Full Text Journal Articles by
Author Hang Lv

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CLEC14A protects against podocyte injury in mice with adriamycin nephropathy.

Zeyu Su, Yujia Li, Hang Lv, Xiaoyang Cui, Min Liu, Ziying Wang, Yan Zhang, Junhui Zhen, Wei Tang, Xiaojie Wang, Fan Yi,

Podocyte injury is a major determinant of focal segmental glomerular sclerosis (FSGS) and the identification of potential therapeutic targets for preventing podocyte injury has clinical importance for the treatment of FSGS. CLEC14A is a single-pass transmembrane glycoprotein belonging to the vascular expressed C-type lectin family. CLEC14A is found to be ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21711]

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PADI4 mediates autophagy and participates in the role of ganoderic acid A monomers in delaying the senescence of Alzheimer's cells through the Akt/mTOR pathway.

Shuhua Shen, Xiaoming Wang, Hang Lv, Yuan Shi, Luwei Xiao,

The effects of PADI4 and GAA on the senescence of Alzheimer's cells were explored in the present work. HT22 cells were treated with Aβ25-35 to establish an Alzheimer's model, and were then treated with different concentrations of GAA and transfected with a siPADI4 lentiviral vector. GAA could reverse the effects ... Read more >>

Biosci Biotechnol Biochem (Bioscience, biotechnology, and biochemistry)
[2021, :]

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Influence of rice husk addition on phosphorus fractions and heavy metals risk of biochar derived from sewage sludge.

Qiao Xiong, Xiang Wu, Hang Lv, Shuhua Liu, Haobo Hou, Xu Wu,

This study investigated the effects of rice husk dose and pyrolysis temperature on the phosphorus (P) fractions and environmental risk of heavy metals in biochar co-pyrolyzed from sewage sludge and rice husk. Biochar properties were analyzed, and the transformation of P and heavy metals speciation during co-pyrolysis were also discussed. ... Read more >>

Chemosphere (Chemosphere)
[2021, 280:130566]

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Bipolar transurethral enucleation of the prostate combined with open cystolithotomy in the treatment of large and giant prostate with bladder stones: Case series.

Rami Walid Abdullah Alshayyah, Yang Yu, Hang Lv, Wengtong Liu, Bo Yang,

The surgical management of large or giant prostate still has challenges to urologists, especially if combined with bladder stones, and the traditional techniques by open prostatectomy and cystolithotomy have significant morbidity rates. The endoscopic procedure might not be feasible to treat both conditions in a single procedure, despite advances in ... Read more >>

Urologia (Urologia)
[2021, :3915603211001686]

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Strong Field Ionization-Photofragmentation on Ultrafast Evolution of Electronic States of Toluene Cations.

Longxing Zhou, Yang Liu, Tian Sun, Hang Yin, Yiwen Zhao, Hang Lv, Haifeng Xu,

Ultrafast time-resolved strong field ionization-photofragmentation (SFI-PF) has emerged as a useful method for investigation of dynamics of molecular cations. Here we perform a SFI-PF study on the electronic states of toluene cations. By measuring the ion yields as a function of delay time, we obtain the transients of both parent ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2021, 125(10):2095-2100]

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Exosomal miR-590-5p in Serum as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer.

Guo-Dian Zheng, Zhi-Yuan Xu, Can Hu, Hang Lv, Hua-Xia Xie, Ting Huang, Yan-Qiang Zhang, Gui-Ping Chen, Yu-Fei Fu, Xiang-Dong Cheng,

The purpose of this study is to explore the expression of miRNA-590-5p, an exosome of gastric cancer (GC), and to evaluate the suitability of miR-590-5p, an exosome with its own clinical characteristics. Serum samples from 168 gastric cancer patients and 50 matched controls were collected and exosomal RNAs were extracted. ... Read more >>

Front Mol Biosci (Frontiers in molecular biosciences)
[2021, 8:636566]

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Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling.

Yufei Fu, Fanfan Zhu, Zhongjun Ma, Bin Lv, Xi Wang, Chunyan Dai, Xiaoqiong Ma, Pei Liu, Hang Lv, Xin Chen, Zhe Chen, Li Shen,

<h4>Background</h4><i>Physalis alkekengi</i> var. <i>franchetii</i> is an herb that possesses various ethnopharmacological applications. Herein, our current study focuses on the antitumor effect of a combination of physalins, which are regarded as the most representative secondary metabolites from calyces of <i>Physalis alkekengi</i> var. <i>franchetii</i>.<h4>Materials and methods</h4>We mainly investigated the antitumor activity of ... Read more >>

Onco Targets Ther (OncoTargets and therapy)
[2021, 14:301-314]

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p-MEK expression predicts prognosis of patients with adenocarcinoma of esophagogastric junction (AEG) and plays a role in anti-AEG efficacy of Huaier.

Li Yuan, Shao-Wei Mo, Zhi-Yuan Xu, Hang Lv, Jing-Li Xu, Kai-Bo Guo, Can Hu, Xiao-Feng Wang, Gui-Ping Chen, Jiang-Jiang Qin, Xiang-Dong Cheng,

The incidence rate of adenocarcinoma of the esophagogastric junction (AEG) is increasing worldwide with poor prognosis and unclear pathogenesis. Trametes robiniophila Murr. (Huaier), a traditional Chinese medicine has been used in the clinical treatment of a variety of solid tumors, including AEG. However, its anticancer components and molecular mechanisms are ... Read more >>

Pharmacol Res (Pharmacological research)
[2021, 165:105411]

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Two Anthracene-Based Ir(III) Complexes [Ir(pbt)2(aip)]Cl and [Ir(pbt)2(aipm)]Cl: Relationship between Substituent Group and Photo-oxidation Activity as Well as Photo-oxidation-Induced Luminescence.

Qin-Zhen Yuan, Qianwenhao Fan, Hang Lv, Wen-Wen Chen, Xue-Xiao Yang, Deng-Ke Cao, Jing Wen,

Two anthracene-based complexes [Ir(pbt)<sub>2</sub>(aip)]Cl (<b>1</b>) and [Ir(pbt)<sub>2</sub>(aipm)]Cl (<b>2</b>) have been synthesized based on the ligands aip = 2-(9-anthryl)-1<i>H</i>-imidazo[4,5-<i>f</i>][1,10]phenanthroline, aipm = 2-(9-anthryl)-1-methyl-imidazo[4,5-<i>f</i>][1,10]phenanthroline, and pbtH = 2-phenylbenzothiazole in order to explore both the influence of the substituent group R<sub>1</sub> (R<sub>1</sub> = H in <b>1</b> and CH<sub>3</sub> in <b>2</b>) on photo-oxidation activity and ... Read more >>

Inorg Chem (Inorganic chemistry)
[2020, 59(23):17071-17076]

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Recurrence in node-negative advanced gastric cancer with novel clinical and pathologic findings

Shangqi Chen, Can Hu, Zhiyuan Xu, Jianfa Yu, Xiaofeng Wang, Hang Lv, Shenyu Wei, Chengwei Shi, Xiangdong Cheng,

<h4>Background: </h4> Node-negative gastric cancer patients carry a better prognosis than node-positive. However, a subset of these patients eventually died due to the high recurrence rate of recurrence. This study investigated the clinic-pathologic factors for recurrent patterns and prognosis. Methods The detailed medical records of 947 gastric cancer patients ... Read more >>

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Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway.

Mengyue Yang, Hang Lv, Qi Liu, Lu Zhang, Ruoxi Zhang, Xingtao Huang, Xuedong Wang, Baihe Han, Shenglong Hou, Dandan Liu, Gang Wang, Jingbo Hou, Bo Yu,

Cholesterol crystal- (CC-) induced endothelial cell inflammation and pyroptosis play an important role in the development of cardiovascular diseases, especially in atherosclerosis (AS). Increasing evidence suggests that cholesterol crystals are known to be a pivotal pathological marker of atherosclerotic plaque vulnerability. As a classical nonspecific anti-inflammatory drug, colchicine has been ... Read more >>

Oxid Med Cell Longev (Oxidative medicine and cellular longevity)
[2020, 2020:9173530]

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Physalis alkekengi var. franchetii extracts exert anti-tumour effects on non-small cell lung cancer and multiple myeloma by inhibiting STAT3 signalli

Yufei Fu, Fanfan Zhu, Zhongjun Ma, Bin Lv, Xi Wang, Chunyan Dai, Xiaoqiong Ma, Pei Liu, Hang Lv, Xin Chen, Li Shen, Zhe Chen,

<h4>Background: </h4> Physalis alkekengi var. franchetii is an herb that possesses various ethnopharmacological applications. Herein, our current study focuses on the anti-tumour effect of the combination of various physalins, which are regarded as the most representative secondary metabolites from calyces of Physalis alkekengi var. franchetii . <h4>Methods: </h4>: We mainly ... Read more >>

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Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.

Shuhua Shen, Chao Li, Luwei Xiao, Xiaoming Wang, Hang Lv, Yuan Shi, Yixue Li, Qi Huang,

<h4>Background</h4>Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.<h4>Methods</h4>We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.<h4>Results</h4>Using SKAT analysis, we found 41 significantly ... Read more >>

Hum Genomics (Human genomics)
[2020, 14(1):23]

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HAND2-AS1 Inhibits Gastric Adenocarcinoma Cells Proliferation and Aerobic Glycolysis via miRNAs Sponge.

Zhiyuan Xu, Hang Lv, Yiping Wang, Can Hu, Shangqi Chen, Yian Du, Chengwei Shi, Xiangdong Cheng,

Objective:To study the effect of lncRNA HAND2-AS1 on gastric adenocarcinoma (GA) cell property and explore its specific mechanism. Methods:Data on stomach adenocarcinoma (STAD) were analyzed to screen differentially expressed lncRNA HAND2-AS1. RNA22-HAS database and dual luciferase reporter assay were applied to confirm the target relationship between HAND2-AS1/HIF3A and miR-184. The ... Read more >>

Cancer Manag Res (Cancer management and research)
[2020, 12:3053-3068]

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Cisplatin resistance in gastric cancer cells is involved with GPR30-mediated epithelial-mesenchymal transition.

Xiaofeng Wang, Zhiyuan Xu, Jiancheng Sun, Hang Lv, Yiping Wang, Yixiu Ni, Shangqi Chen, Can Hu, Lijing Wang, Wei Chen, Xiangdong Cheng,

Cisplatin is the major chemotherapeutic drug in gastric cancer, particularly in treating advanced gastric cancer. Tumour cells often develop resistance to chemotherapeutic drugs, which seriously affects the efficacy of chemotherapy. GPR30 is a novel oestrogen receptor that is involved in the invasion, metastasis and drug resistance of many tumours. Targeting ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(6):3625-3633]

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Overexpression of B7H5/CD28H is associated with worse survival in human gastric cancer.

Can Hu, Zhiyuan Xu, Shangqi Chen, Hang Lv, Yiping Wang, Xiaofeng Wang, Shaowei Mo, Chengwei Shi, Shenyu Wei, Liqiang Hu, Wei Chen, Xiangdong Cheng,

Gastric cancer (GC) is a common malignancy with low 5-year overall survival (OS). Recently, immune therapy has been used to treat cancer. B7H5 and CD28H are novel immune checkpoint molecules. However, the prognostic value of B7H5/CD28H expression in patients with GC remains unclear. In this study, seventy-one patients diagnosed with ... Read more >>

J Cell Mol Med (Journal of cellular and molecular medicine)
[2020, 24(2):1360-1369]

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Long non-coding RNA AFAP1-AS1 promotes proliferation and invasion in prostate cancer via targeting miR-512-3p.

Kai Wang, Hao Sun, Tao Sun, Hongchen Qu, Qingpeng Xie, Hang Lv, Bin Hu,

BACKGROUND (OBJECTIVE):In the development of tumor therapy, the role of long non-coding RNA actin filagenin 1 antisense RNA 1 (1ncRNA AFAP1-AS1) is quite significant, but the actual role of AFAP1-AS1 in the treatment of prostate cancer has not been determined. In view of this, the author took AFAP1-AS1 as the ... Read more >>

Gene (Gene)
[2020, 726:144169]

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Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow.

Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang Wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou, Bo Yu,

<h4>Background</h4>Atherosclerosis preferentially develops in regions of disturbed flow (DF). Emerging evidence indicates that yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which are both effectors of the Hippo pathway, sense different blood flow patterns and regulate atherosclerotic lesions. We previously found that methotrexate (MTX) reduces in-stent neoatherosclerosis, decreases ... Read more >>

J Transl Med (Journal of translational medicine)
[2019, 17(1):378]

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Soluble metal ions migration and distribution in sludge electro-dewatering.

Hang Lv, Siqi Xing, Daoguang Liu, Fang Wang, Wenbiao Zhang, Gangfan Sun, Xu Wu,

In this study, the effects of electro-dewatering technology applied to high-salt industrial sludge dewatering performance were investigated, in terms of ions migrations and distributions by model simulation and layered tests. The simulation results of Na+ and K+ migrations were consistent with layered experiments during electro-dewatering, where Na+ ions migrated faster ... Read more >>

Environ Res (Environmental research)
[2020, 180:108862]

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Quantum dynamics of atomic Rydberg excitation in strong laser fields.

Shilin Hu, Xiaolei Hao, Hang Lv, Mingqing Liu, Tianxiang Yang, Haifeng Xu, Mingxing Jin, Dajun Ding, Qianguang Li, Weidong Li, Wilhelm Becker, Jing Chen,

Neutral atoms have been observed to survive intense laser pulses in high Rydberg states with surprisingly large probability. Only with this Rydberg-state excitation (RSE) included is the picture of intense-laser-atom interaction complete. Various mechanisms have been proposed to explain the underlying physics. However, neither one can explain all the features ... Read more >>

Opt Express (Optics express)
[2019, 27(22):31629-31643]

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Ultrafast Evolution of B2E2g - X2E1g Conical Intersection of Benzene Cations by Strong Field Ionization-Photo Fragmentation.

Longxing Zhou, Yang Liu, Tian Sun, Shuang Feng, Hang Lv, Haifeng Xu,

Benzene cation is a prototypical complex system that exhibits ultrafast conical intersections of different electronic states located close to the Franck-Condon region, yet little information is available about the dynamics of the cationic excited states. Here we utilize femtosecond time-resolved strong field ionization-photo fragmentation (SFI-PF) method to prepare and probe ... Read more >>

J Phys Chem A (The journal of physical chemistry. A)
[2019, 123(39):8365-8369]

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Enhanced electrochemical phosphate recovery from livestock wastewater by adjusting pH with plant ash.

Fang Wang, Jiapu Wei, Xiaoyu Zou, Rao Fu, Juncheng Li, Dandan Wu, Hang Lv, Guoliang Zhu, Xu Wu, Huanchun Chen,

In the field of environmental wastewater treatment, it is a very meaningful topic to recover phosphate from swine wastewater in the form of struvite precipitation. The solution pH is one of the important influencing factors in the process of struvite precipitation. In this paper, an attempt was made to recover ... Read more >>

J Environ Manage (Journal of environmental management)
[2019, 250:109473]

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Intestinal Absorption Profile of Three Polygala Oligosaccharide Esters in Polygalae Radix and the Effects of Other Components in Polygalae Radix on Their Absorption.

YinYing Ba, MengLin Wang, KunFeng Zhang, QiJun Chen, JiaJia Wang, Hang Lv, YanYan Jiang, Renbing Shi,

Oligosaccharide esters, which are among the main active components of Polygalae Radix (PR), demonstrate significant pharmacological activities in the human nervous system. In our previous research, some other constituents in PR were able to improve the bioavailability of oligosaccharide esters such as sibiricose A5 (SA5), sibiricose A6 (SA6), and 3,6'-disinapoyl ... Read more >>

Evid Based Complement Alternat Med (Evidence-based complementary and alternative medicine : eCAM)
[2019, 2019:1379531]

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Apatinib enhances chemosensitivity of gastric cancer to paclitaxel and 5-fluorouracil.

Zhiyuan Xu, Can Hu, Shangqi Chen, Chunli Zhang, Jianfa Yu, Xiaofeng Wang, Hang Lv, Xiangdong Cheng,

<b>Background and aim:</b> Paclitaxel (PTX) plus 5-fluorouracil (5-Fu) has become the standard chemotherapy for advanced gastric cancer (GC). Apatinib, a small-molecule tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor-2, improves outcomes in GC patients as a third-line treatment. However, its impact on the chemosensitivity of GC remains to be ... Read more >>

Cancer Manag Res (Cancer management and research)
[2019, 11:4905-4915]

Cited: 7 times

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Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress.

Hang Lv, Chuan'an Zhu, Ruolin Wu, Hui Ni, Jiating Lian, Yunlong Xu, Yucen Xia, Guoqi Shi, Zhixing Li, Ruth B Caldwell, Robert William Caldwell, Lin Yao, Yongjun Chen,

Chronic stress-induced anxiety disorder is a highly-prevalent, modern social disease in which oxidative stress plays an important role. It is necessary to determine the underlying mechanisms governing this disorder to establish an effective treatment target for anxiety disorders. In this study, we examined the behavioral changes in mice subjected to ... Read more >>

J Psychiatr Res (Journal of psychiatric research)
[2019, 114:55-66]

Cited: 3 times

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