Full Text Journal Articles by
Author Haluk Savli

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Is Neuregulin-4 a predictive marker of microvascular complications in type 2 diabetes mellitus?

Mehmet Zahid Kocak, Gulali Aktas, Burcin M Atak, Tuba T Duman, Ozgur Mehmet Yis, Edip Erkus, Haluk Savli,

BACKGROUND AND AIMS:Neuregulin-4 (Nrg-4) is a new adipokine released from brown adipose tissue. It plays pivotal role in regulating systemic energy balance, glucose and lipid metabolism and in reducing chronic inflammation. We aimed to investigate the relation between diabetic microvascular complications (DMC) and serum (Nrg-4) levels in patients with type ... Read more >>

Eur J Clin Invest (European journal of clinical investigation)
[2020, 50(3):e13206]

Cited: 3 times

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MEAN PLATELET VOLUME: AN OVERLOOKED HERALD OF MALIGNANT THYROID NODULES.

Mustafa Sit, Gulali Aktas, Bahri Ozer, Mehmet Zahid Kocak, Edip Erkus, Hayri Erkol, Semih Yaman, Haluk Savli,

Physicians and surgeons pay much attention to evaluating thyroid nodules due to the malignant potential of these growths. Inflammation has a crucial role in the development of cancer. Increase in the mean platelet volume (MPV) has been described in various inflammatory conditions. Since some of thyroid nodules are malignant, we ... Read more >>

Acta Clin Croat (Acta clinica Croatica)
[2019, 58(3):417-420]

Cited: 5 times

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Is Uric Acid elevation a random finding or a causative agent of diabetic nephropathy?

Mehmet Zahid Kocak, Gulali Aktas, Tuba T Duman, Burcin M Atak, Haluk Savli,

OBJECTIVE:In this study, we aimed to analyze the relationship between serum uric acid (UA) and microalbuminuria as a marker of renal injury in type 2 diabetes mellitus. METHODS:A total of 100 patients with type 2 diabetes mellitus were enrolled in the study. Participants were divided into two groups according to ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2019, 65(9):1155-1160]

Cited: 2 times

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Neuregulin-4 is associated with plasma glucose and increased risk of type 2 diabetes mellitus.

Mehmet Z Kocak, Gulali Aktas, Edip Erkus, Ozgur M Yis, Tuba T Duman, Burcin M Atak, Haluk Savli,

BACKGROUND:Neuregulin-4 is a cytokine with many functions and is primarily produced by fat tissue. AIM OF THE STUDY:The aim of the study was to observe the relationship between serum neuregulin-4 levels and diabetes regulation in type 2 diabetes mellitus (T2DM), and to compare neuregulin-4 levels of diabetic subjects with those ... Read more >>

Swiss Med Wkly (Swiss medical weekly)
[2019, 149:w20139]

Cited: 2 times

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Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men.

Satilmis Bilgin, Gulali Aktas, M Zahid Kocak, Burcin M Atak, Ozge Kurtkulagi, Tuba T Duman, Haluk Savli,

<h4>Aim</h4>Hemogram indices were proposed as novel inflammatory markers in chronic conditions and inflammation has substantial role in the pathogenesis of type 2 diabetes mellitus (T2DM). We aimed to observe hemogram parameters of type 2 diabetic male subjects with various age groups in well and poorly controlled subsets.<h4>Methods</h4>Data of type 2 ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2020, 23(5):923-927]

Cited: 6 times

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Type 2 diabetes mellitus is more commonly well controlled in younger men compared to older men.

M Zahid Kocak, Gulali Aktas, Tuba T Duman, Burcin M Atak, Satilmis Bilgin, Ozge Kurtkulagi, Haluk Savli,

<h4>Methods</h4>The male patients with T2DM that admitted to the outpatient internal medicine clinics of our institution between November 2018 and April 2019 were included to the study. According to the age, study population divided into two groups; either younger than 60 years (group I) and 60 years or older (group II). Study ... Read more >>

Aging Male (The aging male : the official journal of the International Society for the Study of the Aging Male)
[2020, 23(5):906-910]

Cited: 0 times

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Neutrophil to lymphocyte ratio as an indicative of diabetic control level in type 2 diabetes mellitus.

Tuba T Duman, Gulali Aktas, Burcin M Atak, Mehmet Z Kocak, Edip Erkus, Haluk Savli,

<h4>Background</h4>Type 2 diabetes mellitus is associated with chronic low grade inflammation. One of the novel inflammatory markers is hemogram derived neutrophil to lymphocyte ratio (NLR).<h4>Objective</h4>We aimed to compare NLR levels of diabetic subjects and healthy controls and to observe possible correlation between NLR and HbA1c.<h4>Methods</h4>Medical data of type 2 diabetic ... Read more >>

Afr Health Sci (African health sciences)
[2019, 19(1):1602-1606]

Cited: 17 times

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Neutrophil to Lymphocyte Ratio is Useful in Differentiation of Malign and Benign Thyroid Nodules.

Mustafa Sit, Gulali Aktas, Hayri Erkol, Semih Yaman, Fatih Keyif, Haluk Savli,

OBJECTIVE:Significant amount of thyroid nodules are malignant. Inflammation plays crucial role in the pathogenesis of many disorders, including cancer. Neutrophil to lymphocyte ratio (NLR), has been suggested as an index of inflammatory response and association between increased NLR and cancer has also been reported. In this retrospective analysis, we aimed ... Read more >>

P R Health Sci J (Puerto Rico health sciences journal)
[2019, 38(1):60-63]

Cited: 12 times

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Diabetes control could through platelet-to-lymphocyte ratio in hemograms.

Burcin Atak, Gulali Aktas, Tuba T Duman, Edip Erkus, M Zahid Kocak, Haluk Savli,

<h4>Objective</h4>Association between type 2 diabetes mellitus and inflammation is well-established. We aimed to study platelet-to-lymphocyte ratio (PLR), a novel inflammatory index derived from hemogram, in diabetic patients in comparison to those in healthy volunteers.<h4>Methods</h4>Medical data of type 2 diabetics that showed up in general outpatient medical clinics of our institution ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2019, 65(1):38-42]

Cited: 7 times

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Diabetic regulation of subjects with type 2 diabetes mellitus is associated with serum vitamin D levels.

Edip Erkus, Gulali Aktas, M Zahid Kocak, Tuba T Duman, Burcin M Atak, Haluk Savli,

<h4>Objective</h4>Vitamin D deficiency is not only associated with bone metabolism but also with diabetes mellitus. We aimed to study the possible association between serum vitamin D concentration and HbA1c level in patients with type 2 diabetes mellitus (T2DM) in this retrospective report.<h4>Methods</h4>Patients with T2DM were enrolled to the study either ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2019, 65(1):51-55]

Cited: 4 times

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A Case of Secondary Hypertension due to Giant Hydatid Cyst.

Burcin Atak, Gulali Aktas, M Zahid Kocak, Tuba Duman, Edip Erkus, Kamil Gurel, Haluk Savli,

Hydatid cyst is a parasitic infection which causes enormous morbidity and mortality worldwide. The pathogenic organism responsible for hydatid cyst is Echinococcus granulosus. Despite the fact that the characteristic cysts of the disease usually occur in liver and lungs, they may also occur in aberrant localisations. Subjects either present with ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(10):801-803]

Cited: 0 times

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Haemogram Parameters in Vitamin D Deficiency.

Edip Erkus, Gulali Aktas, Burcin Meryem Atak, Mehmet Zahid Kocak, Tuba T Duman, Haluk Savli,

<h4>Objective</h4>To study haemogram derived inflammatory indices, mean platelet volume (MPV), red cell distribution width (RDW), and neutrophil to lymphocyte ratio (NLR) in vitamin D deficient patients and to compare to those subjects with normal vitamin D levels.<h4>Study design</h4>Descriptive study.<h4>Place and duration of study</h4>Abant Izzet Baysal University Hospital, Bolu, Turkey, from ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(10):779-782]

Cited: 4 times

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Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy.

Mehmet Zahid Kocak, Gulali Aktas, Edip Erkus, Tuba T Duman, Burcin M Atak, Haluk Savli,

<h4>Objective</h4>To compare mean platelet volume to lymphocyte ratio (MPVLR) of diabetic nephropathy subjects to those diabetics without diabetic nephropathy.<h4>Study design</h4>Observational, cross-sectional study.<h4>Place and duration of study</h4>Tertiary referral hospital, in Bolu, Turkey, from July to December 2017.<h4>Methodology</h4>Patients with type 2 diabetes mellitus admitted to the Internal Medicine Clinic, were included. Patients ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(11):844-847]

Cited: 6 times

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Analysis of the Factors Related to the Blood Pressure Control in Hypertension.

Fatih Atik, Gulali Aktas, Mehmet Zahid Kocak, Edip Erkus, Haluk Savli,

OBJECTIVE:To determine the factors associated with blood pressure control and comparing anthropometric and clinical parameters of subjects with well-controlled hypertension to those with poorly controlled blood pressure. STUDY DESIGN:Observational cross-sectional study. PLACE AND DURATION OF STUDY:Abant Izzet Baysal University Hospital, Bolu, Turkey, from January to June 2016. METHODOLOGY:Medical data obtained ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(6):423-426]

Cited: 1 time

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A Rare Non-Hemolytic Case of Idiopathic Cold Agglutinin Disease.

Edip Erkus, Mehmet Z Kocak, Gulali Aktas, Mehmet Ozen, Burcin M Atak, Tuba T Duman, Buket K Tekce, Haluk Savli,

<h4>Background</h4>Cold agglutinin disease is a very rare condition associated with agglutination of erythrocytes in cold environment usually due to IgM type antibodies. Other than hemolytic anemias, it may interfere with routine hemogram tests due to miscalculation of red blood cell count (RBC) and other hemogram parameters calculated with involvement of ... Read more >>

Clin Lab (Clinical laboratory)
[2018, 64(6):1075-1078]

Cited: 2 times

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A Case of Sitagliptin-Induced Mild Acute Pancreatitis.

Mehmet Zahid Kocak, Gulali Aktas, Edip Erkus, Tuba T Duman, Burcin M Atak, Deniz Sahin, Haluk Savli,

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2018, 28(4):334]

Cited: 1 time

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Elevated neutrophil-to-lymphocyte ratio in the diagnosis of Hashimoto's thyroiditis.

Gulali Aktas, Mustafa Sit, Oguz Dikbas, Hayri Erkol, Rabia Altinordu, Edip Erkus, Haluk Savli,

Hashimoto's thyroiditis (HT) is an autoimmune inflammatory disorder. The purpose of this study was to determine the neutrophil-to-lymphocyte ratio (NLR), a novel marker of inflammation, in patients with HT and to compare these values with those from healthy subjects.A total of 154 participants were included in the study, 90 HT ... Read more >>

Rev Assoc Med Bras (1992) (Revista da Associacao Medica Brasileira (1992))
[2017, 63(12):1065-1068]

Cited: 12 times

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Could Red Cell Distribution Width be a Marker of Thyroid Cancer?

Gulali Aktas, Mustafa Sit, Ibrahim Karagoz, Edip Erkus, Bahri Ozer, Mehmet Zahid Kocak, Semih Yaman, Fatih Keyif, Rabia Altinordu, Hayri Erkol, Haluk Savli,

<h4>Objective</h4>To study red cell distribution width (RDW) values, a novel inflammatory marker in routine hemogram, of patients with benign or malignant thyroid nodules and to compare with healthy population.<h4>Study design</h4>Descriptive study.<h4>Place and duration of study</h4>Abant Izzet Baysal University Hospital, Bolu, Turkey, from November 2015 and February 2017.<h4>Methodology</h4>The hemogram values of ... Read more >>

J Coll Physicians Surg Pak (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP)
[2017, 27(9):556-558]

Cited: 6 times

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Red cell distribution width and mean platelet volume in patients with irritable bowel syndrome.

Gulali Aktas, Aytekin Alcelik, Buket Kin Tekce, Vildan Tekelioglu, Mustafa Sit, Haluk Savli,

<h4>Introduction</h4>Possible pathophysiological mechanisms of irritable bowel syndrome (IBS) are interactions between microbial flora of the gut and the mucosal/systemic immune system, post-infectious status and inflammation. Mean platelet volume (MPV) and red cell distribution width (RDW) have been reported as inflammatory markers in patients with inflammatory bowel disease, but they have ... Read more >>

Prz Gastroenterol (Przeglad gastroenterologiczny)
[2014, 9(3):160-163]

Cited: 11 times

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Serum levels of omentin in end-stage renal disease patients.

Aytekin Alcelik, Mehmet Tosun, Mehmet Fatih Ozlu, Mustafa Eroglu, Gulali Aktas, Eray Kemahli, Haluk Savli, Mehmet Yazici,

<h4>Introduction</h4>Cardiovascular disease is the leading cause of morbidity and mortality in hemodialysis patients. Therefore, evaluation and prevention of cardiovascular diseases in end-stage renal disease (ESRD) patients are very important. The plasma level of omentin was found to be associated with different conditions such as insulin resistance. It is one of ... Read more >>

Kidney Blood Press Res (Kidney & blood pressure research)
[2012, 35(6):511-516]

Cited: 15 times

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Takayasu arteritis initially mimicking infective endocarditis.

Aytekin Alcelik, Sevim Karacay, Ismail Necati Hakyemez, Busra Akin, Serkan Ozturk, Haluk Savli,

Takayasu's arteritis (TA) is a chronic inflammatory disease that affects large vessels, predominantly the aorta and its main branches, leading to vessel wall thickening, fibrosis and stenosis. Cardiac and vascular symptoms are also commonly present at disease onset. In TA with thoracic or abdominal involvement, although murmur can be present ... Read more >>

Mediterr J Hematol Infect Dis (Mediterranean journal of hematology and infectious diseases)
[2011, 3(1):e2011040]

Cited: 0 times

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Hand knitting induced thrombosis of the subclavian vein in a young woman: an unusual cause of paget-schroetter syndrome.

Aytekin Alcelik, Haluk Savli, Ahsen Zeyrek, Abdullah Yalcin,

Mediterr J Hematol Infect Dis (Mediterranean journal of hematology and infectious diseases)
[2011, 3(1):e2011022]

Cited: 2 times

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An interesting cause of pulmonary emboli: acute carbon monoxide poisoning.

Alper Sevinc, Haluk Savli, Hasan Atmaca,

Carbon monoxide poisoning, a public health problem of considerable significance, is a relatively frequent event today, resulting in thousands of hospitalizations annually. A 70-year-old lady was seen in the emergency department with a provisional diagnosis of carbon monoxide poisoning. The previous night, she slept in a tightly closed room heated ... Read more >>

Clin Appl Thromb Hemost (Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis)
[2005, 11(3):353-357]

Cited: 4 times

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Hypothyroidism masquerading as depression: the role of noncompliance.

Alper Sevinc, Haluk Savli,

Compliance with prescribed medication is an important but complex issue which is incompletely understood. Depression is also a factor that can lead to noncompliance. A 30-year-old lady was seen in the outpatient clinic with complaints of palpitations and tremor. Her medical history revealed a subtotal thyroidectomy for multinodular goiter five ... Read more >>

J Natl Med Assoc (Journal of the National Medical Association)
[2004, 96(3):379-382]

Cited: 1 time

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The effect of valproate on bone mineral density in adult epileptic patients.

Ayhan Boluk, Mehmet Guzelipek, Haluk Savli, Ismail Temel, Handan Işin Ozişik, Akif Kaygusuz,

The effect of long-term valproate (VPA) treatment on bone mineral density (BMD) in adult epileptic patients is not clearly known, although several studies have been done in children. In adult epileptic patients (n = 50; 24 men, 26 women) treated with VPA, the bone mineral density at lumbar level (L1-L4) ... Read more >>

Pharmacol Res (Pharmacological research)
[2004, 50(1):93-97]

Cited: 64 times

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