Full Text Journal Articles by
Author Hairong Zheng

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Hot electron and thermal effects in plasmonic catalysis of nanocrystal transformation.

Chengyun Zhang, Ting Kong, Zhengkun Fu, Zhenglong Zhang, Hairong Zheng,

Plasmonic metal nanoparticles have the ability to harvest visible light and cause effective energy conversion, and they are considered as promising catalysts to drive chemical reactions. Although plasmonic catalysis has been widely used to mediate the reaction of organic molecules, the mechanism of contribution of thermal and hot carriers remains ... Read more >>

Nanoscale (Nanoscale)
[2020, 12(16):8768-8774]

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Imaging-guided focused ultrasound-induced thermal and sonodynamic effects of nanosonosensitizers for synergistic enhancement of glioblastoma therapy.

Qian Wan, Chao Zou, Dehong Hu, Jun Zhou, Mengjie Chen, Changjun Tie, Yangzi Qiao, Fei Yan, Chuanli Cheng, Zonghai Sheng, Bing Zhang, Xin Liu, Dong Liang, Hairong Zheng,

Glioblastoma (GBM) is a deadly brain tumor with poor prognosis and high mortality in patients. Given the low efficacy and serious side effects of current GBM therapy compared to those of conventional surgery, chemotherapy and radiation therapy, the development of a novel method for GBM management is very urgent. Sonodynamic ... Read more >>

Biomater Sci (Biomaterials science)
[2019, 7(7):3007-3015]

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Arterial culprit plaque characteristics revealed by magnetic resonance Vessel Wall imaging in patients with single or multiple infarcts.

Na Zhang, Jinhao Lyu, Lijie Ren, Lei Zhang, Zhangyan Fan, Liwen Wan, Ye Li, Dong Liang, Hairong Zheng, Xin Liu,

PURPOSE:To investigate characteristics of intra- and extracranial arterial culprit plaques between patients with single infarct and multiple-infarcts by a head-neck combined high resolution magnetic resonance vessel wall imaging (HR-MRVWI). MATERIALS AND METHODS:Forty-three patients with recent ischemic stroke due to large artery atherosclerosis were enrolled. The head-neck combined HR-MRVWI was performed ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2020, :]

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Second near-infrared photodynamic therapy and chemotherapy of orthotopic malignant glioblastoma with ultra-small Cu2-xSe nanoparticles.

Hao Zhang, Tingting Wang, Hanghang Liu, Feng Ren, Weibao Qiu, Qiao Sun, Fei Yan, Hairong Zheng, Zhen Li, Mingyuan Gao,

The treatment of malignant glioblastoma is a huge challenge due to the existence of the blood-brain barrier. Herein, we report the treatment of orthotopic malignant glioblastoma with imaging guided second near-infrared (NIR-II) photodynamic therapy and chemotherapy by using drug-loaded ultra-small Cu2-xSe theranostic nanoparticles (NPs). Ultra-small Cu2-xSe NPs possess a strong ... Read more >>

Nanoscale (Nanoscale)
[2019, 11(16):7600-7608]

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Fiber based Clock Synchronization Method for Medical Ultrasound System.

Juan Zhou, Jincheng Li, Haibo Zhong, Xudong Shi, Ge Yang, Jiqing Huang, Yongchuan Li, Teng Ma, Xiaojing Long, Weibao Qiu, Hairong Zheng,

Brain ultrasound has attracted great attention recently due to its non-invasive treatment function for brain diseases. However, ultrasound is still difficult to pass through an intact skull. Phase correction is recognized as an effective method for skull compensation. Half wavelength pitch transducer is important for the phase correction, and hence ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2020, :]

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Development and External Validation of Radiomics Approach for Nuclear Grading in Clear Cell Renal Cell Carcinoma.

Hongyu Zhou, Haixia Mao, Di Dong, Mengjie Fang, Dongsheng Gu, Xueling Liu, Min Xu, Shudong Yang, Jian Zou, Ruohan Yin, Hairong Zheng, Jie Tian, Changjie Pan, Xiangming Fang,

BACKGROUND AND PURPOSE:Nuclear grades of clear cell renal cell carcinoma (ccRCC) are usually confirmed by invasive methods. Radiomics is a quantitative tool that uses non-invasive medical imaging for tumor diagnosis and prognosis. In this study, a radiomics approach was proposed to analyze the association between preoperative computed tomography (CT) images ... Read more >>

Ann. Surg. Oncol. (Annals of surgical oncology)
[2020, :]

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Artifact removal using a hybrid-domain convolutional neural network for limited-angle computed tomography imaging.

Qiyang Zhang, Zhanli Hu, Changhui Jiang, Hairong Zheng, Yongshuai Ge, Dong Liang,

The suppression of streak artifacts in computed tomography with a limited-angle configuration is challenging. Conventional analytical algorithms, such as filtered backprojection (FBP), are not successful due to incomplete projection data. Moreover, model-based iterative total variation (TV) algorithms effectively reduce small streaks but do not work well at eliminating large streaks. ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, :]

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Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe.

Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng, Rongqin Zheng,

BACKGROUND:To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using a real-time molecular photoacoustic ... Read more >>

BMC Cancer (BMC cancer)
[2020, 20(1):419]

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Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods.

Zihan Mei, Duyang Gao, Dehong Hu, Huichao Zhou, Teng Ma, Liang Huang, Xin Liu, Rongqin Zheng, Hairong Zheng, Ping Zhao, Jianqiao Zhou, Zonghai Sheng,

Multidrug-resistant Staphylococcus aureus (MRSA) seriously endanger human health. The development of efficient methods to eliminate the infections and monitor the treatment process are of great significance. Near-infrared-II (NIR-II) photoacoustic (PA) imaging and photothermal therapy (PTT) are highly integrated theranostic platforms with superior performance including a low imaging background, increased tissue ... Read more >>

Biomaterials (Biomaterials)
[2020, 251:120092]

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Ultrasound Neuromodulation Inhibits Seizures in Acute Epileptic Monkeys.

Junjie Zou, Long Meng, Zhengrong Lin, Yangzi Qiao, Changjun Tie, Yibo Wang, Xiaowei Huang, Tifei Yuan, Yajie Chi, Wen Meng, Lili Niu, Yanwu Guo, Hairong Zheng,

Ultrasound stimulation has recently emerged as a non-invasive method for modulating brain activity in animal and human studies with healthy subjects. Whether brain diseases such as Alzheimer's disease, epilepsy, and depression can be treated using ultrasound stimulation still needs to be explored. Recent studies have reported that ultrasound stimulation suppressed ... Read more >>

iScience (iScience)
[2020, 23(5):101066]

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Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy.

Zhengrong Lin, Long Meng, Junjie Zou, Wei Zhou, Xiaowei Huang, Shan Xue, Tianyuan Bian, Tifei Yuan, Lili Niu, Yanwu Guo, Hairong Zheng,

Non-invasive low-intensity pulsed ultrasound has been employed for direct neuro-modulation. However, its range and effectiveness for different neurological disorders have not been fully elucidated. Methods: We used multiple approaches of electrophysiology, immunohistochemistry, and behavioral tests as potential epilepsy treatments in non-human primate model of epilepsy and human epileptic tissues. Low-intensity ... Read more >>

Theranostics (Theranostics)
[2020, 10(12):5514-5526]

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Quantitative Estimation of Passive Elastic Properties of Individual Skeletal Muscle in Vivo Using Normalized Elastic Modulus-Length Curve.

Yang Xiao, Congzhi Wang, Yang Sun, Xiangnan Zhang, Ligang Cui, Jinhua Yu, Hairong Zheng,

Precise characterization of the passive elastic properties of human skeletal muscle could provide valuable information for functional assessment and medical diagnosis. Using normalized elastic modulus-length curve based on a piecewise exponential model, a non-invasive ultrasonography (US) method was developed for estimating three physiologically meaningful parameters, termed as passive-elastic coefficient k, ... Read more >>

IEEE Trans Biomed Eng (IEEE transactions on bio-medical engineering)
[2020, :]

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Real-time volumetric MR thermometry using 3D echo-shifted sequence under an open source reconstruction platform.

Rui Jiang, Sen Jia, Yangzi Qiao, Qiaoyan Chen, Jianhong Wen, Dong Liang, Xin Liu, Hairong Zheng, Chao Zou,

PURPOSE:The aim of this work is to implement real-time 3D MR thermometry for high intensity focused ultrasound (HIFU) monitoring. METHODS:Volumetric MR thermometry was implemented based on a 3D echo-shifted sequence with short TR to improve temperature sensitivity. The 3D acquisition was accelerated in two phase encoding directions with controlled aliasing ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2020, 70:22-28]

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Targeted Imaging of Orthotopic Prostate Cancer by Using Clinical Transformable Photoacoustic Molecular Probe 

Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng, Rongqin Zheng,

Abstract Background: To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as the gold standard for prostate cancer (PCa) diagnosis. In this paper, we present a targeted PCa imaging strategy using a real-time ... Read more >>

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Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance.

Lili Niu, Yanchen Guo, Zhengrong Lin, Zhe Shi, Tianyuan Bian, Lin Qi, Long Meng, Anthony A Grace, Hairong Zheng, Ti-Fei Yuan,

Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens (NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, ... Read more >>

Sci China Life Sci (Science China. Life sciences)
[2020, :]

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Automatic left ventricle segmentation from cardiac magnetic resonance images using a capsule network.

Yangsu He, Wenjian Qin, Yin Wu, Mengxi Zhang, Yongfeng Yang, Xin Liu, Hairong Zheng, Dong Liang, Zhanli Hu,

PURPOSE:Segmentation of magnetic resonance images (MRI) of the left ventricle (LV) plays a key role in quantifying the volumetric functions of the heart, such as the area, volume, and ejection fraction. Traditionally, LV segmentation is performed manually by experienced experts, which is both time-consuming and prone to subjective bias. This ... Read more >>

J Xray Sci Technol (Journal of X-ray science and technology)
[2020, 28(3):541-553]

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New Sm-PMN-PT Ceramic-based 2D Array for Low-intensity Ultrasound Therapy Application.

Zhiqiang Zhang, Min Su, Fei Li, Rong Liu, Ruilin Cai, Guofeng Li, Qiuju Jiang, Haibo Zhong, Thomas R Shrout, Shujun Zhang, Hairong Zheng, Weibao Qiu,

A two-dimensional (2D) array with a small pitch (approximately 0.5λ in medium) can achieve a complete three-dimensional control of ultrasound beams without grating lobes and enable the generation of multiple focal spots simultaneously, which is a desired tool for noninvasive therapy. However, the large electrical impedance of 2D array elements ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2020, :]

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Dual phase grating based X-ray differential phase contrast imaging with source grating: theory and validation.

Yongshuai Ge, Jianwei Chen, Peiping Zhu, Jun Yang, Shiwo Deng, Wei Shi, Kai Zhang, Jinchuan Guo, Huitao Zhang, Hairong Zheng, Dong Liang,

In this work, we developed a new theoretical framework using wave optics to explain the working mechanism of the grating based X-ray differential phase contrast imaging (XPCI) interferometer systems consist of more than one phase grating. Under the optical reversibility principle, the wave optics interpretation was simplified into the geometrical ... Read more >>

Opt Express (Optics express)
[2020, 28(7):9786-9801]

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AUNet: attention-guided dense-upsampling networks for breast mass segmentation in whole mammograms.

Hui Sun, Cheng Li, Boqiang Liu, Zaiyi Liu, Meiyun Wang, Hairong Zheng, David Dagan Feng, Shanshan Wang,

Mammography is one of the most commonly applied tools for early breast cancer screening. Automatic segmentation of breast masses in mammograms is essential but challenging due to the low signal-to-noise ratio and the wide variety of mass shapes and sizes. Existing methods deal with these challenges mainly by extracting mass-centered ... Read more >>

Phys Med Biol (Physics in medicine and biology)
[2020, 65(5):055005]

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Three-dimensional intra- and extracranial arterial vessel wall joint imaging in patients with cerebrovascular disease.

Lin Jia, Na Zhang, Hanjiaerbieke Kukun, Lijie Ren, Lei Zhang, Jinhao Lyu, Dong Liang, Ye Li, Hairong Zheng, Wenxiao Jia, Xin Liu,

PURPOSE:To evaluate the clinical performance of a newly developed three-dimensional (3D) intra- and extracranial arterial vessel wall joint imaging technique at 3T using T1-weighted 3D variable-flip-angle turbo spin-echo sequence with improved cerebrospinal fluid suppression in patients with cerebrovascular disease. MATERIALS AND METHODS:122 consecutive patients (mean age 45.96 ± 12.16 years) ... Read more >>

Eur J Radiol (European journal of radiology)
[2020, 126:108921]

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Ultrasound stimulation of periaqueductal gray induces defensive behaviors.

Yibo Wang, Lili Niu, Wen Meng, Zhengrong Lin, Junjie Zou, Tianyuan Bian, Xiaowei Huang, Hui Zhou, Long Meng, Ping Xie, Hairong Zheng,

GOAL:Low-intensity focused ultrasound stimulation (LIFUS) has the potential to noninvasively penetrate the intact skull and to modulate neural activity in the cortex and deep brain nuclei. The midbrain periaqueductal gray (PAG) is associated with the generation of defensive behaviors. The aim of this study was to examine whether LIFUS of ... Read more >>

IEEE Trans Ultrason Ferroelectr Freq Control (IEEE transactions on ultrasonics, ferroelectrics, and frequency control)
[2020, :]

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Multi-View Mammographic Density Classification by Dilated and Attention-Guided Residual Learning.

Cheng Li, Jingxu Xu, Qiegen Liu, Yongjin Zhou, Lisha Mou, Zuhui Pu, Yong Xia, Hairong Zheng, Shanshan Wang,

Breast density is widely adopted to reflect the likelihood of early breast cancer development. Existing methods of mammographic density classification either require steps of manual operations or achieve only moderate classification accuracy due to the limited model capacity. In this study, we present a radiomics approach based on dilated and ... Read more >>

IEEE/ACM Trans Comput Biol Bioinform (IEEE/ACM transactions on computational biology and bioinformatics)
[2020, :]

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Vibrational spectra and chemical imaging of cyclo[18]carbon by tip enhanced Raman spectroscopy.

Shafqat Hussain, Huan Chen, Zhenglong Zhang, Hairong Zheng,

Vibrational modes and tip enhanced Raman spectroscopy (TERS) of a new carbon allotrope, cyclo[18]carbon (C18), were studied by density functional theory. A silver cluster tip was used to probe the interaction with C18, which is dependent on the distance and the atomically resolved positions. The TERS images show the position ... Read more >>

Chem. Commun. (Camb.) (Chemical communications (Cambridge, England))
[2020, 56(15):2336-2339]

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ADAPTIVE-NET: deep computed tomography reconstruction network with analytical domain transformation knowledge.

Yongshuai Ge, Ting Su, Jiongtao Zhu, Xiaolei Deng, Qiyang Zhang, Jianwei Chen, Zhanli Hu, Hairong Zheng, Dong Liang,

Background:Recently, the paradigm of computed tomography (CT) reconstruction has shifted as the deep learning technique evolves. In this study, we proposed a new convolutional neural network (called ADAPTIVE-NET) to perform CT image reconstruction directly from a sinogram by integrating the analytical domain transformation knowledge. Methods:In the proposed ADAPTIVE-NET, a specific ... Read more >>

Quant Imaging Med Surg (Quantitative imaging in medicine and surgery)
[2020, 10(2):415-427]

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DeepcomplexMRI: Exploiting deep residual network for fast parallel MR imaging with complex convolution.

Shanshan Wang, Huitao Cheng, Leslie Ying, Taohui Xiao, Ziwen Ke, Hairong Zheng, Dong Liang,

This paper proposes a multi-channel image reconstruction method, named DeepcomplexMRI, to accelerate parallel MR imaging with residual complex convolutional neural network. Different from most existing works which rely on the utilization of the coil sensitivities or prior information of predefined transforms, DeepcomplexMRI takes advantage of the availability of a large ... Read more >>

Magn Reson Imaging (Magnetic resonance imaging)
[2020, 68:136-147]

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