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Author Hainan Li

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A novel imidazolinone metformin-methylglyoxal metabolite promotes endothelial cell angiogenesis via the eNOS/HIF-1α pathway.

Huong Nguyen, Jia Yi Koh, Hainan Li, Argel Islas-Robles, Sai Pranathi Meda Venkata, Jie-Mei Wang, Terrence J Monks,

Peripheral arterial disease (PAD) is one of the major complications of diabetes due to an impairment in angiogenesis. Since there is currently no drug with satisfactory efficacy to enhance blood vessel formation, discovering therapies to improve angiogenesis is critical. An imidazolinone metabolite of the metformin-methylglyoxal scavenging reaction, (E)-1,1-dimethyl-2-(5-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl) guanidine (IMZ), ... Read more >>

FASEB J (FASEB journal : official publication of the Federation of American Societies for Experimental Biology)
[2021, 35(7):e21645]

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Individualized Nomogram for Predicting Survival in Patients with Brain Metastases After Stereotactic Radiosurgery Utilizing Driver Gene Mutations and Volumetric Surrogates.

Cheng Zhou, Changguo Shan, Mingyao Lai, Zhaoming Zhou, Junjie Zhen, Guanhua Deng, Hainan Li, Juan Li, Chen Ren, Jian Wang, Ming Lu, Liang Zhang, Taihua Wu, Dan Zhu, Feng-Ming Spring Kong, Longhua Chen, Linbo Cai, Lei Wen,

It is well-known that genomic mutational analysis plays a significant role in patients with NSCLC for personalized treatment. Given the increasing use of stereotactic radiosurgery (SRS) for brain metastases (BM), there is an emerging need for more precise assessment of survival outcomes after SRS. Patients with BM and treated by ... Read more >>

Front Oncol (Frontiers in oncology)
[2021, 11:659538]

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Selective laser sintering versus conventional lost-wax casting for single metal copings: A systematic review and meta-analysis.

Jun Yang, Hainan Li, Ling Xu, Yuan Wang,

<h4>Statement of problem</h4>Evidence comparing the marginal and internal fit of single metal copings fabricated via selective laser sintering and conventional lost-wax casting is inadequate.<h4>Purpose</h4>The purpose of this systematic review was to compare the fit of single metal copings fabricated via selective laser sintering and lost-wax casting. Moreover, the effects of ... Read more >>

J Prosthet Dent (The Journal of prosthetic dentistry)
[2021, :]

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Bone metastases in an adult patient with diffuse midline glioma: a case report.

Shaoqun Li, Mingyao Lai, Junjie Zhen, Guanhua Deng, Hainan Li, Lina Cheng, Xuchen Liu, Juan Li, Jiangfen Zhou, Qingjun Hu, Minting Ye, Lei Wen, Cheng Zhou, Zhaoming Zhou, Changguo Shan, Weiping Hong, Xiao Xiao, Hui Wang, Yanying Yang, Ruyu Ai, Linbo Cai,

Neurooncol Adv (Neuro-oncology advances)
[2021, 3(1):vdaa156]

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Increased M1 Macrophages Infiltration Correlated With Poor Survival Outcomes and Radiation Response in Gliomas.

Zhaoming Zhou, Lei Wen, Mingyao Lai, Changguo Shan, Jian Wang, Rong Wang, Hainan Li, Longhua Chen, Linbo Cai, Meijuan Zhou, Cheng Zhou,

<h4>Background</h4>Gliomas are the malignance of a poor prognosis. The current WHO classification remains unable to predict survival outcomes accurately. Novel surrogates are highly required for improved stratification of patients and hence, allowing to delivery of the most appropriate treatment.<h4>Methods</h4>Transcriptional profiles of 301 glioma cases on the platform of Chinese Glioma ... Read more >>

Dose Response (Dose-response : a publication of International Hormesis Society)
[2020, 18(4):1559325820964991]

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The Immunoreactivity Patterns of BRAF VE1 and Its Diagnostic Value in Brain Tumors

Hainan Li, Chongzhu Fan, Wendan Chen, Minting Liu, Xuan Xiang, Zhenbin Zhang, Guangyu Jiang, Lei Wang, Zhi Li,

<h4>Background: </h4> BRAF mutations have been detected in a high proportion of melanoma, papillary thyroid carcinoma, and various primary brain tumors. But the sensitivity and specificity of immunohistochemical detection of BRAF-V600E mutant protein were not evaluated in brain tumors. The aim of this study was to assess the utlity of ... Read more >>

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Cooperation and Competition among information on social networks.

Zhiqiang Zhu, Chang Gao, Yumeng Zhang, Hainan Li, Jin Xu, Yongli Zan, Zhi Li,

When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competition. Through a large number of ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):12160]

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Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS).

Wanrong Lin, Jiaming Qin, Guanzhong Ni, Yinchao Li, Haitao Xie, Jiabin Yu, Hainan Li, Lisen Sui, Qiang Guo, Ziyan Fang, Liemin Zhou,

Changes in the expression of HCN ion channels leading to changes in I<sub>h</sub> function and neuronal excitability are considered to be possible mechanisms involved in epileptogenesis in kinds of human epilepsy. In previous animal studies of febrile seizures and temporal lobe epilepsy, changes in the expression of HCN1 and HCN2 ... Read more >>

Hippocampus (Hippocampus)
[2020, 30(10):1112-1126]

Cited: 1 time

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RELA Fusion in Supratentorial Extraventricular Ependymomas: A Morphologic, Immunohistochemical, and Molecular Study of 43 Cases.

Leiming Wang, Lina Liu, Hainan Li, PeiPei Wang, Zeliang Hu, Yukui Wei, Ming Zhang, Wenjuan Wen, Zhi Li, Li Liu, Lihong Zhao, Dehong Lu, Lianghong Teng,

Supratentorial extraventricular ependymomas (STEEs) are relatively rare ependymomas, and their pathologic and genetic characteristics are still poorly understood. The aim of this study was to determine the histologic, immunohistochemical, and RELA fusion features, as well as to clarify in more detail the clinical courses of STEEs. Data from a total ... Read more >>

Am J Surg Pathol (The American journal of surgical pathology)
[2019, 43(12):1674-1681]

Cited: 5 times

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Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina.

Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena J Steinle,

Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction in a common mouse model of type 2 diabetes, the db/db mouse. Retinal lysates ... Read more >>

J Diabetes Clin Res (Journal of diabetes and clinical research)
[2020, 2(1):12-15]

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Genomic Profiling Identified Novel Prognostic Biomarkers in Chinese Midline Glioma Patients.

Hainan Li, Changguo Shan, Shengnan Wu, Baijie Cheng, Chongzu Fan, Linbo Cai, Yedan Chen, Yuqian Shi, Kaihua Liu, Yang Shao, Dan Zhu, Zhi Li,

<h4>Background</h4>Molecular characteristics are essential for the classification and grading of gliomas. However, diagnostic classification of midline glioma is still debatable and substantial molecular and clinical heterogeneity within each subgroup suggested that they should be further stratified. Here, we studied the mutation landscape of Chinese midline glioma patients in hope to ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:607429]

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Insulin signal transduction is impaired in the type 2 diabetic retina

Youde Jiang, Li Liu, Hainan Li, Jie-Mei Wang, Jena Steinle,

Rates of type 2 diabetes are reaching epidemic levels. Yet, the tissue specific alterations due to insulin resistance are only recently being investigated. The goal of the present study was to evaluate retinal insulin signal transduction in a common mouse model of type 2 diabetes, the db/db mouse. Retinal lysates ... Read more >>

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Methylglyoxal triggers human aortic endothelial cell dysfunction via modulation of the KATP/MAPK pathway.

Yihan Wang, Leo M Hall, Marisa Kujawa, Hainan Li, Xiang Zhang, Megan O'Meara, Tomomi Ichinose, Jie-Mei Wang,

Endothelial dysfunction is a key risk factor in diabetes-related multiorgan damage. Methylglyoxal (MGO), a highly reactive dicarbonyl generated primarily as a by-product of glycolysis, is increased in both type 1 and type 2 diabetic patients. MGO can rapidly bind with proteins, nucleic acids, and lipids, resulting in structural and functional ... Read more >>

Am J Physiol Cell Physiol (American journal of physiology. Cell physiology)
[2019, 317(1):C68-C81]

Cited: 4 times

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Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

Hainan Li, Megan O'Meara, Xiang Zhang, Kezhong Zhang, Berhane Seyoum, Zhengping Yi, Randal J Kaufman, Terrence J Monks, Jie-Mei Wang,

Patient-derived progenitor cell (PC) dysfunction is severely impaired in diabetes, but the molecular triggers that contribute to mechanisms of PC dysfunction are not fully understood. Methylglyoxal (MGO) is one of the highly reactive dicarbonyl species formed during hyperglycemia. We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived ... Read more >>

Diabetes (Diabetes)
[2019, 68(6):1287-1302]

Cited: 4 times

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Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.

Shukkur M Farooq, Yuning Hou, Hainan Li, Megan O'Meara, Yihan Wang, Chunying Li, Jie-Mei Wang,

<h4>Background</h4>G protein-coupled receptor 35 (GPR35) is an orphan receptor and is vastly expressed in immune cells and gastrointestinal cells, suggesting the potential physiological importance of GPR35 in these cells. Here, we tested the hypothesis that the lack of GPR35 expression in the colon mucosa exacerbates the severity of dextran sulfate ... Read more >>

Dig Dis Sci (Digestive diseases and sciences)
[2018, 63(11):2910-2922]

Cited: 6 times

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MiR-27b augments bone marrow progenitor cell survival via suppressing the mitochondrial apoptotic pathway in Type 2 diabetes.

Hainan Li, Jenny Liu, Yihan Wang, Zhiyao Fu, Maik Hüttemann, Terrence J Monks, Alex F Chen, Jie-Mei Wang,

Bone marrow-derived progenitor cells (BMPCs) are potential candidates for autologous cell therapy in tissue repair and regeneration because of their high angiogenic potential. However, increased progenitor cell apoptosis in diabetes directly limits their success in the clinic. MicroRNAs are endogenous noncoding RNAs that regulate gene expression at the posttranscriptional level, ... Read more >>

Am J Physiol Endocrinol Metab (American journal of physiology. Endocrinology and metabolism)
[2017, 313(4):E391-E401]

Cited: 5 times

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An oligodeoxynucleotide with CCT repeats restrains CpG ODN-induced TLR9 trafficking.

Xiaoling Zhang, Wei Sun, Xiuli Wu, Hua Wang, Youyou Yan, Sheng Guo, Dandan Song, Hainan Li, Shuang Gao, Luowei Wang, Yongli Yu, Liying Wang,

Toll-like receptor 9 (TLR9) can sense pathogen DNA and CpG ODN or even self-DNA by trafficking assisted by Unc93B1, an endoplasmic reticulum (ER) transmembrane protein, from ER to endolysosomes or cell surface. In previous study, we found that an oligodeoxynucleotide with CCT repeats (SAT05f) could selectively inhibit TLR7/9 activation. However, ... Read more >>

Curr Pharm Biotechnol (Current pharmaceutical biotechnology)
[2014, 15(9):780-789]

Cited: 2 times

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