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Author Hans Ulrich Wittchen

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The modulating impact of cigarette smoking on brain structure in panic disorder: a voxel-based morphometry study.

Stefanie L Kunas, Kevin Hilbert, Yunbo Yang, Jan Richter, Alfons Hamm, André Wittmann, Andreas Ströhle, Bettina Pfleiderer, Martin J Herrmann, Thomas Lang, Martin Lotze, Jürgen Deckert, Volker Arolt, Hans-Ulrich Wittchen, Benjamin Straube, Tilo Kircher, Alexander L Gerlach, Ulrike Lueken,

Cigarette smoking increases the likelihood of developing anxiety disorders, among them panic disorder (PD). While brain structures altered by smoking partly overlap with morphological changes identified in PD, the modulating impact of smoking as a potential confounder on structural alterations in PD has not yet been addressed. In total, 143 ... Read more >>

Soc Cogn Affect Neurosci (Social cognitive and affective neuroscience)
[2020, 15(8):849-859]

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Maternal personality, social support, and changes in depressive, anxiety, and stress symptoms during pregnancy and after delivery: A prospective-longitudinal study.

Eva Asselmann, Stefanie L Kunas, Hans-Ulrich Wittchen, Julia Martini,

BACKGROUND:The role of maternal personality and perceived social support for peripartum changes in psychopathological symptoms remains unresolved. METHODS:In a regional-epidemiological sample of 306 women, depressive, anxiety, and stress symptoms were assessed three times during pregnancy and three times after delivery with the 21-item version of the Depression Anxiety Stress Scale. ... Read more >>

PLoS One (PloS one)
[2020, 15(8):e0237609]

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Fundamental frequency during cognitive preparation and its impact on therapy outcome for panic disorder with Agoraphobia.

Gesine Wieder, Melanie S Fischer, Franziska Einsle, Donald H Baucom, Kurt Hahlweg, Hans-Ulrich Wittchen, Sarah Weusthoff,

BACKGROUND:Cognitive preparation plays a crucial role in CBT with exposure for panic disorder and agoraphobia. High emotional arousal while developing the exposure rationale might impair patients' cognitive capacities for processing information about treatment and impede therapeutic outcome. OBJECTIVE:This study investigates whether patients' vocally encoded emotional arousal, assessed by fundamental frequency ... Read more >>

Behav Res Ther (Behaviour research and therapy)
[2020, 135:103728]

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Correction to: Test-retest reliability of the computer-assisted DIA-X-5 interview for mental disorders.

Jana Hoyer, Catharina Voss, Jens Strehle, John Venz, Lars Pieper, Hans-Ulrich Wittchen, Stefan Ehrlich, Katja Beesdo-Baum,

An amendment to this paper has been published and can be accessed via the original article. ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):364]

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Test-retest reliability of the computer-assisted DIA-X-5 interview for mental disorders.

Jana Hoyer, Catharina Voss, Jens Strehle, John Venz, Lars Pieper, Hans-Ulrich Wittchen, Stefan Ehrlich, Katja Beesdo-Baum,

BACKGROUND:There is a need of comprehensive standardized diagnostic assessment tools of psychopathology that match recent changes in diagnostic classification systems, such as the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). Therefore, the computer-assisted DIA-X-5 was developed and its test-retest reliability was explored. The DIA-X-5 is ... Read more >>

BMC Psychiatry (BMC psychiatry)
[2020, 20(1):280]

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Correction: Augmenting extinction learning with D-cycloserine reduces return of fear: a randomized, placebo-controlled fMRI study.

Claudia Ebrahimi, Johanna Gechter, Ulrike Lueken, Florian Schlagenhauf, Hans-Ulrich Wittchen, Alfons O Hamm, Andreas Ströhle,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(7):1242]

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An investigation of genetic variability of DNA methyltransferases DNMT3A and 3B does not provide evidence for a major role in the pathogenesis of panic disorder and dimensional anxiety phenotypes.

Ann-Cathrine Berking, Christiane Thiel, Miriam A Schiele, Christian Baumann, Raffael Kalisch, Swantje Notzen, Peter Zwanzger, Christiane A Pané-Farré, Alfons Hamm, Georg W Alpers, Thomas Fydrich, Lydia Fehm, Alexander L Gerlach, Benjamin Straube, Tilo Kircher, Winfried Rief, Jens Plag, Andreas Ströhle, Thomas Lang, Hans-Ulrich Wittchen, Volker Arolt, Marcel Romanos, Paul Pauli, Andreas Reif, Jürgen Deckert, Katharina Domschke, Heike Weber,

While DNA methylation patterns have been studied for a role in the pathogenesis of anxiety disorders, the role of the enzymes establishing DNA methylation-DNA methyltransferases (DNMTs)-has yet to be investigated. In an effort to investigate DNMT genotype-specific effects on dimensional anxiety traits in addition to the categorical phenotype of panic ... Read more >>

J Neural Transm (Vienna) (Journal of neural transmission (Vienna, Austria : 1996))
[2020, :]

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Neural correlates of NOS1 ex1f-VNTR allelic variation in panic disorder and agoraphobia during fear conditioning and extinction in fMRI.

Isabelle C Ridderbusch, Yunbo Yang, Heike Weber, Andreas Reif, Sabine Herterich, Andreas Ströhle, Bettina Pfleiderer, Volker Arolt, Hans-Ulrich Wittchen, Ulrike Lueken, Tilo Kircher, Benjamin Straube,

Neuronal nitric oxide synthase (NOS-I) impacts on fear/anxiety-like behavior in animals. In humans, the short (S) allele of a functional promotor polymorphism of NOS1 (NOS1 ex1f-VNTR) has been shown to be associated with higher anxiety and altered fear conditioning in healthy subjects in the amygdala and hippocampus (AMY/HIPP). Here, we ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2020, 27:102268]

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International Journal of Methods in Psychiatric Research transitions to open access.

Hans-Ulrich Wittchen Wittchen, Katja Beesdo-Baum,

Int J Methods Psychiatr Res (International journal of methods in psychiatric research)
[2020, 29(1):e1817]

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Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study.

Tanja B Grammer, Alexander Dressel, Ingrid Gergei, Marcus E Kleber, Ulrich Laufs, Hubert Scharnagl, Uwe Nixdorff, Jens Klotsche, Lars Pieper, David Pittrow, Sigmund Silber, Hans-Ulrich Wittchen, Winfried März,

An amendment to this paper has been published and can be accessed via a link at the top of the paper. ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):5945]

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Do lifetime anxiety disorders (anxiety liability) and pregnancy-related anxiety predict complications during pregnancy and delivery?

Jana Hoyer, Gesine Wieder, Michael Höfler, Linda Krause, Hans-Ulrich Wittchen, Julia Martini,

BACKGROUND:Evidence suggests that maternal anxiety is associated with adverse pregnancy and delivery outcomes, such as preterm birth, vaginal bleedings and low birth weight. AIMS:To examine the association of lifetime anxiety disorders and pregnancy-related anxiety and complications during pregnancy and delivery. STUDY DESIGN:Prospective-longitudinal study (MARI). SUBJECTS:N = 306 pregnant women who were investigated ... Read more >>

Early Hum. Dev. (Early human development)
[2020, 144:105022]

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Quality of life, level of functioning, and its relationship with mental and physical disorders in the elderly: results from the MentDis_ICF65+ study.

Luigi Grassi, Rosangela Caruso, Chiara Da Ronch, Martin Härter, Holger Schulz, Jana Volkert, Maria Dehoust, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Alessandra Canuto, Manuel Muñoz, Mike J Crawford, Yael Hershkovitz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Shalev, Jens Strehle, Kerstin Weber, Hans-Ulrich Wittchen, Sylke Andreas, Martino Belvederi Murri, Luigi Zerbinati, Maria Giulia Nanni,

BACKGROUND:An ageing population worldwide needs to investigate quality of life (QoL) and level of functioning (LoF) in the elderly and its associated variables. We aimed to study the relationship between Quality of Life (QoL) and Level of Functioning (LoF) in an elderly population in Europe. METHOD:As part of the Ment_Dis65+ ... Read more >>

Health Qual Life Outcomes (Health and quality of life outcomes)
[2020, 18(1):61]

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The course of panic disorder during the peripartum period and the risk for adverse child development: A prospective-longitudinal study.

Julia Martini, Katja Beesdo-Baum, Susan Garthus-Niegel, Hans-Ulrich Wittchen,

BACKGROUND:Panic disorders during pregnancy and after delivery may have detrimental effects for mother and child, but no firm conclusions regarding the course and outcomes of peripartum panic disorders can be drawn from previous studies. METHODS:N = 306 women were repeatedly interviewed with the Composite International Diagnostic Interview for Women. Social support and ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 266:722-730]

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A multimodal neuroimaging classifier for alcohol dependence.

Matthias Guggenmos, Katharina Schmack, Ilya M Veer, Tristram Lett, Maria Sekutowicz, Miriam Sebold, Maria Garbusow, Christian Sommer, Hans-Ulrich Wittchen, Ulrich S Zimmermann, Michael N Smolka, Henrik Walter, Andreas Heinz, Philipp Sterzer,

With progress in magnetic resonance imaging technology and a broader dissemination of state-of-the-art imaging facilities, the acquisition of multiple neuroimaging modalities is becoming increasingly feasible. One particular hope associated with multimodal neuroimaging is the development of reliable data-driven diagnostic classifiers for psychiatric disorders, yet previous studies have often failed to ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):298]

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Prospective prediction of suicide attempts in community adolescents and young adults, using regression methods and machine learning.

Marcel Miché, Erich Studerus, Andrea Hans Meyer, Andrew Thomas Gloster, Katja Beesdo-Baum, Hans-Ulrich Wittchen, Roselind Lieb,

BACKGROUND:The use of machine learning (ML) algorithms to study suicidality has recently been recommended. Our aim was to explore whether ML approaches have the potential to improve the prediction of suicide attempt (SA) risk. Using the epidemiological multiwave prospective-longitudinal Early Developmental Stages of Psychopathology (EDSP) data set, we compared four ... Read more >>

J Affect Disord (Journal of affective disorders)
[2020, 265:570-578]

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Effect of CBT on Biased Semantic Network in Panic Disorder: A Multicenter fMRI Study Using Semantic Priming.

Yunbo Yang, Ulrike Lueken, Jan Richter, Alfons Hamm, André Wittmann, Carsten Konrad, Andreas Ströhle, Bettina Pfleiderer, Martin J Herrmann, Thomas Lang, Martin Lotze, Jürgen Deckert, Volker Arolt, Hans-Ulrich Wittchen, Benjamin Straube, Tilo Kircher,

OBJECTIVE:Cognitive-behavioral therapy (CBT) has been hypothesized to act by reducing the pathologically enhanced semantic, anxiety-related associations of patients with panic disorder. This study investigated the effects of CBT on the behavioral and neural correlates of the panic-related semantic network in patients with panic disorder. METHODS:An automatic semantic priming paradigm specifically ... Read more >>

Am J Psychiatry (The American journal of psychiatry)
[2020, 177(3):254-264]

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Perception of alcohol policies by consumers of unrecorded alcohol - an exploratory qualitative interview study with patients of alcohol treatment facilities in Russia.

Maria Neufeld, Hans-Ulrich Wittchen, Lori E Ross, Carina Ferreira-Borges, Jürgen Rehm,

BACKGROUND:Over the last decade Russia has introduced various policy measures to reduce alcohol consumption and alcohol-related harm at the population level. Several of these policies, such as higher pricing and taxation or restrictions of availability, may not work in the case of unrecorded alcohol consumption; they may encourage consumers to ... Read more >>

Subst Abuse Treat Prev Policy (Substance abuse treatment, prevention, and policy)
[2019, 14(1):53]

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Dissociating neural learning signals in human sign- and goal-trackers.

Daniel J Schad, Michael A Rapp, Maria Garbusow, Stephan Nebe, Miriam Sebold, Elisabeth Obst, Christian Sommer, Lorenz Deserno, Milena Rabovsky, Eva Friedel, Nina Romanczuk-Seiferth, Hans-Ulrich Wittchen, Ulrich S Zimmermann, Henrik Walter, Philipp Sterzer, Michael N Smolka, Florian Schlagenhauf, Andreas Heinz, Peter Dayan, Quentin J M Huys,

Individuals differ in how they learn from experience. In Pavlovian conditioning models, where cues predict reinforcer delivery at a different goal location, some animals-called sign-trackers-come to approach the cue, whereas others, called goal-trackers, approach the goal. In sign-trackers, model-free phasic dopaminergic reward-prediction errors underlie learning, which renders stimuli 'wanted'. Goal-trackers ... Read more >>

Nat Hum Behav (Nature human behaviour)
[2020, 4(2):201-214]

Cited: 2 times

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Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study.

Sylke Andreas, Maria Dehoust, Jana Volkert, Holger Schulz, Susanne Sehner, Anna Suling, Karl Wegscheider, Berta Ausín, Alessandra Canuto, Mike J Crawford, Chiara Da Ronch, Luigi Grassi, Yael Hershkovitz, Manuel Muñoz, Alan Quirk, Ora Rotenstein, Ana Belén Santos-Olmo, Arieh Y Shalev, Kerstin Weber, Hans-Ulrich Wittchen, Martin Härter,

OBJECTIVES:Affective disorders are among the most prevalent disorders in the elderly. The present study aims to examine the sociodemographic and clinical correlates of major depressive disorder (MDD) and dysthymia in different European and Associated countries using standardized interview techniques. Furthermore, service utilization for the elderly with depression is assessed. METHODS:The ... Read more >>

PLoS One (PloS one)
[2019, 14(11):e0224871]

Cited: 1 time

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Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.

Andreas J Forstner, Swapnil Awasthi, Christiane Wolf, Eduard Maron, Angelika Erhardt, Darina Czamara, Elias Eriksson, Catharina Lavebratt, Christer Allgulander, Nina Friedrich, Jessica Becker, Julian Hecker, Stefanie Rambau, Rupert Conrad, Franziska Geiser, Francis J McMahon, Susanne Moebus, Timo Hess, Benedikt C Buerfent, Per Hoffmann, Stefan Herms, Stefanie Heilmann-Heimbach, Ingrid Kockum, Tomas Olsson, Lars Alfredsson, Heike Weber, Georg W Alpers, Volker Arolt, Lydia Fehm, Thomas Fydrich, Alexander L Gerlach, Alfons Hamm, Tilo Kircher, Christiane A Pané-Farré, Paul Pauli, Winfried Rief, Andreas Ströhle, Jens Plag, Thomas Lang, Hans-Ulrich Wittchen, Manuel Mattheisen, Sandra Meier, Andres Metspalu, Katharina Domschke, Andreas Reif, Iiris Hovatta, Nils Lindefors, Evelyn Andersson, Martin Schalling, Hamdi Mbarek, Yuri Milaneschi, Eco J C de Geus, Dorret I Boomsma, Brenda W J H Penninx, Thorgeir E Thorgeirsson, Stacy Steinberg, Kari Stefansson, Hreinn Stefansson, Bertram Müller-Myhsok, Thomas Folkmann Hansen, Anders D Børglum, Thomas Werge, Preben Bo Mortensen, Merete Nordentoft, David M Hougaard, Christina M Hultman, Patrick F Sullivan, Markus M Nöthen, David P D Woldbye, Ole Mors, Elisabeth B Binder, Christian Rück, Stephan Ripke, Jürgen Deckert, Johannes Schumacher,

Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically ... Read more >>

Mol. Psychiatry (Molecular psychiatry)
[2019, :]

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Association of NPSR1 gene variation and neural activity in patients with panic disorder and agoraphobia and healthy controls.

Johanna Gechter, Carolin Liebscher, Maximilian J Geiger, André Wittmann, Florian Schlagenhauf, Ulrike Lueken, Hans-Ulrich Wittchen, Bettina Pfleiderer, Volker Arolt, Tilo Kircher, Benjamin Straube, Jürgen Deckert, Heike Weber, Martin J Herrmann, Andreas Reif, Katharina Domschke, Andreas Ströhle,

INTRODUCTION:The neurobiological mechanisms behind panic disorder with agoraphobia (PD/AG) are not completely explored. The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural "fear network". We aimed to ... Read more >>

Neuroimage Clin (NeuroImage. Clinical)
[2019, 24:102029]

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Augmenting extinction learning with D-cycloserine reduces return of fear: a randomized, placebo-controlled fMRI study.

Claudia Ebrahimi, Johanna Gechter, Ulrike Lueken, Florian Schlagenhauf, Hans-Ulrich Wittchen, Alfons O Hamm, Andreas Ströhle,

D-cycloserine (DCS), a partial NMDA-receptor agonist, seems to be a promising enhancer for exposure therapy in anxiety disorders. It has been tested successfully in animal models of fear extinction, where DCS enhanced extinction learning. Applied in clinical studies, results of DCS-augmented exposure therapy remain ambiguous, calling for a deeper understanding ... Read more >>

Neuropsychopharmacology (Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology)
[2020, 45(3):499-506]

Cited: 2 times

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Association of rs7688285 allelic variation coding for GLRB with fear reactivity and exposure-based therapy in patients with panic disorder and agoraphobia.

Isabelle C Ridderbusch, Jan Richter, Yunbo Yang, Michael Hoefler, Heike Weber, Andreas Reif, Alfons Hamm, Christiane A Pané-Farré, Alexander L Gerlach, Andreas Stroehle, Bettina Pfleiderer, Volker Arolt, Hans-Ulrich Wittchen, Andrew Gloster, Thomas Lang, Sylvia Helbig-Lang, Lydia Fehm, Paul Pauli, Tilo Kircher, Ulrike Lueken, Benjamin Straube,

The gene coding for glycine receptor β subunits (GLRB) has been found to be related to panic disorder and agoraphobia (PD/AG) and to be associated with altered insular BOLD activation during fear conditioning, as an intermediate phenotype of defensive system reactivity in healthy subjects. In a multicenter clinical trial on ... Read more >>

Eur Neuropsychopharmacol (European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology)
[2019, 29(10):1138-1151]

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Pavlovian-To-Instrumental Transfer and Alcohol Consumption in Young Male Social Drinkers: Behavioral, Neural and Polygenic Correlates.

Maria Garbusow, Stephan Nebe, Christian Sommer, Sören Kuitunen-Paul, Miriam Sebold, Daniel J Schad, Eva Friedel, Ilya M Veer, Hans-Ulrich Wittchen, Michael A Rapp, Stephan Ripke, Henrik Walter, Quentin J M Huys, Florian Schlagenhauf, Michael N Smolka, Andreas Heinz,

In animals and humans, behavior can be influenced by irrelevant stimuli, a phenomenon called Pavlovian-to-instrumental transfer (PIT). In subjects with substance use disorder, PIT is even enhanced with functional activation in the nucleus accumbens (NAcc) and amygdala. While we observed enhanced behavioral and neural PIT effects in alcohol-dependent subjects, we ... Read more >>

(Journal of clinical medicine)
[2019, 8(8):]

Cited: 1 time

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Neural Response Patterns During Pavlovian-to-Instrumental Transfer Predict Alcohol Relapse and Young Adult Drinking.

Maria Sekutowicz, Matthias Guggenmos, Sören Kuitunen-Paul, Maria Garbusow, Miriam Sebold, Patricia Pelz, Josef Priller, Hans-Ulrich Wittchen, Michael N Smolka, Ulrich S Zimmermann, Andreas Heinz, Philipp Sterzer, Katharina Schmack,

BACKGROUND:Pavlovian-to-instrumental transfer (PIT) describes the influence of conditioned stimuli on instrumental behaviors and is discussed as a key process underlying substance abuse. Here, we tested whether neural responses during alcohol-related PIT predict future relapse in alcohol-dependent patients and future drinking behavior in adolescents. METHODS:Recently detoxified alcohol-dependent patients (n = 52) and ... Read more >>

Biol Psychiatry (Biological psychiatry)
[2019, 86(11):857-863]

Cited: 2 times

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