Full Text Journal Articles by
Author Hailong Huang

Advertisement

Find full text journal articles






Chromosomal Microarray Analysis of Fetuses with Nasal Bone Anomaly

Xiaorui Xie, Xiaoqing Wu, Linjuan Su, Meiying Cai, Ying Li, Hailong Huang, Liangpu Xu,

Abstract Objective: To explore the significance and value of fetal nasal bone anomaly (absence or hypoplasia) as indications of prenatal diagnosis. Methods: A total of 102 fetuses diagnosed with nasal bone absence or hypoplasia by ultrasonography underwent chorionic, amniotic, or umbilical cord blood puncture. Single nucleotide polymorphism microarray (SNP-array) was ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



CD31 and D2-40 Contribute to Peritoneal Metastasis of Colorectal Cancer by Promoting Epithelial-Mesenchymal Transition.

Xinqiang Zhu, Gang Zhou, Peng Ni, Xuetong Jiang, Hailong Huang, Jianqiang Wu, Xiaohong Shi, Xiaoling Jiang, Jianing Liu,

Background/Aims:Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. Methods:The expression profiles of CD31 and D2-40 were analyzed in CRC patients with ... Read more >>

Gut Liver (Gut and liver)
[2020, :]

Cited: 0 times

View full text PDF listing >>



Advertisement

Prenatal diagnosis and pregnancy outcomes of 1492 fetuses with congenital heart disease: role of multidisciplinary-joint consultation in prenatal diagnosis.

Xiuqing Qiu, Zongjie Weng, Min Liu, Xiujuan Chen, Qiumei Wu, Wen Ling, Hong Ma, Hailong Huang, Yuan Lin,

Early diagnosis of congenital heart disease (CHD) can improve the prognosis of neonates with CHD. We retrospectively evaluated the value of prenatal diagnosis of CHD by comparing the pregnancy outcomes. Prenatal diagnosis of CHD was established by echocardiographic evaluation of fetal heart. Amniotic fluid and/or cord blood genetic examination, pathological ... Read more >>

Sci Rep (Scientific reports)
[2020, 10(1):7564]

Cited: 0 times

View full text PDF listing >>



Cooperative deformation in high-entropy alloys at ultralow temperatures.

Muhammad Naeem, Haiyan He, Fan Zhang, Hailong Huang, Stefanus Harjo, Takuro Kawasaki, Bing Wang, Si Lan, Zhenduo Wu, Feng Wang, Yuan Wu, Zhaoping Lu, Zhongwu Zhang, Chain T Liu, Xun-Li Wang,

High-entropy alloys exhibit exceptional mechanical properties at cryogenic temperatures, due to the activation of twinning in addition to dislocation slip. The coexistence of multiple deformation pathways raises an important question regarding how individual deformation mechanisms compete or synergize during plastic deformation. Using in situ neutron diffraction, we demonstrate the interaction ... Read more >>

Sci Adv (Science advances)
[2020, 6(13):eaax4002]

Cited: 0 times

View full text PDF listing >>



Complex Interaction of Hb Q-Thailand with α and β Thalassemia in a Hakka Family

Lin Zheng, Hailong Huang, Xiaoqing Wu, Qingmei Shen, Meihuan Chen, Meiying Wang, Linjuan Su, Liangpu Xu,

Abstract Background HbQ-Thailand is an α-globin chain variant that results from a point mutation at codon 74 of the α1-globin gene on chromosome 16p. It commonly appears with a leftward single α-globin gene deletion (-α 4.2 ). There have been few reports regarding the interaction between HbQ-Thailand and other globin ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



Copy number variations associated with fetal congenital kidney malformations.

Meiying Cai, Na Lin, Linjuan Su, Xiaoqing Wu, Xiaorui Xie, Ying Li, Xuemei Chen, Yuan Lin, Hailong Huang, Liangpu Xu,

Background:Congenital anomalies of the kidney and urinary tract (CAKUT) constitute 20-30% of all congenital malformations. Within the CAKUT phenotypic spectrum, renal hypodysplasia (RHD) is particularly severe. This study aimed to evaluate the applicability of single-nucleotide polymorphism (SNP) array test in prenatal diagnosis of RHD for improving prenatal genetic counseling and ... Read more >>

Mol Cytogenet (Molecular cytogenetics)
[2020, 13:11]

Cited: 0 times

View full text PDF listing >>



Antiviral effect of copper chloride on feline calicivirus and Synergy with Ribavirin in vitro

Dengliang Li, Zhanding Cui, Guohua Li, Liangting Zhang, Ying Zhang, Han Zhao, Shuang Zhang, Yanbing Guo, Yanli Zhao, Fanxing Men, Shihui Zhao, Jiang Shao, Dongju Du, Hailong Huang, Kai Wang, Guixue Hu, Tiansong Li, Yongkun Zhao,

Abstract Background: Feline calicivirus (FCV) is a common pathogen causing widely prevalent upper respiratory disease for kitten and felines in recent years. Due to the substantial genetic variability of the viral genes, existing vaccines cannot provide complete protection. Therefore, researches on FCV antiviral drugs have received much attention. Results: In ... Read more >>

()
[, :]

Cited: 0 times

View full text PDF listing >>



X-linked ichthyosis: Molecular findings in four pedigrees with inconspicuous clinical manifestations.

Min Zhang, Hailong Huang, Na Lin, Shuqiong He, Gang An, Yan Wang, Meihuan Chen, Lingji Chen, Yuan Lin, Liangpu Xu,

BACKGROUND:X-linked ichthyosis (XLI) is the second most common type of ichthyosis, which is characterized by wide and symmetric distribution of adherent, dry, and polygonal scales on the skin. Steroid sulfatase (STS) gene, which is located at chromosome Xp22.31, has been identified as the pathogenic gene of XLI. METHODS:In this study, ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(5):e23201]

Cited: 0 times

View full text PDF listing >>



Development of a cross-priming isothermal amplification assay based on the glycoprotein B gene for instant and rapid detection of feline herpesvirus type 1.

Yuxin Tan, Guoying Dong, Hefeng Xu, Jiangting Niu, Wei Lu, Kai Wang, Hao Dong, Shuang Zhang, Hailong Huang, Guixue Hu,

A cross-priming isothermal amplification (CPA) assay was developed for detection of feline herpesvirus type 1 (FHV-1). In this assay, the target fragment of the FHV-1 glycoprotein B gene is amplified rapidly by Bst DNA polymerase at a constant temperature (63 °C, 45 min), using a simple thermostat. The assay had no ... Read more >>

Arch. Virol. (Archives of virology)
[2020, 165(3):743-747]

Cited: 0 times

View full text PDF listing >>



A Novel Chemoenzymatic Approach to Produce Cilengitide Using the Thioesterase Domain from Microcystis aeruginosa Microcystin Synthetase C.

Longliang Qiao, Jian Fang, Peng Zhu, Hailong Huang, Chenyang Dang, Jianhu Pang, Weifang Gao, Xiaoting Qiu, Lili Huang, Yanrong Li,

Modern organic chemistry faces many difficulties in the reliable production of cyclopeptides, such as poor yields and insufficient regio- and stereoselectivity. Thioesterase (TE) shows impressive stereospecificity, region- and chemoselectivity during the cyclization of peptide substrates. The biocatalytic properties of TE provide high value for industrial applications. Herein, a novel chemoenzymatic ... Read more >>

Protein J. (The protein journal)
[2019, 38(6):658-666]

Cited: 0 times

View full text PDF listing >>



Helical poly(phenyl isocyanide)s grafted selectively on C-6 of cellulose for improved chiral recognition ability.

Hao Qian, Xiaofei Shen, Hailong Huang, Yan Zhang, Mingtao Zhang, Huiqing Wang, Zhongkai Wang,

Cellulose graft copolymers are an effective way to endow new properties to cellulose substrate, as well the rigidity, regularity, and helicity of the cellulose backbone could induce the self-assembly of supramolecular structures. In this work, right-handed helical poly(phenyl isocyanide)s (PPIn) were grafted selectively onto C-6-cellulose. Alkyne-terminated PPIn was synthesized by ... Read more >>

Carbohydr Polym (Carbohydrate polymers)
[2020, 231:115737]

Cited: 0 times

View full text PDF listing >>



Chromosomal microarray analysis for pregnancies with or without ultrasound abnormalities in women of advanced maternal age.

Xiaoqing Wu, Gang An, Xiaorui Xie, Linjuan Su, Meiying Cai, Xuemei Chen, Ying Li, Na Lin, Deqin He, Meiying Wang, Hailong Huang, Liangpu Xu,

BACKGROUND:Chromosomal microarray analysis (CMA) has been suggested to be routinely conducted for fetuses with ultrasound abnormalities (UA), especially with ultrasound structural anomalies (USA). Whether to routinely offer CMA to women of advanced maternal age (AMA) without UA when undergoing invasive prenatal testing is inconclusive. OBJECTIVE:This study aimed to evaluate the ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(4):e23117]

Cited: 0 times

View full text PDF listing >>



Fucoidan exerts antidepressant-like effects in mice via regulating the stability of surface AMPARs.

Mingxing Li, Xuejiao Sun, Qian Li, Yong Li, Can Luo, Hailong Huang, Jing Chen, Chenzi Gong, Yajie Li, Yifeng Zheng, Song Zhang, Xiaolin Huang, Hong Chen,

The inflammatory hypothesis is one of the most important mechanisms of depression. Fucoidan is a bioactive sulfated polysaccharide abundant in brown seaweeds with anti-inflammatory activity. However, the antidepressant effects of fucoidan on chronic stress-induced depressive-like behaviors have not been well elucidated. Here, we used two different depressive-like mouse models, lipopolysaccharide ... Read more >>

Biochem. Biophys. Res. Commun. (Biochemical and biophysical research communications)
[2020, 521(2):318-325]

Cited: 0 times

View full text PDF listing >>



Detection of copy number disorders associated with congenital anomalies of the kidney and urinary tract in fetuses via single nucleotide polymorphism arrays.

Meiying Cai, Na Lin, Linjuan Su, Xiaoqing Wu, Xiaorui Xie, Ying Li, Xuemei Chen, Yifang Dai, Yuan Lin, Hailong Huang, Liangpu Xu,

BACKGROUND:While congenital anomalies of the kidney and urinary tract (CAKUT) constitute one-third of all congenital malformations, the mechanisms underlying their development are poorly understood. Some studies have reported an association between CAKUT and copy number variations (CNVs) in children and adults, but few have focused on chromosomal microarray analysis (CMA) ... Read more >>

J. Clin. Lab. Anal. (Journal of clinical laboratory analysis)
[2020, 34(1):e23025]

Cited: 0 times

View full text PDF listing >>



Development and application of a multiplex PCR method for the simultaneous detection and differentiation of feline panleukopenia virus, feline bocavirus, and feline astrovirus.

Qian Zhang, Jiangting Niu, Shushuai Yi, Guoying Dong, Dejing Yu, Yanbing Guo, Hailong Huang, Guixue Hu,

A multiplex polymerase chain reaction (mPCR) assay was developed to detect and distinguish feline panleukopenia virus (FPV), feline bocavirus (FBoV) and feline astrovirus (FeAstV). Three pairs of primers were designed based on conserved regions in the genomic sequences of the three viruses and were used to specifically amplify targeted fragments ... Read more >>

Arch. Virol. (Archives of virology)
[2019, 164(11):2761-2768]

Cited: 0 times

View full text PDF listing >>



Submicroscopic aberrations of chromosome 16 in prenatal diagnosis.

Xiaoqing Wu, Liangpu Xu, Ying Li, Na Lin, Linjuan Su, Meiying Cai, Xiaorui Xie, Lin Zheng, Hailong Huang, Yuan Lin,

Background:Nearly 9.89% of chromosome 16 consists of segmental duplications, which makes it prone to non-homologous recombination. The present study aimed to investigate the incidence and perinatal characteristics of submicroscopic chromosome 16 aberrations in prenatal diagnosis. Results:A total of 2,414 consecutive fetuses that underwent prenatal chromosomal microarray analysis (CMA) between January ... Read more >>

Mol Cytogenet (Molecular cytogenetics)
[2019, 12:36]

Cited: 0 times

View full text PDF listing >>



Frequencies and hematological manifestations of the HKαα allele in southern Chinese population.

Min Zhang, Hailong Huang, Meihuan Chen, Lingji Chen, Yan Wang, Na Lin, Yuan Lin, Liangpu Xu,

INTRODUCTION:The HKαα (Hong Kong αα) allele containing both the -α3.7 and αααanti4.2 is an unusual rearrangement of the α globin gene cluster. Currently, αααanti4.2 fragments cannot be detected through the routine thalassemia diagnostic kit. The genotype of -α3.7/αα, HKαα/-α3.7 and HKαα/αα is entirely the result of -α3.7/αα by the gap-polymerase ... Read more >>

Int J Clin Exp Pathol (International journal of clinical and experimental pathology)
[2019, 12(8):3058-3062]

Cited: 0 times

View full text PDF listing >>



Identification of a novel pre-terminating mutation in human HBB gene as a cause of β0-thalassemia phenotype.

Liangpu Xu, Meihuan Chen, Hailong Huang, Na Lin, Lingji Chen, Yan Wang, Min Zhang, Deqin He, Yuan Lin,

Beta (β)-thalassemia (thal) is one of the most common genetic disorders of hemoglobin synthesis worldwide. Most cases of β-thal are caused by point mutations in hemoglobin subunit beta (HBB) gene, and only a minority of cases are caused by missing mutations of HBB gene. In this study, a 31-year-old pregnant ... Read more >>

Int J Clin Exp Pathol (International journal of clinical and experimental pathology)
[2019, 12(8):3070-3076]

Cited: 0 times

View full text PDF listing >>



[Analysis of hematological phenotype and genotype of Hb Q-Thailand in Fujian area].

Lingji Chen, Meihuan Chen, Min Zhang, Yan Wang, Hailong Huang, Ying Li, Liangpu Xu,

OBJECTIVE:To explore the hematological phenotype and genotype of hemoglobin Q-Thailand in Fujian area. METHODS:Genomic DNA was extracted from peripheral venous blood samples of patients. Suspected samples were screened by hematological parameters analysis and verified with DNA sequencing. RESULTS:In 35 patients suspected with Hb Q-Thailand, 20 were confirmed, which included one ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2019, 36(8):761-764]

Cited: 0 times

View full text PDF listing >>



Systematic profiling of clinical missence mutation effects on the intermolecular interaction between human growth hormone and its receptor in isolated growth hormone deficiency.

Hui Liu, Liangpu Xu, Hailong Huang, Peiran Zhao, Rongrong Yang, Qing Zhou, Guanghua Liu,

Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and can result from congenital or acquired causes. Among the known factors, genetic mutations in human growth hormone (hGH) remain the most frequent cause of IGHD, which influence the binding of hGH to its cognate receptor (hGHbp). Although ... Read more >>

J. Mol. Graph. Model. (Journal of molecular graphics & modelling)
[2019, 92:1-7]

Cited: 0 times

View full text PDF listing >>



Clinical application of chromosomal microarray analysis in fetuses with increased nuchal translucency and normal karyotype.

Linjuan Su, Hailong Huang, Gang An, Meiying Cai, Xiaoqing Wu, Ying Li, Xiaorui Xie, Yuan Lin, Meiying Wang, Liangpu Xu,

BACKGROUND:Submicroscopic chromosomal imbalance is associated with an increased nuchal translucency (NT). Most previous research has recommended the use of chromosomal microarray analysis (CMA) for prenatal diagnosis if the NT ≥ 3.5 mm. However, there is no current global consensus on the cutoff value for CMA. In this study, we aimed to discuss the ... Read more >>

Mol Genet Genomic Med (Molecular genetics & genomic medicine)
[2019, 7(8):e811]

Cited: 1 time

View full text PDF listing >>



Increased expression of methionine sulfoxide reductases B3 is associated with poor prognosis in gastric cancer.

Xiaoming Ma, Jian Wang, Mingzuo Zhao, Hailong Huang, Jianqiang Wu,

The present study aimed to investigate the expression of methionine sulfoxide reductases B3 (MSRB3) in gastric cancer (GC) and its clinical significance. A total of 90 specimens from patients with GC were collected to evaluate MSRB3 protein expression by immunohistochemical staining. The associations between MSRB3 protein expression, clinicopathological characteristics and ... Read more >>

Oncol Lett (Oncology letters)
[2019, 18(1):465-471]

Cited: 0 times

View full text PDF listing >>



[Prenatal diagnosis and clinical analysis of two fetuses with Cat-eye syndrome].

Xiaoqing Wu, Gang An, Deqin He, Qingmei Shen, Meiying Cai, Hailong Huang, Yuan Lin, Liangpu Xu,

OBJECTIVE:To determine the origin of supernumerary small marker chromosomes (sSMCs) carried by two fetuses. METHODS:Single nucleotide polymorphism array (SNP-array) and fluorescence in situ hybridization (FISH) analysis were carried out on cells cultured from the amniotic fluid samples. RESULTS:SNP-array analysis showed both fetuses to be arr[hg19]22q11.1q11.21(16 888 899-18 649 190)×4, with ... Read more >>

Zhonghua Yi Xue Yi Chuan Xue Za Zhi (Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics)
[2019, 36(5):498-501]

Cited: 0 times

View full text PDF listing >>



The long-term outcome of trabeculotomy: comparison with filtering surgery in Japan.

Wenjun Bao, Kazuhide Kawase, Hailong Huang, Akira Sawada, Tetsuya Yamamoto,

BACKGROUND:To investigate the long-term outcome of trabeculotomy and to compare it with that of trabeculectomy. METHODS:We retrospectively reviewed the medical records of patients who had undergone standalone trabeculotomy. Inclusion criteria included a follow-up period of at least 6 years, availability of reliable static visual field results, etc. Age- and preoperative intraocular ... Read more >>

BMC Ophthalmol (BMC ophthalmology)
[2019, 19(1):99]

Cited: 0 times

View full text PDF listing >>



Critical light-related gene expression varies in two different strains of the dinoflagellate Karlodinium veneficum in response to the light spectrum and light intensity.

Ran Meng, Chengxu Zhou, Xiaojuan Zhu, Hailong Huang, Jilin Xu, Qijun Luo, Xiaojun Yan,

The toxic dinoflagellate Karlodinium veneficum is widely distributed in cosmopolitan estuaries and is responsible for massive fish mortality worldwide. Intraspecific biodiversity is important for the spread to various habitats, interspecific competition to dominate a population, and bloom formation and density maintenance. Strategies for light adaptation may help determine the ecological ... Read more >>

J. Photochem. Photobiol. B, Biol. (Journal of photochemistry and photobiology. B, Biology)
[2019, 194:76-83]

Cited: 0 times

View full text PDF listing >>



Advertisement

Disclaimer
1.0338 s