Asymptomatic Carotid Artery Stenosis within a Controlled Clinical Trial (SPACE-2).

Tilman Reiff, Hans-Henning Eckstein, Ulrich Mansmann, Olav Jansen, Gustav Fraedrich, Harald Mudra, Dittmar Böckler, Michael Böhm, Hartmut Brückmann, E Sebastian Debus, Jens Fiehler, Klaus Mathias, E Bernd Ringelstein, Jürg Schmidli, Robert Stingele, Ralf Zahn, Thomas Zeller, Wolf-Dirk Niesen, Kristian Barlinn, Andreas Binder, Jörg Glahn, Peter Arthur Ringleb, ,

<h4>Background</h4>Asymptomatic carotid artery stenosis (ACS) has a low risk of stroke. To achieve an advantage over noninterventional best medical treatment (BMT), carotid endarterectomy (CEA) or carotid artery stenting (CAS) must be performed with the lowest possible risk of stroke. Therefore, an analysis of risk-elevating factors is essential. Grade of ipsilateral ... Read more >>

J Stroke Cerebrovasc Dis (Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association)
[2021, 30(9):105940]

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Ultrasonography Grading of Internal Carotid Artery Disease: Multiparametric German Society of Ultrasound in Medicine (DEGUM) versus Society of Radiologists in Ultrasound (SRU) Consensus Criteria.

Simon Winzer, Henning Rickmann, Hagen Kitzler, Andrij Abramyuk, Christos Krogias, Henning Strohm, Jessica Barlinn, Lars-Peder Pallesen, Timo Siepmann, Sebastian Arnold, Peter Moennings, Harald Mudra, Jennifer Linn, Heinz Reichmann, Norbert Weiss, Georg Gahn, Andrei Alexandrov, Volker Puetz, Kristian Barlinn,

<h4>Purpose</h4> We sought to determine the diagnostic agreement between the revised ultrasonography approach by the German Society of Ultrasound in Medicine (DEGUM) and the established Society of Radiologists in Ultrasound (SRU) consensus criteria for the grading of carotid artery disease.<h4>Materials and methods</h4> Post-hoc analysis of a prospective multicenter study, in which patients ... Read more >>

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2021, :]

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Management of Pulmonary Embolism: Results from the German Chest Pain Unit Registry.

Stephan Settelmeier, Matthias Hochadel, Evangelos Giannitsis, Stavros Konstantinides, Thomas Voigtländer, Claus Schmitt, Michael Haude, Sebastian Kerber, Harald Mudra, Bernd-Dieter Gonska, Jochen Senges, Frank Breuckmann, Thomas Münzel,

<h4>Introduction</h4>Since 2008, specialized chest pain units (CPUs) were implemented across Germany ensuring structured diagnostics in acute chest pain. This study aims to analyze the management of pulmonary embolism (PE) patients in such certified CPUs.<h4>Methods</h4>Data were retrieved from 13,902 patients enrolled in the German CPU registry and analyzed for the diagnosis ... Read more >>

Cardiology (Cardiology)
[2021, 146(3):304-310]

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WATCHMAN versus ACP or Amulet devices for left atrial appendage occlusion: a sub-analysis of the multicentre LAARGE registry.

Jakob Ledwoch, Jennifer Franke, Ibrahim Akin, Volker Geist, Christian Weiß, Uwe Zeymer, Sven Pleger, Matthias Hochadel, Harald Mudra, Jochen Senges, Thorsten Lewalter, Johannes Brachmann, Horst Sievert,

<h4>Aims</h4>Several left atrial appendage (LAA) closure systems are available. Due to differences in device design, the results of specific occluders derived from trials cannot simply be generalised to all devices. The present analysis sought to assess two contemporary LAA closure devices in clinical practice.<h4>Methods and results</h4>The work represents a non-randomised ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2020, 16(11):e942-e949]

Cited: 1 time

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Further Down the Road?

Harald Mudra,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2020, 13(14):1716-1717]

Cited: 0 times

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Left atrial appendage closure in patients with a reduced left ventricular ejection fraction: results from the multicenter German LAARGE registry.

Christian Fastner, Johannes Brachmann, Thorsten Lewalter, Uwe Zeymer, Horst Sievert, Martin Borggrefe, Christian Weiß, Volker Geist, Alexander Krapivsky, Matthias Käunicke, Harald Mudra, Matthias Hochadel, Steffen Schneider, Jochen Senges, Ibrahim Akin,

<h4>Background</h4>Interventional left atrial appendage closure (LAAC) effectively prevents thromboembolic events in atrial fibrillation patients. Impaired left ventricular ejection fraction (LVEF) increases not only the thromboembolic risk but also the complication rates of cardiac interventions. The LAAC procedure's benefit in patients with an impaired LVEF, therefore, has yet to be investigated.<h4>Methods</h4>LAARGE ... Read more >>

Clin Res Cardiol (Clinical research in cardiology : official journal of the German Cardiac Society)
[2020, 109(11):1333-1341]

Cited: 1 time

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Interventional occlusion of left atrial appendage in patients with atrial fibrillation. Acute and long-term outcome of occluder implantation in the LAARGE Registry.

Johannes Brachmann, Thorsten Lewalter, Ibrahim Akin, Horst Sievert, Volker Geist, Uwe Zeymer, Damir Erkapic, Harald Mudra, Sven Pleger, Matthias Hochadel, Jochen Senges,

BACKGROUND:Left atrial appendage occluder (LAAO) implantation is an alternative method for stroke prevention in atrial fibrillation (AF) patients who are not eligible for long-term oral anticoagulation. The present paper describes the acute and 1-year follow-up outcome data of the prospective, multicenter German left atrial appendage occlusion registry (LAARGE). METHODS:LAARGE enrolled ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2020, 58(3):273-280]

Cited: 2 times

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Long-term transesophageal echocardiography follow-up after percutaneous left atrial appendage closure.

Stephan Staubach, Leonhard Schlatterbeck, Moritz Mörtl, Henning Strohm, Petra Hoppmann, Karl-Ludwig Laugwitz, Harald Mudra, Jakob Ledwoch,

<h4>Background</h4>Peri-device leaks and device thrombi are assumed to lead to ischemic events after percutaneous left atrial appendage occlusion (LAAO). While these device-related complications are well assessed until 12 months after LAAO, no data are available beyond this period.<h4>Objective</h4>The purpose of this study was to assess device-related complications beyond 12 months ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(5 Pt A):728-733]

Cited: 1 time

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Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes.

Stefanie Schüpke, Franz-Josef Neumann, Maurizio Menichelli, Katharina Mayer, Isabell Bernlochner, Jochen Wöhrle, Gert Richardt, Christoph Liebetrau, Bernhard Witzenbichler, David Antoniucci, Ibrahim Akin, Lorenz Bott-Flügel, Marcus Fischer, Ulf Landmesser, Hugo A Katus, Dirk Sibbing, Melchior Seyfarth, Marion Janisch, Duino Boncompagni, Raphaela Hilz, Wolfgang Rottbauer, Rainer Okrojek, Helge Möllmann, Willibald Hochholzer, Angela Migliorini, Salvatore Cassese, Pasquale Mollo, Erion Xhepa, Sebastian Kufner, Axel Strehle, Stefan Leggewie, Abdelhakim Allali, Gjin Ndrepepa, Helmut Schühlen, Dominick J Angiolillo, Christian W Hamm, Alexander Hapfelmeier, Ralph Tölg, Dietmar Trenk, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, ,

<h4>Background</h4>The relative merits of ticagrelor as compared with prasugrel in patients with acute coronary syndromes for whom invasive evaluation is planned are uncertain.<h4>Methods</h4>In this multicenter, randomized, open-label trial, we randomly assigned patients who presented with acute coronary syndromes and for whom invasive evaluation was planned to receive either ticagrelor or ... Read more >>

N Engl J Med (The New England journal of medicine)
[2019, 381(16):1524-1534]

Cited: 50 times

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Diabetes and outcomes following guided de-escalation of antiplatelet treatment in acute coronary syndrome patients undergoing percutaneous coronary intervention: a pre-specified analysis from the randomised TROPICAL-ACS trial.

Ralph Hein, Lisa Gross, Dániel Aradi, Johannes Rieber, Martin Hadamitzky, Béla Merkely, Zenon Huczek, Hüseyin Ince, Astrid Hummel, Monika Baylacher, Steffen Massberg, Dietmar Trenk, Dirk Sibbing, ,

<h4>Aims</h4>A guided de-escalation of P2Y12 inhibitor treatment is considered an alternative treatment strategy in ACS patients undergoing PCI. However, the safety and efficacy of this strategy may differ in diabetic vs non-diabetic patients. The aim of this study was to compare the outcomes of platelet function testing (PFT)-guided de-escalation of ... Read more >>

EuroIntervention (EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology)
[2019, 15(6):e513-e521]

Cited: 2 times

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Authors’ Response to Letter: Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study.

Kristian Barlinn, Georg Gahn, Christos Krogias, Harald Mudra, Andrei V Alexandrov, Norbert Weiss, Volker Puetz,

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2019, 40(4):517]

Cited: 0 times

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Effect of renal insufficiency and diabetes mellitus on in-hospital mortality after acute coronary syndromes treated with primary PCI. Results from the ALKK PCI Registry.

Spyridon Liosis, Matthias Hochadel, Harald Darius, Steffen Behrens, Harald Mudra, Bernward Lauer, Albrecht Elsässer, Anselm K Gitt, Ralf Zahn, Uwe Zeymer, ,

<h4>Background</h4>It is known that patients with acute coronary syndromes (ACS) and diabetes mellitus (DM) are at higher risk for in-hospital adverse events. However, we hypothesized that the higher event rate is due to the patients' subgroup with renal failure (RF), a common sequel of DM.<h4>Methods and results</h4>We used data of ... Read more >>

Int J Cardiol (International journal of cardiology)
[2019, 292:43-49]

Cited: 1 time

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Evaluating Real-World Clinical Outcomes in Atrial Fibrillation Patients Receiving the WATCHMAN Left Atrial Appendage Closure Technology: Final 2-Year Outcome Data of the EWOLUTION Trial Focusing on History of Stroke and Hemorrhage.

Lucas V Boersma, Hueseyin Ince, Stephan Kische, Evgeny Pokushalov, Thomas Schmitz, Boris Schmidt, Tommaso Gori, Felix Meincke, Alexey Vladimir Protopopov, Timothy Betts, Patrizio Mazzone, David Foley, Marek Grygier, Horst Sievert, Tom De Potter, Elisa Vireca, Kenneth Stein, Martin W Bergmann, ,

BACKGROUND:Left atrial appendage occlusion with WATCHMAN has emerged as viable alternative to vitamin K antagonists in randomized controlled trials. Evaluating real-life clinical outcomes in atrial fibrillation patients receiving the WATCHMAN left atrial appendage closure technology was designed to collect prospective multicenter outcomes of thromboembolic events, bleeding, and mortality for patients ... Read more >>

Circ Arrhythm Electrophysiol (Circulation. Arrhythmia and electrophysiology)
[2019, 12(4):e006841]

Cited: 16 times

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A New Milestone in Carotid Stenting?

Harald Mudra, Jakob Ledwoch,

JACC Cardiovasc Interv (JACC. Cardiovascular interventions)
[2018, 11(23):2412-2413]

Cited: 0 times

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Immediate unselected coronary angiography versus delayed triage in survivors of out-of-hospital cardiac arrest without ST-segment elevation: Design and rationale of the TOMAHAWK trial.

Steffen Desch, Anne Freund, Tobias Graf, Stephan Fichtlscherer, Hendrik Haake, Michael Preusch, Fabian Hammer, Ibrahim Akin, Martin Christ, Christoph Liebetrau, Carsten Skurk, Stephan Steiner, Ingo Voigt, Roland Schmitz, Harald Mudra, Jakob Ledwoch, Niels Menck, Jan Horstkotte, Klaus Pels, Anna-Lena Lahmann, Sylvia Otto, Karsten Lenk, Marc-Alexander Ohlow, Christian Hassager, Peter Nordbeck, Uwe Zeymer, Alexander Jobs, Suzanne de Waha-Thiele, Denise Olbrich, Inke König, Kathrin Klinge, Holger Thiele,

Patients experiencing out-of-hospital cardiac arrest (OHCA) without ST-segment elevation are a heterogenic group with a variety of underlying causes. Up to one-third of patients display a significant coronary lesion compatible with myocardial infarction as OHCA trigger. There are no randomized data on patient selection and timing of invasive coronary angiography ... Read more >>

Am Heart J (American heart journal)
[2019, 209:20-28]

Cited: 3 times

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One-Year Outcomes after PCI Strategies in Cardiogenic Shock.

Holger Thiele, Ibrahim Akin, Marcus Sandri, Suzanne de Waha-Thiele, Roza Meyer-Saraei, Georg Fuernau, Ingo Eitel, Peter Nordbeck, Tobias Geisler, Ulf Landmesser, Carsten Skurk, Andreas Fach, Alexander Jobs, Harald Lapp, Jan J Piek, Marko Noc, Tomaž Goslar, Stephan B Felix, Lars S Maier, Janina Stepinska, Keith Oldroyd, Pranas Serpytis, Gilles Montalescot, Olivier Barthelemy, Kurt Huber, Stephan Windecker, Lukas Hunziker, Stefano Savonitto, Patrizia Torremante, Christiaan Vrints, Steffen Schneider, Uwe Zeymer, Steffen Desch, ,

<h4>Background</h4>Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found to be lower with percutaneous coronary intervention (PCI) of the culprit lesion only than ... Read more >>

N Engl J Med (The New England journal of medicine)
[2018, 379(18):1699-1710]

Cited: 48 times

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Guideline-adherence regarding critical time intervals in the German Chest Pain Unit registry.

Mehrshad Vafaie, Matthias Hochadel, Thomas Münzel, Birgit Hailer, Burghard Schumacher, Gerd Heusch, Thomas Voigtländer, Harald Mudra, Michael Haude, Sebastian Barth, Claus Schmitt, Harald Darius, Lars S Maier, Hugo A Katus, Jochen Senges, Evangelos Giannitsis,

BACKGROUND:Since 2008, the German Cardiac Society certified 256 Chest Pain Units (CPUs). Little is known about adherence to recommended performance measures in patients with suspected acute coronary syndrome (ACS) presenting to CPUs. We investigated guideline-adherence regarding critical time intervals and selected performance measures in German Chest Pain Units. METHODS:From 2008 ... Read more >>

Eur Heart J Acute Cardiovasc Care (European heart journal. Acute cardiovascular care)
[2020, 9(1):52-61]

Cited: 3 times

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Validation of Multiparametric Ultrasonography Criteria with Digital Subtraction Angiography in Carotid Artery Disease: A Prospective Multicenter Study.

Kristian Barlinn, Henning Rickmann, Hagen Kitzler, Christos Krogias, Henning Strohm, Andrij Abramyuk, Jessica Barlinn, Timo Siepmann, Ali Rabahi, Xina Graehlert, Uta Schwanebeck, Simon Winzer, Sebastian Arnold, Peter Moennings, Lars-Peder Pallesen, Ulf Bodechtel, Harald Mudra, Jennifer Linn, Heinz Reichmann, Andrei V Alexandrov, Georg Gahn, Norbert Weiss, Volker Puetz,

PURPOSE: The German Society of Ultrasound in Medicine (DEGUM) recently revised its multiparametric criteria for duplex ultrasonography (DUS) grading of internal carotid artery (ICA) disease. We determined the diagnostic accuracy of the revised DEGUM criteria for ultrasonography grading of ICA disease in a prospective multicenter study. MATERIALS AND METHODS: We evaluated consecutive ... Read more >>

Ultraschall Med (Ultraschall in der Medizin (Stuttgart, Germany : 1980))
[2018, 39(5):535-543]

Cited: 2 times

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Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial.

Karl Heinrich Scholz, Sebastian K G Maier, Lars S Maier, Björn Lengenfelder, Claudius Jacobshagen, Jens Jung, Claus Fleischmann, Gerald S Werner, Hans G Olbrich, Rainer Ott, Harald Mudra, Karlheinz Seidl, P Christian Schulze, Christian Weiss, Josef Haimerl, Tim Friede, Thomas Meyer,

Aims:The aim of this study was to investigate the effect of contact-to-balloon time on mortality in ST-segment elevation myocardial infarction (STEMI) patients with and without haemodynamic instability. Methods and results:Using data from the prospective, multicentre Feedback Intervention and Treatment Times in ST-Elevation Myocardial Infarction (FITT-STEMI) trial, we assessed the prognostic ... Read more >>

Eur Heart J (European heart journal)
[2018, 39(13):1065-1074]

Cited: 59 times

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Invasive treatment of NSTEMI patients in German Chest Pain Units - Evidence for a treatment paradox.

Frank P Schmidt, Claus Schmitt, Matthias Hochadel, Evangelos Giannitsis, Harald Darius, Lars S Maier, Claus Schmitt, Gerd Heusch, Thomas Voigtländer, Harald Mudra, Tommaso Gori, Jochen Senges, Thomas Münzel, ,

BACKGROUND:Patients with non ST-segment elevation myocardial infarction (NSTEMI) represent the largest fraction of patients with acute coronary syndrome in German Chest Pain units. Recent evidence on early vs. selective percutaneous coronary intervention (PCI) is ambiguous with respect to effects on mortality, myocardial infarction (MI) and recurrent angina. With the present ... Read more >>

Int J Cardiol (International journal of cardiology)
[2018, 255:15-19]

Cited: 3 times

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PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock.

Holger Thiele, Ibrahim Akin, Marcus Sandri, Georg Fuernau, Suzanne de Waha, Roza Meyer-Saraei, Peter Nordbeck, Tobias Geisler, Ulf Landmesser, Carsten Skurk, Andreas Fach, Harald Lapp, Jan J Piek, Marko Noc, Tomaž Goslar, Stephan B Felix, Lars S Maier, Janina Stepinska, Keith Oldroyd, Pranas Serpytis, Gilles Montalescot, Olivier Barthelemy, Kurt Huber, Stephan Windecker, Stefano Savonitto, Patrizia Torremante, Christiaan Vrints, Steffen Schneider, Steffen Desch, Uwe Zeymer, ,

<h4>Background</h4>In patients who have acute myocardial infarction with cardiogenic shock, early revascularization of the culprit artery by means of percutaneous coronary intervention (PCI) improves outcomes. However, the majority of patients with cardiogenic shock have multivessel disease, and whether PCI should be performed immediately for stenoses in nonculprit arteries is controversial.<h4>Methods</h4>In ... Read more >>

N Engl J Med (The New England journal of medicine)
[2017, 377(25):2419-2432]

Cited: 130 times

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Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial.

Dirk Sibbing, Dániel Aradi, Claudius Jacobshagen, Lisa Gross, Dietmar Trenk, Tobias Geisler, Martin Orban, Martin Hadamitzky, Béla Merkely, Róbert Gábor Kiss, András Komócsi, Csaba A Dézsi, Lesca Holdt, Stephan B Felix, Radoslaw Parma, Mariusz Klopotowski, Robert H G Schwinger, Johannes Rieber, Kurt Huber, Franz-Josef Neumann, Lukasz Koltowski, Julinda Mehilli, Zenon Huczek, Steffen Massberg, ,

<h4>Background</h4>Current guidelines recommend potent platelet inhibition with prasugrel or ticagrelor for 12 months after an acute coronary syndrome managed with percutaneous coronary intervention (PCI). However, the greatest anti-ischaemic benefit of potent antiplatelet drugs over the less potent clopidogrel occurs early, while most excess bleeding events arise during chronic treatment. Hence, ... Read more >>

Lancet (Lancet (London, England))
[2017, 390(10104):1747-1757]

Cited: 101 times

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Carotid artery stenting in clinical practice depending on patient age.

Jakob Ledwoch, Stephan Staubach, Manuela Segerer, Henning Strohm, Harald Mudra,

<h4>Background</h4>The age-dependent outcome of carotid artery stenting (CAS) outside of randomized controlled trials is largely unknown. Therefore, we assessed acute and long-term results of CAS in a single-center real-world registry.<h4>Methods</h4>All symptomatic and asymptomatic patients who consecutively underwent CAS were enrolled into the present analysis. The population was divided into three ... Read more >>

Catheter Cardiovasc Interv (Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions)
[2017, 90(3):451-460]

Cited: 0 times

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Progressive dyspnea and signs of right heart dysfunction.

Stephan Staubach, Henning Strohm, Harald Mudra,

A 40-year-old woman was admitted due to dyspnea and fever. Transthoracic echocardiography revealed signs of right heart volume overload and vegetations on the tricuspid valve with insufficiency. Transesophageal echocardiography showed a sinus venosus defect (SVD) with significant left-to-right shunt. Computed tomography scanning was primarily performed to rule out pulmonary embolism; ... Read more >>

Echocardiography (Echocardiography (Mount Kisco, N.Y.))
[2017, 34(1):119-121]

Cited: 0 times

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