Full Text Journal Articles by
Author Hanna Salmonowicz

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Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice.

Mikolaj Ogrodnik, Shane A Evans, Edward Fielder, Stella Victorelli, Patrick Kruger, Hanna Salmonowicz, Bettina M Weigand, Ayush D Patel, Tamar Pirtskhalava, Christine L Inman, Kurt O Johnson, Stephanie L Dickinson, Azucena Rocha, Marissa J Schafer, Yi Zhu, David B Allison, Thomas von Zglinicki, Nathan K LeBrasseur, Tamar Tchkonia, Nicola Neretti, João F Passos, James L Kirkland, Diana Jurk,

Cellular senescence is characterized by an irreversible cell cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it is still unknown whether ... Read more >>

Aging Cell (Aging cell)
[2021, :e13296]

Cited: 0 times

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Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence.

Mikolaj Ogrodnik, Hanna Salmonowicz, Diana Jurk, João F Passos,

Cellular senescence is a major driver of age-related diseases, and senotherapies are being tested in clinical trials. Despite its popularity, cellular senescence is weakly defined and is frequently referred to as irreversible cell-cycle arrest. In this article we hypothesize that cellular senescence is a phenotype that results from the coordination ... Read more >>

Trends Biochem Sci (Trends in biochemical sciences)
[2019, 44(12):996-1008]

Cited: 9 times

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Mitochondria and cellular senescence: Implications for musculoskeletal ageing.

Leena Habiballa, Hanna Salmonowicz, João F Passos,

Musculoskeletal ageing and its associated diseases are major contributors to the loss of independence and reduced quality of life in older people. Several recent studies indicate that cellular senescence is a contributor to age-related loss of function in various organs including muscle, bones and joints. Importantly, these studies indicate that ... Read more >>

Free Radic Biol Med (Free radical biology & medicine)
[2019, 132:3-10]

Cited: 4 times

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Length-independent telomere damage drives cardiomyocyte senescence

Rhys Anderson, Anthony Lagnado, Damien Maggiorani, Anna Walaszczyk, Emily Dookun, James Chapman, Jodie Birch, Hanna Salmonowicz, Mikolaj Ogrodnik, Diana Jurk, Carole Proctor, Clara Correia-Melo, Stella Victorelli, Edward Fielder, Rolando Berlinguer-Palmini, Andrew Owens, Laura Greaves, Kathy Kolsky, Angelo Parini, Victorine Douin-Echinard, Nathan LeBrasseur, Helen Arthur, Simon Tual-Chalot, Marissa Schafer, Carolyn Roos, Jordan Miller, Neil Robertson, Jelena Mann, Peter Adams, Tamara Tchkonia, James Kirkland, Jeanne Mialet-Perez, Gavin Richardson, João Passos,

Ageing is the biggest risk factor for cardiovascular health and is associated with increased incidence of cardiovascular disease. Cellular senescence, a process driven in part by telomere shortening, has been implicated in age-related tissue dysfunction. Here, we address the question of how senescence is induced in rarely dividing/post-mitotic cardiomyocytes and ... Read more >>

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Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells.

Mikolaj Ogrodnik, Hanna Salmonowicz, Vadim N Gladyshev,

Understanding the aging process and ways to manipulate it is of major importance for biology and medicine. Among the many aging theories advanced over the years, the concept most consistent with experimental evidence posits the buildup of numerous forms of molecular damage as a foundation of the aging process. Here, ... Read more >>

Aging Cell (Aging cell)
[2019, 18(1):e12841]

Cited: 17 times

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Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Matthew D W Piper, George A Soultoukis, Eric Blanc, Andrea Mesaros, Samantha L Herbert, Paula Juricic, Xiaoli He, Ilian Atanassov, Hanna Salmonowicz, Mingyao Yang, Stephen J Simpson, Carlos Ribeiro, Linda Partridge,

Balancing the quantity and quality of dietary protein relative to other nutrients is a key determinant of evolutionary fitness. A theoretical framework for defining a balanced diet would both reduce the enormous workload to optimize diets empirically and represent a breakthrough toward tailoring diets to the needs of consumers. Here, ... Read more >>

Cell Metab (Cell metabolism)
[2017, 25(3):610-621]

Cited: 25 times

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Detecting senescence: a new method for an old pigment.

Hanna Salmonowicz, João F Passos,

Cellular senescence is a state of irreversible cell cycle arrest induced by different types of cellular stresses. The field of senescence has made significant advances in the understanding of many of the mechanisms governing this phenomenon; however, a universal biomarker that unambiguously distinguishes senescent from proliferating cells has not been ... Read more >>

Aging Cell (Aging cell)
[2017, 16(3):432-434]

Cited: 3 times

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Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan.

Matthew D W Piper, George A Soultoukis, Eric Blanc, Andrea Mesaros, Samantha L Herbert, Paula Juricic, Xiaoli He, Ilian Atanassov, Hanna Salmonowicz, Mingyao Yang, Stephen J Simpson, Carlos Ribeiro, Linda Partridge,

Cell Metab (Cell metabolism)
[2017, 25(5):1206]

Cited: 11 times

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Dynamic JUNQ inclusion bodies are asymmetrically inherited in mammalian cell lines through the asymmetric partitioning of vimentin.

Mikołaj Ogrodnik, Hanna Salmonowicz, Rachel Brown, Joanna Turkowska, Władysław Średniawa, Sundararaghavan Pattabiraman, Triana Amen, Ayelet-chen Abraham, Noam Eichler, Roman Lyakhovetsky, Daniel Kaganovich,

Aging is associated with the accumulation of several types of damage: in particular, damage to the proteome. Recent work points to a conserved replicative rejuvenation mechanism that works by preventing the inheritance of damaged and misfolded proteins by specific cells during division. Asymmetric inheritance of misfolded and aggregated proteins has ... Read more >>

Proc Natl Acad Sci U S A (Proceedings of the National Academy of Sciences of the United States of America)
[2014, 111(22):8049-8054]

Cited: 58 times

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