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Author Hao Lian

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Exosomes derived from umbilical cord mesenchymal stem cells alleviate viral myocarditis through activating AMPK/mTOR-mediated autophagy flux pathway.

Xiaohong Gu, Yuechun Li, Kaixin Chen, Xingang Wang, Zhongyu Wang, Hao Lian, Yuanzheng Lin, Xing Rong, Maoping Chu, Jiafeng Lin, Xiaoling Guo,

Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-exosomes) have been implicated as a novel therapeutic approach for tissue injury repair and regeneration, but the effects of hucMSC-exosomes on coxsackievirus B3 (CVB3)-induced myocarditis remain unknown. The object of the present study is to investigate whether hucMSC-exosomes have therapeutic effects on CVB3-induced ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2020, :]

Cited: 0 times

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Influence of Different Inactivation Methods on Severe Acute Respiratory Syndrome Coronavirus 2 RNA Copy Number.

Hailong Chen, Rui Wu, Yuan Xing, Quanli Du, Zerun Xue, Yanli Xi, Yujie Yang, Yangni Deng, Yuewen Han, Kaixin Li, Yang Luan, Yalan Zhang, Xiaoguang Wei, Tongtong Yu, Hao Li, Lingxiang Zhu, Shengshi Su, Hao Lian, Linping Lu, Chianru Tan, Haichao Zheng, Baozhong Chen, Pengbo Yu, Yong Guo, Chaofeng Ma,

The outbreak of COVID-19 has spread across the world and was characterized as a pandemic. To protect medical laboratory personnel from infection, most laboratories inactivate the clinical samples before testing. However, the effect of inactivation on the detection results remains unknown. Here, we used a digital PCR assay to determine ... Read more >>

J. Clin. Microbiol. (Journal of clinical microbiology)
[2020, :]

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Integrative analysis of gene expression and DNA methylation through one-class logistic regression machine learning identifies stemness features in medulloblastoma.

Hao Lian, Yi-Peng Han, Yu-Chao Zhang, Yang Zhao, Shan Yan, Qi-Feng Li, Bao-Cheng Wang, Jia-Jia Wang, Wei Meng, Jian Yang, Qin-Hua Wang, Wei-Wei Mao, Jie Ma,

Most human cancers develop from stem and progenitor cell populations through the sequential accumulation of various genetic and epigenetic alterations. Cancer stem cells have been identified from medulloblastoma (MB), but a comprehensive understanding of MB stemness, including the interactions between the tumor immune microenvironment and MB stemness, is lacking. Here, ... Read more >>

Mol Oncol (Molecular oncology)
[2019, 13(10):2227-2245]

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Non-prescription cold and flu medication-induced transient myopia with uveal effusion: case report.

Rui Zeng, Yun-Peng Li, Chun-Li Chen, Ya-Qian Huang, Hao Lian, Yu-Zhang Hu, Jia-Song Yang,

BACKGROUND:To report a case of non-prescription cold and flu medication-induced transient myopia with uveal effusion. CASE PRESENTATION:Bilateral high intraocular pressure, shallow anterior chambers, uveal effusion, and a myopic shift were encountered in a 39-year-old Chinese male 1 night after taking a non-prescription flu medicine three times than the recommended dose. ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2019, 19(1):136]

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Incidence of metastatic disease and survival among patients with newly diagnosed primary CNS tumors in the United States from 2004-2013.

Hao Lian, Craig Daniels, Yi-Peng Han, Qi-Feng Li, Yang Zhao, Bao-Cheng Wang, Chang-Bin Zhu, Wei-Wei Mao, Michael D Taylor, Jie Ma,

Background: Population-based estimates of the incidence and prognosis of metastatic disease at the initial diagnosis of primary central nervous system (CNS) tumors are currently lacking. Methods: A total of 43,455 patients diagnosed with a primary CNS tumor were enrolled to evaluate metastatic rates utilizing the data from the Surveillance, Epidemiology, ... Read more >>

J Cancer (Journal of Cancer)
[2019, 10(13):3037-3045]

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Eliciting α7-nAChR exerts cardioprotective effects on ischemic cardiomyopathy via activation of AMPK signalling.

Zhong-Hao Lin, Yue-Chun Li, Shu-Jie Wu, Cheng Zheng, Yuan-Zheng Lin, Hao Lian, Wei-Qian Lin, Jia-Feng Lin,

Our previous studies have reported that agonist of α7 nicotinic acetylcholine receptors prevented electrophysiological dysfunction of rats with ischaemic cardiomyopathy (ICM) by eliciting the cholinergic anti-inflammatory pathway (CAP). Adenosine monophosphate-activated protein kinase (AMPK) signalling is widely recognized exerting cardioprotective effect in various cardiomyopathy. Here, we aimed to investigate whether the ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(7):4746-4758]

Cited: 1 time

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Low-intensity pulsed ultrasound attenuates cardiac inflammation of CVB3-induced viral myocarditis via regulation of caveolin-1 and MAPK pathways.

Cheng Zheng, Sen-Min Wu, Hao Lian, Yuan-Zheng Lin, Rong Zhuang, Saroj Thapa, Quan-Zhi Chen, Yi-Fan Chen, Jia-Feng Lin,

The aggressive immunological activity elicited by acute viral myocarditis contributes to a large amount of cardiomyocytes loss and poor prognosis of patients in clinic. Low-intensity pulsed ultrasound (LIPUS), which is an effective treatment modality for osteoarthropathy, has been recently illustrated regulating the overactive inflammatory response in various diseases. Here, we ... Read more >>

J. Cell. Mol. Med. (Journal of cellular and molecular medicine)
[2019, 23(3):1963-1975]

Cited: 3 times

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Fasudil exerts a cardio-protective effect on mice with coxsackievirus B3-induced acute viral myocarditis.

Kezhi Dai, Yaoyao Wang, Sichao Tai, Huajing Ni, Hao Lian, Yan Yu, Weifang Liao, Cheng Zheng, Qing Chen, Aarti Kuver, Jia Li,

AIMS:To investigate whether there exists a cardio-protective effect of Fasudil, a selective Rho kinase (ROCK) inhibitor, in an experimental murine model of acute viral myocarditis. METHODS:Male BALB/c mice were randomly assigned to three groups: control, myocarditis treated with placebo and myocarditis treated with Fasudil (n = 40 animals per group). ... Read more >>

Cardiovasc Ther (Cardiovascular Therapeutics)
[2018, 36(6):e12477]

Cited: 1 time

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Sodium Houttuyfonate Alleviates Post-infarct Remodeling in Rats via AMP-Activated Protein Kinase Pathway.

Cheng Zheng, Jia-Feng Lin, Zhong-Hao Lin, Wei-Qian Lin, Saroj Thapa, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Xiao-Wei Li,

With the chronic ischemia persisting after acute myocardial infarction, the accompanying low-degree inflammation and subsequent fibrosis result in progression of cardiac remodeling and heart failure. Recently, Sodium Houttuyfonate (SH), a pure compound extracted from Houttuynia cordata, has been confirmed exerting anti-inflammatory and anti-fibrotic effects under diseased situations. Here, we aimed ... Read more >>

Front Pharmacol (Frontiers in Pharmacology)
[2018, 9:1092]

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Case presentation: implantation of cardiac resynchronization therapy pacemaker via the coronary sinus in a patient with triple valve replacement.

Cheng Zheng, Wei-Qian Lin, Yuan-Zheng Lin, Hao Lian, Zhi-Rui Liu, Jia-Hui Chen, Jia-Feng Lin,

BACKGROUND:In patients with triple valve replacement developing third-degree atrioventricular block (AVB), the most appropriate approach for permanent pacemaker implantation remains questionable. CASE PRESENTATION:In this case presentation, we first described the approach of implantation of the cardiac resynchronization therapy pacemaker (CRT-P) via one bipolar pacing lead in middle cardiac vein (MCV) ... Read more >>

BMC Cardiovasc Disord (BMC cardiovascular disorders)
[2018, 18(1):37]

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Deciphering the Epitranscriptome in Cancer.

Hao Lian, Qin-Hua Wang, Chang-Bin Zhu, Jie Ma, Wei-Lin Jin,

Technological and methodological advancements have recently revolutionized our understanding of widespread epitranscriptome including RNA modifications and editing. N6-methyladenosine (m6A) represents the most prevalent internal modification in mammalian RNAs. Adenosine to inosine (A-to-I) RNA editing is an important mechanism underlying RNA generation and protein diversity through the post-transcriptional modification of single ... Read more >>

Trends Cancer (Trends in cancer)
[2018, 4(3):207-221]

Cited: 3 times

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Black Phosphorus Quantum Dots with Renal Clearance Property for Efficient Photodynamic Therapy.

Tao Guo, Ying Wu, Yan Lin, Xin Xu, Hao Lian, Guoming Huang, Ji-Zan Liu, Xiaoping Wu, Huang-Hao Yang,

Black phosphorus (BP) nanomaterials have emerged as rapidly rising stars in the field of nanomedicine. In this work, BP quantum dots (BPQDs) are synthesized and their potential as photosensitizers is investigated for the first time. The BPQDs present good stability in physiological medium and no appreciable cytotoxicity. More importantly, the ... Read more >>

Small (Small (Weinheim an der Bergstrasse, Germany))
[2018, 14(4):]

Cited: 5 times

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The emerging insights into catalytic or non-catalytic roles of TET proteins in tumors and neural development.

Hao Lian, Wen-Bin Li, Wei-Lin Jin,

The Ten-eleven translocation (TET) proteins have been recently identified as critical regulators in epigenetic modification, especially in the methylation of cytosine in DNA. TET-mediated DNA oxidation plays prominent roles in a wide variety of physiological and pathological processes, especially in tumor and neural development. TET proteins execute stepwise enzymatic conversion ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(39):64512-64525]

Cited: 8 times

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Transgenic common carp do not have the ability to expand populations.

Hao Lian, Wei Hu, Rong Huang, Fukuan Du, Lanjie Liao, Zuoyan Zhu, Yaping Wang,

The ecological safety of transgenic organisms is an important issue of international public and political concern. The assessment of ecological risks is also crucial for realizing the beneficial industrial application of transgenic organisms. In this study, reproduction of common carp (Cyprinus carpio, CC) in isolated natural aquatic environments was analyzed. ... Read more >>

PLoS ONE (PloS one)
[2013, 8(6):e65506]

Cited: 3 times

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Hepatitis C virus may infect extrahepatic tissues in patients with hepatitis C.

Fu-Ming Yan, An-Shen Chen, Fei Hao, Xi-Ping Zhao, Chang-Hai Gu, Li-Bin Zhao, Dong-Liang Yang, Lian-Jie Hao,

AIM:To explore the status of extrahepatic hepatitis C virus (HCV) infection and replication in hepatitis C patients,and its potential implication in HCV infection and pathogenicity.METHODS:By reverse-transcriptase poly-merase chain reaction (RT-PCR),in situ hybridization (ISH) and immunohis-tochemistry, HCV RNA, HCV replicative intermediate (minus-strand of HCV RNA), and HCV antigens were detected in ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2000, 6(6):805-811]

Cited: 60 times

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FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma.

Bao-Hua Sun, Xi-Ping Zhao, Bao-Ju Wang, Dong-Liang Yang, Lian-Jie Hao,

AIM:To investigate the clinical features of FADD and TRADD expressions in primary hepatocellular carcinoma (HCC) and to determine their relationship with hepatic apoptosis.METHODS:FADD and TRADD expressions were detected by immunohis-tochemistry and hepatic apoptosis were determined by in situ end-labeling (ISEL).RESULTS:Ten (25.6%) cases of HCC were detected to express FADD protein. ... Read more >>

World J. Gastroenterol. (World journal of gastroenterology)
[2000, 6(2):223-227]

Cited: 23 times

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