Full Text Journal Articles by
Author Hailong Shi

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Identification of Novel Biomarkers in Hepatocellular Carcinoma by Integrated Bioinformatical Analysis and Experimental Validation

Chen Liao, Lanlan Wang, Xiaoqiang Li, Jinyu Bai, Jieqiong Wu, Wei Zhang, Hailong Shi, Xuesong Feng, Xu Chao,

<h4>Background: </h4> Hepatocellular carcinoma (HCC) is one of the most common poorly prognosed virulent neoplasms of the digestive system. In this study, we identified novel biomarkers associated with the pathogenesis of HCC aiming to provide new diagnostic and therapeutic approaches for HCC. <h4>Methods: </h4>: Gene expression profiles of GSE62232, GSE84402,GSE121248 ... Read more >>

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ADCY2 rs10059539 C>T polymorphism confers a decreased risk of hepatocellular carcinoma in Chinese Han women.

Xu Chao, Feng Miao, Xuesong Feng, Hailong Shi, Yuewen Wang, Jieqiong Wu, Luyan Zhao, Wei Zhang, Chao Jiang,

<h4>Objective</h4>Hepatocellular carcinoma (HCC) poses a serious threat to human health. ADCY2 gene polymorphisms may be related to HCC susceptibility. Therefore, we investigated whether ADCY2 gene polymorphisms are correlated to the risk of HCC in a Chinese Han population.<h4>Methods</h4>In a case-control study, we examined the associations between single nucleotide polymorphisms (SNPs) ... Read more >>

Eur J Cancer Prev (European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP))
[2021, :]

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An Integrative Serum Pharmacology-Based Approach to Study the Anti-Tumor Activity of B. paniculatum Aqueous Bulb Extract on the Human Hepatocellular Carcinoma Cell Line BEL-7404.

Xuesong Feng, Guangyuan Ma, Hailong Shi, Yuewen Wang, Xu Chao,

The herb <i>Bolbostemma paniculatum</i> (Maxim) <i>Franquet</i> (Cucurbitaceae family), also known as Tu-Bei-Mu (TBM) in Chinese, has shown curative effects to treat several types of cancer as an adjunctive therapy. Thereby we intend to find its effect on the human hepatocellular carcinoma (HCC) and to understand the pharmacological mechanism behind it. ... Read more >>

Front Pharmacol (Frontiers in pharmacology)
[2020, 11:01261]

Cited: 1 time

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A Case-Control Study of ADCY9 Gene Polymorphisms and the Risk of Hepatocellular Carcinoma in the Chinese Han Population.

Xu Chao, Yong Jia, Xuesong Feng, Guoquan Wang, Xiaoping Wang, Hailong Shi, Fei Zhao, Chao Jiang,

<b>Background:</b> Adenylyl cyclase type 9 (<i>ADCY9</i>) modulates signal transduction by producing the second messenger cyclic AMP. It has been reported that <i>ADCY9</i> gene polymorphisms were associated with cancer development. The aim of this study was to investigate whether <i>ADCY9</i> gene polymorphisms could contribute to the susceptibility of hepatocellular carcinoma (HCC) ... Read more >>

Front Oncol (Frontiers in oncology)
[2020, 10:1450]

Cited: 1 time

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Phoenix dactylifera Protects against Doxorubicin-Induced Cardiotoxicity and Nephrotoxicity.

Yuewen Wang, Xu Chao, Fiaz Ud Din Ahmad, Hailong Shi, Hania Mehboob, Waseem Hassan,

Doxorubicin (DOX) is an important anticancer drug used widely in the treatment of leukemia and lymphoma. The suitability of DOX is enhanced by its high therapeutic index, but its potential to cause cardiotoxicity and nephrotoxicity remains a prime concern in anticancer therapeutics. This study is designed to determine the effect ... Read more >>

Cardiol Res Pract (Cardiology research and practice)
[2019, 2019:7395239]

Cited: 2 times

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Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur.

Xing Kang, Hailong Shi, Lirong Zhang, Yanxia Wang, Tingting Zhang, Min Han, Chao Chen, Huijuan Wang,

<h4>Aim</h4>Cytochrome P450 enzymes CYP2S1, CYP2J2 and CYP2R1 are of interest due to their unknown enzymatic function and disease-specific expression property. The aim of this study was to investigate the genetic variations of CYP2S1, CYP2J2 and CYP2R1 genes, and their polymorphic distribution in different Chinese populations.<h4>Materials & methods</h4>All of the exons, exon-intron ... Read more >>

Pharmacogenomics (Pharmacogenomics)
[2018, 19(12):961-977]

Cited: 1 time

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MicroRNA-1 suppresses proliferation, migration and invasion by targeting Notch2 in esophageal squamous cell carcinoma.

Wenzhi Liu, Mengkao Li, Xiangming Chen, Shan Zhu, Hailong Shi, Dawei Zhang, Cheng Cheng, Baosheng Li,

MicroRNAs play an important role in the migration and invasion of tumors, and lower expression of microRNA-1 (miR-1) has been proven in a variety of malignant tumors, including esophageal squamous cell carcinoma (ESCC). In this study, we found that miR-1 expression levels in tumor tissues and preoperative serum from esophageal ... Read more >>

Sci Rep (Scientific reports)
[2018, 8(1):5183]

Cited: 12 times

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Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug.

Hailong Shi, Yaya Cui, Yifei Qin,

Serotonin (5-HT) is an important neurotransmitter and paracrine signaling molecule in the gastrointestinal tract. Two distinct tryptophan hydroxylases (TPH), TPH1 and TPH2, are the rate-limiting enzymes in the 5-HT biosynthesis process. TPH1 expression is mainly limited in the enterochromaffin cells and distributed in peripheries such as the skin and gut, ... Read more >>

Chem Biol Drug Des (Chemical biology & drug design)
[2018, 91(1):202-212]

Cited: 1 time

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Analgesic activity of cynaropicrinon on post-inflammatory irritable bowel syndrome visceral hypersensitivity in a rat model.

Hailong Shi, Xianwei Zhu, Yaya Cui, Yifei Qin, Lin Yang, Xu Deng,

Visceral hypersensitivity is one of the most common symptoms in patients with post-inflammatory-irritable bowel syndrome (PI-IBS). Enterochromaffin (EC) cells and 5-hydroxytryptamine (5-HT) are important in the development of visceral hyperalgesia, and EC cells are influenced by helper T-cell subtype 1 or 2 cytokine predominant environments. In the present study, the ... Read more >>

Exp Ther Med (Experimental and therapeutic medicine)
[2017, 14(5):4476-4482]

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A novel quinazoline-based analog induces G2/M cell cycle arrest and apoptosis in human A549 lung cancer cells via a ROS-dependent mechanism.

Hailong Shi, Yan Li, Xiaorong Ren, Yaohong Zhang, Zhen Yang, Chenze Qi,

6-amino-4-(4-phenoxyphenylethylamino)quinazoline (QNZ) is an excellent quinazoline-containing NF-κB inhibitor also acting as a novel anticancer agent. Considering both the medicinal significance of quinazoline scaffold and the tunable functionality of Michael acceptor-centric pharmacophores in the electrophilicity-based prooxidant strategy, we designed a novel QNZ-inspired electrophilic molecule QNZ-A by introducing a Michael acceptor unit ... Read more >>

Biochem Biophys Res Commun (Biochemical and biophysical research communications)
[2017, 486(2):314-320]

Cited: 6 times

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FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion.

Shuang Wang, Daqi Zhao, Ruihua Tian, Hailong Shi, Xiangming Chen, Wenzhi Liu, Lin Wei,

Gastric cancer is the fourth most common type of cancer and second leading cause of cancer-related death in the world. Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in ... Read more >>

Oncol Res (Oncology research)
[2016, 23(4):197-203]

Cited: 2 times

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Capecitabine metronomic chemotherapy inhibits the proliferation of gastric cancer cells through anti-angiogenesis.

Fei Yuan, Hailong Shi, Jun Ji, Qu Cai, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang,

To evaluate the inhibitory effect and mechanism of capecitabine metronomic chemotherapy on gastric cancer cells. In vitro, the effects of 5-fluorouracil (Fu) metronomic chemotherapy on proliferation, apoptosis, tube formation ability, and angiogenesis were detected. In vivo, Ki-67, CD34 and VEGF were detected by immunohistochemical staining (IHC). Flow cytometry was used ... Read more >>

Oncol Rep (Oncology reports)
[2015, 33(4):1753-1762]

Cited: 12 times

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KRAS and DAXX/ATRX gene mutations are correlated with the clinicopathological features, advanced diseases, and poor prognosis in Chinese patients with pancreatic neuroendocrine tumors.

Fei Yuan, Min Shi, Jun Ji, Hailong Shi, Chenfei Zhou, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang,

<h4>Background and aim</h4>Pancreatic neuroendocrine tumor (pNET) is a clinically rare and heterogeneous group of tumors; its pharmacogenetic characteristics are not fully understood. This study was designed to examine the relationship between key gene variations and disease development and prognosis among Chinese patients with pNET.<h4>Methods</h4>Various pNET associated genes such as DAXX/ATRX, ... Read more >>

Int J Biol Sci (International journal of biological sciences)
[2014, 10(9):957-965]

Cited: 27 times

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Cetuximab inhibits gastric cancer growth in vivo, independent of KRAS status.

Min Shi, Hailong Shi, Jun Ji, Qu Cai, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang,

Mutation status of Kirsten rat sarcoma viral oncogene homolog (KRAS) may serve as a negative predictive marker of Cetuximab in treating colorectal cancer. The present study was to determine the role of KRAS status in EGFR antibody treatment for gastric cancer. KRAS status was clarified in SGC-7901 (wild type) and ... Read more >>

Curr Cancer Drug Targets (Current cancer drug targets)
[2014, 14(2):217-224]

Cited: 6 times

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Anti-angiogenesis participates in antitumor effects of metronomic capecitabine on colon cancer.

Hailong Shi, Jinling Jiang, Jun Ji, Min Shi, Qu Cai, Xuehua Chen, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang,

Inhibitory effects and potential mechanisms of capecitabine metronomic chemotherapy on colon cancer were investigated in this study. Metronomic chemotherapy with fluorouracil or capecitabine inhibited proliferation of colon cancer cells both in vitro and in vivo. Capecitabine metronomic chemotherapy demonstrated equal effects as CTX metronomic chemotherapy. Metronomic capecitabine or CTX chemotherapy ... Read more >>

Cancer Lett (Cancer letters)
[2014, 349(2):128-135]

Cited: 14 times

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Synergistic antitumor effects of dasatinib and oxaliplatin in gastric cancer cells.

Min Shi, Bingxiang Lou, Jun Ji, Hailong Shi, Chenfei Zhou, Yingyan Yu, Bingya Liu, Zhenggang Zhu, Jun Zhang,

<h4>Purpose</h4>The aim of this study is to investigate whether dasatinib, a Src inhibitor, has the synergistic effect with oxaliplatin in treating gastric cancer cells.<h4>Methods</h4>The baseline levels of total Src and p-Src in 10 human gastric cancer cell lines and gastric mucosa epithelial cell line GES-1 were detected by Western blot ... Read more >>

Cancer Chemother Pharmacol (Cancer chemotherapy and pharmacology)
[2013, 72(1):35-44]

Cited: 4 times

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Reliability and accuracy of interview data in non-smoking female lung cancer case-control study.

Desheng Huang, Peng Guan, Hailong Shi, Qincheng He, Baosen Zhou,

<h4>Background</h4>Valid interview data is critical to the final results of the study. The purpose of this study was to investigate the reliability of epidemiological data obtained in non-smoking female lung cancer case-control study in China.<h4>Methods</h4>Fifty-six pairs of cases and controls, 10% percent of all the collected subjects were re-interviewed by ... Read more >>

J Exp Clin Cancer Res (Journal of experimental & clinical cancer research : CR)
[2008, 27:43]

Cited: 1 time

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[Study on risk factors of lung cancer in non-smoking women].

Hailong Shi, Qincheng He, Xiaochun Dai, Baosen Zhou,

<h4>Background</h4>Lung cancer is a serious health problem in public. Its morbidity and mortality have been increasing rapidly. The mortality of lung cancer in women also increases year by year, in which most of the cases are non-smoking women, and the risk factors still are unclear. The aim of this study ... Read more >>

Zhongguo Fei Ai Za Zhi (Zhongguo fei ai za zhi = Chinese journal of lung cancer)
[2005, 8(4):279-282]

Cited: 2 times

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