Full Text Journal Articles by
Author Haoran Zhu


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Oncogene-induced senescence: From biology to therapy.

Haoran Zhu, Shaun Blake, Frances K Kusuma, Richard B Pearson, Jian Kang, Keefe T Chan,

Oncogene-induced senescence (OIS) is a powerful intrinsic tumor-suppressive mechanism, arresting cell cycle progression upon oncogene-activating genomic alterations. The discovery and characterization of the senescence-associated secretome unveiled a rich additional complexity to the senescence phenotype, including extrinsic impacts on the microenvironment and engagement of the immune response. Emerging evidence suggests that ... Read more >>

Mech. Ageing Dev. (Mechanisms of ageing and development)
[2020, 187:111229]

Cited: 0 times

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A functional genetic screen defines the AKT-induced senescence signaling network.

Keefe T Chan, Shaun Blake, Haoran Zhu, Jian Kang, Anna S Trigos, Piyush B Madhamshettiwar, Jeannine Diesch, Lassi Paavolainen, Peter Horvath, Ross D Hannan, Amee J George, Elaine Sanij, Katherine M Hannan, Kaylene J Simpson, Richard B Pearson,

Exquisite regulation of PI3K/AKT/mTORC1 signaling is essential for homeostatic control of cell growth, proliferation, and survival. Aberrant activation of this signaling network is an early driver of many sporadic human cancers. Paradoxically, sustained hyperactivation of the PI3K/AKT/mTORC1 pathway in nontransformed cells results in cellular senescence, which is a tumor-suppressive mechanism ... Read more >>

Cell Death Differ. (Cell death and differentiation)
[2020, 27(2):725-741]

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The RNA N6-methyladenosine modification landscape of human fetal tissues.

Shan Xiao, Shuo Cao, Qitao Huang, Linjian Xia, Mingqiang Deng, Mengtian Yang, Guiru Jia, Xiaona Liu, Junfang Shi, Weishi Wang, Yuan Li, Sun Liu, Haoran Zhu, Kaifen Tan, Qizhi Luo, Mei Zhong, Chunjiang He, Laixin Xia,

A single genome gives rise to diverse tissues through complex epigenomic mechanisms, including N6-methyladenosine (m6A), a widespread RNA modification that is implicated in many biological processes. Here, to explore the global landscape of m6A in human tissues, we generated 21 whole-transcriptome m6A methylomes across major fetal tissues using m6A sequencing. ... Read more >>

Nat. Cell Biol. (Nature cell biology)
[2019, 21(5):651-661]

Cited: 2 times

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Cystathionine β-Synthase in Physiology and Cancer.

Haoran Zhu, Shaun Blake, Keefe T Chan, Richard B Pearson, Jian Kang,

Cystathionine β-synthase (CBS) regulates homocysteine metabolism and contributes to hydrogen sulfide (H2S) biosynthesis through which it plays multifunctional roles in the regulation of cellular energetics, redox status, DNA methylation, and protein modification. Inactivating mutations in CBS contribute to the pathogenesis of the autosomal recessive disease CBS-deficient homocystinuria. Recent studies demonstrating ... Read more >>

Biomed Res Int (BioMed research international)
[2018, 2018:3205125]

Cited: 2 times

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Realization of a compact one-seed laser system for atom interferometer-based gravimeters.

Jie Fang, Jiangong Hu, Xi Chen, Haoran Zhu, Lin Zhou, Jiaqi Zhong, Jin Wang, Mingsheng Zhan,

A simple and compact design of the laser system is important for realization of compact atom interferometers (AIs). We design and realize a simple fiber bench-based 780-nm laser system used for 85Rb AI-based gravimeters. The laser system contains only one 780 nm seed laser, and the traditional frequency-doubling-module is not ... Read more >>

Opt Express (Optics express)
[2018, 26(2):1586-1596]

Cited: 1 time

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Expression levels of TGF-β1 and CTGF are associated with the severity of Duchenne muscular dystrophy.

Yanmin Song, Shuai Yao, Yunhai Liu, Lili Long, Huan Yang, Qiuxiang Li, Jinghui Liang, Xinxin Li, Yuling Lu, Haoran Zhu, Ning Zhang,

The present study aimed to analyze the association of transforming growth factor-β1 (TGF-β1) and connective tissue growth factor (CTGF) expression levels in skeletal muscle with the clinical manifestation of Duchenne muscular dystrophy (DMD). A total of 18 cases of DMD, which were confirmed by routine pathological diagnosis were recruited into ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2017, 13(4):1209-1214]

Cited: 7 times

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(E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1.

Qinghua Hu, Mengze Zhou, Haoran Zhu, Guo Lu, Dongsen Zheng, Huanqiu Li, Kun Hao,

Hyperuricemia is a kind of metabolic disease resulted from imbalance between urate production and excretion. Xanthine oxidase (XOD) or renal urate transporter 1 (URAT1) inhibitors have been applied for hyperuricemia treatment in clinic, but available drugs could not simultaneously target XOD and URAT1 and had various adverse effects. (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone ... Read more >>

Biomed. Pharmacother. (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie)
[2017, 86:88-94]

Cited: 1 time

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GdCl3 suppresses the malignant potential of hepatocellular carcinoma by inhibiting the expression of CD206 in tumor‑associated macrophages.

Fangyu Zhu, Xiangnan Li, Yong Jiang, Haoran Zhu, Haolong Zhang, Chengyao Zhang, Yu Zhao, Fang Luo,

In the present study, we aimed to ascertain whether there is a correlation between CD206 expression in tumor associated-macrophages (TAMs) and the prognosis of primary hepatocellular carcinomas (HCC) and we investigated the effect of GdCl3 on HCC. The expression of CD206 in HCC tumor tissues and peri-carcinoma tissues was measured ... Read more >>

Oncol. Rep. (Oncology reports)
[2015, 34(5):2643-2655]

Cited: 4 times

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The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.

Erinna F Lee, Grant Dewson, Marco Evangelista, Anne Pettikiriarachchi, Grace J Gold, Haoran Zhu, Peter M Colman, W Douglas Fairlie,

Bcl-2 homology 3 (BH3) domains are short sequence motifs that mediate nearly all protein-protein interactions between B cell lymphoma 2 (Bcl-2) family proteins in the intrinsic apoptotic cell death pathway. These sequences are found on both pro-survival and pro-apoptotic members, although their primary function is believed to be associated with ... Read more >>

J. Biol. Chem. (The Journal of biological chemistry)
[2014, 289(52):36001-36017]

Cited: 16 times

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