Full Text Journal Articles by
Author Hannah Wunsch

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Reflections on Critical Care's Past, Present, and Future.

Manu Shankar-Hari, Hannah Wunsch, Kathy Rowan, Mervyn Singer, Gordon D Rubenfeld, Derek C Angus,

Crit Care Med (Critical care medicine)
[2021, 49(11):1855-1865]

Cited: 0 times

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The Epidemiology of Extremity Threat and Amputation Following Vasopressor-dependent Sepsis.

Katherine M Reitz, Jason Kennedy, Caroline Rieser, Callie Hlavin, Hayley B Gershengorn, Matthew D Neal, Nicole Bensen, Kelsey Linstrum, Hallie C Prescott, Matthew R Rosengart, Victor Talisa, Daniel E Hall, Edith Tzeng, Hannah Wunsch, Sachin Yende, Derek C Angus, Christopher W Seymour,

<h4>Rationale</h4>Extremity threat and amputation following sepsis is a well-publicized and devastating event. However, there is a paucity of data exists surrounding theabout the epidemiology of extmreityextremity threat following sepsis onset.<h4>Objectives</h4>We aim toTo estimate the incidence of extremity threat with or without surgical amputation in community sepsis.<h4>Methods</h4>Multihospital Rretrospective cohort study of ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, :]

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Critical illness in patients with hematologic malignancy: a population-based cohort study.

Bruno L Ferreyro, Damon C Scales, Hannah Wunsch, Matthew C Cheung, Vikas Gupta, Refik Saskin, Santhosh Thyagu, Laveena Munshi,

<h4>Purpose</h4>To describe the modern incidence and predictors of ICU admission for adult patients newly diagnosed with a hematologic malignancy.<h4>Methods</h4>We conducted a population-based cohort study of adults with a new diagnosis of hematologic malignancy (April 1, 2006-March 31, 2017) in Ontario, Canada. We described the baseline demographic, clinical and laboratory predictors ... Read more >>

Intensive Care Med (Intensive care medicine)
[2021, 47(10):1104-1114]

Cited: 1 time

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Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial.

Philippe Bégin, Jeannie Callum, Erin Jamula, Richard Cook, Nancy M Heddle, Alan Tinmouth, Michelle P Zeller, Guillaume Beaudoin-Bussières, Luiz Amorim, Renée Bazin, Kent Cadogan Loftsgard, Richard Carl, Michaël Chassé, Melissa M Cushing, Nick Daneman, Dana V Devine, Jeannot Dumaresq, Dean A Fergusson, Caroline Gabe, Marshall J Glesby, Na Li, Yang Liu, Allison McGeer, Nancy Robitaille, Bruce S Sachais, Damon C Scales, Lisa Schwartz, Nadine Shehata, Alexis F Turgeon, Heidi Wood, Ryan Zarychanski, Andrés Finzi, , Donald M Arnold,

The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear. Although most randomized controlled trials have shown negative results, uncontrolled studies have suggested that the antibody content could influence patient outcomes. We conducted an open-label, randomized controlled trial of convalescent plasma for adults with COVID-19 receiving oxygen within ... Read more >>

Nat Med (Nature medicine)
[2021, :]

Cited: 2 times

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Transformations in medical care were never easy or safe.

Hannah Wunsch,

Nature (Nature)
[2021, 597(7878):625-626]

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The association between prescription opioid dispensing and opioid-related morbidity and mortality in Ontario, Canada: an ecological study of public health units.

Karim S Ladha, Duminda N Wijeysundera, Hannah Wunsch, Hance Clarke, Calvin Diep, Tara Gomes,

<h4>Objective</h4>Overdose and death rates from opioids continue to rise. However, the relative contribution of prescription opioids to the ongoing crisis is unclear. The purpose of this study was to assess the association between prescription opioid dispensing and opioid-related morbidity and mortality.<h4>Methods</h4>Regional-level data for this ecological study were extracted from publicly ... Read more >>

Drug Alcohol Depend (Drug and alcohol dependence)
[2021, 227:108989]

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Pinpointing the Cause of Variation in Mortality in COVID-19.

Bijan Teja, Hannah Wunsch,

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 204(4):381-382]

Cited: 0 times

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What Affects Adoption of Specialty Palliative Care in Intensive Care Units: A Qualitative Study.

May Hua, Laura D Fonseca, R Sean Morrison, Hannah Wunsch, Robert Fullilove, Douglas B White,

<h4>Context</h4>Although many patients with critical illness may benefit from involvement of palliative care specialists, adoption of these services in the intensive care unit (ICU) is variable.<h4>Objective</h4>To characterize reasons for variable buy-in for specialty palliative care in the ICU, and identify factors associated with routine involvement of specialists in appropriate cases.<h4>Methods</h4>Qualitative ... Read more >>

J Pain Symptom Manage (Journal of pain and symptom management)
[2021, :]

Cited: 0 times

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Preoperative Sedative-hypnotic Medication Use and Adverse Postoperative Outcomes.

Timothy G Gaulton, Hannah Wunsch, Lakisha J Gaskins, Charles E Leonard, Sean Hennessy, Michael Ashburn, Colleen Brensinger, Craig Newcomb, Duminda Wijeysundera, Brian T Bateman, Jennifer Bethell, Mark D Neuman,

<h4>Objective</h4>To determine the association between preoperative benzodiazepine and nonbenzodiazepine receptor agonist ("Z-drugs") use and adverse outcomes after surgery.<h4>Background</h4>Prescriptions for benzodiazepines and Z-drugs have increased over the past decade. Despite this, the association of preoperative benzodiazepines and Z-drug receipt with adverse outcomes after surgery is unknown.<h4>Methods</h4>Using the Optum Clinformatics Datamart, we ... Read more >>

Ann Surg (Annals of surgery)
[2021, 274(2):e108-e114]

Cited: 1 time

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Suicide and self-harm in adult survivors of critical illness: population based cohort study.

Shannon M Fernando, Danial Qureshi, Manish M Sood, Michael Pugliese, Robert Talarico, Daniel T Myran, Margaret S Herridge, Dale M Needham, Bram Rochwerg, Deborah J Cook, Hannah Wunsch, Robert A Fowler, Damon C Scales, O Joseph Bienvenu, Kathryn M Rowan, Magdalena Kisilewicz, Laura H Thompson, Peter Tanuseputro, Kwadwo Kyeremanteng,

<h4>Objective</h4>To analyse the association between survival from critical illness and suicide or self-harm after hospital discharge.<h4>Design</h4>Population based cohort study using linked and validated provincial databases.<h4>Setting</h4>Ontario, Canada between January 2009 and December 2017 (inclusive).<h4>Participants</h4>Consecutive adult intensive care unit (ICU) survivors (≥18 years) were included. Linked administrative databases were used to compare ... Read more >>

BMJ (BMJ (Clinical research ed.))
[2021, 373:n973]

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Association of the 2016 US Centers for Disease Control and Prevention Opioid Prescribing Guideline With Changes in Opioid Dispensing After Surgery.

Tori N Sutherland, Hannah Wunsch, Ruxandra Pinto, Craig Newcomb, Colleen Brensinger, Lakisha Gaskins, Brian T Bateman, Mark D Neuman,

<h4>Importance</h4>While the 2016 US Centers for Disease Control and Prevention (CDC) guideline for prescribing opioids for chronic pain was not intended to address postoperative pain management, observers have noted the potential for the guideline to have affected postoperative opioid prescribing.<h4>Objective</h4>To assess changes in postoperative opioid dispensing after vs before the ... Read more >>

JAMA Netw Open (JAMA network open)
[2021, 4(6):e2111826]

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Acute healthcare resource utilization by age: A cohort study.

Bourke W Tillmann, Longdi Fu, Andrea D Hill, Damon C Scales, Robert A Fowler, Brian H Cuthbertson, Hannah Wunsch,

<h4>Background</h4>Granular data related to the likelihood of individuals of different ages accessing acute and critical care services over time is lacking.<h4>Methods</h4>We used population-based, administrative data from Ontario to identify residents of specific ages (20, 30, 40, etc. to 100) on January 1st every year from 1995-2019. We assessed rates of ... Read more >>

PLoS One (PloS one)
[2021, 16(5):e0251877]

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Practice Patterns in the Initiation of Secondary Vasopressors and Adjunctive Corticosteroids during Septic Shock in the US.

Nicholas A Bosch, Bijan Teja, Hannah Wunsch, Allan J Walkey,

<h4>Rationale</h4>A central component of septic shock treatment is the infusion of vasopressors, most commonly starting with norepinephrine. However, the optimal approach and practice patterns to initiating adjunctive vasopressors and corticosteroids are unknown.<h4>Objectives</h4>To characterize practice pattern variation in the norepinephrine dose at which secondary vasopressors and adjunctive corticosteroids are initiated and ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, :]

Cited: 0 times

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Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report.

Nafeesa Alibhai, Michael Detsky, Hannah Wunsch, Bijan Teja,

Recent studies have demonstrated that vasopressors can be delivered safely through peripheral intravenous lines. While norepinephrine is usually delivered at a concentration of 16 to 32 μg/mL, out of concern for extravasation and interstitial necrosis, some patients receive more dilute norepinephrine solutions through peripheral intravenous catheters. We describe a case ... Read more >>

A A Pract (A&A practice)
[2021, 15(5):e01479]

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The Pandemic That Always Strains Critical Care: Smoking.

Hannah Wunsch, Daniel Brodie,

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(4):582-583]

Cited: 0 times

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Attention to Immortal Time Bias in Critical Care Research.

Emily A Vail, Hayley B Gershengorn, Hannah Wunsch, Allan J Walkey,

Observational studies in critical care medicine offer a popular and practical approach to questions of treatment effectiveness. Although observational research is widely understood to be susceptible to design and interpretation challenges, one well-described source of bias-immortal time bias (ITB)-is frequently present yet often overlooked. ITB may be introduced by study ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(10):1222-1229]

Cited: 1 time

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Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.

Waleed Alhazzani, Laura Evans, Fayez Alshamsi, Morten Hylander Møller, Marlies Ostermann, Hallie C Prescott, Yaseen M Arabi, Mark Loeb, Michelle Ng Gong, Eddy Fan, Simon Oczkowski, Mitchell M Levy, Lennie Derde, Amy Dzierba, Bin Du, Flavia Machado, Hannah Wunsch, Mark Crowther, Maurizio Cecconi, Younsuck Koh, Lisa Burry, Daniel S Chertow, Wojciech Szczeklik, Emilie Belley-Cote, Massimiliano Greco, Malgorzata Bala, Ryan Zarychanski, Jozef Kesecioglu, Allison McGeer, Leonard Mermel, Manoj J Mammen, Sheila Nainan Myatra, Amy Arrington, Ruth Kleinpell, Giuseppe Citerio, Kimberley Lewis, Elizabeth Bridges, Ziad A Memish, Naomi Hammond, Frederick G Hayden, Muhammed Alshahrani, Zainab Al Duhailib, Greg S Martin, Lewis J Kaplan, Craig M Coopersmith, Massimo Antonelli, Andrew Rhodes,

<h4>Background</h4>The coronavirus disease 2019 pandemic continues to affect millions worldwide. Given the rapidly growing evidence base, we implemented a living guideline model to provide guidance on the management of patients with severe or critical coronavirus disease 2019 in the ICU.<h4>Methods</h4>The Surviving Sepsis Campaign Coronavirus Disease 2019 panel has expanded to ... Read more >>

Crit Care Med (Critical care medicine)
[2021, 49(3):e219-e234]

Cited: 37 times

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Trends in COVID-19-related in-hospital mortality: lessons learned from nationwide samples.

Purnema Madahar, Hannah Wunsch, Prabhat Jha, Arthur S Slutsky, Daniel Brodie,

Lancet Respir Med (The Lancet. Respiratory medicine)
[2021, 9(4):322-324]

Cited: 2 times

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Informing Healthcare Decisions with Observational Research Assessing Causal Effect. An Official American Thoracic Society Research Statement.

Andrea S Gershon, Peter K Lindenauer, Kevin C Wilson, Louise Rose, Allan J Walkey, Mohsen Sadatsafavi, Kevin J Anstrom, David H Au, Bruce G Bender, M Alan Brookhart, Raed A Dweik, MeiLan K Han, Min J Joo, Valery Lavergne, Anuj B Mehta, Marc Miravitlles, Richard A Mularski, Nicolas Roche, Eyal Oren, Kristin A Riekert, Noah C Schoenberg, Therese A Stukel, Curtis H Weiss, Hannah Wunsch, Joel J Africk, Jerry A Krishnan,

<b>Rationale:</b> Decisions in medicine are made on the basis of knowledge and reasoning, often in shared conversations with patients and families in consideration of clinical practice guideline recommendations, individual preferences, and individual goals. Observational studies can provide valuable knowledge to inform guidelines, decisions, and policy.<b>Objectives:</b> The American Thoracic Society (ATS) ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2021, 203(1):14-23]

Cited: 0 times

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Getting out of the 1950s: rethinking old priorities for staffing in critical care.

Hannah Wunsch,

Crit Care (Critical care (London, England))
[2020, 24(1):695]

Cited: 0 times

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Association of Severe Trauma With Work and Earnings in a National Cohort in Canada.

Barbara Haas, Sung-Hee Jeon, Michelle Rotermann, Michael Stepner, Randy Fransoo, Claudia Sanmartin, Hannah Wunsch, Damon C Scales, Theodore J Iwashyna, Allan Garland,

<h4>Importance</h4>Traumatic injury disproportionately affects adults of working age. The ability to work and earn income is a key patient-centered outcome. The association of severe injury with work and earnings appears to be unknown.<h4>Objective</h4>To evaluate the association of severe traumatic injury with subsequent employment and earnings in long-term survivors.<h4>Design, setting, and ... Read more >>

JAMA Surg (JAMA surgery)
[2021, 156(1):51-59]

Cited: 0 times

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Use of Vasoactive Medications after Cardiac Surgery in the United States.

Emily A Vail, Meng-Shiou Shieh, Penelope S Pekow, Hayley B Gershengorn, Allan J Walkey, Peter K Lindenauer, Hannah Wunsch,

<b>Rationale:</b> Patients undergoing cardiac surgery often require vasopressor or inotropic ("vasoactive") medications, but patterns of postoperative use are not well described.<b>Objectives:</b> This study aimed to describe vasoactive medication administration throughout hospitalization for cardiac surgery, to identify patient- and hospital-level factors associated with postoperative use, and to quantify variation in treatment ... Read more >>

Ann Am Thorac Soc (Annals of the American Thoracic Society)
[2021, 18(1):103-111]

Cited: 2 times

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Prescription opioid use after vaginal delivery and subsequent persistent opioid use and misuse.

Yanmin Zhu, Krista F Huybrechts, Rishi J Desai, Jessica M Franklin, Sonia Hernandez-Diaz, Alexis Krumme, Loreen Straub, Mark Neuman, Hannah Wunsch, Raisa Levin, Helen Mogun, Brian T Bateman,

<h4>Background</h4>Vaginal delivery is the most common reason for hospitalization in the United States, and approximately 30% of women fill an opioid prescription after vaginal delivery, making this a common source of opioid exposure in women of reproductive age.<h4>Objective</h4>This study aimed to evaluate the effect of receiving an opioid prescription after ... Read more >>

Am J Obstet Gynecol MFM (American journal of obstetrics & gynecology MFM)
[2021, 3(2):100304]

Cited: 0 times

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Frailty and long-term outcomes following critical illness: A population-level cohort study.

Andrea D Hill, Robert A Fowler, Hannah Wunsch, Ruxandra Pinto, Damon C Scales,

<h4>Purpose</h4>To provide population-level estimates of the association of frailty with one-year outcomes after critical illness.<h4>Materials and methods</h4>Retrospective cohort study of patients who survived an ICU admission between April 2002 and March 2015. Pre-existing frailty was classified using the Johns Hopkins Adjusted Clinical Groups frailty indicator. Multivariable Cox regression and Fine ... Read more >>

J Crit Care (Journal of critical care)
[2021, 62:94-100]

Cited: 0 times

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Use of Hydrocortisone, Ascorbic Acid, and Thiamine in Adults with Septic Shock.

Emily A Vail, Hannah Wunsch, Ruxandra Pinto, Nicholas A Bosch, Allan J Walkey, Peter K Lindenauer, Hayley B Gershengorn,

<b>Rationale:</b> In December 2016, a single-center study describing significant improvements in mortality among a small group of patients with severe sepsis and septic shock treated with hydrocortisone, high-dose ascorbic acid, and thiamine (HAT therapy) was published online.<b>Objectives:</b> This study aims to describe the administration of HAT therapy among U.S. adults ... Read more >>

Am J Respir Crit Care Med (American journal of respiratory and critical care medicine)
[2020, 202(11):1531-1539]

Cited: 2 times

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