Full Text Journal Articles by
Author Hailin Song

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Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.

Dingsheng Zhao, Guohui Zhong, Jianwei Li, Junjie Pan, Yinlong Zhao, Hailin Song, Weijia Sun, Xiaoyan Jin, Yuheng Li, Ruikai Du, Jielin Nie, Tong Liu, Junmeng Zheng, Yixin Jia, Zifan Liu, Wei Liu, Xinxin Yuan, Zizhong Liu, Jinping Song, Guanghan Kan, Youyou Li, Caizhi Liu, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li, Shukuan Ling,

<h4>Background</h4>Without adequate treatment, pathological cardiac hypertrophy induced by sustained pressure overload eventually leads to heart failure. WWP1 (WW domain-containing E3 ubiquitin protein ligase 1) is an important regulator of aging-related pathologies, including cancer and cardiovascular diseases. However, the role of WWP1 in pressure overload-induced cardiac remodeling and heart failure is ... Read more >>

Circulation (Circulation)
[2021, 144(9):694-711]

Cited: 2 times

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Combination of canstatin and arsenic trioxide suppresses the development of hepatocellular carcinoma.

Fan Zhang, Jingjing Duan, Hailin Song, Li Yang, Ming Zhou, Xuewen Wang,

Complication of arsenic trioxide (ATO) and other drugs in cancer treatment has attracted much focus, but is limitedly investigated in hepatocellular carcinoma (HCC). This study aimed to explore the role of ATO combined with canstatin in HCC. HepG2 cells were treated with different concentrations of ATO with or without canstatin, ... Read more >>

Drug Dev Res (Drug development research)
[2021, 82(3):430-439]

Cited: 0 times

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Circulating microRNAs Correlated with Bone Loss Induced by 45 Days of Bed Rest.

Shukuan Ling, Guohui Zhong, Weijia Sun, Fengji Liang, Feng Wu, Hongxing Li, Yuheng Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Xiaorui Wu, Hailin Song, Qi Li, Yinghui Li, Shanguang Chen, Jianghui Xiong, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with bone loss induced by bed rest, and testify whether the selected miRNAs could reflect the bone mineral status of human after bed-rest. We analyzed plasma miRNA levels of 16 subjects after 45 days of -6° head-down ... Read more >>

Front Physiol (Frontiers in physiology)
[2017, 8:69]

Cited: 5 times

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The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.

Zi Xu, Weijia Sun, Yuheng Li, Shukuan Ling, Chenyang Zhao, Guohui Zhong, Dingsheng Zhao, Jinping Song, Hailin Song, Jinqiao Li, Linhao You, Guangjun Nie, Yanzhong Chang, Yingxian Li,

Iron overload inhibits osteoblast function and promotes osteoclastogenesis. Hepcidin plays an important role in this process. The changes in iron content and the regulation of hepcidin under unloading-induced bone loss remain unknown. A hindlimb suspension model was adopted to simulate unloading-induced bone loss in mice. The results showed that iron ... Read more >>

Bone (Bone)
[2017, 94:152-161]

Cited: 16 times

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Simulated Microgravity and Recovery-Induced Remodeling of the Left and Right Ventricle.

Guohui Zhong, Yuheng Li, Hongxing Li, Weijia Sun, Dengchao Cao, Jianwei Li, Dingsheng Zhao, Jinping Song, Xiaoyan Jin, Hailin Song, Xinxin Yuan, Xiaorui Wu, Qi Li, Qing Xu, Guanghan Kan, Hongqing Cao, Shukuan Ling, Yingxian Li,

Physiological adaptations to microgravity involve alterations in cardiovascular systems. These adaptations result in cardiac remodeling and orthostatic hypotension. However, the response of the left ventricle (LV) and right ventricle (RV) following hindlimb unloading (HU) and hindlimb reloading (HR) is not clear and the underlying mechanism remains to be understood. In ... Read more >>

Front Physiol (Frontiers in physiology)
[2016, 7:274]

Cited: 4 times

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Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients.

Wei Liu, Shukuan Ling, Weijia Sun, Tong Liu, Yuheng Li, Guohui Zhong, Dingsheng Zhao, Pengfei Zhang, Jinping Song, Xiaoyan Jin, Zi Xu, Hailin Song, Qi Li, Shujuan Liu, Meng Chai, Qinyi Dai, Yi He, Zhanming Fan, Yu Jie Zhou, Yingxian Li,

The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were ... Read more >>

Sci Rep (Scientific reports)
[2015, 5:16099]

Cited: 29 times

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