Full Text Journal Articles by
Author Haiou Liu

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The prognostic significance of tumor-infiltrating lymphocytes in cervical cancer.

Mengdi He, Yiying Wang, Guodong Zhang, Kankan Cao, Moran Yang, Haiou Liu,

<h4>Objective</h4>To predict the prognosis of cervical cancer, we constructed a novel model with 5 specific cell types and identified a potential biomarker.<h4>Methods</h4>We employed CIBERSORT and xCell method to evaluate the abundances of 23 cells types in tumor microenvironment. Five specific cell types were filtrated to determine different immunotypes by applying ... Read more >>

J Gynecol Oncol (Journal of gynecologic oncology)
[2021, 32(3):e32]

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The immune landscape during the tumorigenesis of cervical cancer.

Yiying Wang, Mengdi He, Guodong Zhang, Kankan Cao, Moran Yang, Hongwei Zhang, Haiou Liu,

<h4>Objective</h4>Deciphering the determinants of the intralesional immune reaction in cervical carcinogenesis may be conducive to improving the understanding of the disease and then improve outcomes.<h4>Methods</h4>Public gene-expression data and full clinical annotation were searched in Gene Expression Omnibus in the joint analysis of the array-based four eligible cohorts. The infiltrating estimation ... Read more >>

Cancer Med (Cancer medicine)
[2021, 10(7):2380-2395]

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Impaired decidualization of human endometrial stromal cells from women with adenomyosis.

Yaoming Peng, Zhixing Jin, Haiou Liu, Congjian Xu,

Differentiation of endometrial stromal cells (ESCs) into secretory decidualized cells (dESCs) is essential for embryo implantation. Adenomyosis is a common benign gynecological disease that causes infertility. However, whether adenomyosis affects decidualization of human endometrial stromal cells is elusive. Primary eutopic ESCs were obtained from patients with adenomyosis (n = 9) and women ... Read more >>

Biol Reprod (Biology of reproduction)
[2021, :]

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Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer.

Moran Yang, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Jiaqi Lu, Haiou Liu, Congjian Xu,

<h4>Background</h4>Tumour associated neutrophils (TANs) play a controversial role in regulating immune surveillance and immune evasion in various malignancies. Here, we investigated the relevance of TANs with the prognosis and immune microenvironment of epithelial ovarian cancer (EOC).<h4>Methods</h4>We characterised TANs using flow cytometric analysis and immunofluorescence analysis. The prognostic merit of TANs ... Read more >>

Br J Cancer (British journal of cancer)
[2020, 123(9):1404-1416]

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Celecoxib, a selective COX-2 inhibitor, markedly reduced the severity of tamoxifen-induced adenomyosis in a murine model.

Zhixing Jin, Xiaoyi Wu, Haiou Liu, Congjian Xu,

The aim of the present study was to evaluate the effects of the selective cyclooxygenase (COX)-2 inhibitor celecoxib on the development of uterine adenomyosis in mice. ICR neonatal mice were first exposed to tamoxifen to establish a mouse model of adenomyosis. Following 60 days of celecoxib treatment, pathological formation of ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2020, 19(5):3289-3299]

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Estrogen degrades Scribble in endometrial epithelial cells through E3 ubiquitin ligase HECW1 in the development of diffuse adenomyosis†.

Zhixing Jin, Haiou Liu, Congjian Xu,

Despite its prevalence and the severity of symptoms, little is known about the pathogenesis and etiology of adenomyosis. In previous studies, the protein expression level of the polarity protein Scribble in the eutopic endometrium of patients with adenomyosis was found to be significantly decreased; however, little is known about its ... Read more >>

Biol Reprod (Biology of reproduction)
[2020, 102(2):376-387]

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Rosiglitazone ameliorates senescence and promotes apoptosis in ovarian cancer induced by olaparib.

Zehua Wang, Jianwen Gao, Yuko Ohno, Haiou Liu, Congjian Xu,

OBJECTIVE:Senescence mechanisms are vital to resistance to long-term olaparib maintenance treatment. Recently, peroxisome proliferator-activated receptor-γ agonists (e.g., rosiglitazone) have been reported to ameliorate the senescence-like phenotype by modulating inflammatory mediator production. This study examined synergistic effects on the anti-tumor activity of rosiglitazone combined with olaparib in ovarian cancer treatment. METHODS:A2780 ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2020, 85(2):273-284]

Cited: 2 times

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Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer.

Guodong Zhang, Jiaqi Lu, Moran Yang, Yiying Wang, Haiou Liu, Congjian Xu,

High grade ovarian serous cancer (HGSC) is a malignant disease with high mortality. Glycosylation plays important roles in tumor invasion and immune evasion, but its effect on the immune microenvironment of HGSC remains unclear. This study examined the association of glycosyltransferase expression with HGSC prognosis and explored the underlying mechanism ... Read more >>

Cancer Immunol Immunother (Cancer immunology, immunotherapy : CII)
[2020, 69(2):175-187]

Cited: 2 times

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Decreased expression of cell polarity protein Scribble correlated with altered subcellular localization of the Crumbs homologue 3 protein in human adenomyotic endometrial cells.

Xiaoyi Wu, Weiwen Zuo, Haiou Liu, Zehua Wang, Congjian Xu,

AIM:Previous studies have revealed that loss of cell apical-basal polarity contributed to the early stages of tumorigenesis. Adenomyosis involves a down-growth and aberrant implantation of the endometrial basalis into the myometrium. This study discovered aberrant expression of polarity protein Scribble (Scrib) and Crumbs homologue 3 protein (CRB3) in epithelial cells ... Read more >>

J Obstet Gynaecol Res (The journal of obstetrics and gynaecology research)
[2019, 45(6):1148-1159]

Cited: 0 times

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P21-Activated Kinase 1 Overactivates in Eutopic Endometrium of Adenomyosis.

Weiwen Zuo, Xiaoyi Wu, Haiou Liu, Congjian Xu,

Adenomyosis is a common gynecological disease, characterized by the existence of endometrium in the myometrium. The pathogenesis of adenomyosis is not fully understood. P21-activated kinase 1 (PAK1) is an effector of small Rho GTPases including CDC42 and RAC1 and plays various roles in cellular biology, especially cytoskeletal remodeling. This study ... Read more >>

Reprod Sci (Reproductive sciences (Thousand Oaks, Calif.))
[2019, 26(9):1235-1242]

Cited: 2 times

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Cervical microbiome is altered in cervical intraepithelial neoplasia after loop electrosurgical excision procedure in china.

Hongwei Zhang, Jiaqi Lu, Yingying Lu, Qingqing Cai, Haiou Liu, Congjian Xu,

Although human papillomavirus (HPV) infection is a major cause leading to the development of cervical intraepithelial neoplasia (CIN), the relationship between genital microbiome and HPV persistence/clearance is not well established. Loop electrosurgical excision procedure (LEEP) is one of standard treatments of CIN 2/3 globally, yet little is known about how ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):4923]

Cited: 9 times

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Cellular Senescence in the Treatment of Ovarian Cancer.

Zehua Wang, Haiou Liu, Congjian Xu,

OBJECTIVE:This review aimed to update the research and development of cellular senescence in the treatment of ovarian cancer. We discussed the current mechanisms of senescence and the major biomarkers of senescence, especially the methods of cellular senescence in the treatment of ovarian cancer. MATERIALS AND METHODS:We collected all relevant studies ... Read more >>

Int J Gynecol Cancer (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society)
[2018, 28(5):895-902]

Cited: 1 time

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ZnO Nanorod-Induced Heteroepitaxial Growth of SOD Type Co-Based Zeolitic Imidazolate Framework Membranes for H2 Separation.

Pei Nian, Yujia Li, Xiang Zhang, Yi Cao, Haiou Liu, Xiongfu Zhang,

Up to now, the fabrication of well-intergrown Co-based zeolitic imidazolate framework (ZIF) membranes on porous tubular supports is still a major challenge. We report here a heteroepitaxial growth for preparing well-intergrown Co-based ZIFs (ZIF-67 and ZIF-9) tubular membranes with high performance and excellent thermal stability by employing a thin layer ... Read more >>

ACS Appl Mater Interfaces (ACS applied materials & interfaces)
[2018, 10(4):4151-4160]

Cited: 1 time

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Prognostic significance and predictors of the system inflammation score in ovarian clear cell carcinoma.

Hongwei Zhang, Jiaqi Lu, Yingying Lu, Jiayi Zhou, Zehua Wang, Haiou Liu, Congjian Xu,

Chronic inflammation is a well-known epidemiologic factor of ovarian clear cell carcinomas (OCCC), but has an uncertain role in prognosis. We developed a systemic inflammation score (SIS) based on preoperative serum albumin and neutrophil-to-lymphocyte ratio (NLR) for predicting progression-free survival (PFS) and overall survival (OS) in OCCC patients. A retrospective ... Read more >>

PLoS One (PloS one)
[2017, 12(5):e0177520]

Cited: 8 times

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Loss of N-Acetylgalactosaminyltransferase-4 Orchestrates Oncogenic MicroRNA-9 in Hepatocellular Carcinoma.

Yidong Liu, Haiou Liu, Liu Yang, Qian Wu, Weisi Liu, Qiang Fu, Weijuan Zhang, Haijian Zhang, Jiejie Xu, Jianxin Gu,

Deregulated expression of <i>N</i>-acetylgalactosaminyltransferases (GALNTs), which is responsible for the initial step of mucin-type <i>O</i>-glycosylation, could produce abnormal truncated <i>O</i>-glycans and thereby exert pivotal functions during malignant transformation. GALNT4 is one of the few isoforms preferring to catalyze partial GalNAc-glycosylated substrates and modify the sites not utilized by other known ... Read more >>

J Biol Chem (The Journal of biological chemistry)
[2017, 292(8):3186-3200]

Cited: 5 times

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High expression of Mucin13 associates with grimmer postoperative prognosis of patients with non-metastatic clear-cell renal cell carcinoma.

Zhiying Xu, Yidong Liu, Yuanfeng Yang, Jieti Wang, Guodong Zhang, Zheng Liu, Hangcheng Fu, Zewei Wang, Haiou Liu, Jiejie Xu,

<h4>Background</h4>Mucin13 (MUC13) is a transmembrane glycoprotein that is aberrantly expressed in ovarian and gastro-intestinal tumors, but its role in renal cell carcinoma remains elusive. The purpose of this study is to evaluate the prognostic value of MUC13 expression in patients with non-metastatic clear cell renal cell carcinoma (ccRCC) after surgical ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(5):7548-7558]

Cited: 1 time

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Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis.

Jiaqi Lu, Xiang Tao, Jiayi Zhou, Yingying Lu, Zehua Wang, Haiou Liu, Congjian Xu,

<h4>Background</h4>Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the prognosis in patients with ovarian cancer.<h4>Results</h4>Ovarian cancer arising in ... Read more >>

Oncotarget (Oncotarget)
[2017, 8(4):5843-5852]

Cited: 5 times

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High expression of galectin-7 associates with poor overall survival in patients with non-metastatic clear-cell renal cell carcinoma.

Jieti Wang, Yidong Liu, Yuanfeng Yang, Zhiying Xu, Guodong Zhang, Zheng Liu, Hangcheng Fu, Zewei Wang, Haiou Liu, Jiejie Xu,

<h4>Background</h4>Galectin-7, has a controversial role in tumor progression, can either suppress tumor growth or induce chemoresistance depends on different tumor histology types. The aim was to appraise Galectin-7 expression on the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery.<h4>Results</h4>High galectin-7 expression was specifically ... Read more >>

Oncotarget (Oncotarget)
[2016, 7(27):41986-41995]

Cited: 4 times

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Prognostic significance of β1,6-N-acetylglucosaminyltransferase V expression in patients with hepatocellular carcinoma.

Haiou Liu, Qian Wu, Yidong Liu, Weisi Liu, Weijuan Zhang, Deng Pan, Jiejie Xu,

<h4>Objective</h4>Alterations to the N-glycans in glycoproteins have been suggested to play important roles in the proliferation, differentiation, invasion and metastasis of hepatocellular carcinoma (HCC). This study aims to evaluate the potential prognostic value of β1,6-N-acetylglucosaminyltransferase V (Mgat5) in hepatocellular carcinoma patients after surgical resection.<h4>Methods</h4>We retrospectively enrolled 300 patients (156 in ... Read more >>

Jpn J Clin Oncol (Japanese journal of clinical oncology)
[2015, 45(9):844-853]

Cited: 7 times

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High expression of interleukin-11 is an independent indicator of poor prognosis in clear-cell renal cell carcinoma.

Deng Pan, Le Xu, Haiou Liu, Weijuan Zhang, Weisi Liu, Yidong Liu, Qiang Fu, Jiejie Xu,

Interleukin-11 (IL-11), a member of the IL-6 family of cytokines, exerts pleiotropic oncogenic activities by stimulating angiogenesis and metastasis in many cancer types. The present study aims to evaluate the impact of IL-11 expression on recurrence and mortality of patients with clear-cell renal cell carcinoma (ccRCC). We retrospectively enrolled 193 ... Read more >>

Cancer Sci (Cancer science)
[2015, 106(5):592-597]

Cited: 10 times

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β1,6-N-acetylglucosaminyltransferase V predicts recurrence and survival of patients with clear-cell renal cell carcinoma after surgical resection.

Yidong Liu, Haiou Liu, Weisi Liu, Weijuan Zhang, Huimin An, Jiejie Xu,

<h4>Purpose</h4>β1,6-N-acetylglucosaminyltransferase V (MGAT5), which is required for the biosynthesis of β1,6GlcNAc-branched N-linked glycans attached to cell surface and secreted glycoproteins, accounts for oncogenic growth signal transduction during the development and progression of various malignancies. Our present study aimed to evaluate the impact of MGAT5 expression on recurrence and survival of ... Read more >>

World J Urol (World journal of urology)
[2015, 33(11):1791-1799]

Cited: 2 times

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p21-Activated kinase 4 predicts early recurrence and poor survival in patients with nonmetastatic clear cell renal cell carcinoma.

Weisi Liu, Yuanfeng Yang, Yidong Liu, Haiou Liu, Weijuan Zhang, Le Xu, Yu Zhu, Jiejie Xu,

<h4>Background</h4>p21-Activated kinase 4 (PAK4), a serine/threonine kinase implicated in the cytoskeleton organization to orchestrate cell morphology, adhesion, and motility, is associated with angiogenesis and vessel branching, which are important events in the progression of clear cell renal cell carcinoma (ccRCC). We investigated the effect of PAK4 expression on recurrence and ... Read more >>

Urol Oncol (Urologic oncology)
[2015, 33(5):205.e13-21]

Cited: 3 times

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Galectin-8 predicts postoperative recurrence of patients with localized T1 clear cell renal cell carcinoma.

Yidong Liu, Le Xu, Yu Zhu, Weijuan Zhang, Weisi Liu, Haiou Liu, Jiejie Xu,

<h4>Background</h4>Galectin-8 (Gal-8), belonging to a family of the "tandem repeat"-type galectins that contain 2 carbohydrate recognition domains, serves to retain cell surface residency and signaling of glycoproteins including cytokine and growth factor receptors, and thereby promoting development and progression of various malignancies. This study aims to evaluate the effect of ... Read more >>

Urol Oncol (Urologic oncology)
[2015, 33(3):112.e1-8]

Cited: 2 times

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Prognostic value of purinergic P2X7 receptor expression in patients with hepatocellular carcinoma after curative resection.

Haiou Liu, Weisi Liu, Zheng Liu, Yidong Liu, Weijuan Zhang, Le Xu, Jiejie Xu,

The family of type 2 purinergic (P2) receptors, especially P2X7, is responsible for the direct tumor-killing functions of extracellular adenosine triphosphate (ATP), but the precise role of P2X7 in the progression of hepatocellular carcinoma (HCC) remains elusive. This study aims to evaluate prognostic value of P2X7 expression in HCC patients ... Read more >>

Tumour Biol (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2015, 36(7):5039-5049]

Cited: 4 times

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Galectin-9 predicts postoperative recurrence and survival of patients with clear-cell renal cell carcinoma.

Hangcheng Fu, Yidong Liu, Le Xu, Weisi Liu, Qiang Fu, Haiou Liu, Weijuan Zhang, Jiejie Xu,

Galectin-9 (Gal-9), a member of animal lectin family with evolutionary conserved carbohydrate recognition domains, has been reported to exert a large variety of functional roles in tumorigenesis due to its β-galactoside-binding affinity. The aim of this study is to evaluate the expression and prognostic significance of Gal-9 in patients with ... Read more >>

Tumour Biol (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine)
[2015, 36(8):5791-5799]

Cited: 15 times

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