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Predicting atrial fibrillation episodes with rapid ventricular rates associated with low levels of activity.

Zhi Li, Kevin M Wheelock, Sangeeta Lathkar-Pradhan, Hakan Oral, Daniel J Clauw, Pujitha Gunaratne, Jonathan Gryak, Kayvan Najarian, Brahmajee K Nallamothu, Hamid Ghanbari,

<h4>Background</h4>Rapid and irregular ventricular rates (RVR) are an important consequence of atrial fibrillation (AF). Raw accelerometry data in combination with electrocardiogram (ECG) data have the potential to distinguish inappropriate from appropriate tachycardia in AF. This can allow for the development of a just-in-time intervention for clinical treatments of AF events. ... Read more >>

BMC Med Inform Decis Mak (BMC medical informatics and decision making)
[2021, 21(1):364]

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Disseminated Brucella melitensis infection following canakinumab treatment.

Hakan Oral, Meliha Çağla Sönmezer, Adalet Elçin Yıldız, Gülşen Hazırolan, Gökhan Metan, Ahmet Çağkan İnkaya,

Travel Med Infect Dis (Travel medicine and infectious disease)
[2022, 45:102227]

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Efficacy and tolerability of quinidine as salvage therapy for monomorphic ventricular tachycardia in patients with structural heart disease.

Amrish Deshmukh, John Larson, Michael Ghannam, Mohammed Saeed, Ryan Cunnane, Hamid Ghanbari, Rakesh Latchamsetty, Thomas Crawford, Krit Jongnarangsin, Frank Pelosi, Aman Chugh, Hakan Oral, Fred Morady, Frank Bogun, Jackson J Liang,

<h4>Introduction</h4>Quinidine is an effective therapy for a subset of polymorphic ventricular tachycardia and ventricular fibrillation (VF) syndromes; however, the efficacy of quinidine in scar-related monomorphic ventricular tachycardia (MMVT) is unclear.<h4>Methods and results</h4>Between 2009 and 2020 a single VT referral center, a total of 23 patients with MMVT and structural heart ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(12):3173-3178]

Cited: 1 time

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Mediastinal mass in a patient with rheumatoid arthritis: lymphoid cystic thymic hyperplasia.

Hakan Oral, Emre Bilgin, Selma Yıldırım, Sevgen Çelik Önder, Figen Demirkazık, Serkan Uysal, Ömer Karadağ,

Rheumatol Adv Pract (Rheumatology advances in practice)
[2021, 5(2):rkab049]

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Association between symptoms, affect and heart rhythm in patients with persistent or paroxysmal atrial fibrillation: an ambulatory pilot study.

Kevin M Wheelock, Anna Kratz, Sangeeta Lathkar-Pradhan, Kayvan Najarian, Jonathan Gryak, Zhi Li, Hakan Oral, Daniel J Clauw, Brahmajee K Nallamothu, Hamid Ghanbari,

Symptoms in atrial fibrillation are generally assumed to correspond to heart rhythm; however, patient affect - the experience of feelings, emotion or mood - is known to frequently modulate how patients report symptoms but this has not been studied in atrial fibrillation. In this study, we investigated the relationship between ... Read more >>

Am Heart J (American heart journal)
[2021, 241:1-5]

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Comment on: Hypereosinophilic bronchiolitis in ANCA-associated vasculitis: where does it stand? by Sebastiani et al.

Emre Bilgin, Hakan Oral, Ebru Damadoğlu, Ömer Karadağ,

Clin Exp Rheumatol (Clinical and experimental rheumatology)
[2021, 39 Suppl 129(2):196]

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Clinical characteristics and long-term outcomes of catheter ablation in young adults with atrial fibrillation.

Michael Ghannam, Aman Chugh, David J Bradley, Thomas Crawford, Rakesh Latchamsetty, Hamid Ghanbari, Ryan Cunnane, Mohammed Saeed, Krit Jongnarangsin, Frank Pelosi, Fred Morady, Hakan Oral,

<h4>Purpose</h4>We aim to describe the long-term safety and efficacy of catheter ablation (CA) in young patients (<30 years) with atrial fibrillation (AF).<h4>Methods</h4>This was a retrospective study of patients aged 18-30 who underwent CA for AF, and clinical characteristics and long-term outcomes are reported. Survival analyses were performed between the study ... Read more >>

J Interv Card Electrophysiol (Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing)
[2021, :]

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Comparative Efficacy of Dofetilide Versus Amiodarone in Patients With Atrial Fibrillation.

Ghanshyam Shantha, Aman Chugh, Thomas Crawford, Rakesh Latchamsetty, Hamid Ghanbari, Michael Ghannam, Jackson Liang, Atiqa Batul, Eugene Chung, Mohammed Saeed, Ryan Cunnane, Krit Jongnarangsin, Frank Bogun, Frank Pelosi, Fred Morady, Hakan Oral,

<h4>Objectives</h4>The study's goal was to compare the efficacy and safety of dofetilide (DOF) versus amiodarone (AMIO) in patients with atrial fibrillation (AF).<h4>Background</h4>Comparative efficacy of DOF versus AMIO in patients with AF has not been well established. In addition, proarrhythmia has been a concern with DOF therapy.<h4>Methods</h4>Rhythm control was attempted by ... Read more >>

JACC Clin Electrophysiol (JACC. Clinical electrophysiology)
[2021, 7(5):642-648]

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Lead damage after cardiac implantable device replacement procedure: Comparison between electrical plasma tool and electrocautery.

Teetouch Ananwattanasuk, Sina Jamé, Frank M Bogun, Aman Chugh, Thomas C Crawford, Ryan Cunnane, Hamid Ghanbari, Rakesh Latchamsetty, Sangeeta Lathkar-Pradhan, Hakan Oral, Frank Pelosi, Mohammed Saeed, Krit Jongnarangsin,

<h4>Background</h4>Lead damage is a complication caused by lead manipulation or heating damage from conventional electrocautery (EC) after cardiovascular implantable electronic device (CIED) replacement. Application of electrical plasma (PEAK PlasmaBlade) is a new technology that reportedly reduces this risk.<h4>Objectives</h4>This study was designed to compare the effect of EC versus PEAK PlasmaBlade ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(4):1124-1128]

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Cardiac phenotype in familial partial lipodystrophy.

Abdelwahab Jalal Eldin, Baris Akinci, Andre Monteiro da Rocha, Rasimcan Meral, Ilgin Yildirim Simsir, Suleyman Cem Adiyaman, Ebru Ozpelit, Nicole Bhave, Ramazan Gen, Banu Yurekli, Nilufer Ozdemir Kutbay, Zeynep Siklar, Adam H Neidert, Rita Hench, Marwan K Tayeh, Jeffrey W Innis, Jose Jalife, Hakan Oral, Elif A Oral,

<h4>Objectives</h4>LMNA variants have been previously associated with cardiac abnormalities independent of lipodystrophy. We aimed to assess cardiac impact of familial partial lipodystrophy (FPLD) to understand the role of laminopathy in cardiac manifestations.<h4>Study design</h4>Retrospective cohort study.<h4>Methods</h4>Clinical data from 122 patients (age range: 13-77, 101 females) with FPLD were analysed. Mature human ... Read more >>

Clin Endocrinol (Oxf) (Clinical endocrinology)
[2021, 94(6):1043-1053]

Cited: 1 time

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Effect of metformin on outcomes of catheter ablation for atrial fibrillation.

Amrish Deshmukh, Michael Ghannam, Jackson Liang, Mohammed Saeed, Ryan Cunnane, Hamid Ghanbari, Rakesh Latchamsetty, Thomas Crawford, Syeda A Batul, Eugene Chung, Frank Bogun, Krit Jongnarangsin, Frank Pelosi, Aman Chugh, Fred Morady, Elif Oral, Hakan Oral,

<h4>Background</h4>Diabetes mellitus (DM) is a risk factor for atrial fibrillation (AF). The effect of antidiabetic medications on AF or the outcomes of catheter ablation (CA) has not been well described. We sought to determine whether metformin treatment is associated with a lower risk of atrial arrhythmias after CA in patients ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2021, 32(5):1232-1239]

Cited: 2 times

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Catheter ablation of the left and right atrial appendages without isolation in persistent atrial fibrillation.

Michael Ghannam, Sina Jame, Krit Jongnarangsin, Yuet Wong Cheng, Sampath Gunda, Opeyemi Fadahunsi, Andrew Hughey, Zhigang Liu, Ghanshyam Shantha, Ronpichai Chokesuwattanaskul, Miki Yokokawa, Hakan Oral, Fred Morady, Aman Chugh,

<h4>Background</h4>Electrical isolation of the left atrial appendage (LAA) improves outcomes of patients with persistent atrial fibrillation (AF) but may increase the risk of thromboembolism.<h4>Objective</h4>The purpose of this study was to describe a method to map and ablate appendage drivers without complete electrical isolation.<h4>Methods</h4>One hundred thirteen patients underwent an ablation procedure ... Read more >>

Heart Rhythm (Heart rhythm)
[2021, 18(5):694-701]

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Conversion of positive-pressure cardiac catheterization and electrophysiology laboratories to a novel 2-zone negative-pressure system during COVID-19 pandemic.

Monica Truesdell, Paul Guttman, Barbara Clarke, Sheryl Wagner, Jim Bloom, Jeff DuShane, Linda Richardson, Kristen VanderElzen, Stanley Chetcuti, Hakan Oral,

During coronavirus disease-2019 (COVID-19) pandemic, there continues to be a need to utilize cardiac catheterization and electrophysiology laboratories for emergent and urgent procedures. Per infection prevention guidelines and hospital codes, catheterization and electrophysiology laboratories are usually built as positive-pressure ventilation rooms to minimize the infection risk. However, patients with highly ... Read more >>

J Cardiovasc Electrophysiol (Journal of cardiovascular electrophysiology)
[2020, 31(8):1901-1903]

Cited: 1 time

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Baseline and decline in device-derived activity level predict risk of death and heart failure in patients with an ICD for primary prevention.

Sina Jamé, Tom Cascino, Raymond Yeow, Teetouch Ananwattanasuk, Michael Ghannam, John Coatney, Ghanshyam Shantha, Eugene H Chung, Mohammed Saeed, Ryan Cunnane, Thomas Crawford, Rakesh Latchamsetty, Hamid Ghanbari, Aman Chugh, Frank Pelosi, Frank Bogun, Hakan Oral, Krit Jongnarangsin,

<h4>Background</h4>Implanted defibrillators are capable of recording activity data based on company-specific proprietary algorithms. This study aimed to determine the prognostic significance of baseline and decline in device-derived activity level across different device companies in the real world.<h4>Methods</h4>We performed a retrospective cohort study of patients (n = 280) who underwent a defibrillator implantation ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2020, 43(8):775-780]

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SUN-556 Cardiac Phenotype in Familial Partial Lipodystrophy

Abdelwahab Jalal Eldin, Baris Akinci, Andre Monteiro da Rocha, Rasimcan Meral, Ilgin Yildirim Simsir, Suleyman Cem Adiyaman, Ebru Ozpelit, Nicole Bhave, Ramazan Gen, Banu Sarer Yurekli, Nilufer Ozdemir Kutbay, Zeynep Siklar, Adam Neidert, Mario Swaidan, Diana Rus, Rita Hench, Jose Jalife, Hakan Oral, Elif A Oral,

Abstract Background Pathogenic variants in Lamin A/C (LMNA) gene are the most common monogenic etiology in Familial Partial Lipodystrophy (FPLD) causing FPLD2. LMNA pathogenic variants have been previously associated with cardiomyopathy, familial arrhythmias or conduction system abnormalities independent of lipodystrophy. We aimed to assess cardiac impacts of FPLD, and to ... Read more >>

J Endocr Soc (Journal of the Endocrine Society)
[2020, 4(Suppl 1):]

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Sex-specific efficacy and safety of cryoballoon versus radiofrequency ablation for atrial fibrillation: An individual patient data meta-analysis.

Jeanne du Fay de Lavallaz, Patrick Badertscher, Atsushi Kobori, Karl-Heinz Kuck, Josep Brugada, Serge Boveda, Rui Providência, Ziad Khoueiry, Armin Luik, Fabien Squara, Ioanna Kosmidou, Karapet V Davtyan, Arif Elvan, Nicasio Perez-Castellano, Ross J Hunter, Richard Schilling, Sven Knecht, Pipin Kojodjojo, Jeremiah Wasserlauf, Hakan Oral, Mario Matta, Sandeep Jain, Matteo Anselmino, Michael Kühne,

<h4>Background</h4>Atrial fibrillation (AF) is a growing health burden, and pulmonary vein isolation (PVI) using cryoballoon (CB) or radiofrequency (RF) represents an attractive therapeutic option. Sex-specific differences in the epidemiology, pathophysiology, and clinical presentation of AF and PVI are recognized.<h4>Objective</h4>We aimed at comparing the efficacy, safety, and procedural characteristics of CB ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(8):1232-1240]

Cited: 1 time

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Programming implantable cardioverter-defibrillator in primary prevention: Guideline concordance and outcomes.

Teetouch Ananwattanasuk, Tanyanan Tanawuttiwat, Ronpichai Chokesuwattanaskul, Sangeeta Lathkar-Pradhan, Waseem Barham, Hakan Oral, Ranjan K Thakur, Krit Jongnarangsin,

<h4>Background</h4>Inappropriate therapy is a common adverse effect in patients with an implantable cardioverter-defibrillator (ICD) that may be prevented by appropriate programming.<h4>Objective</h4>The purpose of this study was to assess the outcomes of device programming based on a 2015 HRS/EHRA/APHRS/SOLAECE expert consensus statement and a 2019 focused update on optimal ICD programming ... Read more >>

Heart Rhythm (Heart rhythm)
[2020, 17(7):1101-1106]

Cited: 1 time

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Mapping and Imaging in Non-paroxysmal AF.

Michael Ghannam, Hakan Oral,

Despite intense research efforts, maintenance of sinus rhythm in patients with non-paroxysmal AF remains challenging with suboptimal outcomes. A major limitation to the success of current ablation-based treatments is that our understanding of AF pathophysiology is incomplete. Advances in imaging and mapping tools have been reported to improve ablation outcomes. ... Read more >>

Arrhythm Electrophysiol Rev (Arrhythmia & electrophysiology review)
[2019, 8(3):202-209]

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Antiarrhythmic drug therapy and all-cause mortality after catheter ablation of atrial fibrillation: A propensity-matched analysis.

Ghanshyam Shantha, Daniel Alyesh, Hamid Ghanbari, Miki Yokokawa, Mohammed Saeed, Ryan Cunnane, Rakesh Latchamsetty, Thomas Crawford, Krit Jongnarangsin, Frank Bogun, Frank Pelosi, Aman Chugh, Fred Morady, Hakan Oral,

<h4>Background</h4>It is not clear if antiarrhythmic drug therapy (AAD) after catheter ablation (CA) of atrial fibrillation (AF) increases mortality.<h4>Objective</h4>To determine whether there is an association between AAD therapy and mortality after CA of AF.<h4>Methods</h4>There were 3624 consecutive patients with AF (mean age: 59 ± 11 years, women: 27%, paroxysmal AF: ... Read more >>

Heart Rhythm (Heart rhythm)
[2019, 16(9):1368-1373]

Cited: 1 time

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Atrioventricular conduction in patients undergoing pacemaker implant following self-expandable transcatheter aortic valve replacement.

Michael Ghannam, Ryan Cunnane, Daniel Menees, Michael P Grossman, Stanley Chetcuti, Himanshu Patel, Michael Deeb, Krit Jongnarangsin, Frank Pelosi, Hakan Oral, Rakesh Latchamsetty,

<h4>Background</h4>Heart block requiring a pacemaker is common after self-expandable transcatheter aortic valve replacement (SE-TAVR); however, conduction abnormalities may improve over time. Optimal device management in these patients is unknown.<h4>Objective</h4>To evaluate the long-term, natural history of conduction disturbances in patients undergoing pacemaker implantation following SE-TAVR.<h4>Methods</h4>All patients who underwent new cardiac implantable ... Read more >>

Pacing Clin Electrophysiol (Pacing and clinical electrophysiology : PACE)
[2019, 42(7):980-988]

Cited: 0 times

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Atrial fibrillation and dementia: Understanding the risks in hopes of brighter tomorrows.

Michael Ghannam, Hakan Oral,

Heart Rhythm (Heart rhythm)
[2019, 16(1):10-11]

Cited: 0 times

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Bimodal classification algorithm for atrial fibrillation detection from m-health ECG recordings.

Grant H Kruger, Rakesh Latchamsetty, Nicholas B Langhals, Miki Yokokawa, Aman Chugh, Fred Morady, Hakan Oral, Omer Berenfeld,

<h4>Introduction</h4>Atrial Fibrillation (AF) is the most common cardiac arrhythmia, presenting a significant independent risk factor for stroke and thromboembolism. With the emergence of m-Health devices, the importance of automatic detection of AF in an off-clinic setting is growing. This study demonstrates the performance of a bimodal classifier for distinguishing AF ... Read more >>

Comput Biol Med (Computers in biology and medicine)
[2019, 104:310-318]

Cited: 2 times

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Multiparametric assessment of left atrial remodeling using 18F-FDG PET/CT cardiac imaging: A pilot study.

Michael Ghannam, Hong Jun Yun, Edward P Ficaro, Hamid Ghanbari, John J Lazarus, Matthew Konerman, Ravi V Shah, Richard Weinberg, James R Corbett, Hakan Oral, Venkatesh L Murthy,

<h4>Background</h4>Left atrial (LA) remodeling is associated with structural, electric, and metabolic LA changes. Integrated evaluation of these features in vivo is lacking.<h4>Methods</h4>Patients undergoing <sup>18</sup>F-fluorodeoxyglucose (FDG) PET-CT during a hyperinsulinemic-euglycemic clamp were classified into sinus rhythm (SR), paroxysmal AF (PAF), and persistent AF (PerAF). The LA was semiautomatically segmented, and global ... Read more >>

J Nucl Cardiol (Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology)
[2020, 27(5):1547-1562]

Cited: 2 times

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Cryoballoon antral pulmonary vein isolation vs contact force-sensing radiofrequency catheter ablation for pulmonary vein and posterior left atrial isolation in patients with persistent atrial fibrillation.

Miki Yokokawa, Aman Chugh, Rakesh Latchamsetty, Hamid Ghanbari, Thomas Crawford, Krit Jongnarangsin, Ryan Cunnane, Mohammed Saeed, Bipin Sunkara, Mehmet Tezcan, Frank Bogun, Frank Pelosi, Fred Morady, Hakan Oral,

<h4>Background</h4>The role of cryoballoon ablation (CBA) for antral pulmonary vein isolation (APVI) has not been well established in persistent atrial fibrillation (PerAF). Isolation of the left atrial posterior wall (BOX) after APVI has been suggested to improve the efficacy of radiofrequency catheter ablation (RFA) in PerAF.<h4>Objective</h4>The purpose of this study ... Read more >>

Heart Rhythm (Heart rhythm)
[2018, 15(12):1835-1841]

Cited: 3 times

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Protamine to expedite vascular hemostasis after catheter ablation of atrial fibrillation: A randomized controlled trial.

Michael Ghannam, Aman Chugh, Patrick Dillon, Daniel Alyesh, Konstantinos Kossidas, Shikha Sharma, John Coatney, Auras Atreya, Miki Yokokawa, Mohammed Saeed, Ryan Cunnane, Hamid Ghanbari, Rakesh Latchamsetty, Thomas Crawford, Krit Jongnarangsin, Frank Bogun, Frank Pelosi, Fred Morady, Hakan Oral,

<h4>Background</h4>There are no randomized controlled studies of the efficacy and safety of protamine to reverse anticoagulant effects of heparin after catheter ablation (CA) of atrial fibrillation (AF).<h4>Objective</h4>The purpose of this study was to determine the efficacy and safety of protamine to expedite vascular hemostasis and ambulation after CA of AF.<h4>Methods</h4>CA ... Read more >>

Heart Rhythm (Heart rhythm)
[2018, 15(11):1642-1647]

Cited: 8 times

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