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Overexpression of microRNA-129-5p in glioblastoma inhibits cell proliferation, migration, and colony-forming ability by targeting ZFP36L1.

Xu Guo, Haozhe Piao, Ye Zhang, Peixin Sun, Bing Yao,

Glioblastoma multiforme (GBM) is a highly invasive cancer with a high recurrence rate. The prognosis of GBM patients remains poor, even after standard surgical resection combined with chemoradiotherapy. Thus, there is an urgent need for new therapeutic targets in GBM. In recent years, microRNAs have received considerable attention due to ... Read more >>

Bosn J Basic Med Sci (Bosnian journal of basic medical sciences)
[2020, 20(4):459-470]

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LMX1B-associated gankyrin expression predicts poor prognosis in glioma patients.

Xu Guo, Haozhe Piao, Yixue Xue, Yunhui Liu, Hongyu Zhao,

OBJECTIVE:To explore the potential of the transcription factor LMX1B and downstream gankyrin as prognostic biomarkers of glioma. METHODS:The expression levels of gankyrin and LMX1B were detected in 52 normal brain specimens and 339 glioma specimens. Correlations of gankyrin and LMX1B expression levels with pathological stages and clinical characteristics were statistically ... Read more >>

J Int Med Res (The Journal of international medical research)
[2020, 48(9):300060520954764]

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Thyroid receptor-interacting protein 13 and EGFR form a feedforward loop promoting glioblastoma growth.

Lulu Hu, Dachuan Shen, Dapeng Liang, Ji Shi, Chunyan Song, Ke Jiang, Menglin Ren, Sha Du, Wei Cheng, Jianmei Ma, Shao Li, Xiaolin Bi, Martin P Barr, Zhiyou Fang, Qing Xu, Wenbin Li, Haozhe Piao, Songshu Meng,

Epidermal growth factor receptor (EGFR) amplification and EGFRvIII mutation drive glioblastoma (GBM) pathogenesis, but their regulation remains elusive. Here we characterized the EGFR/EGFRvIII "interactome" in GBM and identified thyroid receptor-interacting protein 13 (TRIP13), an AAA + ATPase, as an EGFR/EGFRvIII-associated protein independent of its ATPase activity. Functionally, TRIP13 augmented EGFR pathway activation ... Read more >>

Cancer Lett (Cancer letters)
[2020, 493:156-166]

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Multi-center Clinical Study Using Optical Coherence Tomography for Evaluation of Cervical Lesions In-vivo

Chenchen Ren, Xianxu Zeng, Zhongna Shi, Chunyan Wang, Huifen Wang, Xiuqin Wang, Baoping Zhang, Zhaoning Jiang, Huan Ma, Hao Hu, Haozhe Piao, Xiaoan Zhang, Baojin Wang,

Objective: In this prospective study of an in-vivo cervical examination using optical coherence tomography (OCT), we evaluated the diagnostic value of non-invasive and real-time OCT in cervical precancerous lesions and cancer diagnosis, and determined the characteristics of OCT images. Methods: 733 patients from 5 Chinese hospitals were inspected with OCT ... Read more >>

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Letter to the Editor. Residual meningiomas.

Rui Sui, Haozhe Piao,

J. Neurosurg. (Journal of neurosurgery)
[2020, :1-3]

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Administration with hyperoside sensitizes breast cancer cells to paclitaxel by blocking the TLR4 signaling.

Ting Sun, Yunyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao,

Breast cancer is a malignancy and one of the most frequent causes of cancer death among women worldwide. Paclitaxel is a common chemotherapeutic drug and has recently been shown to facilitate tumor cell escape during cytotoxic chemotherapy by inducing inflammatory mediators and pro-survival protein expression. Hyperoside is a flavonoid glycoside ... Read more >>

Mol. Cell. Probes (Molecular and cellular probes)
[2020, 53:101602]

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MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling.

Ke Jiang, Gang Yao, Lulu Hu, Yumei Yan, Jia Liu, Ji Shi, Youwei Chang, Ye Zhang, Dapeng Liang, Dachuan Shen, Guirong Zhang, Songshu Meng, Haozhe Piao,

Mps one binder 2 (MOB2) regulates the NDR kinase family, however, whether and how it is implicated in cancer remain unknown. Here we show that MOB2 functions as a tumor suppressor in glioblastoma (GBM). Analysis of MOB2 expression in glioma patient specimens and bioinformatic analyses of public datasets revealed that ... Read more >>

Cell Death Dis (Cell death & disease)
[2020, 11(4):230]

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N-terminal truncated carboxypeptidase E represses E-cadherin expression in lung cancer by stabilizing the Snail-HDAC complex.

Jing Sun, Dawei Meng, Tao Yu, Feng Li, Guirong Zhang, Xin Tian, Nannan Zhao, Guimin Li, Lu Li, Hongyue Wang, Yeqiu Liu, Yiming Meng, Yushu Ma, Zhong Wan, Jimin Bao, Haozhe Piao,

The N-terminal truncated carboxypeptidase E (CPEΔN) protein, an alternative splicing product of the carboxypeptidase E gene, has recently been recognized as an independent predictor for the recurrence and metastasis of lung adenocarcinoma. In this study, we showed that CPEΔN may accelerate lung cancer invasion via an E-cadherin-dependent mechanism. In vitro ... Read more >>

Am J Cancer Res (American journal of cancer research)
[2020, 10(3):925-938]

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FKBP9 promotes the malignant behavior of glioblastoma cells and confers resistance to endoplasmic reticulum stress inducers.

Huizhe Xu, Peng Liu, Yumei Yan, Kun Fang, Dapeng Liang, Xiukun Hou, Xiaohong Zhang, Songyan Wu, Jianmei Ma, Ruoyu Wang, Tao Li, Haozhe Piao, Songshu Meng,

BACKGROUND:FK506-binding protein 9 (FKBP9) is amplified in high-grade gliomas (HGGs). However, the roles and mechanism(s) of FKBP9 in glioma are unknown. METHODS:The expression of FKBP9 in clinical glioma tissues was detected by immunohistochemistry (IHC). The correlation between FKBP9 expression levels and the clinical prognosis of glioma patients was examined by ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2020, 39(1):44]

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Application of molecular imaging technology in tumor immunotherapy.

Yiming Meng, Jing Sun, Na Qv, Guirong Zhang, Tao Yu, Haozhe Piao,

Cancer immunotherapy, due to its high anti-tumor efficacy, has attracted considerable attention globally from experts in various fields. However, immunotherapy could be severely toxic; not all patients may respond, thus requiring combination therapy. Therefore, a reasonable selection strategy for early treatment is urgently needed. It is vital to capture the ... Read more >>

Cell. Immunol. (Cellular immunology)
[2020, 348:104039]

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Application of Radiomics for Personalized Treatment of Cancer Patients.

Yiming Meng, Jing Sun, Na Qu, Guirong Zhang, Tao Yu, Haozhe Piao,

Radiomics is a novel concept that relies on obtaining image data from examinations such as computed tomography (CT), magnetic resonance imaging (MRI), or positron emission tomography (PET). With the appropriate algorithm, the extracted results have broad applicability and potential for a massive positive impact in radiology. For example, clinicians can ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:10851-10858]

Cited: 1 time

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lncRNA CYTOR promotes tamoxifen resistance in breast cancer cells via sponging miR‑125a‑5p.

Yungyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao,

Development of resistance to endocrine therapy, such as tamoxifen, remains a tricky clinical problem during the treatment of breast cancer. Accumulating evidence suggested that dysregulation of long noncoding (lnc_RNAs contributes to the development of tamoxifen resistance. In the current study, via screening, cytoskeleton regulator RNA (CYTOR) was identified as the ... Read more >>

Int. J. Mol. Med. (International journal of molecular medicine)
[2020, 45(2):497-509]

Cited: 2 times

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LncRNA SRA1 is down-regulated in HPV-negative cervical squamous cell carcinoma and regulates cancer cell behaviors.

Yunyong Liu, Mengdan Li, Huihui Yu, Haozhe Piao,

LncRNA SRA1 plays important roles in several types of human diseases. The present study aimed to explore the role of SRA1 in cervical squamous cell carcinoma (CSCC). In the present study, we showed that plasma SRA1 was down-regulated in human papillomavirus (HPV)-negative CSCC patients but not in HPV-positive CSCC patients ... Read more >>

Biosci. Rep. (Bioscience reports)
[2019, 39(8):]

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Effects of somatic alterations at pathway level are more mechanism-explanatory and clinically applicable to quantity of liver metastases of colorectal cancer.

Zhong-Guo Zhang, Fei Ma, Shuang Zhao, Xiaoyu Yang, Fang Liu, Chenghai Xue, Liren Liu, Jin Gu, Haozhe Piao,

BACKGROUND:The quantity of metastases lesions is an important reference when it comes to making a more informed treatment decision for patients with colorectal cancer liver metastases. However, the molecular alterations in patients with different numbers of lesions have not been systematically studied. METHODS:We investigated somatic alterations and microsatellite instability (MSI) ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(10):4732-4742]

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The prevalence, trends, and geographical distribution of human papillomavirus infection in China: The pooled analysis of 1.7 million women.

Bo Zhu, Yunyong Liu, Tingting Zuo, Xiaoli Cui, Mengdan Li, Jing Zhang, Huihui Yu, Haozhe Piao,

Human papillomavirus (HPV) infection which continues to be the most common sexually transmitted disease, has been identified as a major risk factor for cervical cancer. Therefore, it is very important to understand and grasp the distribution of HPV in Chinese population, and make the foundation for the development of cervical ... Read more >>

Cancer Med (Cancer medicine)
[2019, 8(11):5373-5385]

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Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.

Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng, Haozhe Piao,

BACKGROUND:Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clinical and preclinical activities against GBM. (Silent mating type information regulation 2 homolog, Sirt1) abbreviated as Sirtuin 1, has been implicated in GBM. ... Read more >>

BMC Cancer (BMC cancer)
[2019, 19(1):706]

Cited: 3 times

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Downregulation of miR-485-3p promotes glioblastoma cell proliferation and migration via targeting RNF135.

Ye Zhang, Rui Sui, Yi Chen, Haiyang Liang, Ji Shi, Haozhe Piao,

MicroRNAs (miRNAs) are small non-coding RNAs that serve pivotal roles in human diseases. Several miRNAs, such as miR-485-3p, have been identified as potential biomarkers for predicting overall survival of patients with glioblastoma (GBM). However, the underlying mechanism of miRNAs in promoting GBM progression remains unknown. In the present study, decreased ... Read more >>

(Experimental and therapeutic medicine)
[2019, 18(1):475-482]

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Long noncoding RNA MT1JP inhibits proliferation, invasion, and migration while promoting apoptosis of glioma cells through the activation of PTEN/Akt signaling pathway.

Ye Zhang, Rui Sui, Yi Chen, Hanyang Liang, Ji Shi, Haozhe Piao,

This study is carried out to elucidate the role of long noncoding RNAs (lncRNAs) MT1JP in proliferation, invasion, migration, and apoptosis of glioma cells through the regulation of PTEN/Akt signaling pathway. The expression of MT1JP in 80 normal brain tissues and 138 glioma tissues, as well as glioma cell lines, ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, 234(11):19553-19564]

Cited: 3 times

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The biological macromolecule Nocardia rubra cell-wall skeleton as an avenue for cell-based immunotherapy.

Yiming Meng, Jing Sun, Xiaonan Wang, Yushu Ma, Cuicui Kong, Guirong Zhang, Heng Dou, Ning Nan, Mingsheng Shi, Tao Yu, Haozhe Piao,

Promoting the antitumor effects of cell-based immunotherapy for clinical application remains a difficult challenge. Nocardia rubra cell-wall skeleton (N-CWS) is an immunotherapeutic agent for cancers that have been proven to possess the ability to activate immune response without showing toxicity. However, its effects on immune cells that are derived from ... Read more >>

J. Cell. Physiol. (Journal of cellular physiology)
[2019, :]

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MicroRNA-374a Governs Aggressive Cell Behaviors of Glioma by Targeting Prokineticin 2.

Ye Zhang, Rui Zhang, Rui Sui, Yi Chen, Haiyang Liang, Ji Shi, Haozhe Piao,

MicroRNA-374a has been abnormally expressed in several cancer types; however, its role in glioma remains unclear. Therefore, we aimed to investigate whether microR-374a participated in the progression of glioma. Expression of microR-374a in glioma cell lines and normal cell line was measured by quantitative real-time polymerase chain reaction. Luciferase reporter ... Read more >>

Technol. Cancer Res. Treat. (Technology in cancer research & treatment)
[2019, 18:1533033818821401]

Cited: 1 time

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Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer.

Yiming Meng, Jing Sun, Xiaonan Wang, Tingting Hu, Yushu Ma, Cuicui Kong, Haozhe Piao, Tao Yu, Guirong Zhang,

Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. Therefore, the exploration of a series of circulating ... Read more >>

Technol. Cancer Res. Treat. (Technology in cancer research & treatment)
[2019, 18:1533033818821421]

Cited: 5 times

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MicroRNA-153-3p enhances cell radiosensitivity by targeting BCL2 in human glioma.

Deyu Sun, Yi Mu, Haozhe Piao,

BACKGROUND:Glioma is the most prevalent malignant tumor in human central nervous systems. Recently, the development of resistance to radiotherapy in glioma patients markedly vitiates the therapy outcome. MiR-153-3p has been reported to be closely correlated with tumor progression, but its effect and molecular mechanism underlying radioresistance remains unclear in glioma. ... Read more >>

Biol. Res. (Biological research)
[2018, 51(1):56]

Cited: 9 times

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Bufalin Induces Apoptosis and Improves the Sensitivity of Human Glioma Stem-Like Cells to Temozolamide.

Jia Liu, Ying Zhang, Shulan Sun, Guirong Zhang, Ke Jiang, Peixin Sun, Ye Zhang, Bing Yao, Rui Sui, Yi Chen, Xu Guo, Tao Tang, Ji Shi, Haiyang Liang, Haozhe Piao,

Glioma is the most common malignant tumor of the central nervous system, and it is characterized by high relapse and fatality rates and poor prognosis. Bufalin is one of the main ingredients of Chan-su, a traditional Chinese medicine (TCM) extracted from toad venom. Previous studies revealed that bufalin exerted inhibitory ... Read more >>

Oncol. Res. (Oncology research)
[2019, 27(4):475-486]

Cited: 2 times

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Oncolytic Newcastle disease virus induces autophagy-dependent immunogenic cell death in lung cancer cells.

Tian Ye, Ke Jiang, Liwen Wei, Martin P Barr, Qing Xu, Guirong Zhang, Chan Ding, Songshu Meng, Haozhe Piao,

In addition to direct oncolysis, oncolytic viruses trigger immunogenic cell death (ICD) and primes antitumor immunity. We have previously shown that oncolytic Newcastle disease virus (NDV), strain FMW (NDV/FMW), induces apoptosis and/or autophagy in cancer cells. In this study, we investigated whether oncolytic NDV can induce ICD in lung cancer ... Read more >>

(American journal of cancer research)
[2018, 8(8):1514-1527]

Cited: 9 times

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Vacquinol‑1 induces apoptosis in hepatocellular carcinoma cell.

Shu-Lan Sun, Xiaoxi Li, Nan Su, Shi Chen, Xiaoxin Gao, Guirong Zhang, Haozhe Piao,

Vacquinol‑1 (Vacq), a quinolone derivative, has recently been reported to display potent antitumor effects in glioblastomas by inducing cellular massive vacuolization and cell death. However, whether Vacq induces cytotoxicities in other types of cancers, and the potential underlying mechanism, remain to be investigated. In the present study, it was revealed ... Read more >>

Mol Med Rep (Molecular medicine reports)
[2018, 18(1):557-563]

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